Category: 5471-63-6

Buchanan, Eric A.; Johnson, Justin C.; Tan, Melissa; Kaleta, Jiri; Shtukenberg, Alexander G.; Bateman, Gage; Benedict, Jason B.; Kobayashi, Shinjiro; Wen, Jin; Kahr, Bart; Cisarova, Ivana; Michl, Josef published their research in Journal of Physical Chemistry C in 2021. The article was titled 《Competing Singlet Fission and Excimer Formation in Solid Fluorinated 1,3-Diphenylisobenzofurans》.Recommanded Product: 5471-63-6 The article contains the following contents:

Singlet fission (kSF) and excimer formation (kEXC) rate constants along with other photophys. properties of thin solid layers of 1,3-diphenylisobenzofuran and 11 of its fluorinated derivatives have been determined The mol. properties of these compounds are similar, but their crystal packing varies widely. Most of them undergo singlet fission whereas excitation in others is trapped in excimers. The trend in rate constants kSF agrees qual. with results of calculations by a simplified version of the frontier orbital model for a mol. pair. The main shortcoming of the model is discussed. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant Staphylococcus aureus (MRSA)》 was written by Li, Juan; Gopal, Ashna; Karaosmanoglu, Sena; Lin, Jiafu; Munshi, Tasnim; Zhang, Wenjun; Chen, Xianfeng; Yan, Li. COA of Formula: C20H14OThis research focused onzeolitic imidazolate nanocomposite antibiotic methicillin resistant Staphylococcus; Antibacterial therapy; Photodynamic therapy; Photosensitizer; Zeolitic imidazolate framework 8. The article conveys some information:

Antibiotics have played an important role in the treatment of bacteria related infections. However, the rapid emergence of multidrug-resistant bacteria and limited number of antibiotics available is a great challenge to humankind. To address this problem, we are proposing a photosensitizer-modified biodegradable zeolitic imidazolate framework-8 nanocomposite that can kill not only Gram-pos. bacteria Staphylococcus aureus, but also methicillin-resistant Staphylococcus aureus (MRSA) with high efficacy. In vivo testing revealed that these nanocomposites are highly effective for in vivo wound disinfection with minimal side-effects. In conclusion, this photosensitizer-modified biodegradable nanocomposite could be very promising for a synergistic antibacterial therapy to overcome MRSA. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6COA of Formula: C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.COA of Formula: C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

SDS of cas: 5471-63-6In 2021 ,《Penetration of Singlet Oxygen into Films with Oxygen Permeability Coefficient Close to that of Skin》 was published in Photochemistry and Photobiology. The article was written by Harada, Nobuyuki; Kataoka, Mika; Nakanosho, Masahiro; Uyama, Hiroshi. The article contains the following contents:

Although its antiviral and antibacterial functions help prevent infection, singlet oxygen (1O2)-which is generated by the action of light on an endogenous photosensitizer-is cytotoxic. In the present study, we investigated the ability of 1O2-generated by the action of visible light on a photosensitizer-to penetrate skin. We used two polymer films with oxygen permeability coefficients similar to that of skin-i.e. cellulose acetate (CA) and Et cellulose (EC). Both films contained 1,3-diphenylisobenzofuran (DPBF), which was used as an 1O2 probe. 1O2 Generated externally did not permeate the films by mere contact. Therefore, we conclude that the potential for 1O2 to penetrate the skin is very low, and films that generate 1O2 are safe and useful for preventing infections by contact. We also proved that 1O2 can move between the layers of integrated polymer films when they are joined together.1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Synthetic Route of C20H14OIn 2021 ,《Photodynamic treatment of colorectal cancer using chlorin e6-loaded poly(lactide-co-glycolide)-based nanoparticles》 appeared in Journal of Biomedical Nanotechnology. The author of the article were Lin, Beibei; Xu, Xuegu; Zhang, Xiaobi; Yu, Yinfei; Wang, Xiaoling. The article conveys some information:

We prepared poly(lactide-co-glycolide) (PLGA) encapsulated with chlorin e6 (Ce6) in an effort to increase the stability and efficiency of photosensitizers for photodynamic therapy (PDT). We determined that Ce6-loaded PLGA nanoparticles (PLGA-Ce6 NPs) had drug-loading efficiency of 5%. The efficiency of encapsulation was 82%, the zeta potential was-25 mV, and the average diameter was 130 nm. The encapsulation of Ce6 in PLGA nanoparticles showed excellent stability. The nanoparticles exhibited sustained Ce6 release profiles with 50% released at the end of 3 days, whereas free Ce6 showed rapid release within 1 day. Ce6 release patterns were controlled by encapsulation into PLGA. The uptake of PLGA-Ce6 NPs was significantly enhanced by endocytosis in the first 8 h in the HCT-116 cell line. An intracellular reactive oxygen species assay revealed the enhanced uptake of the nanoparticles. An in vitro anti-tumor activity assay showed that the PLGA-Ce6 NPs exhibited enhanced phototoxicity toward HCT-116 cells and a slightly lower IC50 value in HCT-116 cells than Ce6 solution alone. Exposure of HCT-116 cell spheroids to PLGA-Ce6 NPs penetrated more profoundly and had better phototoxicity than pure drugs. These findings suggest that PLGA-Ce6 NPs might serve as PDT for colorectal cancer. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Synthetic Route of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Synthetic Route of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Harada, Nobuyuki; Masuda, Kiyoshi; Nakamura, Jun-ich; Uyama, Hiroshi published their research in Polymer Journal (Tokyo, Japan) in 2021. The article was titled 《Fabrication and evaluation of durable, optically clear, and self-disinfecting films》.Name: 1,3-Diphenylisobenzofuran The article contains the following contents:

Phenoxy-substituted phthalocyanine zinc (PPcZn) was synthesized and used as a photosensitizer to prepare a variety of self-disinfecting films by incorporating it into a cellulose acetate (CA) film at various concentrations The generation of singlet oxygen (1O2) from the films containing PPcZn irradiated with visible light was detected by a film containing 1,3-diphenylisobenzofuran (DPBF). The rate of 1O2 generation followed a pseudofirst-order kinetic model. Antiviral activity was confirmed under visible light irradiation using Bacteriophage Qβ. The film exhibited superior water resistance, photostability, mech. strength, and sustained 1O2 production over 6 mo under continuous exposure to room light. These data show the promise of this film in real-life applications as self-disinfecting surfaces. In addition to this study using 1,3-Diphenylisobenzofuran, there are many other studies that have used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Name: 1,3-Diphenylisobenzofuran) was used in this study.

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Name: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Romero, Maria P; Buzza, Hilde H; Stringasci, Mirian D; Estevão, Bianca M; Silva, Cecilia C C; Pereira-da-Silva, Marcelo A; Inada, Natalia M; Bagnato, Vanderlei S published their research in International journal of nanomedicine in 2021. The article was titled 《Graphene Oxide Theranostic Effect: Conjugation of Photothermal and Photodynamic Therapies Based on an in vivo Demonstration.》.Application of 5471-63-6 The article contains the following contents:

INTRODUCTION: Cancer is the second leading cause of death globally and is responsible, where about 1 in 6 deaths in the world. Therefore, there is a need to develop effective antitumor agents that are targeted only to the specific site of the tumor to improve the efficiency of cancer diagnosis and treatment and, consequently, limit the unwanted systemic side effects currently obtained by the use of chemotherapeutic agents. In this context, due to its unique physical and chemical properties of graphene oxide (GO), it has attracted interest in biomedicine for cancer therapy. METHODS: In this study, we report the in vivo application of nanocomposites based on Graphene Oxide (nc-GO) with surface modified with PEG-folic acid, Rhodamine B and Indocyanine Green. In addition to displaying red fluorescence spectra Rhodamine B as the fluorescent label), in vivo experiments were performed using nc-GO to apply Photodynamic Therapy (PDT) and Photothermal Therapy (PTT) in the treatment of Ehrlich tumors in mice using NIR light (808 nm 1.8 W/cm2). RESULTS: This study based on fluorescence images was performed in the tumor in order to obtain the highest concentration of nc-GO in the tumor as a function of time (time after intraperitoneal injection). The time obtained was used for the efficient treatment of the tumor by PDT/PTT. DISCUSSION: The current study shows an example of successful using nc-GO nanocomposites as a theranostic nanomedicine to perform simultaneously in vivo fluorescence diagnostic as well as combined PDT-PTT effects for cancer treatments. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wang, Xiao-Hui; Wei, Xiao-Fei; Liu, Jin-Hua; Yang, Wei; Liu, Yuan-An; Cheng, Kun; He, Xiao-Ying; Fu, Xiu-Li; Zhang, Yu; Zhang, Hong-Xin published an article in 2021. The article was titled 《Chlorin e6-1,3-diphenylisobenzofuran polymer hybrid nanoparticles for singlet oxygen-detection photodynamic abaltion》, and you may find the article in Methods and Applications in Fluorescence.Recommanded Product: 5471-63-6 The information in the text is summarized as follows:

Adual-functional nanosysterm is developed by means of Chlorin e6 (Ce6) as photosensitizer and 1,3- Diphenylisobenzofuran (DPBF) as fluorescent singlet oxygen (1O2) probe. Under 660 nmlaser irradation, Ce6 exhibites efficient 1O2 generation, and subsequently the production of 1O2 is assessed by the ratiometric fluorescence of PFO and DPBF under one-photon and two-photon excitation mode. The nanoparticles with excellent biocompatibility can be internalized into Hela cells and applied for tumor treatment. For intracellular PDT, the nanoparticles perform a high phototoxicity, while the PDT proccess can be evaluated in time by monitoring fluorescence signals of DPBF. This theranostic nanosysterm provides a facile strategy to fabricate 1O2-detection PDT, which can realize accurate and efficient photodynamic therapy based on singlet oxygen detection. In the part of experimental materials, we found many familiar compounds, such as 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Gold nanoshells coated 5-aminolevulinic liposomes for photothermal-photodynamic antitumor therapy》 was written by Jiang, Yifei; Liu, Yang; Fang, Siyuan; Ji, Min. SDS of cas: 5471-63-6 And the article was included in Journal of Nanoscience and Nanotechnology in 2020. The article conveys some information:

In this study, a novel antitumor system was designed on the basis of photodynamic therapy and photothermal therapy using gold nanoshells coated 5-aminolevulinic acid (5-ALA) liposomes (GNALs). As a widely used photosensitizer prodrug, 5-aminolevulinic acid (5-ALA)-derived protoporphyrin IX (PpIX) can accumulate to a higher level in tumors than in normal tissues. Protoporphyrin IX (PpIX) initiates a series of cytotoxic reactions after irradiation of target tissue with a measured dose of light with appropriate wavelength, which may be dependent on the generation of reactive oxygen species. Gold nanoshells can strongly absorb NIR lasers at the same time, and can generate hyperthermia to provide photothermic effects. Gold nanoshells coated 5-ALA-Liposomes (GNALs) exhibit a uniform-sized spherical shape of 185.8±0.91 nm, with a zeta potential of 33±1.6 mV. Liposomes with specific sizes ranging from 100 to 200 nm can escape into the tumor interstitial tissue and accumulate preferentially in tumor tissue owing to the EPR effect. In addition, NIR light-excited nanosystems significantly promoted antitumor effects in this study compared to single photodynamic therapy. It was also found that the increased temperature promoted inhibition rate of SKOV3 cells. The novel drug delivery system shows great potential in photothermal-photodynamic antitumor therapy. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《A bacteria-triggered wearable colorimetric band-aid for real-time monitoring and treating of wound healing》 was written by Dong, Mengna; Sun, Xinyu; Li, Lihua; He, Kunyi; Wang, Jiao; Zhang, Hui; Wang, Li. Computed Properties of C20H14OThis research focused onwearable colorimetric band aid wound healing bacterial infection; Film-based band-aid; PDT/PTT; Wearable; Wound healing; pH-sensing. The article conveys some information:

Early diagnosis of bacterial infection and tracking of treatment effect are of great importance for developing a “”sense-and-treat”” integrated system. Herein, we developed a bacteria-triggered, portable, wearable and colorimetric film-based band-aid (FBA) for closed-loop monitoring and light-controlled therapy of wound infection. FBA with high photothermal conversion efficiency of 52.56% was prepared by wrapping Bi2S3 nanoflowers (BS NFs) loaded with rhodium nanoparticles (Rh NPs) and bromothymol blue (BTB) into LB agar film, integrating bacteria-triggered color change, photothermal/photodynamic therapy (PTT/PDT) synergistic bactericidal therapy and agar-based band aid in one intelligent system. Initially, FBA effectively simulates the pH sensing mechanism, and monitors the occurrence of bacterial infections within 5 min through color changes of Staphylococcus aureus (S. aureus) from blue to yellow and Escherichia coli (E. coli) from yellow to blue. Addnl., the short-term and controlled antibacterial strategy of “”one light dual-mode responses”” (photothermal and photodynamic responses) was implemented with the introduce of near-IR (NIR). Ultimately, the effectiveness of FBA was fully validated in the monitoring and treating of S. aureus-infected mouse wounds. Notably, the designed FBA decisively abandoned off-target side effects maximizing the treatment effect and nakedly tracking therapeutic situation in real time, contributing an effective antibacterial alternative strategy for reducing the use of antibiotics. To the best of our knowledge, such integrated system is still unreported on film-fixed model. In view of the advantages of the low cost and convenience of the simple device, the integrated design is expected to provide a solution for the development of a closed-loop biomedical system combining diagnosis and treatment. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Computed Properties of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Computed Properties of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

In 2022,Wang, Ya-Ning; Zhang, Wen-Shu; Liu, Xiao-Peng; Wei, Yun-Yun; Xu, Zhang-Run published an article in Colloids and Surfaces, B: Biointerfaces. The title of the article was 《A nanohybrid of Prussian blue supported by boracic acid-modified g-C3N4 for Raman recognition of cell surface sialic acid and photothermal/photodynamic therapy》.SDS of cas: 5471-63-6 The author mentioned the following in the article:

Theranostic nanoplatforms with accurate diagnosis and effective therapy show a bright prospect for tumor treatments. Herein, a novel boracic acid-modified graphite carbon nitride and Prussian blue nanohybrid (PB@B-g-3N4) was developed, which provides sialic acid-targeted Raman recognition and synergistic photothermal/photodynamic therapy in the near-IR region. Owing to the specific interaction between boracic acid and sialic acid and Raman response at 2157 cm-1 of PB, the nanohybrids exhibit high specificity and Raman sensitivity for detection of the overexpressed sialic acid on tumor cells. Moreover, the photothermal conversion efficiency of PB@B-g-3N4 is as high as 47.0% with 808 nm laser irradiation due to the enhanced absorbance of PB@B-g-3N4. PB@B-g-3N4 also possesses excellent photodynamic activity, which is attributed to the energy transfer of PB (type I) and electron transfer between PB and B-g-3N4 (type II). This nanotheranostic agent for Raman recognition of cancer markers and synergistic photothermal/photodynamic therapy holds great potential for the development of efficient theranostic nanoplatforms. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6SDS of cas: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.SDS of cas: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem