Category: 5471-63-6

Safety of 1,3-DiphenylisobenzofuranIn 2022 ,《Singlet oxygen formation from photoexcited P3HT:PCBM films applied in oxidation reactions》 appeared in Materials Advances. The author of the article were Nyga, Aleksandra; Blacha-Grzechnik, Agata; Podsiadly, Przemyslaw; Duda, Alicja; Kepska, Kinga; Krzywiecki, Maciej; Motyka, Radoslaw; Janssen, Rene A. J.; Data, Przemyslaw. The article conveys some information:

Poly(3-hexylthiophene) thin films containing carbon-based nanostructures, i.e. fullerenes such as buckminsterfullerene (C60) or phenyl-C61-butyric acid Me ester (PCBM), or single-walled carbon nanotubes, were investigated as heterogeneous photosensitizers producing singlet oxygen (1O2) in aerated organic solvents. Thin films were deposited on borosilicate glass using spin coating and characterized by profilometry, UV-vis, Raman and XPS. Photogeneration of 1O2 was confirmed by photooxidation of 1,3-diphenylisobenzofuran and by reaction of 1,5-dihydroxynaphthalene to juglone. The photochem. efficiency of the blends was found to depend on the carbon-based photosensitizer and can be increased by varying its concentration in the poly(3-hexylthiophene) matrix. After reading the article, we found that the author used 1,3-Diphenylisobenzofuran(cas: 5471-63-6Safety of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Safety of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cheng, Jianjun; Wang, Shu; Zhao, Haitian; Liu, Yan; Yang, Xin published an article in 2021. The article was titled 《Exploring the self-assembly mechanism and effective synergistic antitumor chemophototherapy of a biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug》, and you may find the article in Biomaterials Science.Application In Synthesis of 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Supermolecularly assembled photochemotherapeutic nanocomposites composed of pure drug small mols. are promising for synergistically improved tumor therapy, yet potential multiple challenges remain to be addressed. Herein, we rationally designed a novel multifunctional small mol. disulfide modified natural pentacyclic triterpene of ursolic acid (UASS) that simultaneously possesses self-assembly ability, glutathione (GSH) responsivity, anticancer activity, biocompatibility and biodegradability and further constructed carrier-free GSH-sensitive photosensitive nanocomposite UASS-Ce6 NPs for safe and synergistically improved chemophototherapy. Specifically, UASS-Ce6 NPs exhibit improved 1 O2 generation by reducing the energy gap (ΔEST) of Ce6 as determined by d. functional theory. Meanwhile, mol. dynamics simulation revealed the possible reasons why free UASS self-assembles and UASS-Ce6 NPs with different assembled morphologies may be primarily attributed to the coplanar arrangement of UASS dimer units. Importantly, via noncovalent π-stacking and hydrophobic interactions, the resulting co-assemblies showed improved water solubility, increased intercellular ROS generation, desirable GSH sensibility, excellent biocompatibility, and enhanced tumor accumulation accompanied by rapid biodegradation, thus leading to significant in vitro and in vivo synergistic antitumor efficacy with favorable biosafety. This study provides a promising insight into the development of a self-assembled active single component platform with desirable stimuli responsiveness and biosafety toward synergistic antitumor therapy based on terpenoid natural small mols. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Ground- and Excited-State Properties of Iron(II) Complexes Linked to Organic Chromophores》 was written by Dierks, Philipp; Paepcke, Ayla; Bokareva, Olga S.; Altenburger, Bjoern; Reuter, Thomas; Heinze, Katja; Kuehn, Oliver; Lochbrunner, Stefan; Bauer, Matthias. HPLC of Formula: 5471-63-6 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Two new bichromophoric complexes, [Fe(bim-ant)2]2+ and [Fe(bim-pyr)2]2+ ([H2-bim]2+ = 1,1′-(pyridine-2,6-diyl)bis(3-methyl-1H-imidazol-3-ium); ant = 9-anthracenyl; pyr = 1-pyrenyl), are investigated to explore the possibility of tuning the excited-state behavior in photoactive iron(II) complexes to design substitutes for noble-metal compounds The ground-state properties of both complexes are characterized thoroughly by electrochem. methods and optical absorption spectroscopy, complemented by time-dependent d. functional theory calculations The excited states are investigated by static and time-resolved luminescence and femtosecond transient absorption spectroscopy. Both complexes exhibit room temperature luminescence, which originates from singlet states dominated by the chromophore (1Chrom). In the cationic pro-ligands and in the iron(II) complexes, the emission is shifted to red by up to 110 nm (5780 cm-1). This offers the possibility of tuning the organic chromophore emission by metal-ion coordination. The fluorescence lifetimes of the complexes are in the nanosecond range, while triplet metal-to-ligand charge-transfer (3MLCT) lifetimes are around 14 ps. An antenna effect as in ruthenium(II) polypyridine complexes connected to an organic chromophore is found in the form of an internal conversion within 3.4 ns from the 1Chrom to the 1MLCT states. Because no singlet oxygen forms from triplet oxygen in the presence of the iron(II) complexes and light, efficient intersystem crossing to the triplet state of the organic chromophore (3Chrom) is not promoted in the iron(II) complexes. Two new multichromophoric iron(II) pyridyl N-heterocyclic carbene complexes functionalized with anthracene and pyrene in its backbones are presented. Ground- and excited-state characterization in combination with time-dependent d. functional theory shows that the triplet metal-to-ligand charge-transfer lifetime is prolonged efficiently, and an antenna effect is observed from the excited chromophore to the singlet metal-to-ligand charge-transfer state. In the experiment, the researchers used 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Synergistic antibacterial activity of physical-chemical multi-mechanism by TiO2 nanorod arrays for safe biofilm eradication on implant》 was written by Zhang, Xiangyu; Zhang, Guannan; Chai, Maozhou; Yao, Xiaohong; Chen, Weiyi; Chu, Paul K.. Related Products of 5471-63-6This research focused ontitanium dioxide nanorod array antibacterial activity biofilm eradication implant; Anti-biofilm; Light-triggered therapy; Physical insertion; TiO2 nanorod; Titanium implants. The article conveys some information:

Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of the implants. Developing multi-mechanism antibacterial methods to combat bacterial biofilm infections by the synergistic effects are superior to those based on single modality due to avoiding the adverse effects arising from the latter. In this work, TiO2 nanorod arrays in combination with irradiation with 808 near-IR (NIR) light are proven to eradicate single specie biofilms by combining photothermal therapy, photodynamic therapy, and phys. killing of bacteria. The TiO2 nanorod arrays possess efficient photothermal conversion ability and produce a small amount of reactive oxygen species (ROS). Physiol., the combined actions of hyperthermia, ROS, and puncturing by nanorods give rise to excellent antibacterial properties on titanium requiring irradiation for only 15 min as demonstrated by our experiments conducted in vitro and in vivo. More importantly, bone biofilm infection is successfully treated efficiently by the synergistic antibacterial effects and at the same time, the TiO2 nanorod arrays improve the new bone formation around implants. In this protocol, besides the biocompatible TiO2 nanorod arrays, an extra photosensitizer is not needed and no other ions would be released. Our findings reveal a rapid bacteria-killing method based on the multiple synergetic antibacterial modalities with high biosafety that can be implemented in vivo and obviate the need for a second operation. The concept and antibacterial system described here have large clin. potential in orthopedic and dental applications. In the experimental materials used by the author, we found 1,3-Diphenylisobenzofuran(cas: 5471-63-6Related Products of 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Related Products of 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

HPLC of Formula: 5471-63-6In 2022 ,《Photophysical behaviors of a shape-persistent zinc porphyrin organic cage》 appeared in New Journal of Chemistry. The author of the article were Yang, Wei; Wang, Chen; Liu, Kunhui; Liu, Chao; Jiang, Jianzhuang. The article conveys some information:

A pair of chiral metallic porphyrin cages, (R)/(S)-PTC-1(Zn), were afforded by pure chiral cyclohexanediamine reacting with the zinc 5,15-di[3′,5′-diformyl-(1,1′-biphenyl)]porphyrin. Both their chiral tubular structures were demonstrated via single crystal diffraction and CD studies. In addition, the photophys. behavior of the metallic organic cage, in combination with the monomeric reference zinc 5,15-di[3′,5′-cyclohexyliminomethyl-1,1′-biphenyl]porphyrin (ZnCBPP), was systematically explored by using UV-visible, fluorescence and transient absorption (TA) spectroscopy in solution TA data disclose that PTC-1(Zn) possesses a much longer triplet lifetime than monomer ZnCBPP. In addition, the homogeneous system of the cage enables the production of more singlet oxygen than the monomeric compound according to 1,3-diphenylisobenzofuran photodegradation, ESR spectroscopy and aerobic oxidation of benzylamine under visible light irradiation The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6HPLC of Formula: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.HPLC of Formula: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Su, Qianqian; Wei, Han-Lin; Liu, Yachong; Chen, Chaohao; Guan, Ming; Wang, Shuai; Su, Yan; Wang, Haifang; Chen, Zhigang; Jin, Dayong published an article in 2021. The article was titled 《Six-photon upconverted excitation energy lock-in for ultraviolet-C enhancement》, and you may find the article in Nature Communications.Recommanded Product: 1,3-Diphenylisobenzofuran The information in the text is summarized as follows:

Photon upconversion of near-IR (NIR) irradiation into UV-C (UVC) emission offers many exciting opportunities for drug release in deep tissues, photodynamic therapy, solid-state lasing, energy storage, and photocatalysis. However, NIR-to-UVC upconversion remains a daunting challenge due to low quantum efficiency. Here, we report an unusual six-photon upconversion process in Gd3+/Tm3+-codoped nanoparticles following a heterogeneous core-multishell architecture. This design efficiently suppresses energy consumption induced by interior energy traps, maximizes cascade sensitizations of the NIR excitation, and promotes upconverted UVC emission from high-lying excited states. We realized the intense six-photon-upconverted UV emissions at 253 nm under 808 nm excitation. This work provides insight into mechanistic understanding of the upconversion process within the heterogeneous architecture, while offering exciting opportunities for developing nanoscale UVC emitters that can be remotely controlled through deep tissues upon NIR illumination. The experimental part of the paper was very detailed, including the reaction process of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used as quencher during the photoinactivation of TA-3 mouse mammary carcinoma cells containing hematoporphyrin.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Shih, Yi-Fan; Lee, Hsin-Yi; Huang, Ying-Hsuan; Chuang, Fu-Yu; Lee, Gon-Ann published their research in Journal of Fluorine Chemistry in 2021. The article was titled 《Study of properties of 3-fluorinated cyclopropene derivatives》.Recommanded Product: 1,3-Diphenylisobenzofuran The article contains the following contents:

Treatment of 1-bromo-2,2-dichloro-3-trimethylsilylcyclopropane with 5 equiv of CsF resulted in the formation of a chlorocyclopropenyl cation, which, under different conditions, further reacted with fluoride ion selectively to generate 3,3-difluorocyclopropene or 1-chloro-3-fluorocyclopropene. The Diels-Alder reactions of fluorinated cyclopropene derivatives with DPIBF yielded only exo or exo-anti adducts. On treatment of fused tricyclic cis-1-chloro-3-fluorocyclopropane derivative with n-BuLi, 3-fluorocyclopropene derivative was formed, which underwent Diels-Alder reaction with DPIBF to give an endo-endo adduct. Addnl., fused tricyclic 3,3-difluorocyclopropane and cis-1-chloro-3-fluorocyclopropane derivatives underwent ring-opening reaction of cyclopropane by BF3·Et2O, resp., and 1,4-diphenylnaphthalene derivatives were obtained. The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Recommanded Product: 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Xing, Enyun; Du, Yingying; Yin, Juanjuan; Chen, Minghui; Zhu, Mengyao; Wen, Xiaona; Xu, Jialiang; Feng, Yaqing; Meng, Shuxian published their research in Advanced Healthcare Materials in 2021. The article was titled 《Multi-functional Nanodrug Based on a Three-dimensional Framework for Targeted Photo-chemo Synergetic Cancer Therapy》.Application In Synthesis of 1,3-Diphenylisobenzofuran The article contains the following contents:

Targeted synergistic therapy has broad prospects in tumor treatments. Here, a multi-functional nanodrug GDYO-CDDP/DOX@DSPE-PEG-MTX (GCDM) based on three traditional anticancer drugs (doxorubicin (DOX), cisplatin (CDDP) and methotrexate (MTX)) modified graphdiyne oxide (GDYO) is described, for diagnosis and targeted cancer photo-chemo synergetic therapy. In this system, for the first time, these three traditional anti-cancer drugs have played new roles and can reduce multidrug resistance through synergistic anti-tumor effects. Cisplatin can be hybridized with GDYO to form a multifunctional and well-dispersed three-dimensional framework, which can not only be used as nano-drug carriers to achieve high drug loading rates (40.3%), but also exhibit excellent photothermal conversion efficiency (47%) and good photodynamic effects under NIR irradiation Doxorubicin (DOX) is loaded onto GDYO-CDDP through π-π stacking, which is used as an anticancer drug and as a fluorescent probe for nanodrug detection. Methotrexate (MTX) can be applied in tumor targeting and play a role in synergistic chemotherapy with DOX and CDDP. The synthesized multi-functional nanodrug GCDM has good biocompatibility, active targeting, long-term retention, sustained drug release, excellent fluorescence imaging capabilities, and remarkable photo-chemo synergistic therapeutic effects. The experimental process involved the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Application In Synthesis of 1,3-Diphenylisobenzofuran)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) can be used as a fluorescent probe for detection of superoxide anion radical (O2−) inside the membrane lipid layer by DPBF fluorescence quenching method. 1,3-Diphenylisobenzofuran(DPBF) can be used to study the single crystal molecular structure and solution photophysical properties of DPBF.Application In Synthesis of 1,3-Diphenylisobenzofuran

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《Unsymmetrical zinc(II) phthalocyanine and zinc(II) naphthalocyanine with 2,3-Dicyano-1,4-diphenylnaphthalene precursor》 was written by de Souza, Thalita F. M.; Torres Antonio, Felipe Cesar; Homem-de-Mello, Paula; Ribeiro, Anderson O.. Electric Literature of C20H14OThis research focused onunsym zinc phthalocyanine naphthalocyanine preparation photophys photochem; dicyanodiphenylnaphthalene precursor preparation; Diels Alder diphenylisobenzofuran fumaronitrile. The article conveys some information:

The synthesis, photophys. and photochem. properties of an unsym. zinc(II) phthalocyanine and zinc(II) naphthalocyanine derivative are described. The precursor 2,3-Dicyano-1,4-diphenylnaphthalene was synthesized by Diels-Alder reaction with 1,3-diphenylisobenzofuran and fumaronitrile. The macrocycles were characterized by MALDI-TOF, FTIR, 1H NMR and UV-vis. On their spectroscopy, the impact of the added aromatic moiety was investigated in solution, observing a bathochromic shift in UV-vis absorption, emission and excitation spectra. The structural and electronic properties indicated that the geometry reorganization during the excitation and relaxation processes, and the dipole moment of the ground state, increases the generation of singlet oxygen in solution The results came from multiple reactions, including the reaction of 1,3-Diphenylisobenzofuran(cas: 5471-63-6Electric Literature of C20H14O)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Electric Literature of C20H14O

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

《An Ultrasound-Excitable Aggregation-Induced Emission Dye for Enhanced Sonodynamic Therapy of Tumors》 was written by Zeng, Weiwei; Xu, Yan; Yang, Weitao; Liu, Kai; Bian, Kexin; Zhang, Bingbo. Recommanded Product: 5471-63-6This research focused ontumor sonodynamic therapy ultrasound aggregation induced emission dye; aggregation‐induced emission; reactive oxygen species; sonodynamic therapy; sonosensitizers. The article conveys some information:

Ultrasound (US)-triggered sonodynamic therapy (SDT) can significantly solve the problem of tissue penetrability of light of photodynamic therapy (PDT) that has long vexed physicians in clinics. However, there is a great shortage of sonosensitizers for SDT. Currently, several photosensitizers and their derivatives have been reported for SDT but these dyes are usually quenched when aggregated due to aggregation-caused quenching (ACQ) effect. In this work, aggregation-induced emission (AIE) dye (TTMN) assembled nanoparticles (S-AIE) are synthesized and employed as sonosensitizers for enhanced SDT due to the unique properties of the AIE dye and the deep tissue penetration of ultrasound. Results show that S-AIE can generate potent singlet oxygen (1O2) under US irradiation to induce cancer cells apoptosis and clearly inhibit tumor growth in vitro and in vivo. In particular, the intrinsic fluorescence of AIE dye can guide the procedure of SDT. To the best of current knowledge, this is the first demonstration of AIE dyes being used as sonosensitizers for SDT and importantly, this work could inspire other more efficient AIE dyes for being used as sonosensitizers for SDT of deep-seated tumors. In the experiment, the researchers used many compounds, for example, 1,3-Diphenylisobenzofuran(cas: 5471-63-6Recommanded Product: 5471-63-6)

1,3-Diphenylisobenzofuran(cas: 5471-63-6) is a fluorescent dye. 1,3-Diphenylisobenzofuran is the model compound in studies of singlet fission.Recommanded Product: 5471-63-6

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem