Chemistry is traditionally divided into organic and inorganic chemistry. COA of Formula: C8H5BrO2, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent,Which mentioned a new discovery about 54450-20-3
BTK and PI3Kdelta play crucial roles in the progression of leukemia, and studies confirmed that the dual inhibition against BTK and PI3Kdelta could provide superior anticancer agents to single targeted therapies. Herein, a new series of novel benzofuro[3,2-b]pyridin-2(1H)-one derivatives were optimized based on a BTK/PI3Kdelta inhibitor 2 designed by our group. Biological studies clarified that compound 6f exhibited the most potent inhibitory activity (BTK: IC50 = 74 nM; PI3Kdelta: IC50 = 170 nM) and better selectivity than 2. Moreover, 6f significantly inhibited the proliferation of Raji and Ramos cells with IC50 values of 2.1 muM and 2.65 muM respectively by blocking BTK and PI3K signaling pathways. In brief, 6f possessed of the potency for further optimization as an anti-leukemic drug by inhibiting BTK and PI3Kdelta kinase.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3613O – PubChem