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We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pKa of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pKa of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1231O – PubChem

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Highly enantioselective catalytic asymmetric intramolecular cascade imidization-nucleophilic addition-lactamization of N1-alkylethane-1,2-diamine with methyl 2-formylbenzoate catalyzed by a chiral phosphoric acid represents the first efficient method for the preparation of medicinally interesting chiral 2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-ones with high yields and excellent enantioselectivities. This strategy has been shown to be quite general toward various methyl 2-formylbenzoates.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1238O – PubChem

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The invention discloses a method for preparing substituted phthalide compounds and intermediates thereof. The invention substituted phthalide compound preparation method comprises the following steps: in water, under acidic conditions, the compound B to cyclization reaction, compound A can be obtained. The process is simple, low cost, less wastes, it is suitable for industrial production. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1230O – PubChem

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[Problem] catalyst and the presence of carbon monoxide, the halogen compound is a carbonyl compound in the carbonylation reaction, catalysts or carbon monoxide source technique has problems. [Solution] the presence of the catalyst and the carbon monoxide, the halogen compound is carbonylation reaction method for producing a carbonyl compound, As a heterogeneous palladium catalyst, carbon monoxide is produced from an aldehyde carbonyl compound used in the method. [Drawing] no (by machine translation)

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Reference:
Benzofuran – Wikipedia,
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o-Alkylbenzenecarboxylic acids are treated with a sodium bromate and sodium hydrogen sulfite reagent under a two-phase system using ethyl acetate as solvent, under mild conditions to give the corresponding cyclized phthalides in moderate to satisfactory yield. Intermediately the alpha-brominated alkylbenzenecarboxylic acids are formed by the in situ generated hypobromous acid. These alpha-brominated acids undergo an intramolecular nucleophilic substitution reaction to afford the corresponding gamma-lactones.

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Benzofuran – Wikipedia,
Benzofuran | C8H1237O – PubChem

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A combination of different sampling techniques was applied to cover the wide range of volatility of the various organic compounds in the emission of incineration plants: The sampling steps consist of a condensation of the water vapor, adsorption/thermodesorption and adsorption/elution on selected XAD-resins. In total ca. 250 individual compounds were identified at concentrations above 50 ng/m3. These represent ca. 42 percent of the total organic carbon (TOC) of the emission. Additionally ca. 58 percent of the TOC could be shown to consist of non-identified aliphatic hydrocarbons. – Keywords: municipal waste incineration; identification; emission; organic pollutants; sampling; adsorption; thermodesorption; extraction; elution

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Benzofuran – Wikipedia,
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A new catalytic system for the dehydrogenative lactonization of a variety of benzylic and aliphatic diols in aqueous media was developed. By using a water-soluble, dicationic iridium catalyst bearing 6,6?-dihydroxy-2, 2?-bipyridine as a functional ligand, highly atom economical and environmentally benign synthesis of various lactones was achieved in good to excellent yields. Recovery and reuse of the catalyst were also accomplished by a simple phase separation and the recovered catalyst maintained its high activity at least until the fifth run. Copyright

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Benzofuran – Wikipedia,
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This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.

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Benzofuran – Wikipedia,
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Benzofuran – Wikipedia,
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REGIOSELECTIVE SYNTHESIS OF SUBSTITUTED PHTHALIDES VIA INTRAMOLECULAR “DIENE-REGENERATIVE” DIELS-ALDER REACTION OF 2-PYRONES

Some 2-pyrone-6-carboxylates bearing appropriate dienophiles in ester moieties underwent “diene-regenerative” Diels-Alder reaction to afford the dihydrophthalides, which were aromatized to phthalide derivatives in the presence of palladium-charcoal.In these reactions the substituents at 4 or 7-position of phthalides arose from those on yhe dienophile moieties in the starting 2-pyrones.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1244O – PubChem