Category: 53724-96-2

On July 1, 2007, Salih, Kifah S. M.; Ayoub, Mikdad T.; Saadeh, Haythem A.; Al-Masoudi, Najim A.; Mubarak, Mohammad S. published an article.COA of Formula: C13H14O4 The title of the article was Synthesis, characterization, and biological activities of new benzofuran derivatives. And the article contained the following:

New benzofuran derivatives, Et 3-[(alkylamino)methyl]-6-methoxy-1-benzofuran-2-carboxylates, e.g., I, were obtained via the reaction between Et 3-(bromomethyl)-6-methoxy-1-benzofuran-2-carboxylate (II) and amines or amino acid Et esters. In addition, 1,4-bis[(Et 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]piperazine, N,N’-diethyl-N,N’-bis[(6-methoxy-1-benzofuran-3-yl-2-carboxylate) methyl]but-2-ene-1,4-diamine, and 1,2-bis[(Et 6-methoxy-1-benzofuran-3-yl-2-carboxylate)methyl]-1,2-dimethylhydrazine were also obtained from the reaction of II with diamines. Their in vitro anti-HIV-1 (strain IIIB) and HIV-2 (strain ROD) activities of the synthesized compounds in human T-lymphocyte were tested; II displayed an ability to inhibit HIV-1 and HIV-2 replication in cell culture at non-toxic concentrations The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).COA of Formula: C13H14O4

The Article related to benzofurancarboxylate derivative preparation antihiv activity, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.COA of Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 1991, Suzuki, Tsuneo published an article.Electric Literature of 53724-96-2 The title of the article was The reaction of ethyl 2-acetyl-5-methoxyphenoxyacetate with some bases in various solvents. And the article contained the following:

The reaction of the title compound (I) with KOH, NaOH, KOCMe3, EtONa, NaH, or NaNH2 in dioxane, THF, DMF, Me2SO, MeOH, EtOH, or Me3COH was reported. E.g., reaction of I with KOH in dioxane gave 19% benzofuran II, 44% benzofuran III, and 25% benzoxepin III. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Electric Literature of 53724-96-2

The Article related to acetylmethoxyphenoxyacetate cyclization solvent effect, Heterocyclic Compounds (One Hetero Atom): Areno- and Diarenofurans and other aspects.Electric Literature of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On March 31, 2021, Wu, Xiaowei; Dai, Mengdi; Cui, Rongrong; Wang, Yulan; Li, Chunpu; Peng, Xia; Zhao, Jihui; Wang, Bao; Dai, Yang; Feng, Dan; Yang, Tianbiao; Jiang, Hualiang; Geng, Meiyu; Ai, Jing; Zheng, Mingyue; Liu, Hong published an article.Synthetic Route of 53724-96-2 The title of the article was Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors. And the article contained the following:

Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy. In this study, we synthesized and evaluated the biol. activity of 66 pyrazolo[3,4-d]pyridazinone derivatives Kinase inhibition, cell proliferation, and whole blood stability assays were used to evaluate their activity on FGFR, allowing us to explore structure-activity relationships and thus to gain understanding of the structural requirements to modulate covalent inhibitors′ selectivity and reactivity. Among them, compound 10h exhibited potent enzymic activity against FGFR and remarkably inhibited proliferation of various cancer cells associated with FGFR dysregulation, and suppressed FGFR signaling pathway in cancer cells by the immunoblot anal. Moreover, 10h displayed highly potent antitumor efficacy (TGI = 91.6%, at a dose of 50 mg/kg) in the FGFR1-amplified NCI-H1581 xenograft model. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Synthetic Route of 53724-96-2

The Article related to pyrazolo pyridazinone derivative covalent fgfr inhibitor biol evaluation, pyridazinone derivative covalent fgfr inhibitor biol evaluation sar, antitumor efficacy, btk, brutons tyrosine kinase, cadd, computer-aided drug design, covalent fgfr inhibitors, egfr, epidermal growth factor receptor and other aspects.Synthetic Route of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On September 1, 2018, Wang, Shuxiang; Li, Bo; Liu, Bo; Huang, Min; Li, Deyi; Guan, Lihong; Zang, Jie; Liu, Dan; Zhao, Linxiang published an article.COA of Formula: C13H14O4 The title of the article was Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design. And the article contained the following:

A novel series of 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives featured with various C-2 substituents were designed and synthesized as Mnks inhibitors through fragment-based drug design. Among them, 5b, 5i, 5o and 8k showed the best Mnk2 inhibitory activity with IC50 values of 1.45, 1.16, 3.55 and 0.27 μM, resp. And these compounds inhibited the activity of Mnk1 at the same time. Furthermore, compounds 5o and 8k exhibited anti-proliferative effects to human leukemia cancer THP-1 and MOLM-13 cell lines and colon cancer HCT-116 cell line. Moreover, Western blot assay suggested that 8k could decrease the levels of p-eIF4E in a dose-dependent manner in HCT-116 cells. Docking studies demonstrated strong interactions between 8k and Mnk2. Therefore, this unique benzofuran scaffold demonstrated great potential to be further explored as potent Mnks inhibitors with improved potency. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).COA of Formula: C13H14O4

The Article related to benzofuran synthesis antitumor mnk kinase leukemia, 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives, anti-proliferative effects, fragment-based drug design, mnks inhibitors and other aspects.COA of Formula: C13H14O4

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

On June 30, 1988, Redondo, Jordi; Sanchez-Ferrando, Francisco; Valls, Montserrat; Virgili, Albert published an article.Electric Literature of 53724-96-2 The title of the article was Selective heteronuclear NOE enhancements in benzoheterocycles. Effect of ring size on indirect three-spin effects. And the article contained the following:

The 80 MHz 1H NMR and 20 MHz 13C NMR spectra of 5 4-methylcoumarins, 6 4-methyl-2(1H)-quinolones and 9 3-methylbenzo[b]furans, including 6 new compounds, were fully assigned. Homonuclear 1H〈1H〉 NOEs and selective heteronuclear 13C〈1H〉 NOEs were measured after low-power pre-saturation of the Me protons. Indirect, neg. heteronuclear NOE enhancements were found in suitable 3-spin systems of the 13C-1H-〈1H〉 type, and their magnitude was dependent on ring size. The 1st examples of indirect, heteronuclear NOE enhancements on non-protonated carbons are described. The experimental process involved the reaction of Ethyl 6-methoxy-3-methylbenzofuran-2-carboxylate(cas: 53724-96-2).Electric Literature of 53724-96-2

The Article related to benzoheterocycle noe heteronuclear, nmr benzoheterocycle, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Electric Literature of 53724-96-2

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem