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This paper describes the synthesis and blocking activities of twelve new isoindolinone- and isobenzofura-none-containing phenoxylalkylamines as potent alpha1-Adrenoceptor antagonists. These compounds were synthesized in moderate to good yields starting from 3,4-dimethylphenol, and characterized with 1H-NMR, MS, IR and elemental analysis. Their blocking activities toward alpha1-Adrenoceptors were evaluated on isolated rat anococcygeus muscles. The results indicated that these compounds were very strong in blocking alpha1-Adrenoceptors, and most of them exhibited activities that were comparable to that of known potent alpha1- Adrenoceptor antagonist 1-(2,6-dimethylphenoxy)-2-(3,4- dimethoxyphenylethylamino)propane hydrochloride (DDPH).

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Benzofuran – Wikipedia,
Benzofuran | C8H2277O – PubChem

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Addition of lateral lithiated amides and phthalide anions to enantiopure sulfinimines (N-sulfinyl imines) represents a new approach for the asymmetric synthesis of 3-substituted isoquinolones and 3-substituted 4-hydroxy isoquinolones, respectively, important chiral building blocks for isoquinoline alkaloid synthesis. In one example 3-phenylisoquinolone (-)-15b was prepared in >95% ee by treatment of amide ion 10b with sulfinimine (S)- (+)-11 and subsequent deprotection of the N-sulfinyl auxiliary and cyclization. Oxaziridine-mediated hydroxylation of the anion of 16 afforded 4-hydroxy isoquinolone 19, which was transformed into 4-hydroxy-3- phenyltetrahydroisoquinoline (-)-22. In another approach 22 was prepared more directly by addition of phthalide ion 26 to (S)-(+)-11, creating the two stereogenic centers simultaneously. The selectivity proved to be highly counterion dependent.

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Benzofuran – Wikipedia,
Benzofuran | C8H2256O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 5-Methoxyisobenzofuran-1(3H)-one, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 4741-62-2, Name is 5-Methoxyisobenzofuran-1(3H)-one, molecular formula is C9H8O3

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pKa of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pKa of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values.

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Benzofuran – Wikipedia,
Benzofuran | C8H2253O – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 5-Methoxyisobenzofuran-1(3H)-one, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 4741-62-2

Efficient C-N and C-O coupling reactions of aryl halides with amines and alcohols have been developed by using the strategy of heterogeneous visible light photoredox and nickel dual catalysis. Obviously, the joint use of inexpensive and bench-stable CdS and nickel salts, together with mild reaction conditions, makes these two transformations attractive for the synthetic community. This heterogeneous dual catalysis system also proved to be successful in the ligand-free catalytic hydroxylation of aryl bromide with water as a nucleophile. The practicality of this protocol is further emphasized by the scaled-up reaction and the reusability of heterogeneous photocatalysts.

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Benzofuran – Wikipedia,
Benzofuran | C8H2265O – PubChem

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A fast method utilizing in situ generated CO for the synthesis of phthalides has been developed. DMF and Mo(CO)6 were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. Mo(CO)6 was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, dihydroisoindone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1h reaction time.

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2275O – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4741-62-2, name is 5-Methoxyisobenzofuran-1(3H)-one, introducing its new discovery. Recommanded Product: 4741-62-2

The thallation and subsequent palladium-catalyzed carbonylation of simple arenes, benzylic and beta-phenethyl alcohols, benzoic and phenylacetic acids, benzamide, and acetanilide afford benzoate esters, phthalides, 3,4-dihydroisocoumarins, phthalic and homophthalic anhydrides, phthalimide, and acetylanthranil, respectively.The carbonylation reaction proceeds in excellent yield at room temperature and atmospheric pressure and is highly stereo- and regioselective.

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Benzofuran – Wikipedia,
Benzofuran | C8H2263O – PubChem

4741-62-2, Name is 5-Methoxyisobenzofuran-1(3H)-one, belongs to benzofurans compound, is a common compound. Computed Properties of C9H8O3In an article, once mentioned the new application about 4741-62-2.

Benzylic ethers undergo a visible light induced C-H activation and oxygen insertion to give the corresponding benzoate esters in moderate to good yields. The conditions employ substoichiometric amounts of 1,4-hydroquinone with copper(ii) chloride dihydrate as an electron-transfer mediator, oxygen as the terminal oxidant and dimethyl carbonate as solvent under visible light irradiation. The naturally occurring glucoside, arbutin, which is commercially available or can be accessed via extraction of the leaves of bearberry (Arctostaphylos uva-ursi) or elephant ears (Bergenia crassifolia) can be used as a biorenewable source of 1,4-hydroquinone. The methodology exploits the increase in oxidizing ability of quinones upon irradiation with visible light, and offers a sustainable alternative for the late stage oxidative functionalization of benzylic C-H bonds. It is applicable to a range of cyclic benzylic ethers such as isochromans and phthalans, and simple benzyl alkyl ethers. It can also be applied in the oxidation of benzylic amines into amides, and of diarylmethanes into the corresponding ketones. Mechanistic studies suggest that the reaction proceeds by H-abstraction by the photo-excited triplet benzoquinone to give a benzylic radical that subsequently reacts with molecular oxygen.

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Benzofuran – Wikipedia,
Benzofuran | C8H2258O – PubChem

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Safety of 5-Methoxyisobenzofuran-1(3H)-one, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 4741-62-2, name is 5-Methoxyisobenzofuran-1(3H)-one. In an article，Which mentioned a new discovery about 4741-62-2

The present invention disclosed herein is a novel commercially feasible, one pot synthesis of library of 3-substituted phthalides of formula I via CuCN mediated oxidative cyclization in high yield. Formula I

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Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H2251O – PubChem