Awesome and Easy Science Experiments about Benzo[b]furan-2-carboxaldehyde

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4265-16-1, name is Benzo[b]furan-2-carboxaldehyde, introducing its new discovery. Product Details of 4265-16-1

Mukaiyama aldol reactions of enol ethers with a variety of aldehydes and ketones are efficiently catalyzed at 0-25 C by the sterically bulky trimeric organo aluminum(III) alkoxide 1 synthesized via the reaction of 3 equiv of AlMe3 with tripodal tris(2-hydroxy-3-tert-butyl-5-methylphenyl) methane and the elimination of 3 equiv of methane. Comparisons of its catalytic properties with the less sterically hindered analogue 2, the more sterically hindered analogue 3, a monomeric aluminum near-analogue 4, and a dimeric alumatrane 5 revealed that 1 possesses superior activity.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H884O – PubChem

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Secondary benzylic ethers undergo stereospecific substitution reactions with Grignard reagents in the presence of nickel catalysts. Reactions proceed with inversion of configuration and high stereochemical fidelity. This reaction allows for facile enantioselective synthesis of biologically active diarylethanes from readily available optically enriched carbinols.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1071O – PubChem

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The invention relates to a benzyl substituted benzofuran – imidazoline such water-resistant rice sheath blight compound and its preparation method, the states the phenmethyl substituted benzofuran – imidazoline compound structure shown in formula I: The formula I compound to the galenical exhibits a very strong inhibiting activity, is expected to be developed for the prevention and treatment of rice sheath blight. (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H650O – PubChem

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The direct beta-selective hydrocarboxylation of styrenes under atmospheric pressure of CO2 has been developed using photoredox catalysis in continuous flow. The scope of this methodology was demonstrated with a range of functionalized terminal styrenes, as well as alpha-substituted and beta-substituted styrenes.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H1039O – PubChem

Awesome Chemistry Experiments For Benzo[b]furan-2-carboxaldehyde

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With the focus of designing new fluorescent probes, four new 3-hydroxy-chromone derivatives bearing benzofuran and naphthofuran groups were synthesized. They show bathochromic absorption shifts relative to 3-hydroxyflavone with the ability of retention to display the excited-state proton transfer. Disruption of the planarity by the methyl group in the furan ring leads to a decrease of both the extinction coefficient and the contribution of long wavelength absorption band, while molecules without a methyl group showed two distinct absorption bands. Shifts to longer wavelengths are also observed in fluorescent spectra, and the absence of the methyl group results in a dramatic increase of fluorescence quantum yield and lifetime. Of the extended 3-hydroxychromone derivatives, 3-hydroxy-2-naphtho[2,1-b]furan-2-yl-chromone has shown comparable, and in some cases better, absorption and fluorescence properties than the 3-hydroxychromones synthesized so far, which make it a highly promising candidate as molecular probe for analytical chemistry, biophysics, and cellular biology.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H887O – PubChem

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Aqueous Compatible Protocol to Both Alkyl and Aryl Thioamide Synthesis

An efficient aqueous synthesis of thioamides through aldehydes, sodium sulfide, and N-substituted formamides has been developed. Both alkyl and aryl aldehydes are amenable to this protocol. N-Substituted formamides are essential for this transformation. Readily available inorganic salt (sodium sulfide) serves as the sulfur source in water, which makes this method much more practical and efficient. Furthermore, the late-stage modification of bioactive molecules and derivatives through this protocol has been established.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H1102O – PubChem

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Cu-Catalyzed highly selective reductive functionalization of 1,3-diene using H2O as a stoichiometric hydrogen atom donor

A copper-catalyzed highly regio- A nd diastereo-selective reductive reaction of terminal 1,3-diene with water and aldehyde has been developed. This chemistry afforded a product containing a terminal alkenyl group, which is a versatile kind of precursor for organic synthesis, with the scope for various substrates. The present reaction system could realize the catalytic transfer of hydrogen to diene using water as a stoichiometric H atom donor. In this transformation, B2Pin2, a mild and practical kind of reductant was used as the mediator. The reaction pathway of this practical strategy was illustrated by a control experiment.

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Reference£º
Benzofuran – Wikipedia,
Benzofuran | C8H925O – PubChem

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Photocatalytic decarboxylative alkenylation of alpha-amino and alpha-hydroxy acid-derived redox active esters by NaI/PPh3 catalysis

Herein, we report the photocatalytic decarboxylative alkenylation reactions of N-(acyloxy)phthalimide derived from alpha-amino and alpha-hydroxy acids with 1,1-diarylethene, and with cinnamic acid derivatives through double decarboxylation, using sodium iodide and triphenylphosphine as redox catalysts. The reaction proceeds under mild irradiation conditions with visible blue light (440 nm or 456 nm) in an acetone solvent without recourse to transition-metal or organic dye based photoredox catalysts. The reaction proceeds via photoactivation of a transiently self-assembled chromophore from N-(acyloxy)phthalimide and NaI/PPh3. Solvation plays a crucial role in the reactivity.

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Benzofuran – Wikipedia,
Benzofuran | C8H822O – PubChem

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HIV protease inhibitor

This invention relates to a sulfate salt of an HIV protease inhibitor, Compound A, of formula: STR1 Compound A is useful in the treatment of AIDS, ARC or HIV infection in adults and children. Processes for making the sulfate salt of Compound A are also disclosed.

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Benzofuran – Wikipedia,
Benzofuran | C8H648O – PubChem

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3-AMINO-2-PHENYLPYRROLIDINE DERIVATIVES

3-amino-2-phenylpyrrolidine compounds useful as NK-1 antagonists, with pharmaceutical compositions and methods of treatment comprising same, are disclosed.

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Benzofuran – Wikipedia,
Benzofuran | C8H676O – PubChem