Category: 28808-62-0

Inhibition of double-stranded RNA-induced inducible nitric oxide synthase expression by fraxinellone and sauchinone in murine microglia was written by Lee, Chang Seok;Won, Cheolhee;Yoo, Hyouna;Yi, Eun Hee;Cho, Yuri;Maeng, Jung Woo;Sung, Sang Hyun;Ye, Sang-Kyu;Chung, Myung-Hee. And the article was included in Biological & Pharmaceutical Bulletin in 2009.Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one This article mentions the following:

Fraxinellone and sauchinone, isolated from natural substance, are known to have an anti-inflammatory effect in inflammatory conditions. However, the anti-inflammatory actions of these compounds have been insufficiently demonstrated in viral-induced neuroinflammation. A viral component (double-stranded (ds)RNA) triggers a toll-like receptor 3-dependent inflammatory response that stimulates pro-inflammatory mediators in the brain. In present study, we initially examined the biol. effects of fraxinellone and sauchinone on anti-inflammatory actions in dsRNA-stimulated microglia. Both compounds inhibited dsRNA-induced inducible nitric oxide synthase (iNOS) expression, a major pro-inflammatory enzyme. To demonstrate the mechanism of inhibitory effect on iNOS expression, we further examined the signaling pathway induced by dsRNA in microglia. Our data show that dsRNA promotes the expression of signal transducers and activators of transcription (STAT)1/3 identified as major inflammatory transcription factors as well as activates c-Jun N-terminal kinase (JNK) in an early time. Moreover, both compounds suppressed activation of JNK-STAT1/3 signaling pathway. These results suggest that an anti-inflammatory effect by fraxinellone and sauchinone is mediated via blockade of the JNK-STAT1/3-iNOS signaling pathway in viral-infected microglia. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Two New Limonoids from the Root Bark of Chinese Medicinal Plant Dictamnus dasycarpus was written by Wang, Li-Li;Jiang, Cheng-Shi;Fu, Yan;Chen, Fei-Fei;Lan, Le-Fu;Zhang, Hai-Yan;Guo, Yue-Wei. And the article was included in Helvetica Chimica Acta in 2014.Recommanded Product: 28808-62-0 This article mentions the following:

Two new limonoids, kihadanin C (I) and 23-methoxydasylactone A (II), together with seven related known ones, were isolated from the root bark of the plant Dictamnus dasycarpus. The structures of the new compounds were elucidated on the basis of extensive analyses of their spectroscopic data (1D- and 2D-NMR, MS) and by comparison of their NMR data with those reported in the literature. To the best of our knowledge, I presents the first example of A,D-seco limonoid with an unusual 3,4-dihydroxy-2,5-dimethoxytetrahydrofuran moiety as ring E. In the bioassay in vitro, dasylactone B7 showed moderate antibacterial activity against Staphylococcus aureus, while fraxinellone and isofraxinellone displayed neuroprotective activities against H₂O₂-induced injury in SH-SY5Y cells. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Recommanded Product: 28808-62-0).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 28808-62-0

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Sequential targeting TGF-β signaling and KRAS mutation increases therapeutic efficacy in pancreatic cancer was written by Pei, Yuanyuan;Chen, Liang;Huang, Yukun;Wang, Jiahao;Feng, Jingxian;Xu, Minjun;Chen, Yu;Song, Qingxiang;Jiang, Gan;Gu, Xiao;Zhang, Qian;Gao, Xiaoling;Chen, Jun. And the article was included in Small in 2019.Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one This article mentions the following:

Pancreatic cancer is a highly aggressive malignancy that strongly resists extant treatments. The failure of existing therapies is majorly attributed to the tough tumor microenvironment (TME) limiting drug access and the undruggable targets of tumor cells. The formation of suppressive TME is regulated by transforming growth factor beta (TGF-β) signaling, while the poor response and short survival of almost 90% of pancreatic cancer patients results from the oncogenic KRAS mutation. Hence, simultaneously targeting both the TGF-β and KRAS pathways might dismantle the obstacles of pancreatic cancer therapy. Here, a novel sequential-targeting strategy is developed, in which antifibrotic fraxinellone-loaded CGKRK-modified nanoparticles (Frax-NP-CGKRK) are constructed to regulate TGF-β signaling and siRNA-loaded lipid-coated calcium phosphate (LCP) biomimetic nanoparticles (siKras-LCP-ApoE3) are applied to interfere with the oncogenic KRAS. Frax-NP-CGKRK successfully targets the tumor sites through the recognition of overexpressed heparan sulfate proteoglycan, reverses the activated cancer-associated fibroblasts (CAFs), attenuates the dense stroma barrier, and enhances tumor blood perfusion. Afterward, siKras-LCP-ApoE3 is efficiently internalized by the tumor cells through macropinocytosis and specifically silencing KRAS mutation. Compared with gemcitabine, this sequential-targeting strategy significantly elongates the lifespans of pancreatic tumor-bearing animals, hence providing a promising approach for pancreatic cancer therapy. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Safety of (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biological activity of Dictamnus dasycarpus against Mythimna separata was written by Yuan, Chun-lan;Wang, Xiao-ling. And the article was included in Baoji Wenli Xueyuan Xuebao, Ziran Kexueban in 2012.Synthetic Route of C14H16O3 This article mentions the following:

This paper is to gain the active compounds from Dictamnus dasycarpus. The solvent partition, preparative TLC, spectral anal. and bioassay are used to gain the active compounds Fraxinellone is a main biol. actives substance from D. dasycarpus. Its antifeeding rate and death rate of 72h at 0.21%(mass percent) against Mythimna separata were 90.4%and 95.2%, resp. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Synthetic Route of C14H16O3).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C14H16O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Biological activity of Dictamnus dasycarpus against Mythimna separata was written by Yuan, Chun-lan;Wang, Xiao-ling. And the article was included in Baoji Wenli Xueyuan Xuebao, Ziran Kexueban in 2012.Synthetic Route of C14H16O3 This article mentions the following:

This paper is to gain the active compounds from Dictamnus dasycarpus. The solvent partition, preparative TLC, spectral anal. and bioassay are used to gain the active compounds Fraxinellone is a main biol. actives substance from D. dasycarpus. Its antifeeding rate and death rate of 72h at 0.21%(mass percent) against Mythimna separata were 90.4%and 95.2%, resp. In the experiment, the researchers used many compounds, for example, (3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0Synthetic Route of C14H16O3).

(3R,3aR)-3-(Furan-3-yl)-3a,7-dimethyl-3a,4,5,6-tetrahydroisobenzofuran-1(3H)-one (cas: 28808-62-0) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Synthetic Route of C14H16O3

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem