Category: 17403-47-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17403-47-3,5-Nitro-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

A mixture of 21 (6.3 g, 38.1 mmol) and 10% palladium on carbon (1.0 g) in EtOH (50 mL) and THF (50 mL) was stirred under an atmosphere of H2 (1 atm) at room temperature for 13 h. The catalyst was removed by filtration, and then the filtrate was concentrated. The residue was purified by flash chromatography on SiO2 with a gradient eluent of 0-10% MeOH/EtOAc to provide 22 (4.63 g, 90%) as a pale brown powder; 1H NMR (CDCl3) delta: 3.12 (2H, t, J = 8.6 Hz), 3.37 (2H, s), 4.49 (2H, t, J = 8.6 Hz), 6.43-6.47 (1H, m) 6.57-6.61 (2H, m); Anal. Calcd for C8H9NO: C, 71.09; H, 6.71; N, 10.36. Found: C, 70.92; H, 6.60; N, 10.09.

17403-47-3, The synthetic route of 17403-47-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 19; 21; (2011); p. 6430 – 6446;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

17403-47-3, 5-Nitro-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 21 (6.3 g, 38.1 mmol) and 10% palladium on carbon (1.0 g) in EtOH (50 mL) and THF (50 mL) was stirred under an atmosphere of H2 (1 atm) at room temperature for 13 h. The catalyst was removed by filtration, and then the filtrate was concentrated. The residue was purified by flash chromatography on SiO2 with a gradient eluent of 0-10% MeOH/EtOAc to provide 22 (4.63 g, 90%) as a pale brown powder; 1H NMR (CDCl3) delta: 3.12 (2H, t, J = 8.6 Hz), 3.37 (2H, s), 4.49 (2H, t, J = 8.6 Hz), 6.43-6.47 (1H, m) 6.57-6.61 (2H, m); Anal. Calcd for C8H9NO: C, 71.09; H, 6.71; N, 10.36. Found: C, 70.92; H, 6.60; N, 10.09.

17403-47-3, The synthetic route of 17403-47-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shirai, Junya; Yoshikawa, Takeshi; Yamashita, Masayuki; Yamamoto, Yasuharu; Kawamoto, Makiko; Tarui, Naoki; Kamo, Izumi; Hashimoto, Tadatoshi; Ikeura, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 19; 21; (2011); p. 6430 – 6446;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17403-47-3,5-Nitro-2,3-dihydrobenzofuran,as a common compound, the synthetic route is as follows.

17403-47-3, To a suspension of 10.3 g (62.37 mmol) of 5-nitro-2, 3-dihydrobenzofuran in 50 mL of MeOH and 10 mL of dichloromethane was added 350 mg of 10% palladium on carbon and the mixture was placed under 55 psi of hydrogen gas. Hydrogen gas uptake was evident during the first 30 minutes. After 18 hours, the mixture was then filtered through diatomaceous earth and concentrated to afford 8.2 g of 2,3-dihydrobenzofuran-5-ylamine as a gray solid which was used without further purification.

As the paragraph descriping shows that 17403-47-3 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2003/82787; (2003); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

17403-47-3, 5-Nitro-2,3-dihydrobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of 5-amino-2,3-dihydrobenzofuran [Show Image] The product (1 g, 6.1 mmol) obtained in Step 1, Raney Ni (0.1 g) and MeOH(10 mL) were used for hydrogenation at room temperature and hydrogen pressure of 50 PSI, until the reaction was finished. The catalyst was removed by filtration, the fitrate was concentrated under vacuum to obtain a product (800 mg, 97.2%)., 17403-47-3

As the paragraph descriping shows that 17403-47-3 is playing an increasingly important role.

Reference£º
Patent; Xuanzhu Pharma Co., Ltd.; EP2532665; (2012); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem