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The invention relates to the technical field of pharmaceuticals, and provides a substituted aryl tetracyclic antifungal compound and pharmaceutically acceptable salts. The substituted aryl tetracyclic antifungal compound is as shown in a structural formula of the description. The invention further provides a preparation method of the compound and an application of the compound in preparing antifungal medicaments.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2324O – PubChem

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Certain novel 3-(dihaloalkenyl)phenyl derivatives have unexpected insecticidal activity. These compounds are represented by formula (I), where R through R5, a, b, D, E, G and U are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of second compound, with at least one insecticidally compatible carrier ar also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2282O – PubChem

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Related Products of 1563-38-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, and a compound is mentioned, 1563-38-8, 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, introducing its new discovery.

Human biomonitoring provides information about chemicals measured in biological matrices, but their interpretation remains uncertain because of pharmacokinetic (PK) interactions. This study examined the PKs in blood from Long?Evans rats after a single oral dose of 0.4 mg/kg bw of each pesticide via a mixture of the 17 pesticides most frequently measured in humans. These pesticides are beta-endosulfan; beta-hexachlorocyclohexane [beta-HCH]; gamma-hexachlorocyclohexane [gamma-HCH]; carbofuran; chlorpyrifos; cyhalothrin; cypermethrin; diazinon; dieldrin; diflufenican; fipronil; oxadiazon; pentachlorophenol [PCP]; permethrin; 1,1-dichloro-2,2bis(4-chlorophenyl)ethylene [p,p?-DDE]; 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane [p,p?-DDT]; and trifluralin. We collected blood at 10 min to 48-h timepoints in addition to one sample before gavage (for a control). We used GS?MS/MS to measure the pesticide (parents and major metabolites) concentrations in plasma, determined the PK parameters from 20 sampling timepoints, and analyzed the food, litter, and cardboard in the rats? environment for pesticides. We detected many parents and metabolites pesticides in plasma control (e.g., diethyl phosphate [DEP]; PCP; 3-phenoxybenzoic acid [3-PBA]; 3,5,6-trichloro-2-pyridinol [TCPy], suggesting pre-exposure contamination. The PK values post-exposure showed that the AUC0?? and Cmax were highest for TCPy and PCP; beta-endosulfan, permethrin, and trifluralin presented the lowest values. Terminal T1/2 and MRT for gamma-HCH and beta-HCH ranged from 74.5 h to 117.1 h; carbofuran phenol presented the shortest values with 4.3 h and 4.8 h. These results present the first PK values obtained through a realistic pattern applied to a mixture of 17 pesticides to assess exposure. This study also highlights the issues of background exposure and the need to work with a relevant mixture found in human matrices.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2348O – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1563-38-8, name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, introducing its new discovery. Recommanded Product: 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol

A process for preparing 2,3-dihydro-2,2-dimethyl-7-hydroxybenzofuran in which 2-methallyloxyphenol is heated to a temperature in the range of 150 C. to 250 C. in the presence of a solvent and a Lewis acid catalyst under an autogenous pressure of 20 to 60 psig is disclosed and exemplified.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2296O – PubChem

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Genetically engineered microorganisms (GEMs) have shown potential for enhanced degradation of a range of substrates. In this study, a DNA fragment including the open reading frame of mpd (methyl parathion hydrolase encoding gene) and cognate regulator of a methyl parathion (MP)-degrading strain Pseudomonas putida DLL-1 was cloned by the shotgun method. The fragment was cloned into a broad-host vector pBBR1MCS-2 to produce a recombinant plasmid pBBR-mpd. CDS-pBBR-mpd, a GEM, was successfully constructed by transforming it into a carbofuran-degrading strain Sphingomonas sp. CDS-1, and it degraded both carbofuran and MP. CDS-pBBR-mpd maintained stable and high MP hydrolase activity (50.72 nmol min-1 mug-1 protein, which was 6.57 times higher than that of P. putida strain DLL-1). and appears to be a promising GEM for environmental bioremediation.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2384O – PubChem

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The invention provides a furan-based oxadiazole derivative represented by formula (I) as well as a preparation method and application, wherein R is selected from 4 – CN-C. 6 H4 , 4 – F-C6 H4 , 4 – Cl-C6 H4 , 4 – Br-C6 H4 , 3 – F-C6 H4 , 3 – Br-C6 H4 , 4 – NO2 – C6 H4 , 3 – NO2 – C6 H4 , 2 – Br-C6 H4 , 3 – CH3 – C6 H4 , 4 – CH3 – C6 H4 , 4 – OOMe-C6 H4 , 3 – OOMe-C6 H4 , 2 – OOMe-C6 H4 , Phenyl, isopropyl, cyclohexylmethyl, styryl, furyl, thienyl or naphthyl. The compound and the pharmaceutically acceptable salt thereof show high inhibitory activity on weeds, such as barnyard grass and the like, can not cause damage to crops, and provide a new choice for eliminating weeds. (I). (by machine translation)

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2312O – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1563-38-8, name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, introducing its new discovery. Safety of 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol

A large series of bulky 1,2-dialkoxy- and 1,2,3-trialkoxy-benzenes was efficiently prepared via Williamson etherification. Preparation of their contiguous bromine-containing derivatives was also achieved.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2418O – PubChem

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I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1563-38-8, help many people in the next few years.Computed Properties of C10H12O2

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C10H12O2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1563-38-8, name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol. In an article,Which mentioned a new discovery about 1563-38-8

Carbofuran degradation in microwave (MW)-assisted granular activated carbon (GAC)/zero-valent iron (ZVI)/hydrogen peroxide (H2O2) system(s) was investigated under different reaction temperatures, i.e. 30 C, 50 C and 80 C, and at varying pHs, i.e. 2, 4, 6, 8 and 10. Batch experiments were conducted using a modified-MW reactor (750 W power and 2450 MHz frequency) at 100 mg L-1 carbofuran concentration. The lower MW-reaction temperatures, i.e. 30 C and 50 C, have produced poor carbofuran degradation efficiencies whereas complete carbofuran degradation (100%) was observed at 80 C and pH 6 in all the systems, i.e. MW with GAC, ZVI and H2O2. Under the similar conditions, insignificant carbofuran removal/degradation (2-24%) was observed in the presence of GAC/ZVI/H2O2 without MW. On the other hand, the carbofuran degradation rate was accelerated under the alkaline pHs, i.e. pH 8 and 10 (at 80 C), and 100% carbofuran degradation was observed within 10 min in all the MW-assisted systems. However, the complete carbofuran degradation was accomplished rapidly (5 min) in the MW-assisted GAC and ZVI systems under pH 10 and 80 C. Carbofuran removal in the MW-assisted systems was modeled using the first-order reaction kinetics and a maximum removal rate constant of 4.17 min-1 was obtained in the MW-assisted ZVI system. A maximum of 86% carbofuran mineralization was achieved in the MW-assisted GAC system via hydrolysis and the removal of carbamate group. The comparison of energy consumption in MW-assisted systems with other processes reveals that the MW-assisted process is highly efficient and cost-effective for carbofuran degradation and mineralization.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2406O – PubChem

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Global pollution from excessive pesticide use has become a serious environmental and public health problem. The aim of the study was to optimize the fungal mediated simultaneous removal of carbofuran and carbaryl from soil. Carb-PV5 strain was isolated from contaminated soil following enrichment culture technique; based on 18S rRNA sequencing, strain was identified as Acremonium sp. (MK514615); Field Emission Scanning Electron Microscopic analysis reflected its morphology. Towards the development of bioaugmentation strategy for the bioremediation of carbamate-contaminated soil, the process parameters were optimized employing Central Composite Rotatable Method. The experimental studies were performed in the range of biomass (0.2?0.6 g kg?1), temperature (23?33 C), pH (6?9) and moisture (10?30%). The degradation rate parameters, k and t1/2 were determined to as 0.475, 0.325 d?1 and 5.39, 2.1 d with the corresponding r2 of 0.9491, 0.9964 for zero and first order, respectively. The cube root growth kinetic constant k of Acremonium sp. varied from 0.0469 to 0.0512 (g1/3 L?1/3 h?1) and 0.0378 to 0.0415 (g1/3 L?1/3 h?1) for carbofuran and carbaryl, respectively. To confirm the model appropriacy and sustainability of the optimization procedure, bioremediation experiments were conducted onto real carbamate-contaminated soils. UPLC and GCMS analysis confirmed the successful removal of carbamates. The current study presents the first report on the bioaugmentation studies carried out on the mixed carbamate contaminated soil using newly isolated Acremonium sp.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2373O – PubChem

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Application In Synthesis of 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1563-38-8, name is 2,2-Dimethyl-2,3-dihydrobenzofuran-7-ol. In an article,Which mentioned a new discovery about 1563-38-8

This paper reports the results of a laboratory study aimed at defining the leaching potential of the following pesticides and respective metabolites belonging to the families of N-methylcarbamates and triazines: benfuracarb (BF), carbofuran (CF), 3-keto-carbofuran (3KC) and 3-hydroxy-carbofuran (3HC), atrazine (ATR), simazine (SIM), terbuthylazine (TER), deethylatrazine (DEA), deisopropylatrazine (DIA) and desethylterbuthylazine (DET). All tested compounds, but BF, are very mobile in soil. Triazines exhibited a relatively high persistence, especially DEA, with a DT50 of 72 days. On the contrary, all the tested carbamates resulted easily degradable in soil with a partial exception represented by CF, with a DT50 of 12 days. The GUS indices show high leaching potentials for all the tested triazines and CF. The GUS index of 3KC lies in the typical area of transient compounds; those of BF and 3HC clearly exhibited a non-leaching behaviour. In the leachate corresponding to the BF column, the parent compound was found at low concentration while its main metabolite, CF, reached much higher values. Also, when applied as parent compound, CF was determined at high values, whereas its metabolites 3KC and 3HC were never detected in the leachates. As to triazines, in the ATR column, the parent compound was found at high levels in the leachate, where DEA exhibited values more than 4 times higher than DIA. In the SIM column DIA reached levels 8-fold higher than those in the ATR column. TER occurred at levels close to that of ATR in the respective leachate; DET was found at high levels whereas DIA was not detectable.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2359O – PubChem