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Several studies have shown the positive effects of Ti either with nanotopography or coated with collagen on osteoblast differentiation. Thus, we hypothesized that the association of nanotopography with collagen may increase the in vitro osteogenesis on Ti surface. Ti discs with nanotopography with or without collagen coating were characterized by scanning electron microscopy and atomic force microscopy. Rat calvaria-derived osteoblastic cells were cultured on both Ti surfaces for up to 14 days and the following parameters were evaluated: cell proliferation, alkaline phosphatase (ALP) activity, extracellular matrix mineralization, protein expression of bone sialoprotein (BSP) and osteopontin (OPN), and gene expression of collagen type 1a (Coll1a), runt-related transcription factor 2 (Runx2), osterix (OSX), osteocalcin (OC), Ki67, Survivin, and Bcl2-associated X protein (BAX). Surface characterization evidenced that collagen coating did not alter the nanotopography. Collagen coating increased cell proliferation, ALP activity, extracellular matrix mineralization, and Coll1a, OSX, OC, and BAX gene expression. Also, OPN and BSP proteins were strongly detected in cultures grown on both Ti surfaces. In conclusion, our results showed that the combination of nanotopography with collagen coating stimulates the early, intermediate, and final events of the in vitro osteogenesis and may be considered a potential approach to promote osseointegration of Ti implants.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H4282O – PubChem

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A pharmaceutical composition comprising a compound of formula I or II and a pharmaceutically acceptable carrier. Methods for treating a proliferative disorder mediated by a methyl transferase comprising administering an anti-proliferative effective amount of the compound of formula I or II are also presented.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H4251O – PubChem

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A lotion such as a sunscreen includes a pH indicator which colorizes the lotion until the lotion is applied to the human skin, whereinafter the colored lotion turns clear. A physiologically compatible pH indicator such as phenolphthalein is used which has a red appearance from pH 7.5+ and which has a clear appearance from about pH 7.0 to 7.5, the general pH range of the skin. The invention is suitable for use in any lotion, gel, mousse or medication that is best applied in an even and uniform manner to the skin. Accordingly, one preferred use of the invention is in UV-protecting sunscreens so that a user can ensure even distribution of the sunscreen on the body. In certain aspects of the invention, a cap houses the pH indicator and attaches to a container of the lotion, e.g a sunscreen. The pH indicator mixes with the lotion as it is applied to the skin. The invention further provides methods of manufacturing sunscreens and the like with a pH indicator that turns substantially colorless upon prolonged contact with the skin.

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Benzofuran – Wikipedia,
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SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase (KMT) that monomethylates lysine 20 of histone H4 (H4K20) in vivo. Lysine residues of non-histone proteins including proliferating cell nuclear antigen (PCNA) and p53 are also monomethylated. As a consequence, the methyltransferase activity of the enzyme is implicated in many essential cellular processes including DNA replication, DNA damage response, transcription modulation, and cell cycle regulation. This review aims to provide an overview of the roles of SETD8 in physiological and pathological pathways and to discuss the progress made to date in inhibiting the activity of SETD8 by small molecules, with an emphasis on their discovery, selectivity over other methyltransferases and cellular activity.

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Benzofuran – Wikipedia,
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125-20-2, Name is Thymolphthalein, belongs to benzofurans compound, is a common compound. Safety of ThymolphthaleinIn an article, once mentioned the new application about 125-20-2.

THE modification MAIN objective with various of this types research of water-based is to improve polymer ink latexes printability during paper of papers manufacturing via their process. In order to achieve this target, various types of styrene-acrylate polymer latexes were used for modification of different types of papers. Styrene-acrylate latexes were prepared via emulsion polymerization of styrene with various acrylate monomers using emulsion polymerization technique. The effect of different emulsifying agents on the properties of the prepared emulsions was studied. The obtained results showed a significant improvement in degree of gloss and ink density on the polymer-coated papers which positively affect the ink ability, and ink holding properties of the modified paper. In addition, ink gloss and ink density of the coated papers improved with increasing the concentration of modifying latexes containing TexaponP as emulsifier. These promising results open the way to use polymer latexes in treatment of documented value which can be used in stabilization of disappearing ink on paper leading to prevent forgery.

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Benzofuran – Wikipedia,
Benzofuran | C8H4301O – PubChem

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Objectives: The objective of this study was to investigate the effects of mate tea (MT) [Ilex paraguariensis] on alveolar socket healing after tooth extraction. Materials and methods: Sixteen male rats were divided into MT and control groups. MT was administered by intragastric gavage at a dose of 20 mg/kg/day for 28 days before and 28 days after right maxillary incisor extraction. The control group received an equal volume of water. Histopathological and histometric analysis of the neoformed bone area and osteocyte density were performed, as well as immunohistochemical analysis of osteocalcin (OCN), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), tartrate-resistant acid phosphatase (TRAP), and manganese superoxide dismutase (MnSOD) in the alveolar socket. Calcium, phosphorus, alkaline phosphatase (ALP) activity, total antioxidant capacity (TAC), and malondialdehyde (MDA) were measured in plasma, whereas TRAP activity was determined in serum. Results: Histometry evidenced an increase in bone area (P < 0.0001) and osteocyte density (P < 0.0001). MT increased immunolabeling of MnSOD (P < 0.001), OCN (P < 0.0001), RANKL (P < 0.001), OPG (P < 0.0001), and TRAP (P < 0.001). Calcium and phosphorus concentrations did not differ between the groups. In addition, MT enhanced ALP (P < 0.05) and TRAP (P < 0.0001) activities. MT increased the TAC (P < 0.001), whereas it reduced MDA concentrations (P < 0.0001). Conclusions: MT increases bone area and osteocyte density in the alveolar socket healing on day 28 after tooth extraction. Clinical relevance: Regular MT ingestion improves the antioxidant defenses and bone formation, which is beneficial for alveolar socket bone healing after tooth extraction. Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 125-20-2. In my other articles, you can also check out more blogs about 125-20-2

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H4273O – PubChem

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Photolytic and photocatalytic reactions of sarin (GB), soman (GD), sulfur mustard (HD), cyanogen chloride (CK) and perfluoroisobutylene (PFIB) vapors in air were carried out. It was shown that vapors of GB, GD, HD and PFIB could be efficiently eliminated by UV light from germicidal lamp through either photolysis or photocatalysis, but CK could hardly be done through photodegradation. It was demonstrated that GB, GD and HD might possibly undergo a photo-induced polymerization under UV light irradiation. Photocatalytic reaction would lead to a cleavage of these molecules into small inorganic compounds at TiO2 surface. The experimental results strongly suggested that both photolysis and photocatalysis of GB vapor at static conditions were kinetically slowed down and possibly limited by a low diffusion rate of GB molecule. It has been testified that the static photolysis approach could be applicable for decontamination of GB vapor in an indoor space. And that, a dynamic photocatalysis approach for decontamination of GB vapor was proved to be much more efficient than that through photolysis, and it was also considered to be feasible for decontamination of air polluted by GB vapor.

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Benzofuran – Wikipedia,
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Pancreatic lipase inhibitory effect of methanolic extract of florets Aster sp. was studied. In case of Aster sp. (White florets) the pancreatic lipase inhibition recorded was 82.75% with an Ic50 value of 38mug/mL. Aster sp. (light pink) showed 80.04 % inhibition with an Ic50 of 72 mug/mL. On 2 h dialysis, both the extracts lost their significant pancreatic lipase inhibitory activity, indicating the reversible nature of inhibition. pH slightly affected the performance of pancreatic lipase inhibitory activity. extract (white florets) also showed 22.03% superoxide radical scavenging activity and 22.73% free radical scavenging activity indicating the multifunctional nature of the extract. Light pink florets showed 40.67% superoxide radical scavenging activity and 24.10% free radical scavenging activity. Saponin and alkaloid molecule in white florets of Aster sp. and alkaloid in light pink florets were identified as active principles for pancreatic lipase inhibitory activity.

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Reference:
Benzofuran – Wikipedia,
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Hyperthermostable alkaline lipase from Bacillus sonorensis 4R was purified and characterized. The enzyme production was carried out at 80C and 9.0 pH in glucose-tween inorganic salt broth under static conditions for 96 h. Lipase was purified by anion exchange chromatography by 12.15 fold with a yield of 1.98%. The molecular weight of lipase was found to be 21.87 KDa by SDS-PAGE. The enzyme activity was optimal at 80C with t 1 / 2 of 150 min and at 90C, 100C, 110C, and 120C; the respective values were 121.59 min, 90.01 min, 70.01 min, and 50 min. The enzyme was highly activated by Mg and t 1 / 2 values at 80C were increased from 150 min to 180 min when magnesium and mannitol were added in combination. The activation energy calculated from Arrhenius plot was 31.102 KJ/mol. At 80-120C, values of Delta H and Delta G were in the range of 28.16-27.83 KJ/mol and 102.79 KJ/mol to 111.66 KJ/mol, respectively. Lipase activity was highest at 9.0 pH and stable for 2 hours at this pH at 80C. Pretreatment of lipase with MgSOand CaSOstimulated enzyme activity by 249.94% and 30.2%, respectively. The enzyme activity was greatly reduced by CoCl CdCl HgCl CuCl Pb(NO PMSF, orlistat, oleic acid, iodine, EDTA, and urea.

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Benzofuran – Wikipedia,
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A glassy carbon electrode (GCE) modified with polyaminobenzene sulfonic acid functionalized single-walled carbon nanotubes (f-SWCNT) and electropolymerized aluminon has been developed for the simultaneous determination of naringin and hesperidin. Polyaluminon has been obtained by potentiodynamic electrolysis in basic medium from 100 mumol L?1 monomer solution by 10-fold potential cycling from 0.1 to 0.8 V at potential scan rate of 100 mV s?1. The polyaluminon-based electrode provides a statistically significant increase in the naringin and hesperidin oxidation currents at the same potentials in comparison to the electrode modified with carbon nanotubes. The electrode has been characterized by scanning electron microscopy (SEM) and electrochemical methods. The polyaluminon-modified electrode has demonstrated a 1.5-fold increase in the effective surface area compared to the f-SWCNT/GCE as well as a 2.1-fold lower electron transfer resistance. The electrooxidation parameters of hesperidin and naringin, including the anodic transfer and diffusion coefficients and number of electrons, have been determined. Differential pulse voltammetry in phosphate buffer (PB) pH 5.0 has been employed for the simultaneous determination of naringin and hesperidin. The linear dynamic ranges from 0.10 to 2.5 and 2.5 to 25 mumol L?1 have been obtained for the both analytes with the detection limits of 0.020 and 0.029 mumol L?1 for naringin and hesperidin, respectively. The method has been employed for the analysis of orange and grapefruit juice.

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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H4436O – PubChem