Application of 87-41-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, belongs to benzofurans compound. In a article, author is Ubukata, Shiho, introduce new discover of the category.
Spatial Patterns of Amyloid Deposition in Patients with Chronic Focal or Diffuse Traumatic Brain Injury Using F-18-FPYBF-2 PET
Aim: Amyloid-beta (A beta) accumulation, accelerated by traumatic brain injury (TBI), may play a crucial role in neurodegeneration in chronic-stage TBI. The injury type could influence A beta dynamics because of TBI’s complex, heterogeneous nature. We, therefore, investigated spatial patterns of amyloid deposition according to injury type after TBI using 5-(5-(2-(2-(2-[F]-fluoroethoxy)ethoxy)ethoxy)benzofuran-2-yl)-N-methylpyridin-2-amine (F-18-FPYBF-2) positron emission tomography (PET). Methods: Altogether, 20 patients with chronic TBI [12 with focal injury, 8 with diffuse axonal injury (DAI)] underwent F-18-FPYBF-2 PET, structural magnetic resonance imaging (MRI), and neuropsychological examination. Additionally, 50 healthy controls underwent either F-18-FPYBF-2 PET (n=30) or structural MRI (n=20). Results: Standardized uptake value ratio (SUVR) on PET images and regional brain volumes were measured in four cortical (frontal, parietal, occipital, temporal) and subcortical (combined caudate, putamen, pallidum, thalamus) regions. Patients with DAI showed significantly increased (compared with controls) SUVR in occipital and temporal cortices and decreased brain volume in occipital cortex (corrected p < 0.05). Although patients with focal injury showed decreased SUVR in all regions except occipital cortex, there were no significant differences (compared with controls) in the SUVR in any regions. There were no significant correlations between increased SUVR and neuropsychological impairments in patients with DAI. Conclusion: Varying spatial patterns of amyloid deposition suggest amyloid pathology diversity depending on the injury type in chronic-TBI patients. Application of 87-41-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 87-41-2 is helpful to your research.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem