Reference of 66357-35-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a article, author is Yang Mei, introduce new discover of the category.
Phosphine-Catalyzed [4+1] Annulation of Salicyl Imines with Maleimides and Synthesis of Spiro[benzofuran-2,3 ‘-pyrrolidine] Derivatives
In this work, a phosphine-catalyzed [4+1] annulation between salicyl imines and maleimides has been successfully developed, which readily produces spiro[benzofuran-2,3′-pyrrolidine] derivatives in 44%similar to 99% yields. The annulation products were obtained as a pair of syn- and anti-isomers with dr 1.6 : 1 similar to 5 : 1. The syn-and anti-isomers can be readily separated by column chromatography on silica gel. Thus, this reaction constitutes a simple and efficient method for the synthesis of spiro[benzofuran-2,3’-pyrrolidines]. Presumably, the reaction is initiated by in situ generated non-allylic P-ylide from maleimide and PPh3, and proceeds through a cascade sequence of nucleophilic addition/intramolecular S(N)2-like substitution. It accordingly represents a new example of the phosphine-catalyzed [4+1] annulation via in situ generated non-allylic P-ylides.
Reference of 66357-35-5, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 66357-35-5.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem