Buckley, Benjamin J. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2019 | CAS: 551001-79-7

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Safety of (5-Methoxybenzofuran-2-yl)boronic acid

6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease was written by Buckley, Benjamin J.;Majed, Hiwa;Aboelela, Ashraf;Minaei, Elahe;Jiang, Longguang;Fildes, Karen;Cheung, Chen-Yi;Johnson, Darren;Bachovchin, Daniel;Cook, Gregory M.;Huang, Mingdong;Ranson, Marie;Kelso, Michael J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Safety of (5-Methoxybenzofuran-2-yl)boronic acid This article mentions the following:

Aryldiaminopyrazinecarbonyl guanidines I (R = Ph, 4-MeSC6H4, 4-F3CC6H4, 5-pyrimidinyl, 2,4-dimethoxy-5-pyrimidinyl, 2-methoxy-5-pyrimidinyl, 2,6-dimethoxy-3-pyridinyl, 2-thienyl, 2-furanyl, 3-furanyl, 1-methyl-4-pyrazolyl, 2-benzothienyl, 5-R1-2-benzofuranyl, 6-methoxy-2-benzofuranyl, 2,3-dihydro-5-benzofuranyl; R1 = H, Me, MeO, F, Cl, Br, NC) were prepared as analogs of the potassium ion-sparing diuretic amiloride for the inhibition of urokinase-type plasminogen activator (uPA) and for inhibiting tumor metastasis. The structures of four aryldiaminopyrazinecarbonyl guanidines bound to uPA were determined by X-ray crystallog.; the improved inhibition of uPA by amiloride analogs likely arise from increased occupancy of uPA’s S1β subsite by the aryl substituents. I (R = 2-benzofuranyl, 2-methoxy-5-pyrimidinyl) were selective for uPA over related trypsin-like serine proteases and did not show diuretic or anti-kaliuretic effects in rats. I (R = 2-benzofuranyl) inhibited tumor metastasis in a murine xenograft lung cancer model. In the experiment, the researchers used many compounds, for example, (5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7Safety of (5-Methoxybenzofuran-2-yl)boronic acid).

(5-Methoxybenzofuran-2-yl)boronic acid (cas: 551001-79-7) belongs to benzofurans derivatives. Benzofurans are compounds with a planar structure having 10 pi electrons that include the lone pair on oxygen atom, which makes it more susceptible to electrophilic attack. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Safety of (5-Methoxybenzofuran-2-yl)boronic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem