Black, Kvar C. L.; Ibricevic, Aida; Gunsten, Sean P.; Flores, Jeniree A.; Gustafson, Tiffany P.; Raymond, Jeffery E.; Samarajeewa, Sandani; Shrestha, Ritu; Felder, Simcha E.; Cai, Tianyi; Shen, Yuefei; Lobs, Ann-Kathrin; Zhegalova, Natalia; Sultan, Deborah H.; Berezin, Mikhail; Wooley, Karen L.; Liu, Yongjian; Brody, Steven L. published the article 《In vivo fate tracking of degradable nanoparticles for lung gene transfer using PET and Ĉerenkov imaging》. Keywords: DNA gene therapy transfection vector lung PET imaging; Biodistribution; Cytotoxicity; Degradable nanoparticle; Gene expression; Lung; Čerenkov luminescence imaging.They researched the compound: Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate( cas:70539-42-3 ).Quality Control of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:70539-42-3) here.
Nanoparticles (NPs) play expanding roles in biomedical applications including imaging and therapy, however, their long-term fate and clearance profiles have yet to be fully characterized in vivo. NP delivery via the airway is particularly challenging, as the clearance may be inefficient and lung immune responses complex. Thus, specific material design is required for cargo delivery and quant., noninvasive methods are needed to characterize NP pharmacokinetics. Here, biocompatible poly(acrylamidoethylamine)-b-poly(DL-lactide) block copolymer-based degradable, cationic, shell-cross-linked knedel-like NPs (Dg-cSCKs) were employed to transfect plasmid DNA. Radioactive and optical beacons were attached to monitor biodistribution and imaging. The preferential release of cargo in acidic conditions provided enhanced transfection efficiency compared to non-degradable counterparts. In vivo gene transfer to the lung was correlated with NP pharmacokinetics by radiolabeling Dg-cSCKs and performing quant. biodistribution with parallel positron emission tomog. and Cerenkov imaging. Quantitation of imaging over 14 days corresponded with the pharmacokinetics of NP movement from the lung to gastrointestinal and renal routes, consistent with predicted degradation and excretion. This ability to noninvasively and accurately track NP fate highlights the advantage of incorporating multifunctionality into particle design.
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Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem