Brief introduction of 374706-07-7

As the paragraph descriping shows that 374706-07-7 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.374706-07-7,1-(2,3-Dihydrobenzofuran-6-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(2,3-dihydro-benzofuran-6-yl)-ethanoneBr2 (0.36 ml, 7.01 mmol) was added dropwise to a stirring solution of l-(2,3-dihydro- benzofuran-6-yl)-ethanone (1.13 g, 6.97 mmol) in MeOH (20 mL) held at 00C. The reaction mixture was slowly allowed to reach room temperature. After 3 h, the reaction was quenched by the addition of NaHCO3 (aq, saturated)(until pH=8). Most of the methanol was removed under reduced pressure and the residue was extracted twice with EtOAc (2×20 mL). The organic extracts were pooled, washed with brine (10 mL), dried over MgSO4 and concentrated under reduced pressure. The residue was purified by preparative HPLC using a gradient of 40-70% MeCN in a 0.1M ammonium acetate buffer as eluent. The fractions containing the desired product were pooled and most of the MeCN was removed under EPO reduced pressure. The residue was extracted with EtOAc (2×20 mL) and the combined organic layers was washed with brine, dried over MgSO4 and concentrated. The obtained was finely washed MeOH to give the title compound.1H-NMR (CDC13, 400 MHz): delta 3.25 (t, 2H), 4.39 (s, 2H), 4.61 (t, 2H), 7.24-7.36 (m, 2H), 7.45-7.52 (m, IH).-, 374706-07-7

As the paragraph descriping shows that 374706-07-7 is playing an increasingly important role.

Reference：
Patent; ASTRAZENECA AB; WO2006/137796; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem