Application of 87-41-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 87-41-2, Name is Isobenzofuran-1(3H)-one, SMILES is O=C1OCC2=C1C=CC=C2, belongs to benzofurans compound. In a article, author is Kim, DaWon, introduce new discover of the category.
Orally Administered Benzofuran Derivative Disaggregated A beta Plaques and Oligomers in the Brain of 5XFAD Alzheimer Transgenic Mouse
Amyloid-beta (A beta) aggregated forms are highly associated with the onset of Alzheimer’s disease (AD). A beta abnormally accumulates in the brain and induces neuronal damages and symptoms of AD such as cognitive impairment and memory loss. Since an antibody drug, aducanumab, reduces A beta aggregates and delays clinical decline, clearance of accumulated A beta in the brain is accounted as a therapeutic approach to treat AD. In this study, we synthesized 17 benzofuran derivatives that may disaggregate A beta oligomers and plaques into inert monomers. By a series of A beta aggregation inhibition and aggregates’ disaggregation assays utilizing thioflavin T assays and gel electrophoresis, YB-9, 2-((5-methoxy-3-(4-methoxyphenyl)benzofuran-6-yl)oxy)acetic acid, was selected as the final A beta-disaggregator candidate. When it was orally administered to the 8-month-old male transgenic mouse model with five familial AD mutations (5XFAD) via drinking water daily for two months, A beta oligomers and plaques in hippocampus were reduced. Consequently, decreased astrogliosis and rescued synaptic dysfunction were observed in the hippocampus of YB-9-treated 5XFAD mice compared with the untreated transgenic control group.
Application of 87-41-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 87-41-2 is helpful to your research.
Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem