Synthesis and Evaluation of Antimicrobial Activity of Some Novel Heterocyclic Compounds from 5-Bromosalicylaldehyde was written by Abdel-Aziem, Anhar;Baaiu, Basma S.;Abdelhamid, Abdou O.. And the article was included in Journal of Heterocyclic Chemistry in 2017.Product Details of 38220-75-6 This article mentions the following:
A novel series of coumarins, thiadiazoles, thiazoles, and pyridines were synthesized via reaction of 5-bromosalicylaldehyde with different reagents. Thus, 5-bromosalicylaldehyde was reacted with acetonitrile derivatives affording iminocoumarins, which on hydrolysis with 10% hydrochloric acid, afforded coumarins. On the other hand, reaction of 5-bromosalicylaldehyde with benzylhydrazinecarbodithioate afforded a carbodithioate, which reacted with hydrazonoyl halides, affording 1,3,4-thiadiazoles. Moreover, thiazoles were obtained via reaction of 5-bromosalicylaldehyde with a thiocarbohydrazide derivative and hydrazonoyl halides. However, condensation of 2-acetyl-5-bromobenzofuran with benzaldehyde afforded a chalcone, which reacted with pyridinium bromides to afford pyridine derivatives (I, R = Ph, pMePh, 5-bromobenzofuran-2-yl). Furthermore, pyridines were synthesized from the reaction of a chalcone with different active methylene compounds Reaction of II with ethylchloroacetate, chloroacetone, and chloroacetonitrile afforded thienopyridines (III, Y = CO2Et, Ac, CN). The structures of the newly synthesized compounds were established based on their spectral data and elemental analyses. Also, selected newly synthesized compounds were screened for their antimicrobial activity against various microorganisms by disk diffusion method. In the experiment, the researchers used many compounds, for example, 1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6Product Details of 38220-75-6).
1-(5-Bromobenzofuran-2-yl)ethanone (cas: 38220-75-6) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Product Details of 38220-75-6
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem