23-Sep-2021 News A new application about 14963-96-3

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14963-96-3

Synthetic Route of 14963-96-3, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.14963-96-3, Name is 4-Methoxyisobenzofuran-1,3-dione, molecular formula is C9H6O4. In a article,once mentioned of 14963-96-3

The phthalic anhydrides 4a and 4b are attacked by the Grignard reagents 15 and 33 in tetrahydrofuran/tetramethylethylene diamine almost exclusively at the carbonyl group, which is situated in the meta position of the methoxy substituent(s).This highly regioselective reaction (minimum:95:5) is used as the key step in a short synthesis of daunomycinone (2a), 2-methoxy-7-deoxycarminomycinone (22b),gamma-rhodomycinone (8), and 10-deoxy-gamma-rhodomycinone (9).The products of the addition of 15 to 4a and 4b, the pseudoacids 16 are converted via the olefins 17 and the epoxides 18 into the ketones 19, which lead by application of known reactions to the anthracyclinones 2a, 22a, and 9.The product, formed by addition of 33 to 4a, is converted to gamma-rhodomycinone (8) via the quinone 27.The precursors of the Grignard reagents 15 and 33, the bromides 14 and 32, can be prepared easily and in large scale from the carboxylic acid 10, which is readily available from the cheap chemicals hydroquinone and succinic anhydride.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14963-96-3

Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H2865O – PubChem