Month: December 2021

An article Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters WOS:000589715100001 published article about ENANTIOSELECTIVE C-ACYLATION; SECONDARY ALCOHOLS; DERIVATIVES in [Zhou, Muxing; Zhang, Zhenfeng; He, Ende; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Gridneva, Tatiana; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2021, Cited 47. Category: benzofurans. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Category: benzofurans. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY in [Wang, Zhixin; Zhong, Xiangjian; Li, Jinjie; Wang, Xin; Ji, Linlin; Shang, Xiaoya] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, 191 Beitucheng West Rd, Beijing 100191, Peoples R China; [Liu, Jingyu] Shanxi Agr Univ, Coll Food Sci & Engn, 1 Mingxian South Rd, Jinzhong 030801, Taigu County, Peoples R China published Rapid Characterization of Chemical Components in Edible Mushroom Sparassis crispa by UPLC-Orbitrap MS Analysis and Potential Inhibitory Effects on Allergic Rhinitis in 2019, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 +/- 0.60 mu M. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 ORG PROCESS RES DEV published article about OXIDANT-FREE OXIDATION; CARBOXYLIC-ACID SALTS; ASTERISK-IR COMPLEX; SECONDARY ALCOHOLS; HOMOGENEOUS RUTHENIUM; HYDROGEN-PRODUCTION; N-ALKYLATION; ACCEPTORLESS; PALLADIUM; LIGAND in [Mori, Takamichi] Sanyo Onoda City Univ, Fac Engn, Dept Appl Chem, 1-1-1 Daigakudori, Yamaguchi 7560884, Japan; [Ishii, Chihiro; Kimura, Masanari] Nagasaki Univ, Grad Sch Engn, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan in 2019, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

A dehydrogenative oxidation reaction of primary alcohols to aldehydes catalyzed by a simple Pd/Xantphos catalytic system was developed under an argon or nitrogen atmosphere without oxidizing agents or hydrogen acceptors. The reaction product could be easily changed: under aerobic conditions, esters were obtained in aprotic solvents, whereas the corresponding carboxylic acids were produced in aqueous media. These oxidizing processes were applicable to the efficient synthesis of useful nitrogen-containing heterocyclic compounds such as indole, quinazoline, and benzimidazole via intramolecular versions of this reaction from amino alcohols.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about DIBAL-H REDUCTION; CATALYTIC-HYDROGENATION; CARBONYL REDUCTIONS; CHEMISTRY; GREEN; EFFICIENT; CINACALCET; TOOLS, Saw an article supported by the Austrian Science Fund (FWF)Austrian Science Fund (FWF) [M 2413-B21]. Product Details of 87-41-2. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Otvos, SB; Kappe, CO. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3 center dot DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

Product Details of 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Otvos, SB; Kappe, CO or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. Authors Mourad, AAE; Khodir, AE; Saber, S; Mourad, MAE in MDPI published article about in [Mourad, Ahmed A. E.] Port Said Univ, Fac Pharm, Pharmacol & Toxicol Dept, Port Said 42511, Egypt; [Khodir, Ahmed E.] Horus Univ, Fac Pharm, Pharmacol Dept, New Damietta 34518, Egypt; [Saber, Sameh] Delta Univ Sci & Technol, Fac Pharm, Pharmacol Dept, Mansoura 11152, Dakahlia, Egypt; [Mourad, Mai A. E.] Port Said Univ, Fac Pharm, Med Chem Dept, Port Said 42511, Egypt in 2021, Cited 55. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids +/- metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. Authors Mourad, AAE; Khodir, AE; Saber, S; Mourad, MAE in MDPI published article about in [Mourad, Ahmed A. E.] Port Said Univ, Fac Pharm, Pharmacol & Toxicol Dept, Port Said 42511, Egypt; [Khodir, Ahmed E.] Horus Univ, Fac Pharm, Pharmacol Dept, New Damietta 34518, Egypt; [Saber, Sameh] Delta Univ Sci & Technol, Fac Pharm, Pharmacol Dept, Mansoura 11152, Dakahlia, Egypt; [Mourad, Mai A. E.] Port Said Univ, Fac Pharm, Med Chem Dept, Port Said 42511, Egypt in 2021, Cited 55. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids +/- metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

Welcome to talk about 87-41-2, If you have any questions, you can contact Mourad, AAE; Khodir, AE; Saber, S; Mourad, MAE or send Email.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer-Moest Reaction under Flow Conditions published in 2020. Application In Synthesis of Isobenzofuran-1(3H)-one, Reprint Addresses Linclau, B; Brown, RCD (corresponding author), Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. The first electrochemical functionalisation of cubane by oxidative decarboxylative ether formation (Hofer-Moest reaction) was demonstrated. The mild conditions are compatible with the presence of other oxidisable functional groups, and the use of flow electrochemical conditions allows straightforward upscaling.

Welcome to talk about 87-41-2, If you have any questions, you can contact Collin, DE; Folgueiras-Amador, AA; Pletcher, D; Light, ME; Linclau, B; Brown, RCD or send Email.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

HPLC of Formula: C8H6O2. In 2019 CARBON published article about ACTIVATED CARBON; SELECTIVE HYDROGENATION; GRAPHENE OXIDE; NITROGEN; OXIDATION; NITROBENZENE; NANOTUBES; PERFORMANCE; SITES; ELECTRODES in [Wei, Qinhong; Qin, Fangfang; Shen, Wenzhong] Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Shanxi, Peoples R China; [Ma, Qingxiang] Ningxia Univ, State Key Lab High Efficiency Coal Utilizat & Gre, Yinchuan 750021, Peoples R China in 2019, Cited 57. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Nitroarenes reduction is an important technology in the industrial production of aminoarenes. In this work, we presented an environment-friendly and low-cost green synthesis route for preparation of oxygen and nitrogen co-doped porous carbon (ONPC) via acid oxidation and alkali activation methods using coal tar- and residual oil-based as starting materials, and the prepared ONPC was employed as metal-free carbon catalyst for nitroarenes reduction to aminoarenes in the presence of hydrazine hydrate. This ONPC catalyst showed much higher catalytic activity as compared to those of un-doped porous carbon (PC), activated carbon (AC) and carbon black, which was attributed to its large surface area and developed pore structure as well as O and N co-doping. Additionally, it also exhibited a versatility in various aromatic nitro-compounds reduction to relative aromatic amines. Experimental results by using model catalysts to simulate different carbons with various oxygen-containing groups proved that carbonyl groups were more favorable for nitrobenzene reduction to aniline. Upon co-doping O and N into PC, the two kinds of introduced species synergistically promoted the catalytic activity of PC. Good performance together with low-cost preparation makes oxygen and nitrogen co-doped porous carbon a potential substitution of supported metal catalyst for nitroarenes reduction. (C) 2018 Elsevier Ltd. All rights reserved.

Welcome to talk about 87-41-2, If you have any questions, you can contact Wei, QH; Qin, FF; Ma, QX; Shen, WZ or send Email.. HPLC of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 J AM CHEM SOC published article about C-H BONDS; CATALYZED BORYLATION; PHOTOINDUCED BORYLATION; ORGANOBORON CHEMISTRY; N-TOSYLHYDRAZONES; ADDITIVE-FREE; ESTERS; EFFICIENT; CARBON; FUNCTIONALIZATION in [Li, Jianbin; Wang, Haining; Qiu, Zihang; Huang, Chia-Yu; Li, Chao-Jun] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada; [Li, Jianbin; Wang, Haining; Qiu, Zihang; Huang, Chia-Yu; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, Montreal, PQ H3A 0B8, Canada in 2020, Cited 111. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

Direct conversion of aldehydes and ketones into alkylboronic esters via deoxygenative borylation represents an unknown yet highly desirable transformation. Herein, we present a one-step and metal-free method for carbonyl deoxy-borylation under mild conditions. A wide range of aromatic aldehydes and ketones are tolerated and successfully converted into the corresponding benzylboronates. By the same deoxygenation manifold with aliphatic aldehydes and ketones, we also enable a concise synthesis of 1,1,2-tris(boronates), a family of compounds that currently lack efficient synthetic methods. Given its simplicity and versatility, we expect that this novel borylation approach could show great promise in organoboron synthesis and inspire more carbonyl deoxygenative transformations in both academic and industrial settings.

Welcome to talk about 87-41-2, If you have any questions, you can contact Li, JB; Wang, HN; Qiu, ZH; Huang, CY; Li, CJ or send Email.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. Recently I am researching about METAL-FREE; SELECTIVE OXIDATION; MOLECULAR-OXYGEN; GRAPHENE OXIDE; IONIC LIQUID; FUNCTIONALIZATION; ACTIVATION; KETONES; AIR; DEHYDROGENATION, Saw an article supported by the Open Project of State Key Laboratory for Oxo Synthesis and Selective Oxidation [OSSO-2015-21]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21603060]; Program for Science&Technology Innovation Talents in Universities of Henan Province [15HASTIT004]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Tian, XZ; Cheng, XQ; Yang, XZ; Ren, YL; Yao, KS; Wang, HY; Wang, JJ. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Catalyst-free, additive-free and light-free aerobic conversion of benzylic C-H to C?O bonds is reported. A series of C-H bonds in diphenylmethanes and benzyl ethers underwent this transformation to give the targeted products in low to high yields. The reaction mechanism was also investigated using radical trapping, DFT calculations and O-18-labelled experiments, and the results suggested that the present reaction relied on an activation of oxygen by the bond of the benzene ring.

Recommanded Product: 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem