Day: December 2, 2021

Today I’d like to introduce a new chemical compound, CAS is 1953146-81-0, Name is 36-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-21,21-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontan-1-oic acid, Formula is C75H134N10O35, Molecular Weight is 1735.91g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.. Related Products of 1953146-81-0

The general reactant of this compound is Succinic anhydride;(2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-λ-oxo-N-[2-[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]-1,1-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]ethyl]-1-pyrrolidinedodecanamide, Reagents is Triethylamine, Catalyst(4-(Dimethylamino)pyridine), Solvent is Pyridine；Water, Products 1-[(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] butanedioate, Yield: 100%, Synthetic Methods procedure :1. Dissolve reactant ( 29.20 g, 12.14 mmol ) , succinic anhydride ( 2.45 g, 24.28 mmol ) , polystyrene supported DMAP ( PS-DMAP, 16 g, 1.49 mmol/g, 2 equiv. ) and Et3N ( 10 mL ) in DCM and stir for 48 hours., 2. Filter the reaction mixture, dilute with DCM and wash with saturated brine., 3. Dry the organic layer over anhydrous Na2SO4., 4. Remove solvents and volatiles under reduced pressure., 5. Dry the residue under high vacuum overnight., , Transfornation (Alcoholysis of Anhydrides. Characterization Data include ‘s Proton NMR Spectrum : , Carbon-13 NMR : , HRMS: , State is offwhite solid

I’m so glad you had the patience to read the whole article, if you want know more about 1953146-81-0, you can browse my other blog.. Related Products of 1953146-81-0

Reference:
CAS Reaction Number: 31-355-CAS-9994399,
,CAS Method Number: 3-614-CAS-3165786

An article Pd-Catalyzed Dehydrogenative Oxidation of Alcohols to Functionalized Molecules WOS:000481979500029 published article about OXIDANT-FREE OXIDATION; CARBOXYLIC-ACID SALTS; ASTERISK-IR COMPLEX; SECONDARY ALCOHOLS; HOMOGENEOUS RUTHENIUM; HYDROGEN-PRODUCTION; N-ALKYLATION; ACCEPTORLESS; PALLADIUM; LIGAND in [Mori, Takamichi] Sanyo Onoda City Univ, Fac Engn, Dept Appl Chem, 1-1-1 Daigakudori, Yamaguchi 7560884, Japan; [Ishii, Chihiro; Kimura, Masanari] Nagasaki Univ, Grad Sch Engn, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan in 2019, Cited 63. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A dehydrogenative oxidation reaction of primary alcohols to aldehydes catalyzed by a simple Pd/Xantphos catalytic system was developed under an argon or nitrogen atmosphere without oxidizing agents or hydrogen acceptors. The reaction product could be easily changed: under aerobic conditions, esters were obtained in aprotic solvents, whereas the corresponding carboxylic acids were produced in aqueous media. These oxidizing processes were applicable to the efficient synthesis of useful nitrogen-containing heterocyclic compounds such as indole, quinazoline, and benzimidazole via intramolecular versions of this reaction from amino alcohols.

Welcome to talk about 87-41-2, If you have any questions, you can contact Mori, T; Ishii, C; Kimura, M or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. Recently I am researching about TRADITIONAL CHINESE MEDICINE; CORONARY-HEART-DISEASE; UP-REGULATION; ATHEROGENESIS; CHOLESTEROL; ACTIVATION; MACROPHAGE, Saw an article supported by the National Key Research and Development Program of China [2018YFC1704800, 2018YFC1704805, 2018YFC1704500, 2018YFC1704505]; Fundamental Research Funds for the Central Universities, Nankai University [63191723]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Atherosclerosis is initiated by the local inflammation response to lipid deposition, and the most commonly administered antiatherogenic drugs are statins. Based on traditional Chinese medicine (TCM) evidence, we aimed to find effective therapeutic agents other than statins. A TCM, Suxiao Jiuxin Pill (SX), has been widely used in curing cardiovascular diseases for thirty years. In this paper, a combination of pharmacologic studies and RNA-Seq transcriptomics were employed to explore the pharmacodynamic advantages of SX over atorvastatin in the ApoE(-/-) mouse. 113 differentially expressed genes that were modulated by SX to a greater degree than atorvastatin were primarily involved in immunomodulation. The expression of BTK, AKT1, c-jun and CD137 was effectively regulated by SX with better effect than atorvastatin. Then a dual-luciferase reporter assay for NF-kappa B inhibition was applied to identify active components in SX. As a result, Senkyunolide A (Sen A) and Ligustilide (Lig), the key immunomodulatory ingredients in SX, were found to inhibit the expression of CD137 which is a diagnostic biomarker in atherosclerosis. It was further confirmed that Lig effectively suppressed the expression of AP-1 and NF-kappa B and the phosphorylation of AKT. Therefore, Lig achieved its CD137 inhibition through suppressing the expression of AP-1 and AKT/NF-kappa B signaling pathway, which partly explains the immunomodulation of SX in atherosclerosis. Above all, phthalides may be the primary components of SX improving immune and inflammation response in atherosclerosis.

COA of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Lei, W; Deng, YF; Hu, XY; Ni, JN; Jiang, M; Bai, G or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. Xin, MH; Sun, JJ; Huang, W; Tang, F; Liu, ZY; Jin, Q; Wang, J in [Xin, Minhang; Sun, Jiajia] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Pharm, Dept Med Chem, 76 Yanta West Rd, Xian 710061, Peoples R China; [Huang, Wei] Cent China Normal Univ, Coll Chem, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol,Minist Educ, Wuhan 430079, Peoples R China; [Tang, Feng; Liu, Zhaoyu; Jin, Qiu; Wang, Jia] Jiangsu Simcere Pharmaceut Co Ltd, 699-18 Xuan Wu Dist, Nanjing 210042, Peoples R China published Design and synthesis of novel phthalazinone derivatives as potent poly(ADP-ribose)polymerase 1 inhibitors in 2020, Cited 22. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Aim:The development of effective PARP-1 inhibitors has received great enthusiasm in medicinal chemistry communities.Results:A new series of novel phthalazinone derivatives were designed and synthesized. Among these,B1andB16displayed more potent PARP-1 inhibitory activities than olaparib.B16gave an IC(50)value of 7.8 nM against PARP-1, and a PF(50)value of 3.4 in the sensitizing effect assay. Thein vivopharmacokinetic properties evaluation showedB16displayed insufficient oral exposure, and it was also not stable in rat blood.Conclusion:The results indicated that our design phthalazinone derivatives were potent PARP-1 inhibitors, and compoundB16was a valuable lead compound with siginificantin vitroefficacy, deseaving further optimization so as to develop anticancer drug candidate.

Welcome to talk about 87-41-2, If you have any questions, you can contact Xin, MH; Sun, JJ; Huang, W; Tang, F; Liu, ZY; Jin, Q; Wang, J or send Email.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Investigation of the Potential Environmental Risks of Phthalate Derivatives Designed To Be Environmentally Friendly WOS:000528480300001 published article about ACID ESTERS; DEGRADATION; PHOTOLYSIS; TOXICITY; WATER; DERIVATIZATION; ORGANIZATION; METABOLITES; DIESTERS; PATTERNS in [Zhang, Wenhui; Sun, Ruihao; Hou, Yilin; Li, Yu] North China Elect Power Univ, Coll Environm Sci & Engn, Beijing, Peoples R China; [Zhang, Wenhui; Sun, Ruihao; Hou, Yilin; Li, Yu] North China Elect Power Univ, State Key Lab Reg Optimizat Energy Syst, Beijing, Peoples R China; [Qiu, Youli] North China Inst Sci & Technol, Dept Environm Engn, Beijing, Peoples R China in 2020, Cited 57. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Phthalate derivatives with low estrogenic activity, high infrared spectrum signals, high Raman characteristic vibration spectrum, high fluorescence intensity, and high ultraviolet sensitivity were selected as precursors from our previous studies, so that the changes in their toxicity and estrogenic activity during biological metabolism, ozone oxidation, photocatalytic degradation, photodegradation, and microbial degradation could be studied.The transformation pathways of these derivatives were simulated, and the reaction energy barriers were calculated. To determine the potential environmental risks of these phthalate derivatives, the pharmacophore models of biotoxicity and estrogen activity of phthalates were used to predict the biotoxicity and estrogen activity of the transformed products. The results showed an increase in the biotoxicity and estrogen activity of the biometabolites, ozonation products, photocatalytic degradation products, and microbial degradation products; the only products that did not follow this trend were the photodegradation products. Notably, the pathways that produced more potentially toxic compounds were the less favorable paths. Our results indicate that the transformation products of the designed environmentally friendly phthalate derivatives potentially pose environmental risks. To avoid such risks, the environmental transformation pathway of these derivatives should be simulated to screen for environmentally friendly phthalate molecules. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC

Welcome to talk about 87-41-2, If you have any questions, you can contact Zhang, WH; Sun, RH; Hou, YL; Qiu, YL; Li, Y or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Li, JB; Wang, HN; Qiu, ZH; Huang, CY; Li, CJ in AMER CHEMICAL SOC published article about C-H BONDS; CATALYZED BORYLATION; PHOTOINDUCED BORYLATION; ORGANOBORON CHEMISTRY; N-TOSYLHYDRAZONES; ADDITIVE-FREE; ESTERS; EFFICIENT; CARBON; FUNCTIONALIZATION in [Li, Jianbin; Wang, Haining; Qiu, Zihang; Huang, Chia-Yu; Li, Chao-Jun] McGill Univ, Dept Chem, Montreal, PQ H3A 0B8, Canada; [Li, Jianbin; Wang, Haining; Qiu, Zihang; Huang, Chia-Yu; Li, Chao-Jun] McGill Univ, FRQNT Ctr Green Chem & Catalysis, Montreal, PQ H3A 0B8, Canada in 2020, Cited 111. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Direct conversion of aldehydes and ketones into alkylboronic esters via deoxygenative borylation represents an unknown yet highly desirable transformation. Herein, we present a one-step and metal-free method for carbonyl deoxy-borylation under mild conditions. A wide range of aromatic aldehydes and ketones are tolerated and successfully converted into the corresponding benzylboronates. By the same deoxygenation manifold with aliphatic aldehydes and ketones, we also enable a concise synthesis of 1,1,2-tris(boronates), a family of compounds that currently lack efficient synthetic methods. Given its simplicity and versatility, we expect that this novel borylation approach could show great promise in organoboron synthesis and inspire more carbonyl deoxygenative transformations in both academic and industrial settings.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. Sicignano, M; Schettini, R; Sica, L; Pierri, G; De Riccardis, F; Izzo, I; Maity, B; Minenkov, Y; Cavallo, L; Della Sala, G in [Sicignano, Marina; Schettini, Rosaria; Sica, Luisa; Pierri, Giovanni; De Riccardis, Francesco; Izzo, Irene; Della Sala, Giorgio] Univ Salerno, Dipartimento Chim & Biol Adolfo Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy; [Maity, Bholanath; Cavallo, Luigi] KAUST, KAUST Catalysis Ctr, KCC, Thuwal 239556900, Saudi Arabia; [Minenkov, Yury] MIPT, Inst Pereulok 9, Dolgoprudnyi 141700, Moscow Region, Russia published Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides in 2019, Cited 96. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Invited for the cover of this issue are the groups of Giorgio Della Sala at the Universita degli Studi di Salerno and Luigi Cavallo at the King Abdullah University of Science and Technology. The image depicts the transition state involved in the crown ether catalyzed arylogous Michael reaction of phthalides. Read the full text of the article at 10.1002/chem.201900168.

Product Details of 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Sicignano, M; Schettini, R; Sica, L; Pierri, G; De Riccardis, F; Izzo, I; Maity, B; Minenkov, Y; Cavallo, L; Della Sala, G or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Platinum-on-Carbon-Catalyzed Aqueous Oxidative Lactonization of Diols by Using Molecular Oxygen WOS:000486072800012 published article about AEROBIC OXIDATION; DEHYDROGENATIVE LACTONIZATION; PALLADIUM NANOPARTICLES; ALCOHOLS; EFFICIENT; HYDROXIDE; 1,4-DIOLS; LACTONES; BEARING in [Takakura, Ryoya; Ban, Kazuho; Sajiki, Hironao; Sawama, Yoshinari] Gifu Pharmaceut Univ, Lab Organ Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan in 2019, Cited 49. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. COA of Formula: C8H6O2

A lactonization of various diols catalyzed by platinum on carbon (Pt/C) in water under an atmosphere of molecular oxygen was developed. Derivatives of 1,4- 1,5- and 1,6-diols were transformed into the corresponding five-, six-, and seven-membered lactones by the present oxidative lactonization method.

Welcome to talk about 87-41-2, If you have any questions, you can contact Takakura, R; Ban, K; Sajiki, H; Sawama, Y or send Email.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. In 2019 CHEMOSPHERE published article about POLYCYCLIC AROMATIC-HYDROCARBONS; PHOTOLYSIS HALF-LIVES; SPIRIT OIL-SPILL; CRUDE-OIL; AQUEOUS PHOTODEGRADATION; PHOTOCATALYTIC DEGRADATION; UV-LIGHT; TOXICITY; PAHS; SEDIMENTS in [Kang, Hyun-Joong; Jung, Yerin; Kwon, Jung-Hwan] Korea Univ, Div Environm Sci & Ecol Engn, 145 Anam Ro, Seoul 02841, South Korea in 2019, Cited 65. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Crude oil released into the environment contains many polycyclic aromatic hydrocarbons (PAHs). Alkylated PAHs are more abundant than unsubstituted PAHs and their toxicity is also of serious concern. Among the various physical, chemical, and biological weathering processes of crude oils, photodegradation is one of the most important for determining the environmental fate of oil residues. In this study, the photodegradation rate constants of naphthalene and alkylated naphthalenes were determined under simulated laboratory conditions at different temperature. Changes in the luminescence inhibition of Aliivibrio fischeri, as an indicator of the baseline toxicity, were observed in photodegradation mixtures. The major transformation products were also identified by gas chromatography-mass spectrometry. The photodegradation of naphthalene and the eight alkylated naphthalenes was described well by pseudofirst-order kinetics regardless of experimental temperature. The measured toxicity of the reaction mixtures obtained by photodegradative weathering slightly increased initially and then decreased with further weathering. In all cases, the observed toxicity was greater than accounted for by the parent compounds, indicating that the photodegradation products also contributed significantly to the overall toxicity of the mixtures. The identified photodegradation products were mostly oxygenated compounds such as alcohols, aldehydes, ketones, and quinones, which warrant further investigation. (C) 2019 Elsevier Ltd. All rights reserved.

Computed Properties of C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Kang, HJ; Jung, Y; Kwon, JH or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. In 2020 CATAL SCI TECHNOL published article about METAL-FREE REDUCTION; FRUSTRATED LEWIS PAIRS; H BOND ACTIVATION; CARBONYL-COMPOUNDS; CARBOXYLIC-ACIDS; IRIDIUM(III) METALLACYCLES; HOMOGENEOUS CATALYSIS; UNSYMMETRICAL ETHERS; SELECTIVE REDUCTION; SI-H in [Rysak, Vincent; Merle, Nicolas; Agbossou-Niedercorn, Francine; Michon, Christophe] Univ Lille, Univ Artois, UMR 8181 UCCS Unite Catalyse & Chim Solide, Cent Lille,CNRS, F-59000 Lille, France; [Dixit, Ruchi; Vanka, Kumar] Natl Chem Lab, Phys & Mat Chem Div, CSIR, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [Dixit, Ruchi] Acad Sci & Innovat Res AcSIR, Ghaziahad 201002, India; [Trivelli, Xavier] Univ Lille, Univ Artois, Cent Lille, FR 2638 IMEC Inst Michel Eugene Chevreul,CNRS,INR, F-59000 Lille, France; [Michon, Christophe] Univ Strasbourg, Univ Haute Alsace, Ecole Europeenne Chim Polymeres & Mat, CNRS,LIMA,UMR 7042, 25 Rue Becquerel, F-67087 Strasbourg, France in 2020, Cited 117. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

We report the catalytic and transition metal-free reductive deoxygenation of esters to ethers through the use of a hydrosilane and a fluorinated borate BArF salt as a catalyst. Experimental and theoretical studies support the role of noncovalent interactions between the fluorinated catalyst, the hydrosilane and the ester substrate in the reaction mechanism.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem