Month: December 2021

An article Synthesis of Poly(Arylene Alkenylene)s by Pd-Catalyzed Three-Component Coupling Polycondensation of Diiodoarenes, Non-Conjugated Dienes, and Nucleophiles that Involves Chain Walking Isomerization WOS:000490302000001 published article about ALLYLIC AMINES; ARYL IODIDES; POLYMERIZATION; POLYMERS; COMPLEX; ETHYLENE; CYCLOPOLYMERIZATION; COPOLYMERIZATION; POLYETHYLENES; ALKYLENE)S in [Tan, Liyi; Takeuchi, Daisuke; Osakada, Kohtaro] Tokyo Inst Technol, Lab Chem & Life Sci, R1-03,4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan; [Takeuchi, Daisuke] Hirosaki Univ, Grad Sch Sci & Technol, Dept Frontier Mat Chem, 3 Bunkyo Cho, Hirosaki, Aomori 0368561, Japan in , Cited 41. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and carbonucleophiles afforded poly(arylene alkenylene)s with moderate molecular weight in good yield. The reaction involves Mizoroki-Heck coupling, olefin migration via chain walking, and addition of the carbonucleophile to the resulting pi-allylpalladium species. The polymerization with a slight excess of nucleophile with respect to diiodoarene also proceeded to give the polymer without significant decrease in molecular weight in spite of the nonstoichiometric mixture of the monomers. The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and diimide also proceeded. The base used in the reaction is critical for yield and molecular weight of the product. The reaction using NaHCO3 afforded the product with low solubility, which can be explained by the high molecular weight of the polymer and/or the strong interaction of the electron donating dimethoxyphenylene groups and electron accepting diimide groups in the polymer. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

SDS of cas: 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Efficient hydrogenation of levulinic acid catalysed by spherical NHC-Ir assemblies with atmospheric pressure of hydrogen WOS:000668611600001 published article about IRIDIUM COORDINATION POLYMERS; GAMMA-VALEROLACTONE; BIOMASS; CONVERSION; PLATFORM; RU; NANOSHEETS; COMPLEXES; CHEMICALS; PRODUCTS in [Shen, Lingyun; Zheng, Qingshu; Liu, Yaoqi; Wu, Jiajie; Lu, Zeye; Tu, Tao] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Dept Chem, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Tu, Tao] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China; [Tu, Tao] Zhengzhou Univ, Green Catalysis Ctr, 100 Kexue Ave, Zhengzhou 450001, Peoples R China; [Tu, Tao] Zhengzhou Univ, Coll Chem, 100 Kexue Ave, Zhengzhou 450001, Peoples R China in 2021, Cited 60. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A practical, efficient, and mild hydrogenation of levulinic acid (LA) to gamma-valerolactone (GVL) under 1 atm H-2 was realized by single-sited 3D porous self-supported N-heterocyclic carbene iridium catalysts. Quantitative yields and selectivities were achieved at 0.02 mol% catalyst loading, and the catalyst could be reused for 9 runs without obvious loss of selectivity or activity.

Welcome to talk about 87-41-2, If you have any questions, you can contact Shen, LY; Zheng, QS; Liu, YQ; Wu, JJ; Lu, ZY; Tu, T or send Email.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation WOS:000580634600039 published article about PATHWAY CONTRIBUTES; STROKE; INJURY; NEUROGENESIS; LIGUSTILIDE; DEFICITS; KLOTHO in [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm,Dept Pharmacol,Sichuan Engn, Chengdu 610041, Peoples R China; [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Sichuan Prov Key Lab Qual & Innovat Res Chinese M, Chengdu 610041, Peoples R China; [Duan, Wei] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia; [Duan, Wei] Deakin Univ, Ctr Mol & Med Res, Waurn Ponds, Vic, Australia; [Yang, Yu-Xin] PRIVIS TECHNOL CO LTD, Chengdu 610041, Peoples R China in 2020, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-kappa B expression WOS:000477804500086 published article about TRADITIONAL CHINESE MEDICINE; CORONARY-HEART-DISEASE; UP-REGULATION; ATHEROGENESIS; CHOLESTEROL; ACTIVATION; MACROPHAGE in [Lei, Wei; Deng, Yan-Fang; Hu, Xue-Yan; Jiang, Min; Bai, Gang] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Lei, Wei; Deng, Yan-Fang; Hu, Xue-Yan; Jiang, Min; Bai, Gang] Nankai Univ, Tianjin Key Lab Mol Drug Res, Haihe Educ Pk,38 Tongyan Rd, Tianjin 300353, Peoples R China; [Ni, Jia-Nan] Tianjing Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China in 2019, Cited 36. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

Atherosclerosis is initiated by the local inflammation response to lipid deposition, and the most commonly administered antiatherogenic drugs are statins. Based on traditional Chinese medicine (TCM) evidence, we aimed to find effective therapeutic agents other than statins. A TCM, Suxiao Jiuxin Pill (SX), has been widely used in curing cardiovascular diseases for thirty years. In this paper, a combination of pharmacologic studies and RNA-Seq transcriptomics were employed to explore the pharmacodynamic advantages of SX over atorvastatin in the ApoE(-/-) mouse. 113 differentially expressed genes that were modulated by SX to a greater degree than atorvastatin were primarily involved in immunomodulation. The expression of BTK, AKT1, c-jun and CD137 was effectively regulated by SX with better effect than atorvastatin. Then a dual-luciferase reporter assay for NF-kappa B inhibition was applied to identify active components in SX. As a result, Senkyunolide A (Sen A) and Ligustilide (Lig), the key immunomodulatory ingredients in SX, were found to inhibit the expression of CD137 which is a diagnostic biomarker in atherosclerosis. It was further confirmed that Lig effectively suppressed the expression of AP-1 and NF-kappa B and the phosphorylation of AKT. Therefore, Lig achieved its CD137 inhibition through suppressing the expression of AP-1 and AKT/NF-kappa B signaling pathway, which partly explains the immunomodulation of SX in atherosclerosis. Above all, phthalides may be the primary components of SX improving immune and inflammation response in atherosclerosis.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about ASYMMETRIC BINARY ACID; 3-SUBSTITUTED PHTHALIDES; TRANSFER HYDROGENATION; RELAY CATALYSIS; TRANSFORMATION; DERIVATIVES; FUSCINARIN; CHEMISTRY; ACETALS; ETHERS, Saw an article supported by the NNSFCNational Natural Science Foundation of China (NSFC) [21971120, 21933008]. COA of Formula: C8H6O2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalides as the crucial core skeletons are found extensively in natural products and biological active molecules. Herein we disclose an asymmetric allylation of 3-hydroxyisoben-zofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives. The simple Bi(OAc)(3)/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biological activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations.

Welcome to talk about 87-41-2, If you have any questions, you can contact Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP or send Email.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. I found the field of Research & Experimental Medicine; Pharmacology & Pharmacy very interesting. Saw the article Enhancing insulin sensitivity by dual PPAR gamma partial agonist, beta-catenin inhibitor: Design, synthesis of new alpha phthalimido-o-toluoyl2-aminothiazole hybrids published in 2020, Reprint Addresses Mourad, AAE (corresponding author), Port Said Univ, Fac Pharm, Pharmacol & Toxicol Dept, Port Said, Egypt.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Aims: Partial PPAR gamma agonists attracted substantially heightened interest as safer thiazolidinediones alternatives. On the other hand, Wnt/beta-catenin antagonists have been highlighted as promising strategy for type 2 diabetes management via up-regulating PPAR gamma gene expression. We aimed at synthesizing novel partial PPAR gamma agonists with beta-catenin inhibitory activity which could enhance insulin sensitivity and avoid the side effects of full PPAR gamma agonists. Main methods: We synthesized novel series of alpha-phthlimido-o-toluoyl-2-aminothiazoles hybrids for evaluating their antidiabetic activity and discovering its mechanistic pathway. We assessed effect of the new hybrids on PPAR gamma activation using a luciferase reporter assay system. Moreover, intracellular triglyceride levels, gene levels of c/EBP alpha, PPAR gamma and PPAR gamma targets including GLUT4, adiponectin, aP2 were measured in 3T3-L1 cells. Uptake of 2-DOG together with PPAR gamma and beta-catenin protein levels were evaluated in 3T3-L1cells. In addition, molecular docking studies with PPAR gamma LBD, physicochemical properties and structure activity relationship of the novel hybrids were also studied. Key findings: Three of the synthesized hybrids showed partial PPAR gamma agonistic activity and distinct PPAR gamma binding pattern. These compounds modulated PPAR gamma gene expression and PPAR gamma target genes; and increased glucose uptake in 3T3-L1 and slightly induced adipogenesis compared to rosiglitazone. Moreover, these compounds reduced beta-catenin protein level which reflected in increased both PPAR gamma gene and protein levels that leads to improved insulin sensitivity and increased GLUT4 and adiponectin gene expression. Significance: Our synthesized compounds act as novel partial PPAR gamma agonists and beta-catenin inhibitors that have potent insulin sensitizing activity and mitigate the lipogenic side effects of TZDs.

SDS of cas: 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about RESAZURIN, Saw an article supported by the Thailand Research Fund (TRF)Thailand Research Fund (TRF) [RSA6280019]; National Center for Genetic Engineering and Biotechnology (BIOTEC grant) [P19-50917]. Published in ELSEVIER in AMSTERDAM ,Authors: Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Quality Control of Isobenzofuran-1(3H)-one

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401 WOS:000593184400001 published article about ACETYLCHOLINESTERASE in [Dai, Yu; Li, Kunlong; She, Jianglian; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China; [Li, Kunlong; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China; [Zeng, Yanbo; Wang, Hao; Dai, Haofu] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China; [Liu, Yonghong] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China in 2020, Cited 21. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. SDS of cas: 87-41-2

A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.

Welcome to talk about 87-41-2, If you have any questions, you can contact Dai, Y; Li, KL; She, JL; Zeng, YB; Wang, H; Liao, SR; Lin, XP; Yang, B; Wang, JF; Tao, HM; Dai, HF; Zhou, XF; Liu, YH or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Prodrug Strategies to Improve the Solubility of the HCV NS5A Inhibitor Pibrentasvir (ABT-530) WOS:000580558700022 published article about PROTEASE INHIBITORS; PHARMACOKINETICS; GLECAPREVIR; NUCLEOSIDE; DESIGN; SAFETY; SINGLE in [Randolph, John T.; Voight, Eric A.; Greszler, Stephen N.; Uno, Brice E.; Newton, James N.; Gleason, Kenneth M.; Stolarik, DeAnne; Van Handel, Cecilia; Bow, Daniel A. J.; DeGoey, David A.] Abbvie Inc, Global Pharmaceut Res & Dev, N Chicago, IL 60064 USA in 2020, Cited 26. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alkaline phosphatase. These prodrugs have good hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7) and FESSIF (pH 5). TML prodrug 9 provided superior in vivo performance, delivering high plasma concentrations of PIB in PK studies conducted in mice, dogs, and monkeys. The improved dissolution properties of these phosphate prodrugs provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

Welcome to talk about 87-41-2, If you have any questions, you can contact Randolph, JT; Voight, EA; Greszler, SN; Uno, BE; Newton, JN; Gleason, KM; Stolarik, D; Van Handel, C; Bow, DAJ; DeGoey, DA or send Email.. HPLC of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Lipopeptide Epimers and a Phthalide Glycerol Ether with AChE Inhibitory Activities from the Marine-Derived Fungus Cochliobolus Lunatus SCSIO41401 WOS:000593184400001 published article about ACETYLCHOLINESTERASE in [Dai, Yu; Li, Kunlong; She, Jianglian; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China; [Li, Kunlong; Liao, Shengrong; Lin, Xiuping; Yang, Bin; Wang, Junfeng; Zhou, Xuefeng; Liu, Yonghong] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China; [Zeng, Yanbo; Wang, Hao; Dai, Haofu] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China; [Tao, Huaming] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China; [Liu, Yonghong] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Peoples R China in 2020, Cited 21. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

A pair of novel lipopeptide epimers, sinulariapeptides A (1) and B (2), and a new phthalide glycerol ether (3) were isolated from the marine algal-associated fungus Cochliobolus lunatus SCSIO41401, together with three known chromanone derivates (4-6). The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD), and Mo-2 (OAc)(4)-induced ECD methods. The new compounds 1-3 showed moderate inhibitory activity against acetylcholinesterase (AChE), with IC50 values of 1.3-2.5 mu M, and an in silico molecular docking study was also performed.

Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem