Month: December 2021

Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R in [Patil, Avinash; Duggal, Harleen; Bagul, Kamini T.; Lokhande, Pradeep; Meshram, Rohan] Savitribai Phule Pune Univ, Dept Chem, Pune, Maharashtra, India; [Duggal, Harleen; Bagul, Kamini T.; Meshram, Rohan] Savitribai Phule Pune Univ, Bioinformat Ctr, Dept Biotechnol, Pune, Maharashtra, India; [Kamble, Sonali] Gramin Sci Vocat Coll, Vishnupuri, Nanded, India; [Gacche, Rajesh] Savitribai Phule Pune Univ, Dept Biotechnol, Pune, Maharashtra, India published Synthesis of New 3-Arylaminophthalides and 3-Indolyl-phthalides using Ammonium Chloride, Evaluation of their Anti-Mycobacterial Potential and Docking Study in 2020, Cited 73. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Objective: The study aims at the derivatization of Phthalides and synthesizes 3-arylaminophthalides & 3-indolyl-phthalides compounds, and evaluates their anti-tubercular and antioxidant activities. The study has also intended to employ the in silica methods for the identification of possible drug targets in Mycobacterium and evaluate the binding affinities of synthesized compounds. Methods: This report briefly explains the synthesis of phthalide derivatives using ammonium chloride. The synthesized compounds were characterized using spectral analysis. Resazurin Microtiter Assay (REMA) plate method was used to demonstrate the anti-mycobacterial activity of the synthesized compounds. An in-silico pharmacophore probing approach was used for target identification in Mycobacterium. The structural level interaction between the identified putative drug target and synthesized phthalides was studied using Lamarckian genetic algorithm-based software. Results and Discussion: In the present study, we report an effective, environmentally benign scheme for the synthesis of phthalide derivatives. Compounds 5c and 5d from the current series appear to possess good anti-mycobacterial activity. dCTP: deaminasedUTPase was identified as a putative drug target in Mycobacterium. The docking results clearly showed the interactive involvement of conserved residues of dCTP with the synthesized phthalide compounds. Conclusion: On the eve of evolving anti-TB drug resistance, the data on anti-tubercular and allied activities of the compounds in the present study demonstrates the enormous significance of these newly synthesized derivatives as possible candidate leads in the development of novel anti-tubercular agents. The docking results from the current report provide a structural rationale for the promising anti-tubercular activity demonstrated by 3-arylaminophthalides and 3-indolyl-phthalides compounds.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. Recently I am researching about METAL-FREE REDUCTION; FRUSTRATED LEWIS PAIRS; H BOND ACTIVATION; CARBONYL-COMPOUNDS; CARBOXYLIC-ACIDS; IRIDIUM(III) METALLACYCLES; HOMOGENEOUS CATALYSIS; UNSYMMETRICAL ETHERS; SELECTIVE REDUCTION; SI-H, Saw an article supported by the University of Lille; CNRSCentre National de la Recherche Scientifique (CNRS)European Commission; Chevreul Institute (FR 2638); Ministere de l’Enseignement Superieur et de la RechercheEstonian Research CouncilEuropean Commission; Region Hauts-de-FranceRegion Hauts-de-France; FEDEREuropean Commission; European UnionEuropean Commission; European Regional Development Fund (ERDF)European Commission; Hauts de France Regional Council [17003781]; Metropole Europeenne de Lille [2016_ESR_05]; Pasteur Institute of Lille; Lille University; French CNRSCentre National de la Recherche Scientifique (CNRS); [2017-R3-CTRL-Phase 1]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

We report the catalytic and transition metal-free reductive deoxygenation of esters to ethers through the use of a hydrosilane and a fluorinated borate BArF salt as a catalyst. Experimental and theoretical studies support the role of noncovalent interactions between the fluorinated catalyst, the hydrosilane and the ester substrate in the reaction mechanism.

Welcome to talk about 87-41-2, If you have any questions, you can contact Rysak, V; Dixit, R; Trivelli, X; Merle, N; Agbossou-Niedercorn, F; Vanka, K; Michon, C or send Email.. Name: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Geng, SS; Xiong, BJ; Zhang, Y; Zhang, J; He, Y; Feng, Z in ROYAL SOC CHEMISTRY published article about AEROBIC OXIDATION; HYDROGEN-PEROXIDE; ALPHA-OXYGENATION; TERTIARY-AMINES; FERRIC NITRATE; METAL-FREE; C=C BONDS; ETHERS; PHOTOREDOX; ALDEHYDES in [Geng, Shasha; Xiong, Baojian; Zhang, Yun; Zhang, Juan; He, Yun; Feng, Zhang] Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Feng, Zhang] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China in 2019, Cited 56. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A ligand-free iron-catalyzed method for the oxygenation of benzylic sp(3) C-H bonds by molecular oxygen (1 atm) using a thiyl radical as a cocatalyst has been developed. This transformation provides a facile access to amides, esters and ketones from readily accessible corresponding amines, ethers and alkanes. It features high regioselectivity, mild oxidative conditions and excellent functional group compatibility, providing good opportunities to the site-selective functionalization of complex molecules. Preliminary mechanistic studies suggest that this reaction may not undergo a benzylic cation intermediate pathway and the carbonyl oxygen atom in the products may be derived from molecular oxygen.

Welcome to talk about 87-41-2, If you have any questions, you can contact Geng, SS; Xiong, BJ; Zhang, Y; Zhang, J; He, Y; Feng, Z or send Email.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Lu, C; Yao, J; Knudsen, TS; Amde, M; Gu, JH; Liu, JL; Li, H; Zhang, JY in [Lu, Chao; Yao, Jun; Amde, Meseret; Gu, Jihai; Liu, Jianli; Li, Hao] China Univ Geosci Beijing, Res Ctr Environm Sci & Engn, Sch Water Resource & Environm, 29 Xueyuan Rd, Beijing 100083, Peoples R China; [Knudsen, Tatjana Solevic] Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia; [Amde, Meseret] Haramaya Univ, Coll Nat & Computat Sci, Dept Chem, POB 138, Dire Dawa, Ethiopia; [Zhang, Junyang] Curtin Univ, Western Australia Sch Mines, Dept Min & Met Engn, Kalgoorlie, WA, Australia published Degradation of alpha-nitroso-beta-naphthol by UVA-B activated peroxide, persulfate and monopersulfate oxidants in water in 2019, Cited 47. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Flotation reagents, especially new chelating agents represented by alpha-nitroso-beta-naphthol, are the main components of cobalt mining drainage. This study reports the degradation of alpha-nitroso-beta-naphthol by simulated UVA-B (280-400 nm) activated systems using three common oxidants, hydrogen peroxide, sodium persulfate and potassium monopersulfate at a laboratory scale using a photoreactor. Parameters which can affect the degradation process were investigated and comparison of the degradation performance of the three systems were made. Based on the results, UVA-B/sodium persulfate system exhibited best performance towards the removal of alpha-nitroso-beta-naphthol with a lower cost of oxidant and energy consumption compared to the others. The removal efficiency was found to increase as the oxidant dosage and the UVA-B power increases. Only potassium monopersulfate could be activated by bicarbonate and chloride ions, and SO42- has insignificant effect on the removal efficiency of alpha-nitroso-beta-naphthol for all systems while NO3- inhibited the degradation of alpha-nitroso-beta-naphthol. In the UVA-B/hydrogen peroxide system, the hydroxyl radical had a leading role in the degradation of alpha-nitroso-beta-naphthol, while in the other two systems, the degradation of alpha-nitroso-beta-naphthol was mainly caused by the hydroxyl and sulphate radicals. Ten major intermediates from alpha-nitroso-beta-naphthol degradation in the three oxidation systems were identified by gas chromatography and mass spectrometry. In summary, this report could be a great input in developing UVA-B activated oxidants-based treatment technologies. The UVA-B/sodium persulfate system is strongly recommended for its consideration in the treatment of mine impacted wastewaters. (c) 2019 Elsevier Ltd. All rights reserved.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. Authors Mourad, AAE; Khodir, AE; Saber, S; Mourad, MAE in MDPI published article about in [Mourad, Ahmed A. E.] Port Said Univ, Fac Pharm, Pharmacol & Toxicol Dept, Port Said 42511, Egypt; [Khodir, Ahmed E.] Horus Univ, Fac Pharm, Pharmacol Dept, New Damietta 34518, Egypt; [Saber, Sameh] Delta Univ Sci & Technol, Fac Pharm, Pharmacol Dept, Mansoura 11152, Dakahlia, Egypt; [Mourad, Mai A. E.] Port Said Univ, Fac Pharm, Med Chem Dept, Port Said 42511, Egypt in 2021, Cited 55. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as anti-hyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids +/- metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Category: benzofurans. Authors Liang, XY; Yu, P; Fu, C; Shen, YC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Liang, Xiayu; Yu, Peng; Fu, Chen; Shen, Yongcun] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 122 Luoshi Rd, Wuhan 430070, Peoples R China in 2021, Cited 31. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A new strategy for the facile synthesis of hydroxyalkylamides through the ring-opening reaction of lactone with amine promoted by dibutyltin acetate was developed. A series of hydroxyalkylamide compounds were obtained and the method was successfully applied to the synthesis of pharmaceutically active molecules tyrosinase inhibitor V and HDAC inhibitor VI via a three-step synthetic pathway. The broad substrate scope, mild reaction conditions and practical application proved the effectiveness, compatibility and practicality of this method. (C) 2021 Elsevier Ltd. All rights reserved.

Category: benzofurans. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Antimicrobial drimane – phthalide derivatives from Hypoxylon fendleri BCC32408 WOS:000498290700028 published article about RESAZURIN in [Intaraudom, Chakapong; Bunbamrung, Nantiya; Dramae, Aibrohim; Boonruangprapa, Tanapong; Pittayakhajonwut, Pattama] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathum Thani, Thailand; [Punyain, Wikorn] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok 65000, Thailand in 2019, Cited 12. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Quality Control of Isobenzofuran-1(3H)-one

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Quality Control of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: Isobenzofuran-1(3H)-one. Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S in [Fang, Xin; Ma, Qiang; Feng, Yi; Liang, Shuang] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med, Shanghai 201203, Peoples R China; [Zhang, Kai-Xia; Yao, Song-Yun; Jin, Yong-Sheng] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China published Synthesis of phthalide derivatives and evaluation on their antiplatelet aggregation and antioxidant activities in 2020, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

As part of our continuing efforts to discover structurally interesting bioactive phthalide derivatives, 23 of them with a structure incorporating thiophen or halogens were designed and synthesized, 17 of which are previously unreported. In vitro antiplatelet aggregation activity screening showed that 14b could significantly inhibit platelet aggregation induced by arachidonic acid, compared with edaravone (p < 0.01). Meanwhile, oxidative damage models using SH-SY5Y and PC12 cells induced by H2O2 were built to evaluate the antioxidant activity of the phthalide derivatives. In SH-SY5Y cells, compared with aspirin, 1a significantly increased the relative cell survival rate (p < 0.05). Compared with edaravone, 1a (p < 0.01) and 15b (p < 0.05) significantly increased the relative cell survival rate. In PC12 cells, 1a (p < 0.01), 15b (p < 0.01), and 12a (p < 0.05) remarkably increased the cell survival rate compared with edaravone. The present study identified lead structures to develop potential anti-ischemic stroke agents. Welcome to talk about 87-41-2, If you have any questions, you can contact Fang, X; Ma, Q; Zhang, KX; Yao, SY; Feng, Y; Jin, YS; Liang, S or send Email.. Recommanded Product: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Reversal of diastereoselectivity in palladium-arene interaction directed hydrogenative desymmetrization of 1,3-diketones published in 2020. Formula: C8H6O2, Reprint Addresses Fan, HJ; Zhou, YG (corresponding author), Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

For the metal-catalyzed asymmetric hydrogenation of alpha-substituted ketones, cis reductive products are generally obtained due to steric hindrance of substituents. Herein, an unprecedented trans reductive products were observed in palladium-catalyzed hydrogenative desymmetrization of cyclic and acyclic 1,3-diketones, providing the chiral trans beta-hydroxy ketones with two adjacent stereocenters including one alpha-tertiary or quaternary stereocenter with high enantioselectivity and diastereoselectivity. Mechanistic studies and DFT calculations suggested that the rarely observed diastereoselectivity reversal is ascribed to the charge-charge interaction between the palladium and aromatic ring of the substrate, which could not only result in the reversal of the diastereoselectivity, but also improve the reactivity.

Welcome to talk about 87-41-2, If you have any questions, you can contact Yu, CB; Wang, HD; Song, B; Shen, HQ; Fan, HJ; Zhou, YG or send Email.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 J MED CHEM published article about P2X(1) ION-CHANNEL; MOUSE MODEL; ATP; ACTIVATION; EXPRESSION; RESPONSES; NF449; INHIBITOR; PHARMACOLOGY; NUCLEOTIDES in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England in 2020, Cited 78. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Safety of Isobenzofuran-1(3H)-one

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

Welcome to talk about 87-41-2, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or send Email.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem