Month: December 2021

An article Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters WOS:000589715100001 published article about ENANTIOSELECTIVE C-ACYLATION; SECONDARY ALCOHOLS; DERIVATIVES in [Zhou, Muxing; Zhang, Zhenfeng; He, Ende; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Gridneva, Tatiana; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2021, Cited 47. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Computed Properties of C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Zhou, MX; Gridneva, T; Zhang, ZF; He, ED; Liu, YG; Zhang, WB or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Wei, Q; Yang, JB; Li, L; Su, YL; Wang, AG in ELSEVIER published article about ENANTIOMERIC DERIVATIVES; ABSOLUTE-CONFIGURATION; DILIGUSTILIDE; UMBELLIFERAE in [Wei, Qian; Yang, Jianbo; Li, Li; Su, Yalun; Wang, Aiguo] Chinese Acad Med Sci, Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; [Yang, Jianbo] Natl Inst Food & Drug Control, Inst Control Chinese Tradit Med & Ethn Med, Beijing 100050, Peoples R China in 2019, Cited 21. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Five new phthalide dimers, chaxiongnolides C-G (1-5), the two enantiomers of riligustilide (6a and 6b) and tokinolide B (7) were isolated from the aerial parts of Ligusticum sinense Oliv cv. Chaxiong. The structures of 1-5 were elucidated through extensive spectroscopic analysis, and the relative configurations of compounds 2 and 3 were further confirmed by an X-ray diffraction experiment. The absolute configurations of 1-3 were assigned by comparing calculated and experimental ECD spectra. The ECD exciton chirality method was used to confirm the absolute configurations of compounds 4, 5, 6a and 6b. Compounds 1-3 are the first dimeric phthalides to be reported that are comprising a sedanolide unit. The compounds were evaluated in vitro for their cytotoxic activity against select human cell lines.

Welcome to talk about 87-41-2, If you have any questions, you can contact Wei, Q; Yang, JB; Li, L; Su, YL; Wang, AG or send Email.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Teixeira, AD; Teixeira, RR; Ribeiro, IML; Pereira, WL; Manhabosco, TM; de Brito, ACF; Oliveira, LAM; Nogueira, KDPC in PERGAMON-ELSEVIER SCIENCE LTD published article about PEROXIDE-INDUCED DAMAGE; OXIDATIVE STRESS; 3-SUBSTITUTED ISOCOUMARINS; CELLS; CHEMISTRY in [Teixeira, Aniely dos Reis; Ribeiro, Iara Mariana Lellis; Oliveira, Laser Antonio Machado; Nogueira, Katiane de Oliveira Pinto Coelho] Univ Fed Ouro Preto, Dept Biol Sci, Neurobiol & Biomat Lab, Ouro Preto, MG, Brazil; [Teixeira, Robson Ricardo; Pereira, Wagner Luiz] Univ Fed Vicosa, Dept Chem, Vicosa, MG, Brazil; [Manhabosco, Taise Matte; de Brito, Ana Carolina Ferreira] Univ Fed Ouro Preto, Dept Phys, REDEMAT, Ouro Preto, MG, Brazil in 2020, Cited 52. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The isobenzofuran-1(3H)-ones (phthalides) exhibit various biological activities, including antioxidant activity on reactive oxygen species (ROS). An excess of ROS that cannot be naturally contained by cellular enzymatic systems is called redox imbalance, which damage cell membranes, proteins, and DNA, thereby possibly triggering neuronal death in several neurodegenerative diseases. Considering our ongoing efforts to find useful compounds to control redox imbalance, herein we evaluated the antioxidant activity of two phtalides (compounds 3 and 4), using primary cultures of hippocampal neurons. Spectrophotometric assays showed that compound 3 significantly reduced (p <= 0.05) ROS levels and lipid peroxidation compared to the control treatment, while compound 4 was unable at any of the tested concentrations. Despite their structural similarity, these compounds behave differently in the intracellular environment, which was reliably corroborated by the determination of oxidation potentials via cyclic voltammetry. It was demonstrated that compound 3 presents a lower oxidation potential. The combination of the mentioned methods allowed us to find a strong correlation between the chemical structure of compounds and their biological effects. Taking together, the results indicate that compound 3 presents desirable characteristics to act as a candidate pharmacological agent for use in the prevention and treatment of neurodegenerative diseases. Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article TBSOTf-promoted versatile N-formylation using DMF at room temperature WOS:000469306100016 published article about N,N-DIMETHYLFORMAMIDE; ALLYLATION; ACYLATION; SECONDARY; PEPTIDES; AMINES; ACIDS; MILD in [Sakurai, Masayoshi; Kawakami, Rina; Kihara, Nobuhiro] Kanagawa Univ, Fac Sci, Dept Chem, 2946 Tsuchiya, Hiratsuka, Kanagawa 2591293, Japan in 2019, Cited 34. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

Hydrazides and amines were N-formylated by DMF in the presence of tert-butyldimethylsilyl triflate (TBSOTf) at room temperature, in good to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 87-41-2, If you have any questions, you can contact Sakurai, M; Kawakami, R; Kihara, N or send Email.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. In 2021 ANGEW CHEM INT EDIT published article about ENANTIOSELECTIVE C-ACYLATION; SECONDARY ALCOHOLS; DERIVATIVES in [Zhou, Muxing; Zhang, Zhenfeng; He, Ende; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Gridneva, Tatiana; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China in 2021, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: Isobenzofuran-1(3H)-one. Hassan, AY; Mohamed, MA; Abdel-Aziem, A; Hussain, AO in [Hassan, A. Y.; Abdel-Aziem, A.; Hussain, A. O.] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, POB 11754,Yousef Abbas Str, Cairo, Egypt; [Mohamed, M. A.] Al Azhar Univ, Girls Branch, Fac Sci, Biochem Div,Chem Dept, Cairo, Egypt published Synthesis and Anticancer Activity of Some Fused Heterocyclic Compounds Containing Pyrazole Ring in 2020, Cited 25. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

5-Amino-1-phenyl-1H-pyrazole-4-carbohydraizde(1) was used as a key to synthesize new imidazopyrazol-5(1H)-one 5, pyrazolopyrimidines 7 and 9. Furthermore, imidazopyrazoles 13, 15, pyrazolopyridine 16 and pyrazolopyrazolopyridopyrimidine 17 were prepared from pyrazoles 10 and 11. The structure of the new compounds was confirmed by spectral data as well as elemental analysis. Some compounds were selected by the national cancer institute NCI (USA) for anticancer activity against different human cancer cell lines. The results indicated that compound 12 exhibited strong anticancer activity toward Renal Cancer UO-31(GI, 42.81%), while compound 3 was strong active against Breast Cancer MCF7 (GI, 49.88%) and moderate against T-47D (GI, 38.15%) cell lines. However, compound 17 showed strong activity against Leukemia CCRF-CEM (GI, 41.37%) and SR (GI, 44.95%), whereas, compound 9 showed weak activity toward all tested cancer cell lines.

Recommanded Product: Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Feng, XY; Pi, YH; Song, Y; Xu, ZW; Li, Z; Lin, WB in AMER CHEMICAL SOC published article about in [Feng, Xuanyu; Pi, Yunhong; Song, Yang; Xu, Ziwan; Lin, Wenbin] Univ Chicago, Dept Chem, Chicago, IL 60637 USA; [Pi, Yunhong; Li, Zhong] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China in 2021, Cited 63. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We report here the construction of two metal-organic frameworks (MOFs), Zr-6-Cu/Fe-1 and Zr-6–Cu/Fe-2, by integrating earth-abundant cuprous photosensitizers (Cu-PSs) and Fe catalysts for photocatalytic aerobic oxidation. Site isolation and pore confinement stabilize both Cu-PSs and Fe catalysts, while the proximity between active centers facilitates electron and mass transfer. Upon visible light irradiation and using O-2 as the only oxidant, Zr-6-Cu/Fe-1 and Zr-6-Cu/ Fe-2 efficiently oxidize alcohols and benzylic compounds to afford corresponding carbonyl products with broad substrate scopes, high turnover numbers of up to 500 with a 9.4-fold enhancement over homogeneous analogues, and excellent recyclability in four consecutive runs. Control experiments, spectroscopic evidence, and computational studies revealed the photooxidation mechanism: oxidative quenching of [Cu-PS]* by O-2 affords [Cu-II-PS], which efficiently oxidizes Fe-III-OH to generate a hydroxyl radical for substrate oxidation. This work highlights the potential of MOFs in promoting earth-abundant metal-based photocatalysis.

Welcome to talk about 87-41-2, If you have any questions, you can contact Feng, XY; Pi, YH; Song, Y; Xu, ZW; Li, Z; Lin, WB or send Email.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Quinine-derived thiourea promoted enantioselective Michael addition reactions of 3-substituted phthalides to maleimides WOS:000467500500016 published article about ASYMMETRIC CONJUGATE ADDITION; CARBOXYLIC-ACIDS; FACILE ACCESS; QUATERNARY; DIHYDRONAPHTHOQUINONES; BENZOFURAN-2(3H)-ONES; BENZOFURAN-2-ONES; STEREOCENTERS; DERIVATIVES; CYCLIZATION in [Wang, Jie; Li, Xin; Cheng, Jin-Pei] Nankai Univ, State Key Lab Elementoorgan Chem, Collaborat Innovat Ctr Chem Sci & Engn, Coll Chem, Tianjin 300071, Peoples R China in 2019, Cited 44. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

A highly diastereoselective and enantioselective Michael addition/desymmetrization reaction of maleimides with prochiral 3- substituted phthalides catalyzed by quinine-derived bifunctional thiourea was realized. A broad range of the 3,3-disubstituted phthalides bearing vicinal quaternary-tertiary stereogenic centers were synthesized in moderate to good yields (up to 96%) with high diastereoselectivities (up to >19:1 dr) and enantioselectivities (up to 96:4 er).

Application In Synthesis of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Ligand-Enabled Pd(II)-Catalyzed C(sp(3))-H Lactonization Using Molecular Oxygen as Oxidant published in 2020. COA of Formula: C8H6O2, Reprint Addresses Yu, JQ (corresponding author), Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Pd(II)-catalyzed C-H lactonization of o-methyl benzoic acid substrates has been achieved using molecular oxygen as the oxidant. This finding provides a rare example of C-H oxygenation through Pd(II)/Pd(0) catalysis as well as a method to construct biologically important benzolactone scaffolds. The use of a gas mixture of 5% oxygen in nitrogen demonstrated the possibility for its application in pharmaceutical manufacturing.

COA of Formula: C8H6O2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Syntheses of o-iodobenzyl alcohols-BODIPY structures as potential precursors of bimodal tags for positron emission tomography and optical imaging WOS:000504779400003 published article about ONE-POT SYNTHESIS; ARYLDIAZONIUM SALTS; EXPEDIENT SYNTHESIS; FLUORESCENCE; PET; CHEMISTRY; DYES; DERIVATIVES; MONOXIDE; DESIGN in [Christine, Thifanie; Tabey, Alexis; Cornilleau, Thomas; Fouquet, Eric; Hermange, Philippe] Univ Bordeaux, CNRS, Bordeaux INP, ISM,UMR 5255, 351 Cours Liberat, F-33405 Talence, France in 2019, Cited 77. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Aiming the faster development from bench to bedside of new potential tracers, multimodal tracers for positron emission tomography (PET) and optical imaging (OI) have emerged as a very promising tool. Indeed, they combine the simplicity of use of optical techniques for in vitro/in vivo pre-clinical studies with the various clinical possibilities offered by PET imaging using their radioactive versions. In this context, the preparation of new tags detectable by fluorescence imaging and potentially suitable for PET imaging after a last-step C-11-labeling of the corresponding precursor has been investigated. Various designs and syntheses were explored by linking o-iodobenzyl alcohols and tetramethyl-BODIPY moieties together. Among them, the most promising structure was produced in 30% yield over five steps from a commercially available and inexpensive starting material. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 87-41-2, If you have any questions, you can contact Christine, T; Tabey, A; Cornilleau, T; Fouquet, E; Hermange, P or send Email.. Recommanded Product: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem