Day: December 17, 2021

Stecoza, CE; Nitulescu, GM; Draghici, C; Caproiu, MT; Olaru, OT; Bostan, M; Mihaila, M in [Stecoza, Camelia Elena; Nitulescu, George Mihai; Olaru, Octavian Tudorel] Carol Davila Univ Med & Pharm, Dept Pharmaceut Chem, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania; [Draghici, Constantin; Caproiu, Miron Teodor] Romanian Acad, Costin D Nenitescu Ctr Organ Chem, 202 B Splaiul Independentei, Bucharest 060023, Romania; [Bostan, Marinela; Mihaila, Mirela] Inst Virol, Ctr Immunol Stefan S Nicolau, Bucharest 030304, Romania published Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives in 2021, Cited 54. Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized. The structures of the new compounds were established using elemental analyses, IR and NMR spectral data. The compounds were evaluated for their anticancer potential on two standardized human cell lines, HT-29 (colon adenocarcinoma) and MDA-MB-231 (breast adenocarcinoma). Cytotoxicity was measured by MTS assay, while cell cycle arrest and apoptosis assays were conducted using a flow cytometer, the results showing that the cell line MDA-MB-231 is more sensitive to the compounds’ action. The results of the predictive studies using the PASS application and the structural similarity analysis indicated STAT3 and miR-21 as the most probable pharmacological targets for the new compounds. The promising effect of compound 3e, 2-[2-(phenylsulfanylmethyl)phenyl]-5-(4-pyridyl)-1,3,4-oxadiazole, especially on the MDA-MB-231 cell line motivates future studies to improve the anticancer profile and to reduce the toxicological risks. It is worth noting that 3e produced a low toxic effect in the D. magna 24 h assay and the predictive studies on rat acute toxicity suggest a low degree of toxic risks.

Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Stecoza, CE; Nitulescu, GM; Draghici, C; Caproiu, MT; Olaru, OT; Bostan, M; Mihaila, M or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Unprecedented Diastereoselective Arylogous Michael Addition of Unactivated Phthalides WOS:000469028800011 published article about VINYLOGOUS ALDOL REACTION; PHASE-TRANSFER CATALYSIS; GAUSSIAN-BASIS SETS; ASYMMETRIC-SYNTHESIS; PHTHALIDE-3-CARBOXYLIC ACID; ENANTIOSELECTIVE ADDITION; MACROCYCLIC POLYETHERS; ANNULATION REACTIONS; DENSITY FUNCTIONALS; ENOLATE ACTIVATORS in [Sicignano, Marina; Schettini, Rosaria; Sica, Luisa; Pierri, Giovanni; De Riccardis, Francesco; Izzo, Irene; Della Sala, Giorgio] Univ Salerno, Dipartimento Chim & Biol Adolfo Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy; [Maity, Bholanath; Cavallo, Luigi] KAUST, KAUST Catalysis Ctr, KCC, Thuwal 239556900, Saudi Arabia; [Minenkov, Yury] MIPT, Inst Pereulok 9, Dolgoprudnyi 141700, Moscow Region, Russia in 2019, Cited 96. Safety of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Invited for the cover of this issue are the groups of Giorgio Della Sala at the Universita degli Studi di Salerno and Luigi Cavallo at the King Abdullah University of Science and Technology. The image depicts the transition state involved in the crown ether catalyzed arylogous Michael reaction of phthalides. Read the full text of the article at 10.1002/chem.201900168.

Welcome to talk about 87-41-2, If you have any questions, you can contact Sicignano, M; Schettini, R; Sica, L; Pierri, G; De Riccardis, F; Izzo, I; Maity, B; Minenkov, Y; Cavallo, L; Della Sala, G or send Email.. Safety of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. Recently I am researching about HOMOGENEOUS CATALYSIS; ALCOHOLS; EFFICIENT; AMIDES; KETONES; ESTERS; DESYMMETRIZATION; DEHYDROGENATION; MONOREDUCTION; REDUCTION, Saw an article supported by the Govt. of India; Azrieli Foundation; Planning and Budgeting Committee (PBC). Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Das, UK; Janes, T; Kumar, A; Milstein, D. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Herein we report the selective hydrogenation of cyclic imides to diols and amines, homogeneously catalyzed for the first time by a complex of an earth-abundant metal, a manganese pincer complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.

Product Details of 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article A g-C3N4-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations WOS:000496489100006 published article about GRAPHITIC CARBON NITRIDE; PHOTOREDOX CATALYSIS; ALPHA-OXYGENATION; MOLECULAR-OXYGEN; SINGLET OXYGEN; BOND-CLEAVAGE; OXIDATION; ETHERS; COPPER; EFFICIENT in [Geng, Pengxin; Hu, Jinchuan] Chongqing Normal Univ, Coll Chem, Chongqing 401331, Peoples R China; [Geng, Pengxin; Tang, Yurong; Pan, Guangtong; Cai, Yunfei] Chongqing Univ, Sch Chem & Chem Engn, 174 Shazheng St, Chongqing 400030, Peoples R China; [Geng, Pengxin; Tang, Yurong; Pan, Guangtong; Cai, Yunfei] Chongqing Univ, Chongqing Key Lab Theoret & Computat Chem, 174 Shazheng St, Chongqing 400030, Peoples R China; [Wang, Wentao] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China in 2019, Cited 80. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C3N4) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biologically valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C3N4 catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this green methodology was further demonstrated by applying in bioactive and drug valued target syntheses.

Welcome to talk about 87-41-2, If you have any questions, you can contact Geng, PX; Tang, YR; Pan, GT; Wang, WT; Hu, JC; Cai, YF or send Email.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. I found the field of Toxicology very interesting. Saw the article Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons published in 2020, Reprint Addresses Nogueira, KDPC (corresponding author), Univ Fed Ouro Preto, Inst Ciencias Exatas Biol ICEB, Dept Ciencias Biol DECBI, Campus Morro Cruzeiro S-N, BR-35400000 Ouro Preto, MG, Brazil.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

The isobenzofuran-1(3H)-ones (phthalides) exhibit various biological activities, including antioxidant activity on reactive oxygen species (ROS). An excess of ROS that cannot be naturally contained by cellular enzymatic systems is called redox imbalance, which damage cell membranes, proteins, and DNA, thereby possibly triggering neuronal death in several neurodegenerative diseases. Considering our ongoing efforts to find useful compounds to control redox imbalance, herein we evaluated the antioxidant activity of two phtalides (compounds 3 and 4), using primary cultures of hippocampal neurons. Spectrophotometric assays showed that compound 3 significantly reduced (p <= 0.05) ROS levels and lipid peroxidation compared to the control treatment, while compound 4 was unable at any of the tested concentrations. Despite their structural similarity, these compounds behave differently in the intracellular environment, which was reliably corroborated by the determination of oxidation potentials via cyclic voltammetry. It was demonstrated that compound 3 presents a lower oxidation potential. The combination of the mentioned methods allowed us to find a strong correlation between the chemical structure of compounds and their biological effects. Taking together, the results indicate that compound 3 presents desirable characteristics to act as a candidate pharmacological agent for use in the prevention and treatment of neurodegenerative diseases. Name: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Teixeira, AD; Teixeira, RR; Ribeiro, IML; Pereira, WL; Manhabosco, TM; de Brito, ACF; Oliveira, LAM; Nogueira, KDPC or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Formates plus triazabicyclodecene (TBD): an efficient platform for non-gaseous carbonylation and unexpected hydrogenation WOS:000466794900010 published article about PALLADIUM-CATALYZED CARBONYLATION; METAL-FREE CONSTRUCTION; ARYL HALIDES; N-FORMYLSACCHARIN; EX-SITU; CO; HYDROESTERIFICATION; AMINOCARBONYLATION; ALKYNES; SEQUENCE in [Chen, Dianpeng; Yao, Jinzhong; Chen, Linlin; Hu, Linfeng; Zhou, Hongwei] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China; [Chen, Dianpeng] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China; [Li, Xiaofang] Hunan Univ Sci Technol, Sch Chem & Chem Engn, Xiangtan 411201, Hunan, Peoples R China in 2019, Cited 52. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Product Details of 87-41-2

A highly efficient palladium-catalyzed TBD-formate system for carbonylation/hydrogenation was reported. Based on the obvious solvent effect and reasonable mechanism study, we achieved tunable carbonylation or hydrogenation. With the advantages of simple operation, mild conditions and storable reagents, this protocol should be of interest not only for synthetic scientists but also helpful for laboratory operators.

Welcome to talk about 87-41-2, If you have any questions, you can contact Chen, DP; Yao, JZ; Chen, LL; Hu, LF; Li, XF; Zhou, HW or send Email.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. Recently I am researching about ONE-POT SYNTHESIS; ARYLDIAZONIUM SALTS; EXPEDIENT SYNTHESIS; FLUORESCENCE; PET; CHEMISTRY; DYES; DERIVATIVES; MONOXIDE; DESIGN, Saw an article supported by the Ministere de l’Enseignement et de la Recherche; French Agence Nationale de la RechercheFrench National Research Agency (ANR) [ANR-15-CE18-0015-01]; Investments for the Future Program [ANR-10-LABX-57]; CESAMO [ISM UMR 5255]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Christine, T; Tabey, A; Cornilleau, T; Fouquet, E; Hermange, P. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Aiming the faster development from bench to bedside of new potential tracers, multimodal tracers for positron emission tomography (PET) and optical imaging (OI) have emerged as a very promising tool. Indeed, they combine the simplicity of use of optical techniques for in vitro/in vivo pre-clinical studies with the various clinical possibilities offered by PET imaging using their radioactive versions. In this context, the preparation of new tags detectable by fluorescence imaging and potentially suitable for PET imaging after a last-step C-11-labeling of the corresponding precursor has been investigated. Various designs and syntheses were explored by linking o-iodobenzyl alcohols and tetramethyl-BODIPY moieties together. Among them, the most promising structure was produced in 30% yield over five steps from a commercially available and inexpensive starting material. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 87-41-2, If you have any questions, you can contact Christine, T; Tabey, A; Cornilleau, T; Fouquet, E; Hermange, P or send Email.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. I found the field of Chemistry very interesting. Saw the article Enantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)(3)/Chiral Phosphoric Acid published in 2020, Reprint Addresses Li, X (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Phthalides as the crucial core skeletons are found extensively in natural products and biological active molecules. Herein we disclose an asymmetric allylation of 3-hydroxyisoben-zofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives. The simple Bi(OAc)(3)/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biological activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

SDS of cas: 87-41-2. Authors Shaalan, Y; Boulton, L; Jamieson, C in AMER CHEMICAL SOC published article about in [Shaalan, Youssef; Boulton, Lee] GlaxoSmithKline Med Res Ctr, Chem Dev, Stevenage SG1 2NY, Herts, England; [Shaalan, Youssef; Jamieson, Craig] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland in 2020, Cited 39. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Ruthenium pincer complexes were synthesized and used for catalytic ester reductions under mild conditions (similar to 5 bar of hydrogen). An experimental design approach was used to optimize the conditions for yield, purity, and robustness. Evidence for the catalytically active ruthenium dihydride species is presented. Observed intermediates and side products, as well as time-course data, were used to build mechanistic insight. The optimized procedure was further demonstrated through scaled-up reductions of two pharmaceutically relevant esters, both in batch and continuous flow.

SDS of cas: 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. In 2019 ORGANOMETALLICS published article about N-HETEROCYCLIC CARBENE; EFFICIENT CATALYSTS; BASIS-SETS; SELECTIVE HYDROGENATION; MOLECULAR CALCULATIONS; CARBOXYLIC ESTERS; COMPLEXES; ALCOHOLS; REDUCTION; ACID in [Linh Le; Liu, Jiachen; He, Tianyi; Malek, Jack C.; Cervarich, Tia N.; Buttner, John C.; Pham, John; Keith, Jason M.; Chianese, Anthony R.] Colgate Univ, Dept Chem, 13 Oak Dr, Hamilton, NY 13346 USA in 2019, Cited 68. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

We report the conversion of a series of CNN-pincer-ruthenium complexes Ru(CNN)HCl(CO) to a CC-chelated form Ru(CC)(PR3)(2)H(CO) on reaction with sodium tert-butoxide and monodentate phosphines. When the phosphine is triphenylphosphine, cis-phosphine complexes form at room temperature, which convert to the trans isomer at elevated temperatures. When the phosphine is tricyclohexylphosphine, only the trans-phosphine isomer is observed. The CC-chelated complexes are active catalysts for the hydrogenation of esters, without the need for added base. The ligand structure-activity relationship in the series of CC-chelated complexes mirrors that in the precursor CNN-Ru complexes, potentially indicating a common catalytic mechanism. Density functional theory calculations establish a plausible mechanism for the CNN-to-CC rearrangement and demonstrate that this rearrangement is potentially reversible under the conditions of ester hydrogenation catalysis.

Welcome to talk about 87-41-2, If you have any questions, you can contact Le, L; Liu, JC; He, TY; Malek, JC; Cervarich, TN; Buttner, JC; Pham, J; Keith, JM; Chianese, AR or send Email.. Name: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem