Electric Literature of 6296-53-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4. In a Patent,once mentioned of 6296-53-3
The invention relates to a solvate of apremilast with tetrahydrofuran – THF of formula 1, wherein the molar ratio of apremilast and THF is 2:1. The THF solvate of apremilast exhibits the characteristic melting point of 79.4C. Another aspect provides a process for preparing the THF solvate of apremilast. An alternative process for preparing a solvate of apremilast with tetrahydrofuran comprises a reaction of (S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methylsulfonyl)-ethylamine of formula (S)-3 with 3-acetamidophtalic anhydride of formula 5 in a mixture of tetrahydrofuran and an acid, or a reaction of a diastereoisomeric salt of (S)-1- (3-ethoxy-4-memoxyphenyl)-2-(methylsulfonyl)-ethylamine with tartaric acid or their derivatives of formula (S-6) with a base, producing (S)-1-(3-ethoxy-4-methoxyphenyl)-2- (methylsulfonyl)-ethylamine of formula (S)-3, and its reaction with 3-acetamidophtalic anhydride of formula 5 in a mixture of tetrahydrofuran and an acid. Another aspect provides a pharmaceutical composition comprising the THF solvate of apremilast and at least one pharmaceutically acceptable excipient selected from the group of lactose, microcrystalline cellulose, sodium crosscarmellose, and magnesium stearate.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 6296-53-3, and how the biochemistry of the body works.Electric Literature of 6296-53-3
Reference:
Benzofuran – Wikipedia,
Benzofuran | C8H3453O – PubChem