Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. category: benzofuran. Introducing a new discovery about 57319-65-0, Name is 6-Aminoisobenzofuran-1(3H)-one
The inflammatory response associated with the activation of C-C chemokine receptor CCR2 via it’s interaction with the monocyte chemoattractant protein-1 (MCP-1, CCL2) has been implicated in many disease states, including rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma and neuropathic pain. Small molecule antagonists of CCR2 have been efficacious in animal models of inflammatory disease, and have been advanced into clinical development. The necessity to attenuate hERG binding appears to be a common theme for many of the CCR2 antagonist scaffolds appearing in the literature, presumably due the basic hydrophobic motif present in all of these molecules. Following the discovery of a novel cyclohexyl azetidinylamide CCR2 antagonist scaffold, replacement of the amide bond with heterocyclic rings was explored as a strategy for reducing hERG binding and improving pharmacokinetic properties.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.category: benzofuran, you can also check out more blogs about57319-65-0
Reference：
Benzofuran – Wikipedia,
Benzofuran | C8H1413O – PubChem