Zhang, Ling published the artcileDeconstructive Reorganization: De Novo Synthesis of Hydroxylated Benzofuran, Application of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, the publication is Angewandte Chemie, International Edition (2020), 59(12), 4670-4677, database is CAplus and MEDLINE.
An unprecedented deconstructive reorganization strategy for the de novo synthesis of hydroxylated benzofurans I [R = H, OH; R1 = t-Bu, 3-thienyl, Ph, etc.; R2 = H, OH, Me, OMe, 4-MeOC6H4S; R3 = H, OH, Ph, etc.] from kojic acid- or maltol-derived alkynes was reported. In this reaction, both the benzene and furan rings were simultaneously constructed, whereas the pyrone moiety of the kojic acid or maltol was deconstructed and then reorganized into the benzene ring as a six-carbon component. Through this strategy, at least one free hydroxyl group was introduced into the benzene ring in a substitution-pattern tunable fashion without protection-deprotection and redox adjustment. With this method, a large number of hydroxylated benzofuran derivatives with different substitution-patterns were prepared efficiently. This methodol. was shown as the key step in a collective total synthesis of hydroxylated benzofuran-containing natural products.
Angewandte Chemie, International Edition published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C34H33ClN6O7, Application of 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol.
Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem