With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.174775-48-5,Ethyl 5-aminobenzofuran-2-carboxylate,as a common compound, the synthetic route is as follows.
To the solution of ethyl 5-aminobenzofuran-2-carboxylate (4) (1 mmol), bis-(2-chloro ethyl) amine (1.5 mmol), and sodium carbonate (2.0 mmol), in 1-propanol solvent. Reaction mass is heat to reflux for 24 h and filtered. Add mixture of water and MDC. Extract the compound with MDC twice. The combined organic layer was dried over Na2SO4 and then evaporated to dryness. Compound purified by column chromatography. 35% yield. Get the ethyl-5-(1-piperazinyl) benzofuran-2-carboxylate. White solid, 89% yield, mp 269.4-271.4 C, 1H NMR (300 MHz, CDCl3): delta = 7.68 (s, 1H), 7.36 (m, 1H), 6.84 (m, 2H), 4.35 (q, J = 7.5, 14.4 Hz, 2H), 3.89 (t, J = 4.4 Hz, 4H), 3.15 (t, J = 4.8 Hz, 4H), 1.33 (m, 3H) 6H); 13C NMR (75 MHz, DMSO+CDCl3): 157.3, 154.9, 142.5, 129.7, 120.8, 112.2, 110.4, 109.2, 107.2, 58.8, 59.2, 49.8, 48.2, 43.4, 13.2. MS calcd for C19H23N3O4: 357.4. Found: 358.6, (M+). Anal. Calcd for C19H23N3O4: C, 63.85; H, 6.49; N, 11.76. Found: C, 63.82; H, 6.48; N, 11.78., 174775-48-5
The synthetic route of 174775-48-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Renuka, Janupally; Reddy, Kummetha Indrasena; Srihari, Konduri; Jeankumar, Variam Ullas; Shravan, Morla; Sridevi, Jonnalagadda Padma; Yogeeswari, Perumal; Babu, Kondra Sudhakar; Sriram, Dharmarajan; Bioorganic and Medicinal Chemistry; vol. 22; 17; (2014); p. 4924 – 4934;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem