With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.652-39-1,4-Fluoroisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.
652-39-1, A solution of 4-fluoroisobenzofuran-1,3-dione (200 mg, 1.20 mmol, 1 equiv) in AcOH (4.0mL, 0.3 M)was added 2,6-dioxopiperidin-3-amine hydrochloride (218 mg, 1.32 mmol, 1.1 equiv)and potassium acetate (366 mg, 3.73 mmol, 3.1 equiv). The reaction mixture was heated to 90 C overnight, whereupon it was diluted with water to 20 mL and cooled on ice for 30 mm. The resulting slurry was filtered, and the black solid was purified by flash column chromatography on silica gel (2% MeOH in CH2C12, Rf = 0.3) to afford the title compound as a white solid (288 mg,86%). 1H NMR (500 MHz, DMSO-d6) 11.15 (s, 1H), 7.96 (ddd,J= 8.3, 7.3, 4.5 Hz, 1H), 7.82-7.71 (m, 2H), 5.17(dd,J= 13.0, 5.4 Hz, 1H), 2.90(ddd,J= 17.1, 13.9, 5.4 Hz, 1H), 2.65 -2.47 (m, 2H), 2.10-2.04 (m, 1H), MS (ESI) cald for C13H10FN2O4 [M+H] 277.06, found 277.25.
652-39-1 4-Fluoroisobenzofuran-1,3-dione 69551, abenzofuran compound, is more and more widely used in various fields.
Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ROBERTS, Justin; BEHMAN, Nabet; WINTER, Georg; PHILLIPS, Andrews, J.; HEFFERNAN, Timothy, P.; BUCKLEY, Dennis; (617 pag.)WO2018/148440; (2018); A1;,
Benzofuran – Wikipedia
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