Heterocyclic Building Block-benzofuran

In an article, author is Gallou, Isabelle, once mentioned the application of 6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, molecular formula is C10H7NO4, molecular weight is 205.1669, MDL number is MFCD00453138, category is benzofurans. Now introduce a scientific discovery about this category, Computed Properties of C10H7NO4.

Development of a Robust Protocol for the Synthesis of 6-Hydroxybenzofuran-3-carboxylic Acid

Benzofuran scaffolds are fundamental moieties found in a variety of biologically active natural products and synthetic drugs. In the course of one of our development programs, we needed to develop a practical and cost-effective manufacturing approach to such a benzofuran scaffold. Here we report a highly robust four-step, one-pot process that provides access to a 6-hydroxybenzofuran-3-carboxylic acid structure. An H-1 NMR monitoring study allowed a better understanding of the overall sequence of events and the nature of the detected intermediates. After six steps, including the optimized tandem process, the desired hydroxylated benzofuran was obtained in 40% yield with a purity above 99%.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Tian, Peng,once mentioned of 497-23-4, Computed Properties of C4H4O2.

Effects of different vegetable oils on the aroma characteristics of deep-fried shallot flavoring evaluated by HS-SPME/GC-MS coupled with PLSR

In this study, four fried shallot-flavored oil (FSO) samples prepared with different oil were analyzed by gas chromatography-mass spectrometry (GC-MS), descriptive sensory analysis (DSA), and electronic nose (E-nose). A total of 75 volatile compounds were identified, and 44, 34, 32, and 25 of these compounds were found in the FSOs with rapeseed oil, peanut oil, soybean oil and sunflower oils, respectively, which were conducted for comparison and evaluation of the aroma characteristics of FSOs. Seven sensory attributes (oily, pungent, cooked vegetable, grease, burnt, pickled, and shallot scent) were chosen to evaluate FSOs. DSA results showed a significant difference among these FSO samples for shallot scent and grease, and FSO2 heated by peanut oil presented strong in these two notes, but weaker in burnt, FSO3 also has the weaker burnt flavor. Moreover, E-nose analysis confirmed the results of GC-MS and DSA. Results of correlation analysis partial least squares regression (PLSR) among 50 volatile compounds and DSA data, indicated that 2-Ethyl-3,5-dimethyl-pyrazine, 2,3-Dihydro-benzofuran, and benzaldehyde contribute to grease flavor; 2-Ethyl-3,5-dimethyl-pyrazinemay contribute to shallot scent flavor, and further confirmed that peanut oil may be a suitable carrier oil for the sensory characteristics of FSO. Practical applications The unique shallot flavor and rich fat fragrance of FSO play an increasingly important role in the cooking and processing of dishes. However, there is relatively little research on FSO. In this study, FSO prepared by different types of oil can produce different flavor of FSO with dissimilar volatiles and sensory characteristics. We used PLSR to analyze the relationship between sensory attributes and compounds. These research contents will provide a basis for the industrialization of fried shallot oil.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is , belongs to benzofurans compound. In a document, author is Mancuso, Raffaella, Computed Properties of C6H8O2.

Catalytic Carbonylative Double Cyclization of 2-(3-Hydroxy-1-yn-1-yl)phenols in Ionic Liquids Leading to Furobenzofuranone Derivatives

A catalytic carbonylative double cyclization method for the synthesis of furo[3,4-b]benzofuran-1(3H)-ones is reported. It is based on the reaction between readily available 2-(3-hydroxy-1-yn-1-yl)phenols, CO, and oxygen carried out in the presence of catalytic amounts of PdI2 (1 mol %) in conjunction with KI (20 mol %) and 2 equiv of diisopropylethylamine at 80 degrees C for 24 h under 30 atm of a 1:4 mixture of CO-air. Interestingly, the process was not selective when carried out in classical organic non-nucleophilic solvents (such as MeCN or DME), leading to a mixture of the benzofurofuranone derivative and the benzofuran ensuing from simple cycloisomerization, whereas it turned out chemoselective toward the formation of the double cyclization compound in BmimBF(4) as the reaction medium. Moreover, the ionic liquid solvent containing the catalyst could be easily recycled several times without appreciable loss of activity.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Computed Properties of C13H22N4O3S, 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, in an article , author is Hu, Fan, once mentioned of 66357-35-5.

An investigation of the synthesis of vilazodone

A novel synthetic route toward vilazodone is described by using 4-cyanoaniline and 5-bromo-2-hydroxybenzaldehyde as starting materials, with an overall yield of 24% and 99% purity. First, the intermediate (3-(4-chlorobutyl)-1H-indole-5-carbonitrile) is synthesized via diazotization of 4-cyanoaniline, followed by Fischer indole cyclization with 6-chlorohexanal. Subsequently, another intermediate, 5-(piperazin-1-yl)benzofuran-2-carboxamide, is generated via aromatic nucleophilic substitution of 5-bromobenzofuran-2-carboxamide with piperazine. Finally, vilazodone is obtained via nucleophilic substitution of the above two key intermediates by treatment with Et3N/K2CO3. In comparison to the original process, this route avoids the use of expensive and toxic reagents and resolves issues such as safety, environmental concerns, and high costs.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 66357-35-5, you can contact me at any time and look forward to more communication. Computed Properties of C13H22N4O3S.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C13H22N4O3S, 66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S, belongs to benzofurans compound. In a document, author is Jeong, Joo Young, introduce the new discover.

Synthesis of the Tetracyclic Cores of the Integrastatins, Epicoccolide A and Epicocconigrone A

The integrastatins, epicoccolide A and epicoccongirone A, are natural products containing a unique [6.6.6.6]-tetracyclic core framework that exhibit a broad spectrum of biological activities. A synthesis of the common core of epicoccolide A and epicocconigrone A has been achieved using an umpolung alkylation-lactonization to assemble an isochromanone from which the bridged 1,3-dioxane was readily assembled. A different strategy was required to access the core on the integrastatins; an initial aryllithium addition to an aldehyde, followed by oxidation and treatment of the masked dihydroxyketone with acid gave the desired core structure.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66357-35-5. COA of Formula: C13H22N4O3S.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide6296-53-3, Name is N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide, SMILES is CC(NC1=CC=CC(C(O2)=O)=C1C2=O)=O, belongs to benzofurans compound. In a article, author is Pokharel, Uttam R., introduce new discover of the category.

Synthesis and crystal structures of 2-(ferrocenylcarbonyl)benzoic acid and 3-ferrocenylphthaude

The title compounds, 2-(ferrocenylcarbonyl)benzoic acid, [Fe(C5H5)(C13H9O3)], 1, and 3-ferrocenylphthalide [systematic name: 3-ferroceny1-2-benzofuran-1(3H)-one], [Fe(C5H5)(C13H9O2)], 2, have been synthesized and structurally characterized by single-crystal X-ray diffraction. The crystal structure of compound 1 was solved recently at room temperature [Qin, Y. (2019). CSD Communication (CCDC deposition number 1912662). CCDC, Cambridge, England]. Here we report a redetermination of its crystal structure at 90 K with improved precision by a factor of about three. The molecular structures of both compounds exhibit a typical sandwich structure. In the crystal packing of compound 1, each molecule engages in intermolecular hydrogen bonding, forming a centrosymmetric dimer with graph-set notation R-2(2) (8) and an O center dot center dot center dot O distance of 2.6073 (15) angstrom. There are weak C-H center dot center dot center dot O and C-H center dot center dot center dot pi interactions in the crystal packing of compound 2. The phthalide moiety in 2 is oriented roughly perpendicular to the ferrocene backbone, with a dihedral angle of 77.4 (2)degrees.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 6296-53-3. Name: N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Application In Synthesis of 2,5-Dimethylfuran-3(2H)-one, 14400-67-0, Name is 2,5-Dimethylfuran-3(2H)-one, molecular formula is C6H8O2, belongs to benzofurans compound. In a document, author is Asati, Vivek, introduce the new discover.

PIM kinase inhibitors: Structural and pharmacological perspectives

The PIM kinase, also known as serine/threonine kinase plays an important role in cancer biology and is found in three different isoforms namely PIM-1, PIM-2, and PIM-3. They are extensively distributed and are implicated in a variety of biological processes, including cell proliferation, cell differentiation, and apoptosis. They act as weak oncogene and whenever expressed in exacerbating forms are responsible for different types of human cancer. Recently, different isoforms of PIM kinase have been identified as a clinical biomarker and potential therapeutic target for personalized treatment of advanced cancer. The inhibition of PIM kinase has become a scientific interest and some inhibitors have been developed and/or are under different phases of clinical trials. Several medicinally privileged heterocyclic ring scaffolds such as pyrrole, pyrimidine, thiazolidine, benzofuran, indole, triazole, oxadiazole, and quinoline derivatives have been synthesized and evaluated for their PIM inhibitory activity. This review comprehensively focuses on pharmacological implications of PIM kinases in oncogenesis, structural insights of PIM inhibitors and their structure-activity relationships (SARs). (C) 2019 Elsevier Masson SAS. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14400-67-0. Application In Synthesis of 2,5-Dimethylfuran-3(2H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Corre, Michelle F., once mentioned the application of 497-23-4, Recommanded Product: Furan-2(5H)-one, Name is Furan-2(5H)-one, molecular formula is C4H4O2, molecular weight is 84.07, MDL number is MFCD00005376, category is benzofurans. Now introduce a scientific discovery about this category.

Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H-3 and H(4 )receptors

Histamine acts through four different receptors (H1R-H4R), the H3R and H4R being the most explored in the last years as drug targets. The H3R is a potential target to treat narcolepsy, Parkinson’s disease, epilepsy, schizophrenia and several other CNS-related conditions, while H4R blockade leads to anti-inflammatory and immunomodulatory effects. Our group has been exploring the dihydrobenzofuranyl-piperazines (LINS01 series) as human H3R/H4R ligands as potential drug candidates. In the present study, a set of 12 compounds were synthesized from adequate (dihydro)benzofuran synthons through simple reactions with corresponding piperazines, giving moderate to high yields. Four compounds (1b, 1f, 1g and 1h) showed high hH(3)R affinity (pK(i) > 7), compound 1h being the most potent (pK(i) 8.4), and compound if showed the best efficiency (pKi 8.2, LE 0.53, LLE 5.85). BRET-based assays monitoring G alpha(i) activity indicated that the compounds are potent antagonists. Only one compound (2c, pK(i) 7.1) presented high affinity for hH(4)R. In contrast to what was observed for hH(3)R, it showed partial agonist activity. Docking experiments indicated that bulky substituents occupy a hydrophobic pocket in hH(3)R, while the N-allyl group forms favorable interactions with hydrophobic residues in the TM2, 3 and 7, increasing the selectivity towards hH(3)R. Additionally, the importance of the indole NH in the interaction with Glu5.46 from hH(4)R was confirmed by the modeling results, explaining the affinity and agonistic activity of compound 2c. The data reported in this work represent important findings for the rational design of future compounds for hH(3)R and hH(4)R.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 97148-39-5, Name is Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate, molecular formula is C7H10N2O4. In an article, author is Li, Qing-Hua,once mentioned of 97148-39-5, Recommanded Product: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate.

A novel chiral DMAP-thiourea bifunctional catalyst catalyzed enantioselective Steglich and Black rearrangement reactions

The first novel and efficient chiral DMAP-thiourea bifunctional catalyst has been successfully developed and applied in highly enantioselective acyl-transfer reactions. A series of 1,3-oxazolyl carbonates are efficiently transformed to C-carboxyazlactones (Steglich rearrangement) by employing 5 mol% of this bifunctional nucleophilic catalyst with good yields and excellent enantioselectivities (up to 90% yield and 97% ee), and 2-benzofuranylcarbonates are also converted to 3,3-disubstituted benzofuran-2-ones (Black rearrangement) with satisfactory asymmetric induction (up to 92% yield and 87% ee).

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 87-41-2, Name is Isobenzofuran-1(3H)-one, molecular formula is C8H6O2, belongs to benzofurans compound. In a document, author is Zhu, Xiao-Rui, introduce the new discover, COA of Formula: C8H6O2.

Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl Halides to Aryl Ketones for the Synthesis of Benzofuran Derivatives

A nickel-catalyzed intramolecular nucleophilic addition reaction of aryl halides to aryl ketones for the formation of benzofuran derivatives has been developed. A number of substrates bearing electron-donating or electron-withdrawing groups were subjected to the standard reaction conditions, giving the corresponding products in moderate to good yields.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 87-41-2. COA of Formula: C8H6O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem