Heterocyclic Building Block-benzofuran

Computed Properties of C8H6O2. In 2020 J MED CHEM published article about P2X(1) ION-CHANNEL; MOUSE MODEL; ATP; ACTIVATION; EXPRESSION; RESPONSES; NF449; INHIBITOR; PHARMACOLOGY; NUCLEOTIDES in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England in 2020, Cited 78. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or concate me.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about STRUCTURE-BASED DESIGN; ACARICIDAL ACTIVITY; CNIDIUM-OFFICINALE; PLANTS; BUTYLIDENEPHTHALIDE; TOXICITY; MELANIN; PROPHENOLOXIDASE; DERIVATIVES; INHIBITION, Saw an article supported by the Tarbiat Modares University, Tehran, Iran. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Abbod, M; Safaie, N; Gholivand, K; Mehrabadi, M; Bonsaii, M. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Quality Control of Isobenzofuran-1(3H)-one

In this study, the biological activities and mode of action of 3-butylidene phthalide (3-BPH) were studied. 3-BPH had a superior efficiency against microsclerotia of Macrophomina phaseolina compared to the commercial fungicide tricyclazole. The microsclerotia formation and pigmentation were inhibited at 100 mu g/mL. Moreover, the fungicide exhibited in silico affinity toward trihydroxy naphthalene reductase (3HNR). Both 3-BPH and tricyclazole showed congruence in the orientation and interaction within the 3HNR active site. 3-BPH displayed a strong interaction with SER-164, TYR-178, and TYR-223, with estimated binding energy and inhibition constant of -6.78 kcal mol(-1), and Ki = 12.6 mu M, respectively. Furthermore, it showed in vitro and in silico inhibitory activity against Drosophila melanogaster acetylcholinesterase in a concentration-dependent manner with IC50 = 730 mu g/mL. It also impaired Galleria mellonella phenol oxidase enzyme, which corresponds with the insect’s immune system. Phytotoxicity of 3-BPH was evident against Lemna minor at 1000 mu g/mL; nevertheless, it was nontoxic at the concentrations inhibiting M. phaseolina microsclerotia and dark pigments suggest that it may be safe for use on other plants at low doses. Further assays are wanted to develop 3-BPH as a novel crop protection compound.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Abbod, M; Safaie, N; Gholivand, K; Mehrabadi, M; Bonsaii, M or concate me.. Quality Control of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Selective aerobic oxidation of cyclic ethers to lactones over Au/CeO2 without any additives WOS:000518591800023 published article about COPPER(II) COMPLEXES; CATALYTIC-OXIDATION; TETRAHYDROFURAN; FUNCTIONALIZATION; CLUSTERS in [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Thermodynam Inst Chem, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Han, Buxing; Liu, Huizhen] Univ Chinese Acad Sci, Beijing 100149, Peoples R China in 2020, Cited 40. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Name: Isobenzofuran-1(3H)-one

Selective oxidation of ethers to lactones with O-2 as a benign oxidant using Au/CeO2 as the catalyst has been developed. The oxygen vacancies and Au-0 species on the surface of CeO2 contribute to the activation of O-2. The excellent selectivity of lactones is due to the adsorption of ethers and activation of the C(sp(3))-H bond on Au/CeO2.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Liu, SL; Li, SP; Shen, XJ; Wang, YY; Du, J; Chen, BF; Han, BX; Liu, HZ or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Oxidative Kinetic Resolution of Cyclic Benzylic Ethers WOS:000585986100001 published article about C-H BONDS; RACEMIC SECONDARY ALCOHOLS; HYDROGEN-PEROXIDE; ASYMMETRIC EPOXIDATION; OXOCARBENIUM IONS; AEROBIC OXIDATION; HYDROXYLATION; MECHANISM; COMPLEX; DESYMMETRIZATION in [Sun, Shutao; Ma, Yingang; Liu, Ziqiang; Liu, Lei] Shandong Univ, Sch Pharmaceut Sci, Jinan 250100, Peoples R China; [Sun, Shutao; Liu, Lei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China in 2021, Cited 69. Category: benzofurans. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A manganese-catalyzed oxidative kinetic resolution of cyclic benzylic ethers through asymmetric C(sp(3))-H oxidation is reported. The practical approach is applicable to a wide range of 1,3-dihydroisobenzofurans bearing diverse functional groups and substituent patterns at the alpha position with extremely efficient enantiodiscrimination. The generality of the strategy was further demonstrated by efficient oxidative kinetic resolution of another type of five-membered cyclic benzylic ether, 2,3-dihydrobenzofurans, and six-membered 6H-benzo[c]chromenes. Direct late-stage oxidative kinetic resolution of bioactive molecules that are otherwise difficult to access was further explored.

Category: benzofurans. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sun, ST; Ma, YG; Liu, ZQ; Liu, L or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 J CLEAN PROD published article about ADVANCED OXIDATION PROCESSES; AQUEOUS-SOLUTION; WASTE-WATER; PHOTOCHEMICAL DEGRADATION; HYDROXYL RADICALS; HYDROGEN-PEROXIDE; AZO-DYE; MECHANISM; REMOVAL; KINETICS in [Lu, Chao; Yao, Jun; Amde, Meseret; Gu, Jihai; Liu, Jianli; Li, Hao] China Univ Geosci Beijing, Res Ctr Environm Sci & Engn, Sch Water Resource & Environm, 29 Xueyuan Rd, Beijing 100083, Peoples R China; [Knudsen, Tatjana Solevic] Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia; [Amde, Meseret] Haramaya Univ, Coll Nat & Computat Sci, Dept Chem, POB 138, Dire Dawa, Ethiopia; [Zhang, Junyang] Curtin Univ, Western Australia Sch Mines, Dept Min & Met Engn, Kalgoorlie, WA, Australia in 2019, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

Flotation reagents, especially new chelating agents represented by alpha-nitroso-beta-naphthol, are the main components of cobalt mining drainage. This study reports the degradation of alpha-nitroso-beta-naphthol by simulated UVA-B (280-400 nm) activated systems using three common oxidants, hydrogen peroxide, sodium persulfate and potassium monopersulfate at a laboratory scale using a photoreactor. Parameters which can affect the degradation process were investigated and comparison of the degradation performance of the three systems were made. Based on the results, UVA-B/sodium persulfate system exhibited best performance towards the removal of alpha-nitroso-beta-naphthol with a lower cost of oxidant and energy consumption compared to the others. The removal efficiency was found to increase as the oxidant dosage and the UVA-B power increases. Only potassium monopersulfate could be activated by bicarbonate and chloride ions, and SO42- has insignificant effect on the removal efficiency of alpha-nitroso-beta-naphthol for all systems while NO3- inhibited the degradation of alpha-nitroso-beta-naphthol. In the UVA-B/hydrogen peroxide system, the hydroxyl radical had a leading role in the degradation of alpha-nitroso-beta-naphthol, while in the other two systems, the degradation of alpha-nitroso-beta-naphthol was mainly caused by the hydroxyl and sulphate radicals. Ten major intermediates from alpha-nitroso-beta-naphthol degradation in the three oxidation systems were identified by gas chromatography and mass spectrometry. In summary, this report could be a great input in developing UVA-B activated oxidants-based treatment technologies. The UVA-B/sodium persulfate system is strongly recommended for its consideration in the treatment of mine impacted wastewaters. (c) 2019 Elsevier Ltd. All rights reserved.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lu, C; Yao, J; Knudsen, TS; Amde, M; Gu, JH; Liu, JL; Li, H; Zhang, JY or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England published Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists in 2020, Cited 78. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or concate me.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about CARBON; NANOPARTICLES; COSIX/CNTS; XPS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21373038, 21403026]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [DUT18GJ206]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, LL; Chen, X; Chen, YJ; Peng, ZJ; Liang, CH. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Application In Synthesis of Isobenzofuran-1(3H)-one

Chemoselective hydrogenation of phthalic anhydride is regarded as the most promising route for producing downstream high-performance phthalide. A series of intermetallic cobalt-nickel silicide catalysts embedded in a carbon matrix (CoxNi2-xSi@C) with acid-tolerance prepared by microwave-assisted chemical vapor deposition have been investigated in this reaction system. Activity measurements show a remarkable positive synergistic effect, forming a volcano-shaped plot over the nominal Co metal fraction for CoxNi2-xSi@C catalysts with a peak at x = 1.5, which corresponds to a 4.5-fold enhancement of the yield of phthalide over Co2Si@C and a 2.0-fold enhancement over the Ni2Si@C monometallic silicide catalysts, which can be correlated with the interaction of cobalt-nickel and metal-silicon bonds. In addition, the cobalt-rich bimetallic silicide exhibits an equal activity to the reference noble metal catalysts (Au, Pd, and Pt) and a significantly higher activity than transition metal catalysts. Moreover, the bimetallic silicide as an intermetallic compound catalyst has demonstrated robust acid corrosion resistance compared to the corresponding metal catalysts.

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhang, LL; Chen, X; Chen, YJ; Peng, ZJ; Liang, CH or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. Geng, SS; Xiong, BJ; Zhang, Y; Zhang, J; He, Y; Feng, Z in [Geng, Shasha; Xiong, Baojian; Zhang, Yun; Zhang, Juan; He, Yun; Feng, Zhang] Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Feng, Zhang] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China published Thiyl radical promoted iron-catalyzed-selective oxidation of benzylic sp(3) C-H bonds with molecular oxygen in 2019, Cited 56. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A ligand-free iron-catalyzed method for the oxygenation of benzylic sp(3) C-H bonds by molecular oxygen (1 atm) using a thiyl radical as a cocatalyst has been developed. This transformation provides a facile access to amides, esters and ketones from readily accessible corresponding amines, ethers and alkanes. It features high regioselectivity, mild oxidative conditions and excellent functional group compatibility, providing good opportunities to the site-selective functionalization of complex molecules. Preliminary mechanistic studies suggest that this reaction may not undergo a benzylic cation intermediate pathway and the carbonyl oxygen atom in the products may be derived from molecular oxygen.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Geng, SS; Xiong, BJ; Zhang, Y; Zhang, J; He, Y; Feng, Z or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Photoregulated fluxional fluorophores for live-cell super-resolution microscopy with no apparent photobleaching WOS:000461311900002 published article about INTRAMOLECULAR SPIROCYCLIZATION; MOLECULES; NANOSCOPY in [Halabi, Elias A.; Rivera-Fuentes, Pablo] Swiss Fed Inst Technol, Lab Organ Chem, CH-8093 Zurich, Switzerland; [Pinotsi, Dorothea] Swiss Fed Inst Technol, Sci Ctr Opt & Electron Microscopy, CH-8093 Zurich, Switzerland in 2019, Cited 42. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. COA of Formula: C8H6O2

Photoswitchable molecules have multiple applications in the physical and life sciences because their properties can be modulated with light. Fluxional molecules, which undergo rapid degenerate rearrangements in the electronic ground state, also exhibit switching behavior. The stochastic nature of fluxional switching, however, has hampered its application in the development of functional molecules and materials. Here we combine photoswitching and fluxionality to develop a fluorophore that enables very long (>30 min) time-lapse single-molecule localization microscopy in living cells with minimal phototoxicity and no apparent photobleaching. These long time-lapse experiments allow us to track intracellular organelles with unprecedented spatiotemporal resolution, revealing new information of the three-dimensional compartmentalization of synaptic vesicle trafficking in live human neurons.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Halabi, EA; Pinotsi, D; Rivera-Fuentes, P or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U in [Lukic, Igor; Horvat, Ivana] Inst Agr & Tourism, K Huguesa 8, Porec 52440, Croatia; [Lukic, Igor] Ctr Excellence Biodivers & Mol Plant Breeding, Svetosimunska 25, Zagreb 10000, Croatia; [Carlin, Silvia; Vrhovsek, Urska] Fdn Edmund Mach FEM, Res & Innovat Ctr, Dept Food Qual & Nutr, Via E Mach 1, I-38010 San Michele All Adige, TN, Italy; [Carlin, Silvia] Univ Udine, Dept Agr Food Environm & Anim Sci, Via Sci 208, I-33100 Udine, Italy published Combined targeted and untargeted profiling of volatile aroma compounds with comprehensive two-dimensional gas chromatography for differentiation of virgin olive oils according to variety and geographical origin in 2019, Cited 35. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC-TOF-MS) was combined with conventional mono-dimensional GC-MS to differentiate Croatian virgin olive oils (VOO) according to variety and geographical origin, based on the profile of volatile aroma compounds isolated by HS-SPME. More than 1000 compounds were detected after untargeted profiling and 256 were identified or tentatively identified, providing one of the most detailed profiles of volatile aroma compounds in VOO up to date. Among them, 131 volatile compounds were significantly different across monovarietal VOOs, while 60 were found useful for the discrimination according to geographical origin. Many major lipoxygenase and minor non-lipoxygenase-generated compounds were shown to have discriminating ability with respect to both factors. Multivariate statistical analysis extracted twenty-one volatile markers with the highest discriminant power for varietal differentiation. The approach reported may have practical application in better understanding, defining, managing, and communicating the varietal or geographical typicity of monovarietal VOOs.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U or concate me.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem