Heterocyclic Building Block-benzofuran

An article Surface adsorption configurations of H3PO4 modified TiO2 and its influence on the photodegradation intermediates of gaseous o-xylene WOS:000543713600044 published article about VOLATILE ORGANIC-COMPOUNDS; ENHANCED PHOTOCATALYTIC ACTIVITY; VISIBLE-LIGHT PHOTOCATALYSIS; TOTAL-ENERGY CALCULATIONS; TITANIUM-DIOXIDE; CATALYTIC COMBUSTION; INDOOR AIR; OXIDATION; PHOSPHATE; REMOVAL in [Wang, Zhuang; Mahmood, Asad; Xie, Xiaofeng; Wang, Xiao; Sun, Jing] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China; [Wang, Zhuang; Qiu, Hanxun] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China in 2020, Cited 75. SDS of cas: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

For the oxide-based photocatalysts, polyoxylic acid modification can affect their adsorption/desorption properties and further regulate photocatalytic reaction pathway, which is crucial for enhancing photocatalytic activity and selectivity. Herein, phosphoric acid modified TiO2 was synthesized by a facile impregnation-calcination method for photocatalytic degradation of gaseous o-xylene. According to FTIR, XPS, and EDS analysis, phosphoric acid was anchored on the surface of TiO2 successfully. The surface P atomic percentages for PT1 was 2.45%. The as-prepared phosphoric acid modified TiO2 (PTx) had a photocatalytic performance superior to that of commercial TiO2 and unmodified TiO2 (PT0), with increasing by 2.2 times at most. Interestingly, the phosphoric acid molecules strongly adsorbed on anatase TiO2 surface by forming H-O-2C and =O-Ti-5C chemical bonds according to the first principle calculations, which changed TiO2 surface properties (specific surface area and surface negative electrostatic field) and further improved adsorption and charge carrier separation and transfer, thus improving the photocatalytic activity. Additionally, according to the intermediates results, the relative abundance of intermediates shows obvious difference. Acetone was detected as the most abundant intermediates during o-xylene degradation for PT0, whereas that was o-methyl benzaldehyde for PT1, which could be ascribed to the difference of surface adsorption configuration of o-xylene. According to the temperature-programmed desorption (TPD) results, the surface modified by phosphoric acid could change the o-xylene adsorption configuration to favor its methyl oxidation (standing configuration), whereas the unmodified surface could be more favorable to the benzene ring-open reaction (lying configuration). This work will deepen the understanding of the relevance of surface modification and surface photocatalytic reaction, which also provides a feasible strategy to improve photocatalytic selectivity.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, Z; Mahmood, A; Xie, XF; Wang, X; Qiu, HX; Sun, J or concate me.. SDS of cas: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis of Phthalides and alpha,beta-butenolides by Transition Metal-Catalyzed Activation of CH Bonds published in 2019. Product Details of 87-41-2, Reprint Addresses Renzetti, A (corresponding author), Univ Ryukyus, Fac Educ, 1 Senbaru, Nishihara, Okinawa 9030213, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalides and ,-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on CH bond functionalization reactions, in which two simple, unfunctionalized molecules are coupled together with cleavage of a CH bond and formation of a CX bond (X=C or heteroatom). This paper reviews the methods for the synthesis of phthalides and ,-butenolides by CH bond functionalization from non-halogenated starting materials. Over 30 methods are reported, mostly developed during the past ten years.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Renzetti, A; Fukumoto, K or concate me.. Product Details of 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 J MED CHEM published article about P2X(1) ION-CHANNEL; MOUSE MODEL; ATP; ACTIVATION; EXPRESSION; RESPONSES; NF449; INHIBITOR; PHARMACOLOGY; NUCLEOTIDES in [Tian, Maoqun; Abdelrahman, Aliaa; Azazna, Djamil; Spanier, Claudia; Densborn, Sabrina; Hinz, Sonja; Mueller, Christa E.] Univ Bonn, PharmaCtr Bonn, Pharmaceut Inst, Pharmaceut & Med Chem, D-53121 Bonn, Germany; [Baqi, Younis] Sultan Qaboos Univ, Dept Chem, Fac Sci, Muscat 123, Oman; [Fuentes, Eduardo] Univ Talca, Dept Clin Biochem & Immunohaematol, Thrombosis Res Ctr, Med Technol Sch,Fac Hlth Sci,Interdisciplinary Ct, Talca 3460000, Chile; [Schmid, Ralf] Univ Leicester, Dept Mol & Cell Biol, Leicester LE1 7RH, Leics, England; [Schmid, Ralf] Univ Leicester, Leicester Inst Struct & Chem Biol, Leicester LE1 7RH, Leics, England in 2020, Cited 78. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic potency was assessed in 1321N1 astrocytoma cells stably transfected with the human P2X1 receptor by measuring inhibition of the ATP-induced calcium influx. Structure-activity relationships were analyzed, and selectivity versus other P2X receptor subtypes was assessed. The most potent compounds, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide (1, IC50 0.0192 mu M) and N-[3,5-bis(trifluoromethyl)phenyl]-4-chloro-2-hydroxybenzamide (14, IC50 0.0231 mu M), displayed >500-fold selectivity versus P2X2 and P2X3, and 10-fold selectivity versus P2X4 and P2X7 receptors, and inhibited collagen-induced platelet aggregation. They behaved as negative allosteric modulators, and molecular modeling studies suggested an extracellular binding site. Besides selective P2X1 antagonists, compounds with ancillary P2X4 and/or P2X7 receptor inhibition were discovered. These compounds represent the first potent, non-acidic, allosteric P2X1 receptor antagonists reported to date.

HPLC of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tian, MQ; Abdelrahman, A; Baqi, Y; Fuentes, E; Azazna, D; Spanier, C; Densborn, S; Hinz, S; Schmid, R; Muller, CE or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Antimicrobial drimane – phthalide derivatives from Hypoxylon fendleri BCC32408 published in 2019. Recommanded Product: Isobenzofuran-1(3H)-one, Reprint Addresses Pittayakhajonwut, P (corresponding author), Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathum Thani, Thailand.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P in [Intaraudom, Chakapong; Bunbamrung, Nantiya; Dramae, Aibrohim; Boonruangprapa, Tanapong; Pittayakhajonwut, Pattama] Natl Sci & Technol Dev Agcy, Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk,Phaholyothin Rd, Klongluang 12120, Pathum Thani, Thailand; [Punyain, Wikorn] Naresuan Univ, Fac Sci, Dept Chem, Phitsanulok 65000, Thailand published Antimicrobial drimane – phthalide derivatives from Hypoxylon fendleri BCC32408 in 2019, Cited 12. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Fourteen new compounds including thirteen drimane – phthalide derivatives (fendlerals A – C, fendlerins A – D, fendlerols A – B, fendleric acids A – C, fendlerinine G) and one terphenyl derivative (fendleryl E) along with eight known compounds, fendlerinine A, rickenyls C – D, fendleryls C – D, atromentin, tetramethyl atromentin, and ( +/- )-microsphaerophthalide F, were isolated from the wood fungus Hypoxylon fendleri BCC32408. Compared with the prior work, the results indicated the agitation effect on the production of bioactive drimane – phthalides. The chemical structures were determined based upon spectroscopic analyses and the absolute configurations were verified by comparison of the ECD spectral data with the calculated ECD spectra of the related compounds. Compounds 1-3 exhibited antimicrobial activity against Plasmodium falciparum (IC50 4.15-4.39 mu M), Colletotrichum capsici (MIC 6.25-12.5 mu g/mL), and Bacillus cereus (MIC 1.56-3.13 mu g/mL). All tested compounds displayed broad cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells.

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Intaraudom, C; Punyain, W; Bunbamrung, N; Dramae, A; Boonruangprapa, T; Pittayakhajonwut, P or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Aniline-Type Hypervalent Iodine(III) for Intramolecular Cyclization via C-H Bond Abstraction of Hydrocarbons Containing N- and O-Nucleophiles WOS:000647954700001 published article about REAGENTS; FUNCTIONALIZATION; REACTIVITY; CHEMISTRY in [Nishiguchi, Yuna; Moriyama, Katsuhiko] Chiba Univ, Grad Sch Sci, Dept Chem, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan; [Nishiguchi, Yuna; Moriyama, Katsuhiko] Chiba Univ, Soft Mol Activat Res Ctr, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan in 2021, Cited 42. Recommanded Product: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We developed a method for the preparation of (diacetoxyiodo)-2-(N-alkylamido)benzene as an aniline-type hypervalent iodine(III). We also achieved direct cyclizations via C-H bond abstraction, such as the Hofmann-Loffler-Freytag reaction, a direct amination, and a direct lactonization, using the aniline-type hypervalent iodine(III) to obtain corresponding products in high yields.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Nishiguchi, Y; Moriyama, K or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Thiyl radical promoted iron-catalyzed-selective oxidation of benzylic sp(3) C-H bonds with molecular oxygen published in 2019. Recommanded Product: Isobenzofuran-1(3H)-one, Reprint Addresses He, Y; Feng, Z (corresponding author), Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China.; Feng, Z (corresponding author), Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A ligand-free iron-catalyzed method for the oxygenation of benzylic sp(3) C-H bonds by molecular oxygen (1 atm) using a thiyl radical as a cocatalyst has been developed. This transformation provides a facile access to amides, esters and ketones from readily accessible corresponding amines, ethers and alkanes. It features high regioselectivity, mild oxidative conditions and excellent functional group compatibility, providing good opportunities to the site-selective functionalization of complex molecules. Preliminary mechanistic studies suggest that this reaction may not undergo a benzylic cation intermediate pathway and the carbonyl oxygen atom in the products may be derived from molecular oxygen.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Geng, SS; Xiong, BJ; Zhang, Y; Zhang, J; He, Y; Feng, Z or concate me.. Recommanded Product: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Formula: C8H6O2. In 2020 INT IMMUNOPHARMACOL published article about ISCHEMIA/REPERFUSION INJURY; INFLAMMASOME ACTIVATION; LIGUSTILIDE; STROKE; NEUROTOXICITY; PATHWAY; RATS in [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, Educ Minist, Sichuan Engn Lab Plant Sourced Drug, Dept Pharmacol,Key Lab Drug Targeting & Drug Deli, Chengdu 610041, Peoples R China; [Li, Xin; Shi, Meng-Qi; Du, Jun-Rong] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Chengdu 610041, Peoples R China in 2020, Cited 43. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The activation of NLRP3 inflammasome is closely related to ischemic brain injury and inhibition of NLRP3 inflammasome activation may be a new therapeutic strategy for ischemic stroke. Our previous studies showed that ligustilide (LIG) had a dose-dependent neuroprotective effect on various models of cerebral ischemia and dementia in vivo and in vitro. CD21, a kind of phthalide derivative, was modified from LIG. In this study, we established a global cerebral ischemia-reperfusion model in mice by bilateral common carotid artery ligation (2VO), and explored the neuroprotective effect of CD21 and its anti-inflammatory mechanism on cerebral ischemia mice. CD21 significantly improved weight loss, neurobehavioral deficits and neurons loss in hippocampal CA1 and caudate putamen (CPu) subregions, which were induced by 2VO in mice. CD21 significantly inhibited the overactivation of astrocyte and microglia, and decreased the mRNA level of IL-6, TNF-alpha and IL-1 beta. Moreover, CD21 significantly inhibited the activation of TLR4/NF-kappa B signaling pathway mediated by HMGB1 and NLRP3/ASC/Caspase-1 signaling pathway mediated by Cathepsin B, thus inhibiting the activation of NLRP3 inflammasome. Our results demonstrated that CD21 may exert a neuroprotection by inhibiting NLRP3 inflammasome activation after cerebral ischemia. These findings provide a new strategy for the treatment of ischemic stroke.

Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Li, X; Shi, MQ; Chen, C; Du, JR or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 TETRAHEDRON LETT published article about GENERAL-ACID CATALYSIS; NUCLEOPHILIC-ATTACK; HYDROLYSIS; CONJUGATE; RESONANCE; DESIGN; FIELD; OXIDE in [Backer, Brian S.; Choy, Cindy J.; Davis, Austen L.; Browne, Zachery S.; Berkman, Clifford E.] Washington State Univ, Dept Chem, Pullman, WA 99164 USA in 2020, Cited 28. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Application In Synthesis of Isobenzofuran-1(3H)-one

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Rao, ZP; Shi, GS; Wang, Z; Mahmood, A; Xie, XF; Sun, J in ELSEVIER SCIENCE SA published article about TM-DOPED TIO2; UP-CONVERSION; GAS-PHASE; CATALYTIC-OXIDATION; OPTICAL-PROPERTIES; FACILE SYNTHESIS; ANATASE TIO2; TOLUENE; NANOPARTICLES; NANOTUBES in [Rao, Zepeng; Shi, Gansheng; Wang, Zhuang; Mahmood, Asad; Xie, Xiaofeng; Sun, Jing] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China; [Rao, Zepeng] Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China in 2020, Cited 59. Product Details of 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

In this work, we synthesized thulium (Tm3+) modified TiO2 nanoparticles by a facile sol-gel route. We show that Tm3+-modified TiO2 exhibit superior photocatalytic activity than pure TiO2 towards gas-phase degradation of acetaldehyde, o-xylene, and their mixture. The photocatalytic activity enhances with the increasing Tm content from 0.1 to 0.5 mol%. The 0.5 mol%Tm-TiO2 sample demonstrated the highest photodegradation efficiency (> 90.0%) for acetaldehyde and o-xylene. According to the systematic characterization such as photoluminescence (PL), photocurrent, up-conversion spectra, UV-Vis diffuse reflectance spectroscopy and electron spin resonance (ESR) analysis, the enhanced photocatalytic performance can be attributed to introducing the new Tm-4f states between the original band gap of TiO2, which led to the increase of efficiency of light-induced electron-hole separation and the increase of hydrophilicity which resulted in the increased adsorption capacity towards acetaldehyde and o-xylene. Gas Chromatography-Mass Spectrometer (GC-MS) analysis suggested that o-xylene was first oxidized to o-benzaldehyde, which was eventually converted to butanol before being mineralized into CO2. However, new intermediates including phthalide, o-methyl acetophenone, naphthalene and 5-Methyl-4-octanone were detected in the mixture.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Rao, ZP; Shi, GS; Wang, Z; Mahmood, A; Xie, XF; Sun, J or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem