Heterocyclic Building Block-benzofuran

Recommanded Product: Isobenzofuran-1(3H)-one. Recently I am researching about AEROBIC OXIDATION; COORDINATION POLYMERS; BONDS ACTIVATION; HIGHLY EFFICIENT; FACILE SYNTHESIS; KETONES; WATER; ARYLALKANES; CONVERSION; SORPTION, Saw an article supported by the National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [21771163, 21671174, 21371155, 21701201]; Science Foundation of Henan Province [162300410243]; Project for the Leading Young Teachers in Henan Provincial Institutions of Higher Education of China. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gao, K; Huang, C; Yang, YS; Li, H; Wu, J; Hou, HW. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The enantioselective transformation of ubiquitous C-H bonds into valuable C=O bonds offers an efficient synthetic approach to construct carbonyl functionalized molecules. However, the grand obstacles in the reaction are the selectivity issues and side reactions under the harsh reaction conditions. In order to overcome the limits, two Cu(I)-based MOFs {(NEt4)(0.5)[Cu-3 (TTPB)(0.75) (CN)(0.5)(H2O)]center dot H2O}(n) (1) and {[Cu-2 (TTPB)(0.5)]center dot DMF center dot 2H(2)O}(n) (2) were synthesized (H-4 TTPB = 5,5′ – (4′,5′ -bis (4- (1H-tetrazol-5-yl)phenyl)- [1,1′ :2′,1 ”-terphenyl]-4,4 ”-diyl) bis(1H-tetrazole)) under hydrothermal conditions with (triethylamine (TEA) and ethyldiisopropylamine (DIPEA) as structure-directing agents, respectively. Of these, 1 shows an anionic three-dimensional (3D) framework composed of two kinds of cagelike micropores with 7 X 17 angstrom and 10 x 17 angstrom, respectively. In comparison, 2 exhibits a 3D framework with open channels (14 x 8 angstrom). The stability studies showed that the crystallinity of 1 and 2 could remain in a series of organic solvents (ethanol, N,N-dimethylformamide, chloroform, dioxane, toluene) and acid and alkali aqueous solutions (pH = 1-13) at room temperature for 48 h. 1 and 2 with coordinatively unsaturated Cu(I) sites were applied as heterogeneous catalysts for the oxidation of arylacycloalkanes in aqueous medium and exhibited excellent catalytic activities, selectivities, and recyclabilities. Moreover, free-radical reaction mechanism and reversible valence-tautomeric conversions of central copper were confirmed during the process by control experiment.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Gao, K; Huang, C; Yang, YS; Li, H; Wu, J; Hou, HW or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Liu, SL; Li, SP; Shen, XJ; Wang, YY; Du, J; Chen, BF; Han, BX; Liu, HZ in ROYAL SOC CHEMISTRY published article about COPPER(II) COMPLEXES; CATALYTIC-OXIDATION; TETRAHYDROFURAN; FUNCTIONALIZATION; CLUSTERS in [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid & Interface, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Chen, Bingfeng; Han, Buxing; Liu, Huizhen] Chinese Acad Sci, Thermodynam Inst Chem, Beijing 100190, Peoples R China; [Liu, Shulin; Li, Shaopeng; Shen, Xiaojun; Wang, Yanyan; Du, Juan; Han, Buxing; Liu, Huizhen] Univ Chinese Acad Sci, Beijing 100149, Peoples R China in 2020, Cited 40. COA of Formula: C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Selective oxidation of ethers to lactones with O-2 as a benign oxidant using Au/CeO2 as the catalyst has been developed. The oxygen vacancies and Au-0 species on the surface of CeO2 contribute to the activation of O-2. The excellent selectivity of lactones is due to the adsorption of ethers and activation of the C(sp(3))-H bond on Au/CeO2.

COA of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Liu, SL; Li, SP; Shen, XJ; Wang, YY; Du, J; Chen, BF; Han, BX; Liu, HZ or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. In 2019 CHEM-EUR J published article about VINYLOGOUS ALDOL REACTION; PHASE-TRANSFER CATALYSIS; GAUSSIAN-BASIS SETS; ASYMMETRIC-SYNTHESIS; PHTHALIDE-3-CARBOXYLIC ACID; ENANTIOSELECTIVE ADDITION; MACROCYCLIC POLYETHERS; ANNULATION REACTIONS; DENSITY FUNCTIONALS; ENOLATE ACTIVATORS in [Sicignano, Marina; Schettini, Rosaria; Sica, Luisa; Pierri, Giovanni; De Riccardis, Francesco; Izzo, Irene; Della Sala, Giorgio] Univ Salerno, Dipartimento Chim & Biol Adolfo Zambelli, Via Giovanni Paolo II 132, I-84084 Fisciano, SA, Italy; [Maity, Bholanath; Cavallo, Luigi] KAUST, KAUST Catalysis Ctr, KCC, Thuwal 239556900, Saudi Arabia; [Minenkov, Yury] MIPT, Inst Pereulok 9, Dolgoprudnyi 141700, Moscow Region, Russia in 2019, Cited 96. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Invited for the cover of this issue are the groups of Giorgio Della Sala at the Universita degli Studi di Salerno and Luigi Cavallo at the King Abdullah University of Science and Technology. The image depicts the transition state involved in the crown ether catalyzed arylogous Michael reaction of phthalides. Read the full text of the article at 10.1002/chem.201900168.

COA of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sicignano, M; Schettini, R; Sica, L; Pierri, G; De Riccardis, F; Izzo, I; Maity, B; Minenkov, Y; Cavallo, L; Della Sala, G or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry; Food Science & Technology; Nutrition & Dietetics very interesting. Saw the article Combined targeted and untargeted profiling of volatile aroma compounds with comprehensive two-dimensional gas chromatography for differentiation of virgin olive oils according to variety and geographical origin published in 2019. Recommanded Product: Isobenzofuran-1(3H)-one, Reprint Addresses Lukic, I (corresponding author), Inst Agr & Tourism, K Huguesa 8, Porec 52440, Croatia.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GC x GC-TOF-MS) was combined with conventional mono-dimensional GC-MS to differentiate Croatian virgin olive oils (VOO) according to variety and geographical origin, based on the profile of volatile aroma compounds isolated by HS-SPME. More than 1000 compounds were detected after untargeted profiling and 256 were identified or tentatively identified, providing one of the most detailed profiles of volatile aroma compounds in VOO up to date. Among them, 131 volatile compounds were significantly different across monovarietal VOOs, while 60 were found useful for the discrimination according to geographical origin. Many major lipoxygenase and minor non-lipoxygenase-generated compounds were shown to have discriminating ability with respect to both factors. Multivariate statistical analysis extracted twenty-one volatile markers with the highest discriminant power for varietal differentiation. The approach reported may have practical application in better understanding, defining, managing, and communicating the varietal or geographical typicity of monovarietal VOOs.

Recommanded Product: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lukic, I; Carlin, S; Horvat, I; Vrhovsek, U or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 CHEM ENG J published article about VOLATILE ORGANIC-COMPOUNDS; ENHANCED PHOTOCATALYTIC ACTIVITY; VISIBLE-LIGHT PHOTOCATALYSIS; TOTAL-ENERGY CALCULATIONS; TITANIUM-DIOXIDE; CATALYTIC COMBUSTION; INDOOR AIR; OXIDATION; PHOSPHATE; REMOVAL in [Wang, Zhuang; Mahmood, Asad; Xie, Xiaofeng; Wang, Xiao; Sun, Jing] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, 1295 Dingxi Rd, Shanghai 200050, Peoples R China; [Wang, Zhuang; Qiu, Hanxun] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, 516 Jungong Rd, Shanghai 200093, Peoples R China in 2020, Cited 75. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Recommanded Product: 87-41-2

For the oxide-based photocatalysts, polyoxylic acid modification can affect their adsorption/desorption properties and further regulate photocatalytic reaction pathway, which is crucial for enhancing photocatalytic activity and selectivity. Herein, phosphoric acid modified TiO2 was synthesized by a facile impregnation-calcination method for photocatalytic degradation of gaseous o-xylene. According to FTIR, XPS, and EDS analysis, phosphoric acid was anchored on the surface of TiO2 successfully. The surface P atomic percentages for PT1 was 2.45%. The as-prepared phosphoric acid modified TiO2 (PTx) had a photocatalytic performance superior to that of commercial TiO2 and unmodified TiO2 (PT0), with increasing by 2.2 times at most. Interestingly, the phosphoric acid molecules strongly adsorbed on anatase TiO2 surface by forming H-O-2C and =O-Ti-5C chemical bonds according to the first principle calculations, which changed TiO2 surface properties (specific surface area and surface negative electrostatic field) and further improved adsorption and charge carrier separation and transfer, thus improving the photocatalytic activity. Additionally, according to the intermediates results, the relative abundance of intermediates shows obvious difference. Acetone was detected as the most abundant intermediates during o-xylene degradation for PT0, whereas that was o-methyl benzaldehyde for PT1, which could be ascribed to the difference of surface adsorption configuration of o-xylene. According to the temperature-programmed desorption (TPD) results, the surface modified by phosphoric acid could change the o-xylene adsorption configuration to favor its methyl oxidation (standing configuration), whereas the unmodified surface could be more favorable to the benzene ring-open reaction (lying configuration). This work will deepen the understanding of the relevance of surface modification and surface photocatalytic reaction, which also provides a feasible strategy to improve photocatalytic selectivity.

Recommanded Product: 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wang, Z; Mahmood, A; Xie, XF; Wang, X; Qiu, HX; Sun, J or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 J ORG CHEM published article about MICHAEL ADDITION; CONVENIENT SYNTHESIS; METHYL ETHERS; CHEMISTRY; ACIDS; DIHYDRONAPHTHOQUINONES; CITALOPRAM; INHIBITORS; KETONES; CENTERS in [Sicignano, Marina; Schettini, Rosaria; Pierri, Giovanni; Marino, Maria Leda; Izzo, Irene; De Riccardis, Francesco; Della Sala, Giorgio] Univ Salerno, Dipartimento Chim & Biol Zambelli, I-84084 Fisciano, SA, Italy; [Bernardi, Luca] Alma Mater Studiorum Univ Bologna, Dept Ind Chem Toso Montanari, I-40136 Bologna, Italy; [Bernardi, Luca] Alma Mater Studiorum Univ Bologna, INSTM RU Bologna, I-40136 Bologna, Italy in 2020, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Computed Properties of C8H6O2

A novel asymmetric phase-transfer-catalyzed gamma-alkylation of phthalide 3-carboxylic esters has been developed, giving access to 3,3-disubstituted phthalide derivatives, which present a chiral quaternary gamma-carbon in good to excellent yields and good enantioselectivities (74-88% ee). The enantiomeric purity could be substantially enhanced to 94-95% ee by recrystallization. Both electron-withdrawing and electron-releasing substituents are well tolerated on the phthalide core as well as on the aromatic moiety of the alkylating agent. This methodology, enabling the introduction of an unfunctionalized group at the phthalide gamma-position, fully complements previously reported organocatalytic strategies involving functionalized electrophiles, thus expanding the scope of accessible 3,3-disubstituted products. The high synthetic value of this asymmetric reaction has been proven by the formal synthesis of the naturally occurring alkaloid (+)-(9S,13R)-13-hydroxyisocyclocelabenzine.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Sicignano, M; Schettini, R; Pierri, G; Marino, ML; Izzo, I; De Riccardis, F; Bernardi, L; Della Sala, G or concate me.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Modular Synthetic Approach to Silicon-Rhodamine Homologues and Analogues via Bis-aryllanthanum Reagents published in 2021. Safety of Isobenzofuran-1(3H)-one, Reprint Addresses Butkevich, AN (corresponding author), Max Planck Inst Med Res, Dept Opt Nanoscopy, D-69120 Heidelberg, Germany.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A modular synthetic approach toward diverse analogues of the far-red fluorophore silicon-rhodamine (SiR), based on a regioselective double nucleophilic addition of aryllanthanum reagents to esters, anhydrides, and lactones, is proposed. The reaction has improved functional group tolerance and represents a unified strategy toward cell-permeant, spontaneously blinking, and photoactivatable SiR fluorescent labels. In tandem with Pd-catalyzed hydroxy- or aminocarbonylation, it serves a streamlined synthetic pathway to a series of validated live-cell-compatible fluorescent dyes.

Safety of Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Butkevich, AN or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. Recently I am researching about AEROBIC OXIDATION; SELECTIVE OXIDATION; ETHERS; COPPER; ISOCOUMARINS; PHTHALIDES; ALKANES, Saw an article supported by the Science and Engineering Research Board (SERB), New Delhi [EEQ/2016/000203]; SERB, New DelhiDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [PDF/2016/002733]; UGC, New DelhiUniversity Grants Commission, India [PDF/2016/002733]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Thatikonda, T; Deepake, SK; Kumar, P; Das, U. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

A metal-free organocatalytic system has been developed for highly efficient benzylic C-H oxygenations of cyclic ethers using oxygen as an oxidant. This oxidation reaction utilizes alpha-angelica lactone as a low cost/low molecular weight catalyst. The optimized reaction conditions allow the synthesis of valued isocoumarins and phthalides from readily available precursors in good yields. Mechanistic studies indicate that the reaction pathway likely involves a radical process via a peroxide intermediate.

Name: Isobenzofuran-1(3H)-one. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Thatikonda, T; Deepake, SK; Kumar, P; Das, U or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation WOS:000580634600039 published article about PATHWAY CONTRIBUTES; STROKE; INJURY; NEUROGENESIS; LIGUSTILIDE; DEFICITS; KLOTHO in [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist & Sichuan Prov, West China Sch Pharm,Dept Pharmacol,Sichuan Engn, Chengdu 610041, Peoples R China; [Gan, Yu-Miao; Liu, Dong-Ling; Yang, Yu-Xin; Du, Jun-Rong] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China; [Chen, Chu] Sichuan Acad Chinese Med Sci, Sichuan Prov Key Lab Qual & Innovat Res Chinese M, Chengdu 610041, Peoples R China; [Duan, Wei] Deakin Univ, Sch Med, Waurn Ponds, Vic, Australia; [Duan, Wei] Deakin Univ, Ctr Mol & Med Res, Waurn Ponds, Vic, Australia; [Yang, Yu-Xin] PRIVIS TECHNOL CO LTD, Chengdu 610041, Peoples R China in 2020, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Name: Isobenzofuran-1(3H)-one

Microglia can be activated to become the classic phenotype (M1) or alternative phenotype (M2), which play an important role in regulating neuroinflammatory response and tissue repair after ischemic stroke. CD21, a novel phthalide derivative, is a potential neuroprotectant against ischemic brain injury. The present study further investigated the effects of CD21 on post-ischemic microglial polarization and the underlying mechanisms. Transient middle cerebral artery occlusion (tMCAO) was used as a mouse model of ischemic stroke, while BV2 cells stimulated with conditioned medium collected from oxygen-glucose deprivation-treated HT22 cells were used in in vitro ischemic studies. The current results showed that CD21 dose-dependently and significantly improved neurological outcomes in tMCAO mice. Biochemical analyses revealed that CD21 decreased the expression of M1 phenotype markers (CD86, interleukin-1 beta and inducible nitric oxide synthase) and increased the expression of M2 phenotype markers (CD206, interleukin-10 and YM1/2) in both ischemic brain tissues and BV2 cells. Meanwhile, CD21 decreased the production of proinflammatory cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha), promoted the release of the antiinflammatory cytokine (interleukin-10), and enhanced the phosphorylation of adenosine 5′-monophosphate-activated protein kinase (AMPK) in ischemic brain tissue and BV2 cells. Furthermore, the AMPK inhibitor (compound C) reversed these effects of CD21 in BV2 cells. These findings indicate that CD21 alleviates post-ischemic neuroinflammation through induction of microglial M2 polarization that is at least in part medicated by AMPK activation, suggesting that CD21 may be a promising candidate for protecting against ischemic brain injury.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Gan, YM; Liu, DL; Chen, C; Duan, W; Yang, YX; Du, JR or concate me.. Name: Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 DALTON T published article about SOLVENT-FREE HYDROBORATION; CYCLIC CARBONATES; TRANSFER HYDROGENATION; SELECTIVE REDUCTION; COMPLEXES SYNTHESES; METHANOL; CO2; DERIVATIVES; REACTIVITY; ALDEHYDES in [Cao, Xu; Wang, Weifan; Lu, Kai; Xue, Fei; Ma, Mengtao] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Peoples R China; [Yao, Weiwei] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China in 2020, Cited 55. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. HPLC of Formula: C8H6O2

A low-valent magnesium(i) complex [((Xyl)Nacnac)Mg](2) was employed as a highly efficient precatalyst for the hydroboration of a variety of cyclic and linear organic carbonates, polycarbonates, CO2 and esters with HBpin under mild conditions. The resultant boronates can be used for the preparation of the corresponding value-added diols, triols or alcohols through hydrolysis.

HPLC of Formula: C8H6O2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Cao, X; Wang, WF; Lu, K; Yao, WW; Xue, F; Ma, MT or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem