Heterocyclic Building Block-benzofuran

I found the field of Chemistry very interesting. Saw the article Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters published in 2021. COA of Formula: C8H6O2, Reprint Addresses Zhang, WB (corresponding author), Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.; Zhang, WB (corresponding author), Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99 % ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH-pi interactions and not the previously considered cation/pi-pi interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Zhou, MX; Gridneva, T; Zhang, ZF; He, ED; Liu, YG; Zhang, WB or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 J CLEAN PROD published article about ADVANCED OXIDATION PROCESSES; AQUEOUS-SOLUTION; WASTE-WATER; PHOTOCHEMICAL DEGRADATION; HYDROXYL RADICALS; HYDROGEN-PEROXIDE; AZO-DYE; MECHANISM; REMOVAL; KINETICS in [Lu, Chao; Yao, Jun; Amde, Meseret; Gu, Jihai; Liu, Jianli; Li, Hao] China Univ Geosci Beijing, Res Ctr Environm Sci & Engn, Sch Water Resource & Environm, 29 Xueyuan Rd, Beijing 100083, Peoples R China; [Knudsen, Tatjana Solevic] Univ Belgrade, Inst Chem Technol & Met, Njegoseva 12, Belgrade 11000, Serbia; [Amde, Meseret] Haramaya Univ, Coll Nat & Computat Sci, Dept Chem, POB 138, Dire Dawa, Ethiopia; [Zhang, Junyang] Curtin Univ, Western Australia Sch Mines, Dept Min & Met Engn, Kalgoorlie, WA, Australia in 2019, Cited 47. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Product Details of 87-41-2

Flotation reagents, especially new chelating agents represented by alpha-nitroso-beta-naphthol, are the main components of cobalt mining drainage. This study reports the degradation of alpha-nitroso-beta-naphthol by simulated UVA-B (280-400 nm) activated systems using three common oxidants, hydrogen peroxide, sodium persulfate and potassium monopersulfate at a laboratory scale using a photoreactor. Parameters which can affect the degradation process were investigated and comparison of the degradation performance of the three systems were made. Based on the results, UVA-B/sodium persulfate system exhibited best performance towards the removal of alpha-nitroso-beta-naphthol with a lower cost of oxidant and energy consumption compared to the others. The removal efficiency was found to increase as the oxidant dosage and the UVA-B power increases. Only potassium monopersulfate could be activated by bicarbonate and chloride ions, and SO42- has insignificant effect on the removal efficiency of alpha-nitroso-beta-naphthol for all systems while NO3- inhibited the degradation of alpha-nitroso-beta-naphthol. In the UVA-B/hydrogen peroxide system, the hydroxyl radical had a leading role in the degradation of alpha-nitroso-beta-naphthol, while in the other two systems, the degradation of alpha-nitroso-beta-naphthol was mainly caused by the hydroxyl and sulphate radicals. Ten major intermediates from alpha-nitroso-beta-naphthol degradation in the three oxidation systems were identified by gas chromatography and mass spectrometry. In summary, this report could be a great input in developing UVA-B activated oxidants-based treatment technologies. The UVA-B/sodium persulfate system is strongly recommended for its consideration in the treatment of mine impacted wastewaters. (c) 2019 Elsevier Ltd. All rights reserved.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Lu, C; Yao, J; Knudsen, TS; Amde, M; Gu, JH; Liu, JL; Li, H; Zhang, JY or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R in BENTHAM SCIENCE PUBL LTD published article about BIFUNCTIONAL DCTP DEAMINASE; DRUG TARGET IDENTIFICATION; MYCOBACTERIUM-TUBERCULOSIS; FORCE-FIELD; ESCHERICHIA-COLI; WEB SERVER; DERIVATIVES; INHIBITORS; DUTPASE; SUSCEPTIBILITY in [Patil, Avinash; Duggal, Harleen; Bagul, Kamini T.; Lokhande, Pradeep; Meshram, Rohan] Savitribai Phule Pune Univ, Dept Chem, Pune, Maharashtra, India; [Duggal, Harleen; Bagul, Kamini T.; Meshram, Rohan] Savitribai Phule Pune Univ, Bioinformat Ctr, Dept Biotechnol, Pune, Maharashtra, India; [Kamble, Sonali] Gramin Sci Vocat Coll, Vishnupuri, Nanded, India; [Gacche, Rajesh] Savitribai Phule Pune Univ, Dept Biotechnol, Pune, Maharashtra, India in 2020, Cited 73. Computed Properties of C8H6O2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Objective: The study aims at the derivatization of Phthalides and synthesizes 3-arylaminophthalides & 3-indolyl-phthalides compounds, and evaluates their anti-tubercular and antioxidant activities. The study has also intended to employ the in silica methods for the identification of possible drug targets in Mycobacterium and evaluate the binding affinities of synthesized compounds. Methods: This report briefly explains the synthesis of phthalide derivatives using ammonium chloride. The synthesized compounds were characterized using spectral analysis. Resazurin Microtiter Assay (REMA) plate method was used to demonstrate the anti-mycobacterial activity of the synthesized compounds. An in-silico pharmacophore probing approach was used for target identification in Mycobacterium. The structural level interaction between the identified putative drug target and synthesized phthalides was studied using Lamarckian genetic algorithm-based software. Results and Discussion: In the present study, we report an effective, environmentally benign scheme for the synthesis of phthalide derivatives. Compounds 5c and 5d from the current series appear to possess good anti-mycobacterial activity. dCTP: deaminasedUTPase was identified as a putative drug target in Mycobacterium. The docking results clearly showed the interactive involvement of conserved residues of dCTP with the synthesized phthalide compounds. Conclusion: On the eve of evolving anti-TB drug resistance, the data on anti-tubercular and allied activities of the compounds in the present study demonstrates the enormous significance of these newly synthesized derivatives as possible candidate leads in the development of novel anti-tubercular agents. The docking results from the current report provide a structural rationale for the promising anti-tubercular activity demonstrated by 3-arylaminophthalides and 3-indolyl-phthalides compounds.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R or concate me.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Product Details of 87-41-2. In 2020 CHEM ENG RES DES published article about THERMAL-CONDUCTIVITY; HEAT-TRANSFER; SIMULATION; FLOW; TRANSPORT in [Dixon, Anthony G.; Wu, Yan] Worcester Polytech Inst, Dept Chem Engn, 100 Inst Rd, Worcester, MA 01609 USA in 2020, Cited 37. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

The present study analyses the thermowell system for monitoring temperatures in a fixed bed catalytic reactor for the highly exothermic partial oxidation of o-xylene to phthalic anhydride. Particle-resolved computational fluid dynamics (CFD) simulations are presented for the cases of randomly-packed spheres inside cylindrical tubes with tube-to-particle diameter ratios (N) of 3.96, 5.96 and 7.99. Results are obtained for each N value for cases with inner thermowell radius to outer tube radius ratios of 0.0 (no thermowell), 0.05, 0.1 and 0.2. Comparisons of radial void fraction and axial velocity profiles, axial pressure drop and axial temperature profiles under reaction conditions are presented. The presence of the thermowell did change the mass and heat transfer and reaction inside and around the particles, especially at the bed center. The configurations of catalyst particles were rearranged, leading to changes in voidage, flow and temperature profile. The axial temperature profiles from the thermowells differed from the profiles in the undisturbed beds. (C) 2020 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Product Details of 87-41-2. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Dixon, AG; Wu, Y or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 PHYS CHEM CHEM PHYS published article about OXIDATIVE DEHYDROGENATION; CARBON NANOTUBES; LIQUID-PHASE; EFFICIENT; GRAPHENE; HYDROGENATION; CARBOCATALYST; NITROARENES; OXIDE; BN in [Wu, Shuchang] Taizhou Univ, Sch Pharmaceut & Mat Engn, Taizhou 318000, Zhejiang, Peoples R China; [Lin, Yangming; Wen, Guodong; Liu, Hongyang; Su, Dang Sheng] Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China; [Zhong, Bingwei] Zhejiang A&F Univ, JiYang Coll, 77 Puyang Rd, Zhuji 311800, Peoples R China in 2019, Cited 28. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

A zigzag-type quinone performs better than an armchair-type quinone in the reduction of nitrobenzene. When different kinds of functionalities co-exist, the reaction is dominated by the most active sites, but the most negative sites should also be taken into consideration if the acitive sites have zigzag structures.

Category: benzofurans. About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Wu, SC; Lin, YM; Zhong, BW; Wen, GD; Liu, HY; Su, DS or concate me.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Category: benzofurans. I found the field of Chemistry very interesting. Saw the article Tunable pH-sensitive 2-carboxybenzyl phosphoramidate cleavable linkers published in 2020, Reprint Addresses Berkman, CE (corresponding author), Washington State Univ, Dept Chem, Pullman, WA 99164 USA.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pK(a) of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pK(a) of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their sigma-values. (C) 2020 Elsevier Ltd. All rights reserved.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Backer, BS; Choy, CJ; Davis, AL; Browne, ZS; Berkman, CE or concate me.. Category: benzofurans

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

COA of Formula: C8H6O2. I found the field of Chemistry very interesting. Saw the article Formates plus triazabicyclodecene (TBD): an efficient platform for non-gaseous carbonylation and unexpected hydrogenation published in 2019, Reprint Addresses Zhou, HW (corresponding author), Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

A highly efficient palladium-catalyzed TBD-formate system for carbonylation/hydrogenation was reported. Based on the obvious solvent effect and reasonable mechanism study, we achieved tunable carbonylation or hydrogenation. With the advantages of simple operation, mild conditions and storable reagents, this protocol should be of interest not only for synthetic scientists but also helpful for laboratory operators.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, DP; Yao, JZ; Chen, LL; Hu, LF; Li, XF; Zhou, HW or concate me.. COA of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Tseplin, EE; Tseplina, SN in ELSEVIER SCIENCE BV published article about AQUEOUS-SOLUTION; FLUORESCENCE; MOLECULES; DYNAMICS; URACIL in [Tseplin, Evgeniy E.; Tseplina, Svetlana N.] Russian Acad Sci, Ufa Fed Res Ctr, Inst Mol & Crystal Phys, Prospekt Oktyabrya 151, Ufa 450075, Russia in 2019, Cited 37. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The optical absorption spectra of phthalide in polar (methanol) and nonpolar (n-hexane) solvents are recorded. The electronic phthalide spectrum was calculated by TDDFT B3LYP/6-311 + G(d, p) using the polarisable continuum model. Based on an analysis of calculation data and the displacement of absorption bands in a polar solvent, it was established that the absorption bands of phthalide at energies of 3.51 and 3.96 eV correspond to singlet-triplet transitions to the T-1 and T-2 states, respectively.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Tseplin, EE; Tseplina, SN or concate me.. Recommanded Product: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Manganese catalyzed selective hydrogenation of cyclic imides to diols and amines WOS:000537870500006 published article about HOMOGENEOUS CATALYSIS; ALCOHOLS; EFFICIENT; AMIDES; KETONES; ESTERS; DESYMMETRIZATION; DEHYDROGENATION; MONOREDUCTION; REDUCTION in [Das, Uttam Kumar; Janes, Trevor; Kumar, Amit; Milstein, David] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel; [Kumar, Amit] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland in 2020, Cited 43. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Herein we report the selective hydrogenation of cyclic imides to diols and amines, homogeneously catalyzed for the first time by a complex of an earth-abundant metal, a manganese pincer complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Das, UK; Janes, T; Kumar, A; Milstein, D or concate me.. Recommanded Product: 87-41-2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about NF-KAPPA-B; TNF-ALPHA PRODUCTION; HEME OXYGENASE-1; INNATE IMMUNITY; INFLAMMATION; PATHWAY; NRF2; MACROPHAGES; ACTIVATION; INDUCTION, Saw an article supported by the National Natural Science Funding of ChinaNational Natural Science Foundation of China (NSFC) [21977001]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Formula: C8H6O2

Phthalide is a promising chemical scaffold and has been proved to show potent anti-inflammatory efficacy. In this study, three series, total of 31 novel phthalide derivatives were designed and synthesized, their anti-inflammatory activities were screened in vitro and in vivo. The anti-inflammatory activity of all the compounds were screened on LPS induced NO production to evaluating their inhibitory effects. Structure-activity relationship has been concluded, and finally 3-((4-((4-ufluorobenzyl)oxy)phenyl)(-hydroxy)methyl)-5,7-dimethoxyisobenzofuran-1 (3H)-one (compound 9o) was found to be the active one with low toxicity, which showed 95.23% inhibitory rate at 10 mu M with IC50 value of 0.76 mu M against LPS-induced NO over expression. Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappa B/MAPK signaling pathway. The in vivo anti-inflammatory activity shown that compound 90 had obvious therapeutic effect against the adjuvant-induced rat arthritis model. (C) 2020 Elsevier Masson SAS. All rights reserved.

About Isobenzofuran-1(3H)-one, If you have any questions, you can contact Chen, LZ; Wu, J; Li, K; Wu, QQ; Chen, R; Liu, XH; Ruan, BF or concate me.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem