New learning discoveries about 610-93-5

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.610-93-5,6-Nitroisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.,610-93-5

General procedure: To a screw top vial (5 mL) under N2 containing freshly distilled toluene (0.6 mL) were successively added an aromatic nitro compound (0.60 mmol), InI3 (14.9 mg, 0.030 mmol), and TMDS (318 muL, 1.80 mmol). After the vial was sealed with a cap that contained a PTFE septum, the mixture was stirred at 60 C (bath temperature), and monitored via TLC analysis. Sat. aq NaHCO3 solution (5 mL) was added to the resultant mixture, which was then extracted with EtOAc (3 ¡Á 6 mL). The combined organic phases were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (n-hexane-EtOAc, 9:1 to 4:1) to afford the corresponding aniline derivative.

610-93-5 6-Nitroisobenzofuran-1(3H)-one 223584, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Sakai, Norio; Asama, Shun; Konakahara, Takeo; Ogiwara, Yohei; Synthesis; vol. 47; 20; (2015); p. 3179 – 3185;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 15832-09-4

15832-09-4, As the paragraph descriping shows that 15832-09-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15832-09-4,6-Methoxy-3(2H)-benzofuranone,as a common compound, the synthetic route is as follows.

Step 4: A mixture of 6-methoxy-benzofuran-3 (2H)-one (1.64 g, 10 mmol) and (carboxymethylene)triphenylphosphorane (5.22 g, 15 mmol) was refluxed in toluene (100 ml) for 48 hrs. At the end, reaction mixture was concentrated and loaded over silica-gel column. The column was eluted with hexane (500 ml) and later with 25% ethyl acetate. The product, ethyl(6-methoxy-1-benzofuran-3-yl)acetate was obtained as a white oil. Yield: 1.8 g (76%); 235 (M+H).

15832-09-4, As the paragraph descriping shows that 15832-09-4 is playing an increasingly important role.

Reference£º
Patent; Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Gu, Yansong; US2005/4162; (2005); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Analyzing the synthesis route of 57319-65-0

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

57319-65-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57319-65-0,6-Aminoisobenzofuran-1(3H)-one,as a common compound, the synthetic route is as follows.

General procedure: An oven-dried Schlenk tube (A) equipped with a magnetic stir bar was charged with AgF (132.2 mg, 1.05 mmol, 3.5 equiv), sealed with a septum, and degassed by alternating vacuum evacuation and nitrogen backfill (three times) before freshly distilled EtCN (3 mL)was added. To the resulting suspension, which was precooled to -78 C (dry ice-acetone bath), was added TMSCF3 (149.3 mg, 1.05 mmol, 3.5 equiv) by microsyringe. The mixture was allowed towarm to r.t. and stirring was continued for an additional 15 min. In due course, AgF solid dissolved and a gray, dark solution of [Ag-CF3] formed. Another Schlenk tube (B) equipped with a magnetic stir bar was charged with the aniline (ArNH2; 0.30 mmol, 1.0 equiv) in freshly distilled EtCN (1.5 mL). To the resulting solution, which was precooled to 0 C (ice bath), aq HCl (12 M; 50.0 muL, 0.60mmol, 2.0 equiv) was added; precipitate formed immediately. After 5 min stirring, t-BuONO (37.7 mg, 0.33 mmol, 1.1 equiv) was added by microsyringe, and the mixture was allowed to stir at 0 C for 15 min. The resulting suspension in Schlenk tube (B) was degassed by alternating vacuum evacuation at -196 C (liquid nitrogen), then the solution was allowed to warm to r.t. under a nitrogen atmosphere (three times), and finally cooled to -78 C (dry ice-acetone bath). The gray, dark solution of [AgCF3] in Schlenk tube (A), which was precooled to -78 C (dry ice-acetone bath), was added to Schlenk tube (B) (ArN2+Cl-) by syringe at -78 C (dry ice-acetone bath) over a period of 1 h. After the addition was complete, the reaction mixture was stirred for 3 h at -78 C (dry ice-acetone bath), allowed to warm to r.t., and stirring was continued for an additional 1 h. An off-white precipitate was observed, and the reaction mixture was diluted with EtOAc (3 mL) and filtered through a short silica gel column. The solvent was removed under reduced pressure with a rotatory evaporator, and the crude residue was purified by silica gel column chromatography to give the desired trifluoromethylation product 3. The yields of products 3a, 3f, 3g, 3l, 3o, 3r, 3x, and 3zb are based on the 19F NMR spectra with 4-F3COC6H4OMe as internal standard. Analytical data for the representative product ethyl 4-(trifluoromethyl)benzoate (3i) are provided below. Data for other products can be found in the literature.

As the paragraph descriping shows that 57319-65-0 is playing an increasingly important role.

Reference£º
Article; Wang, Xi; Xu, Yan; Zhou, Yujing; Zhang, Yan; Wang, Jianbo; Synthesis; vol. 46; 16; (2014); p. 2143 – 2148;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 35700-40-4

35700-40-4, The synthetic route of 35700-40-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35700-40-4,2,3-Dihydrobenzofuran-7-carboxylic acid,as a common compound, the synthetic route is as follows.

[0359] 2,3-Dihydrobenzofuran-7-carboxylic acid (820 mg, 5 mmol) was dissolved inTHF (10 rtiL). To the solution was added TEA (0.7 mL, 5 mmol) and methylchloroformate (0.43 mL, 5 mmol). The solution was stirred for 0.5 hour. The white precipitates were removed by filtration, the filtrate was added to a solution OfNaBH4 (437 mg, 12.5 mmol) in H2O (5 mL). The resulting solution was stirred overnight. The reaction mixture was neutralized with 2 M aqueous HCl solution and then extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The crude alcohol was dissolved in DCM. To the solution was added PCC (1.83 g, 7.5 mmol). The mixture was stirred for 2 hours at room temperature and diluted with diethyl ether, then ether layers were decanted. Combined organic layer was filtered though a layer of Celite. The filtrate was concentrated to give crude product. The crude was purified from column with 10% EtOAc/hexane to afford 450 mg of 2,3-dihydrobenzofuran-7-carbaldehyde as a slightly yellow solid. HPLC 4.3 min.

35700-40-4, The synthetic route of 35700-40-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2008/106139; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Some tips on 69999-16-2

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

69999-16-2, 2,3-Dihydrobenzofuranyl-5-acetic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

69999-16-2, EXAMPLE 6 2-(2,3-Dihydro-5-benzofuranyl)malonic acid To a solution of diisopropylamide (20 mmole) in 50 ml of anhydrous tetrahydrofuran (THF) maintained under a nitrogen atmosphere at -40 C. is added n-butyllithium (20 mmole). The mixture is stirred for 15 minutes and then (2,3-dihydro-5-benzofuranyl)acetic acid (10 mmole) is added. The mixture is heated at 50 C. for 1 hour and then cooled to -70 C. and ethyl chloroformate (10 mmole) is added. The temperature is increased and the mixture is stirred for about 20 minutes. The mixture is poured over ice and hydrochloric acid. The aqueous phase is extracted with ether. The ether extracts are combined, dried and evaporated to give 2-(2,3-dihydro-5-benzofuranyl)malonic acid, monoethyl ester.

As the paragraph descriping shows that 69999-16-2 is playing an increasingly important role.

Reference£º
Patent; Richardson-Merrell Inc.; US4229575; (1980); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Simple exploration of 23681-89-2

23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various fields.

23681-89-2, 2,3-Dihydrobenzofuran-6-ol is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 1 benzaldehyde (221 mg, 1.25 mmol), Preparation 12 phenol (170 mg, 1.25 mmol), K2CO3 (518 mg, 3.75 mmol), and DMF (5 mL) were combined and heated at 100¡ã C. for 24 h. The mixture was cooled to rt, poured into H2O and extracted with EtOAc (2.x.). The combined extracts were washed with 1M NaOH and brine, dried (MgSO4), filtered, concentrated, and chromatographed (loaded with CH2Cl2; eluted with 10percent EtOAc in hexanes). The isolated solid (140 mg) was dissolved in acetonitrile (10 mL) at rt. To the solution was added acetic acid (0.082 mL, 1.44 mmol) and methylamine (0.479 mL of a 2M solution in THF, 0.957 mmol). After 1 h NaBH(OAc)3 (152 mg, 0.718 mmol) was added. The mixture was stirred at rt for 3 d, poured into sat. NaHCO3 (50 mL) and 1 M NaOH (5 mL) and extracted with EtOAc (2.x.50 mL). The combined extracts were dried (MgSO4), filtered, concentrated, and chromatographed (loaded with CH2Cl2; eluted with 10percent MeOH in CH2Cl2). The resulting yellow gum was dissolved in EtOAc (3 mL) at rt and p-toluenesulfonic acid hydrate (70 mg) was added. After 14 h the mixture was filtered and the resulting solid dried under high vacuum to provide 100 mg of the above named compound as a solid. MS (M+)=308, 310. 1H NMR (400 MHz, CD3OD): delta 7.69 (d, 2, J=9.1), 7.25 (s, 1), 7.22 (d, 2, J=8.1), 6.90 (d, 1, J=6.4), 6.56 (dd, 1, J=7.9, 2.3), 6.52 (d, 1, J=2.1), 4.62 (t, 2, J=8.7), 4.27 (s, 2), 3.21 (t, 2, J=8.7), 2.76 (s, 3), 2.36 (s, 3)., 23681-89-2

23681-89-2 2,3-Dihydrobenzofuran-6-ol 12236540, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Pfizer Inc; US2006/58361; (2006); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 37418-88-5

As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.37418-88-5,4-Hydroxyisobenzofuran-1,3-dione,as a common compound, the synthetic route is as follows.

A mixture of 3-hydroxyphthalic anhydride (1.24 g, 7.6 mmol), 2,4-dimethoxybenzylamine (1.14 mL, 7.6 mmol) and acetic acid (5 mL) was heated at 80¡ãC for 24 hours. The mixture was allowed to cool and diluted with water (20 mL). The white solid was collected by filtration, washed well with water and dried to give the title compound (1.73 g, 73percent). 1H NMR (DMSOd6) 11.00 (1 H, s), 7.62 (1 H, dd), 7.29 (1 H, d), 7.21 (1 H, d), 6.90 (1 H, d), 6.56 (1 H, d), 6.43 (1 H, dd), 4.59 (2H, S)1 3.79 (3H, s), 3.72 (3H, s). MS: [M-H+] 314., 37418-88-5

As the paragraph descriping shows that 37418-88-5 is playing an increasingly important role.

Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; WO2008/44041; (2008); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Brief introduction of 4265-16-1

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.,4265-16-1

To a solution of 2-benzofuran carbaldehyde (1.00 g, 6.85 mmol) in methanol (20 ml) were added hydroxylammonium chloride (530 mg, 7.63 mmol) and pyridine (2.8 ml), followed by stirring at room temperature for 6.5 hours. After completion of the reaction, the reaction solution was concentrated under reduced pressure. Ethyl acetate was added to the resulting residue, followed by washing sequentially with a 5% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogen carbonate solution and then a saturated aqueous sodium chloride solution. The resulting organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to afford the title compound (1.07 g) as a white solid. (Yield: 97%) 1H-NMR spectrum (CDCl3, ppm): 8.47 & 7.81 (brs, total 1H), 8.14 & 7.67 (s, total 1H), 7.69 & 6.96 (d, J=0.9Hz, total 1H), 7.67 & 7.60 (ddd, J=7.7, 1.2, 0.9Hz, total 1H), 7.55-7.49 (m, 1H), 7.43-7.22 (m, 2H).

As the paragraph descriping shows that 4265-16-1 is playing an increasingly important role.

Reference£º
Patent; Ube Industries, Ltd.; EP2264009; (2010); A1;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 496-41-3

496-41-3 Benzofuran-2-carboxylic acid 10331, abenzofuran compound, is more and more widely used in various fields.

496-41-3,496-41-3, Benzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

SOCl2 (2.38g, 20mmol) was added drop-wise to a stirringsolution of 3-chlorobenzoic acid (6b, 0.78 g, 5 mmol) inCHCl3 (10 mL) under ice-water bath, and the mixture wasrefluxed for 1 h and then was concentrated under reducedpressure to get the intermediate.The intermediate in CHCl3 was added drop-wise to a stirringsolution of 1-(m-tolyl)piperazine hydrochloride (4b,0.53 g, 2.5 mmol) and TEA (10 mmol) in CHCl3 under icewaterbath. After being refluxed for 8h, the mixture waswashed with H2O and NaHCO3 saturated solution, then driedover Na2SO4 and concentrated under reduced pressure. Thecrude material was purified by CC (petroleum ether AcEt =4:1) and was acidulated with HCl and then was recrystallizedin EtOH to give the title compound 7c as white solid (0.30 g,34.19%)

496-41-3 Benzofuran-2-carboxylic acid 10331, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Article; Guo, Xiaoke; Sun, Haopeng; Du, Lvpei; Huang, Lu; Xu, Jing; Zhu, Yingying; Yu, Peng; Zhang, Xiaojin; Tang, Yiqun; You, Qidong; Medicinal Chemistry; vol. 10; 5; (2014); p. 497 – 505;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem

Downstream synthetic route of 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

24673-56-1, 3-Methylbenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4- (2-Aminoethoxy) benzoic acid methyl ester hydrochloride (78.90 g, 0.340 mol) and 3- methylbenzofuran-2-carboxylic acid (60.0 g, 0.340 mol) were suspended in acetonitrile (360 ml) and cooled to 0-5 C. Pyridine (137.6 mL, 1.702 mol) was added quickly. A solution of phosphorous oxychloride (52.2 g, 0.340 mol) in acetonitrile (60 ML) was added drop wise over thirty to forty-five minutes with the temperature kept below 20 C. The reaction mixture was allowed to stir for one hour and warm slowly to ambient temperature. After completion of reaction, the solution was added to a rapidly stirred 0-5 C mixture of chlorobenzene (1000 ML) and IN hydrochloric acid (1000 ml). The reaction mixture was stirred rapidly and allowed to warm to room temperature. The organic layer was washed with water, 3% potassium hydroxide, and again with water. Chlorobenzene (100 ML) was added to the washed organic layer. Solvent (100 ML) was then distilled at atmospheric pressure until the pot temperature reached 132 C. After cooling to ambient temperature, 4- {2- [ (3-METHYLBENZOFURAN-2- carbonyl) amino] ethoxy} benzoic acid methyl ester was stored in solution for use in the next step., 24673-56-1

As the paragraph descriping shows that 24673-56-1 is playing an increasingly important role.

Reference£º
Patent; AXYS PHARMACEUTICALS INC.; WO2004/92115; (2004); A2;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem