Downstream synthetic route of 59434-19-4

59434-19-4 4-Aminophthalide 12284649, abenzofuran compound, is more and more widely used in various fields.

59434-19-4, 4-Aminophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

59434-19-4, Example 1 18A2-Oxo-N-(l-oxo- l,3-dihydroisobenzofuran-4-yl)-2-phenylacetamide[00735] To a solution of 4-aminoisobenzofuran-l(3H)-one (4.0 g, 26.8 mmol), 2-oxo-2-phenylacetic acid (4.1 g, 26.8 mmol), and HBTU (15.2 g, 40.2 mmol) in dichloromethane (240 mL) was added TEA (8 mL). The reaction mixture was stirred at room temperature overnight. The resulting mixture was added water and adjusted to pH 6-7 with 1% aq. HCl, and then was filtered. The filtrate was extracted with ethyl acetate. The ethyl acetate layer was evaporated and the crude product was purified by gradient chromatography (silica gel, petroleum ether / ethyl acetate 6: 1 to 3: 1) to give the title compound (5.0 g, yield 66%). LC-MS (ESI) m/z: 282(M+1)+.

59434-19-4 4-Aminophthalide 12284649, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
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Downstream synthetic route of 23145-07-5

23145-07-5, As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

23145-07-5, 5-Bromobenzofuran is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromobenzofuran (250 mg, 1.27 mmol, 1.0 equiv.) and 2-methylpiperazine (508.4 mg, 5.08 mmol, 4.0 equiv.) in toluene (7 mL) was added PdCl2[P(o-Tol)3]2 (30 mg, 0.04 mmol, 0.04 equiv.) followed by sodium tert-butoxide (183 mg, 1.91 mmol, 1.5 equiv.). The resulting mixture was heated to 100¡ã C. with stirring under nitrogen. After stirred at same temperature for 16 hours, the reaction mixture was cooled to room temperature and then diluted with ethyl acetate (100 mL). The resulting solution was washed with water, brine and then dried over Na2SO4. After removal of solvent, the crude product was purified by chromatography to give 132 mg (48percent yield) of 1-Benzofuran-5-yl-3-methyl-piperazine. 1H NMR (400 MHz, CDCl3), delta (ppm): 7.56 (d, 1H), 7.39(d, 1H), 7.10 (d, 1H), 7.00 (dd, 1H), 6.69 (m, 1H), 3.44 (d, 2H), 306 (m, 3H), 2.72 (dt, 1H), 2.38 (d, 1H), 1.14 (d, 3H).

23145-07-5, As the paragraph descriping shows that 23145-07-5 is playing an increasingly important role.

Reference£º
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
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Analyzing the synthesis route of 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

28418-88-4, 4-Iodoisobenzofuran-1,3-dione is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0592] To a solution of 4-iodoisobenzofuran-1,3-dione (2.97 g, 10.84 mmol) and (S)-3-aminoazepan-2-one (1.39 g, 10.84 mmol) in ACN (15 mL) and AcOH (21 mL) at rt. The suspension was heated to 80 C and stirred overnight. Cooled to rt, sodium acetate (2.22 g, 27.1 mmol) and AcOH (10 mL) were added. The reaction mixture was heated to 80 C and stirred overnight. TLC showed the starting material was consumed and a new spot was present. Upon removal of the solvent, the residue was diluted with water (8 mL) and stirred 30 minutes. The mixture was extracted with EA and concentrated providing (S)-4-iodo-2-(2- oxoazepan-3-yl)isoindoline-1,3-dione (2.4 g, 57.7% yield) as a white solid. MS (ESI) m/z = 385 [M+H]+., 28418-88-4

As the paragraph descriping shows that 28418-88-4 is playing an increasingly important role.

Reference£º
Patent; BIOTHERYX, INC.; CHAN, Kyle, W.H.; FUNG, Leah; SULLIVAN, Robert; ERDMAN, Paul, E.; MERCURIO, Frank; (225 pag.)WO2017/201069; (2017); A1;,
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Analyzing the synthesis route of 10242-10-1

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

10242-10-1, 5-Chlorobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 33 (General Procedure (A)) (5-Chlorobenzofuran-2-yl)-((S)-2-((pyrrolidin-1-yl)methyl)pyrrolidin-1-yl)methanone 400 mg of the title compound were synthesised as described for (E)-3-(4-bromophenyl)-1-((S)-2-((pyrrolidin-1-yl)methyl)pyrrolidin-1-yl)propenone, using 5-chlorobenzo[b]furane-2-carboxylic acid instead of (E)-4-bromocinnamic acid. 1H-NMR (CDCl3, 2 sets of signals) delta 1.70 (m, 4 H); 1.85-2.90 (m, 10 H); 3.65-4.10 (m, 2 H); 4.50 and 4.85(both m, together 1 H); 7.30-7.50 (m, 3 H); 7.65 (s, 1 H). HPLC method A: elution at 8.62 min. MS: calc. for [M+H]+: 333; found: 333.

10242-10-1, The synthetic route of 10242-10-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Peschke, Bernd; Pettersson, Ingrid; US2003/195190; (2003); A1;,
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Analyzing the synthesis route of 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

6940-49-4, 3-Bromophthalide is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

678.5 mg of material was dissolved in 8 ml of N,N-dimethylacetamide, then 0.172 g of potassium carbonate and 263 mg of 7-bromo-2-benzofuranone were added in turn. The mixture was reacted at 40-45 C. for 4 hours. At the end of the reaction, 30 ml of water was added. The resulting mixture was extracted twice with 25 ml of ethyl ether. The organic phase was dried and concentrated to give 606.4 mg of esterified intermediate with a yield of 75%. The intermediate was dissolved in 15 ml of dioxane and 4 ml of 4N HCl was added. The mixture was reacted at room temperature for 16 hours. The resulting solution was poured into water, extracted with ethyl acetate, dried, concentrated and flash chromatographed (eluent: ethyl acetate/petroleum ether=1/2) to give 284.7 mg of pure product (+/-)2-butyl-4-chloro-1-[2′-(1H-tetrazol-5-yl)1,1′-biphenyl-methyl]imidazole-5-carboxylic acid, 2[C]-benzofuranonyl ester with a yield of 67%.1H-NMR (DMSO-d6) delta H (ppm): 0.88 (t, 3H, J=21.6), 1.26 (m, 4H, J=29.6), 1.58 (m, 2H, J=30.5), 2.50 (t, 2H, J=15.5), 5.34 (s, 2H), 6.95-7.63 (12H), 8.06 (d, 2H, J=9.1)ESI (+) m/z: 569.5Mp: 120.6-124.6 C., 6940-49-4

6940-49-4 3-Bromophthalide 96218, abenzofuran compound, is more and more widely used in various fields.

Reference£º
Patent; Guo, Jianhui; An, Dong; US2009/36505; (2009); A1;,
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Some tips on 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

496-16-2, 2,3-Dihydrobenzo[b]furan is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 44.4 g (0.37 moles) of 2,3-dihydrobenzofuran and 37.8 g (0.37 moles) of acetic anhydride were added with 5.0 g (37 mmoles) of anhydrous zinc chloride. The mixture was heated to 95-105 0C for 10 hrs; after cooling to room temperature the mixture is added with 50 ml of water and 50 ml of dichloromethane. The organic phase was separated and the aqueous phase was extracted twice with dichloromethane (2x 30 ml). The organic phases were collected together, and washed with 50 ml of a saturated aqueous solution of sodium carbonate. The organic phase was separated and evaporated u.v. (20 C/21 mbar). The residue was then distilled at 99-100 C/0.08 mbar obtaining 14.5 g (0.089 moles) of 5-acetyl-2,3- dihydrobenzofuran. 1H NMR (400 MHz; CDCI3): delta: 2.50 (s, 3H); 3.20 (t, 2H, J = 8.7 Hz); 4.64 (t, 2H, J = 8.7 Hz); 6.76 (d, 1 H, J = 8.4 Hz); 7.76 (m, 1 H); 7.81 (m, 1 H).13C-NMR (CDCI3, 100MHz): delta: 26.22; 28.79; 72.02; 108.72; 125.34; 127.50; 130.17; 130.48; 164.19; 196.41., 496-16-2

As the paragraph descriping shows that 496-16-2 is playing an increasingly important role.

Reference£º
Patent; ENDURA S.P.A.; ROTHAMSTED RESEARCH LTD.; BORZATTA, Valerio; CAPPARELLA, Elisa; MORONI, Leni; MOORES, Graham; PHILIPPOU, Despina; WO2011/20848; (2011); A1;,
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Analyzing the synthesis route of 54008-77-4

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.54008-77-4,2-Bromobenzofuran,as a common compound, the synthetic route is as follows.

54008-77-4, General procedure: In a hot oven-dried Schlenk tube under N2 atmosphere were added Ph3Bi (0.25 mmol, 110 mg, 1.0 equiv), 2-bromobenzofuran (0.825 mmol, 163 mg, 3.3 equiv), Cs2CO3 (0.75 mmol, 244 mg, 3.0 equiv), Pd(OAc)2 (0.025 mmol, 5.6 mg, 0.1 equiv), PPh3 (0.1 mmol, 26 mg, 0.4 equiv), and NMP (3 mL) solvent. The resulting mixture was stirred in preheated oil bath at 90 C for 1 h. After the reaction is over, the mixture was cooled, quenched with dil HCl and extracted with ethyl acetate. The combined organic extract was washed with water, brine, and dried over MgSO4 and concentrated. The crude was subjected to silica gel column chromatography (230-400 mesh) using petroleum ether as the eluent to obtain the pure 2-phenylbenzofuran (2.1) as a white solid (140 mg, 96%). The product was characterized by spectroscopy and in comparison with the literature data.

As the paragraph descriping shows that 54008-77-4 is playing an increasingly important role.

Reference£º
Article; Rao, Maddali L.N.; Awasthi, Dheeraj K.; Talode, Jalindar B.; Tetrahedron Letters; vol. 53; 21; (2012); p. 2662 – 2666;,
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Some tips on 1914-60-9

1914-60-9, As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

1914-60-9, 2,3-Dihydrobenzofuran-2-carboxylic acid is a benzofuran compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a mixture of 7 (1 eq) and 1,1?-carbodiimidazole (1.2 eq) in anhydrous THF was stirred for 1h then substituted aniline (0.9 eq) was added at room temperature. After stirring for 14 h, solvent was evaporated then the mixture acidified with 6N HCl to pH 2. The mixture was extracted with EtOAc (3 ¡Á 20 mL). The combined extracts were dried over anhydrous Na2SO4and the solvent was evaporated. After evaporation, the residue was purified by column chromatography (EtOAc/hexane = 1:3 – 1:50).

1914-60-9, As the paragraph descriping shows that 1914-60-9 is playing an increasingly important role.

Reference£º
Article; Choi, Minho; Jo, Hyeju; Park, Hyun-Jung; Sateesh Kumar, Arepalli; Lee, Joonkwang; Yun, Jieun; Kim, Youngsoo; Han, Sang-Bae; Jung, Jae-Kyung; Cho, Jungsook; Lee, Kiho; Kwak, Jae-Hwan; Lee, Heesoon; Bioorganic and Medicinal Chemistry Letters; vol. 25; 12; (2015); p. 2545 – 2549;,
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Simple exploration of 4265-16-1

4265-16-1, The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4265-16-1,Benzo[b]furan-2-carboxaldehyde,as a common compound, the synthetic route is as follows.

The 2-(thiophen-2-yl) acetonitrile (1 g, 8.118mmole), benzofuran-2-carbaldehyde (1.2 g, 8.118 mmol), and 2 g ofNaOH were dissolved in 45 ml of ethanol. Then, these reactionmixtures were stirred vigorously at normal room temperature for24 h. The improvement of the reactionwas monitored by TLC. Aftercompletion of the reaction, the mixtures were poured into ice coldwater. The solid product was filtered, washed with cold ethanol toremove excess benzofuran-2-carbaldehyde, and dried in a vacuumchamber to collect the green colouredcrude product. The precipitatewas allowed to purify by column chromatography techniqueusing the mixture of Hexane: Ethyl Acetate (2/8): eluent. Rectangularslabsof green colour crystals (yield was 88%) of the TACNBNFwas grown using slow evaporation method by DCM (2 ml) andmethanol (1 ml) mixture solvents.

4265-16-1, The synthetic route of 4265-16-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ahamed, J. Irshad; Priya; Vinothkumar; Sathyamoorthy; MuraliManohar; Liu, Jinghe; Valan; Journal of Molecular Structure; vol. 1202; (2020);,
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Simple exploration of 6940-49-4

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6940-49-4,3-Bromophthalide,as a common compound, the synthetic route is as follows.

(2) Preparation of 1-(3-oxo-1,3-dihydro-1-isobenzofuranyl)-5-fluorouracil STR26 In the same manner as in Example 3-(2), a mixture of the compound 11 provided in the above step (1) and 5-FU in dimethylsulfoxide is allowed to react in the presence of 1 equimolar amount of anhydrous potassium carbonate at room temperature to give the titled compound 3 in good yield.

6940-49-4, As the paragraph descriping shows that 6940-49-4 is playing an increasingly important role.

Reference£º
Patent; Shionogi & Co., Ltd.; US4605738; (1986); A;,
Benzofuran – Wikipedia
Benzofuran | C8H6O – PubChem