Heterocyclic Building Block-benzofuran

An article Synthesis of New 3-Arylaminophthalides and 3-Indolyl-phthalides using Ammonium Chloride, Evaluation of their Anti-Mycobacterial Potential and Docking Study WOS:000588581900004 published article about BIFUNCTIONAL DCTP DEAMINASE; DRUG TARGET IDENTIFICATION; MYCOBACTERIUM-TUBERCULOSIS; FORCE-FIELD; ESCHERICHIA-COLI; WEB SERVER; DERIVATIVES; INHIBITORS; DUTPASE; SUSCEPTIBILITY in [Patil, Avinash; Duggal, Harleen; Bagul, Kamini T.; Lokhande, Pradeep; Meshram, Rohan] Savitribai Phule Pune Univ, Dept Chem, Pune, Maharashtra, India; [Duggal, Harleen; Bagul, Kamini T.; Meshram, Rohan] Savitribai Phule Pune Univ, Bioinformat Ctr, Dept Biotechnol, Pune, Maharashtra, India; [Kamble, Sonali] Gramin Sci Vocat Coll, Vishnupuri, Nanded, India; [Gacche, Rajesh] Savitribai Phule Pune Univ, Dept Biotechnol, Pune, Maharashtra, India in 2020, Cited 73. Application In Synthesis of Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Objective: The study aims at the derivatization of Phthalides and synthesizes 3-arylaminophthalides & 3-indolyl-phthalides compounds, and evaluates their anti-tubercular and antioxidant activities. The study has also intended to employ the in silica methods for the identification of possible drug targets in Mycobacterium and evaluate the binding affinities of synthesized compounds. Methods: This report briefly explains the synthesis of phthalide derivatives using ammonium chloride. The synthesized compounds were characterized using spectral analysis. Resazurin Microtiter Assay (REMA) plate method was used to demonstrate the anti-mycobacterial activity of the synthesized compounds. An in-silico pharmacophore probing approach was used for target identification in Mycobacterium. The structural level interaction between the identified putative drug target and synthesized phthalides was studied using Lamarckian genetic algorithm-based software. Results and Discussion: In the present study, we report an effective, environmentally benign scheme for the synthesis of phthalide derivatives. Compounds 5c and 5d from the current series appear to possess good anti-mycobacterial activity. dCTP: deaminasedUTPase was identified as a putative drug target in Mycobacterium. The docking results clearly showed the interactive involvement of conserved residues of dCTP with the synthesized phthalide compounds. Conclusion: On the eve of evolving anti-TB drug resistance, the data on anti-tubercular and allied activities of the compounds in the present study demonstrates the enormous significance of these newly synthesized derivatives as possible candidate leads in the development of novel anti-tubercular agents. The docking results from the current report provide a structural rationale for the promising anti-tubercular activity demonstrated by 3-arylaminophthalides and 3-indolyl-phthalides compounds.

Welcome to talk about 87-41-2, If you have any questions, you can contact Patil, A; Duggal, H; Bagul, KT; Kamble, S; Lokhande, P; Gacche, R; Meshram, R or send Email.. Application In Synthesis of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Name: Isobenzofuran-1(3H)-one. Recently I am researching about ACID ESTERS; DEGRADATION; PHOTOLYSIS; TOXICITY; WATER; DERIVATIZATION; ORGANIZATION; METABOLITES; DIESTERS; PATTERNS, Saw an article supported by the Key Projects in the National Science & Technology Pillar Program in the Eleventh Five-Year Plan Period [2008BAC43B01]. Published in WILEY in HOBOKEN ,Authors: Zhang, WH; Sun, RH; Hou, YL; Qiu, YL; Li, Y. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalate derivatives with low estrogenic activity, high infrared spectrum signals, high Raman characteristic vibration spectrum, high fluorescence intensity, and high ultraviolet sensitivity were selected as precursors from our previous studies, so that the changes in their toxicity and estrogenic activity during biological metabolism, ozone oxidation, photocatalytic degradation, photodegradation, and microbial degradation could be studied.The transformation pathways of these derivatives were simulated, and the reaction energy barriers were calculated. To determine the potential environmental risks of these phthalate derivatives, the pharmacophore models of biotoxicity and estrogen activity of phthalates were used to predict the biotoxicity and estrogen activity of the transformed products. The results showed an increase in the biotoxicity and estrogen activity of the biometabolites, ozonation products, photocatalytic degradation products, and microbial degradation products; the only products that did not follow this trend were the photodegradation products. Notably, the pathways that produced more potentially toxic compounds were the less favorable paths. Our results indicate that the transformation products of the designed environmentally friendly phthalate derivatives potentially pose environmental risks. To avoid such risks, the environmental transformation pathway of these derivatives should be simulated to screen for environmentally friendly phthalate molecules. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC

Name: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Zhang, WH; Sun, RH; Hou, YL; Qiu, YL; Li, Y or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Science & Technology – Other Topics very interesting. Saw the article Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319 published in 2019. Safety of Isobenzofuran-1(3H)-one, Reprint Addresses Lumyong, S (corresponding author), Chiang Mai Univ, Dept Biol, Fac Sci, Chiang Mai, Thailand.; Lumyong, S (corresponding author), Chiang Mai Univ, Ctr Excellence Microbial Divers & Sustainable Uti, Chiang Mai, Thailand.; Lumyong, S (corresponding author), Royal Soc Thailand, Acad Sci, Bangkok, Thailand.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Melanin is a natural pigment that is produced by filamentous fungi. In this study, the endophytic species, Spissiomyces endophytica (strain SDBR-CMU319), produced a brownblack pigment in the mycelia. Consequently, the pigment was extracted from the dried fungal biomass. This was followed by pigment purification, characterization and identification. Physical and chemical characteristics of the pigment showed acid precipitation, alkali solubilization, decolorization with oxidizing agents, and insolubility in most organic solvents and water. The pigment was confirmed as melanin based on ultraviolet-visible spectroscopy, Fourier-transform infrared, and electron paramagnetic resonance spectra analyses. The analyses of the elemental composition indicated that the pigment possessed a low percentage of nitrogen, and therefore, was not 3,4-dihydroxyphenylalanine melanin. Inhibition studies involving specific inhibitors, both tricyclazole and phthalide, and suggest that fungal melanin could be synthesized through the 1,8-dihydroxynaphthalene pathway. The optimum conditions for fungal pigment production from this species were investigated. The highest fungal pigment yield was observed in glucose yeast extract peptone medium at an initial pH value of 6.0 and at 25 degrees C over three weeks of cultivation. This is the first report on the production and characterization of melanin obtained from the genus Spissiomyces.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application In Synthesis of Isobenzofuran-1(3H)-one. Cui, JL; Gong, Y; Vijayakurnar, V; Zhang, G; Wang, ML; Wang, JH; Xue, XZ in [Cui, Jin-Long; Gong, Yi; Wang, Meng-Liang; Wang, Jun -Hong; Xue, Xiao-Zan] Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi, Peoples R China; [Zhang, Gang] Shaanxi Univ Chinese Med, Coll Pharm, Xianyang 712046, Shaanxi, Peoples R China; [Vijayakurnar, Vinod] Ohio State Univ, Dept Food Sci & Technol, Coll Food Agr & Environm Sci, Columbus, OH 43210 USA; [Gong, Yi; Xue, Xiao-Zan] Shanxi Univ, Inst Biotechnol, Taiyuan 030006, Shanxi, Peoples R China published Correlation in Chemical Metabolome and Endophytic Mycobiome in Cynomorium songaricum from Different Desert Locations in China in 2019, Cited 42. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Cynomorium songaricum Rupr. is a valuable food and medicinal plant with functions, such as an increase in sexual function, mainly attributed to its complex secondary metabolites. However, the effect of internal microbes on metabolite production in C. songaricum is still largely unclear. In this study, the relationship between endophytes and differential secondary metabolites in C. songaricum from seven major producing regions of China were explored based on established methods of metabolomics and high-throughput sequencing. The results showed that there were 13 different marker metabolites, seven shared fungal OTUs, and numerous unshared OTUs among C. songaricum distributed at different locations in China and identified significant correlations between metabolites and endophytic fungi. Our study revealed that endophytic fungi may be one possible factor that can affect the plant secondary metabolite composition.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Cui, JL; Gong, Y; Vijayakurnar, V; Zhang, G; Wang, ML; Wang, JH; Xue, XZ or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2019 MOLECULES published article about MASS-SPECTROMETRY; FATTY-ACIDS; A-D; LIQUID-CHROMATOGRAPHY; KINASE INHIBITOR; FRUITING BODY; IDENTIFICATION; ANTIOXIDANT; HANABIRATAKE; METABOLITES in [Wang, Zhixin; Zhong, Xiangjian; Li, Jinjie; Wang, Xin; Ji, Linlin; Shang, Xiaoya] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Food, 191 Beitucheng West Rd, Beijing 100191, Peoples R China; [Liu, Jingyu] Shanxi Agr Univ, Coll Food Sci & Engn, 1 Mingxian South Rd, Jinzhong 030801, Taigu County, Peoples R China in 2019, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Computed Properties of C8H6O2

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 +/- 0.60 mu M. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

Welcome to talk about 87-41-2, If you have any questions, you can contact Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY or send Email.. Computed Properties of C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about 1,10-PHENANTHROLINE COMPLEXES; PHOTOOXIDATION; MECHANISM; NITRATE; LIGNIN, Saw an article supported by the Nuclear Decommissioning Authority; European Research Council (ERC) under the European UnionEuropean Research Council (ERC) [740311]; University of Edinburgh; EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/N022122/1, EP/M010554/1]; Uppsala University, Sweden. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Arnold, PL; Purkis, JM; Rutkauskaite, R; Kovacs, D; Love, JB; Austin, J. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Application In Synthesis of Isobenzofuran-1(3H)-one

Controlled, photocatalytic C-H bond activations are key reactions in the toolkits of the modern synthetic chemist. While it is known that the uranyl(VI) ion, [(UO2)-O-VI](2+), the environmentally dominant form of uranium, is photoactive, most literature examines its luminescent properties, neglecting its potential synthetic utility for photocatalytic C-H bond cleavage. Here, we synthesise and fully characterise an air-stable and hydrocarbon-soluble uranyl phenanthroline complex, [(UO2)-O-VI(NO3)(2)(Ph(2)phen)], U-Ph2phen, and demonstrate that it can catalytically abstract hydrogen atoms from a variety of organic substrates under visible light irradiation. We show that the commercially available parent complex, uranyl nitrate ([(UO2)-O-VI(NO3)(2)(OH2)(2)]center dot 4H(2)O; U-NO3), is also competent, but from electronic spectroscopy we attribute the higher rates and selectivity of U-Ph2phen to ligand-mediated electronic effects. Ketones are selectively formed over other oxygenated products (alcohols, etc.), and the catalytic oxidation of substrates containing a benzylic C-H position is particularly improved for U-Ph2phen. We also show uranyl-mediated photocatalytic C-C bond cleavage in a model lignin compound for the first time.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Arnold, PL; Purkis, JM; Rutkauskaite, R; Kovacs, D; Love, JB; Austin, J or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 ENVIRON TOXICOL CHEM published article about ACID ESTERS; DEGRADATION; PHOTOLYSIS; TOXICITY; WATER; DERIVATIZATION; ORGANIZATION; METABOLITES; DIESTERS; PATTERNS in [Zhang, Wenhui; Sun, Ruihao; Hou, Yilin; Li, Yu] North China Elect Power Univ, Coll Environm Sci & Engn, Beijing, Peoples R China; [Zhang, Wenhui; Sun, Ruihao; Hou, Yilin; Li, Yu] North China Elect Power Univ, State Key Lab Reg Optimizat Energy Syst, Beijing, Peoples R China; [Qiu, Youli] North China Inst Sci & Technol, Dept Environm Engn, Beijing, Peoples R China in 2020, Cited 57. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Name: Isobenzofuran-1(3H)-one

Phthalate derivatives with low estrogenic activity, high infrared spectrum signals, high Raman characteristic vibration spectrum, high fluorescence intensity, and high ultraviolet sensitivity were selected as precursors from our previous studies, so that the changes in their toxicity and estrogenic activity during biological metabolism, ozone oxidation, photocatalytic degradation, photodegradation, and microbial degradation could be studied.The transformation pathways of these derivatives were simulated, and the reaction energy barriers were calculated. To determine the potential environmental risks of these phthalate derivatives, the pharmacophore models of biotoxicity and estrogen activity of phthalates were used to predict the biotoxicity and estrogen activity of the transformed products. The results showed an increase in the biotoxicity and estrogen activity of the biometabolites, ozonation products, photocatalytic degradation products, and microbial degradation products; the only products that did not follow this trend were the photodegradation products. Notably, the pathways that produced more potentially toxic compounds were the less favorable paths. Our results indicate that the transformation products of the designed environmentally friendly phthalate derivatives potentially pose environmental risks. To avoid such risks, the environmental transformation pathway of these derivatives should be simulated to screen for environmentally friendly phthalate molecules. Environ Toxicol Chem 2020;00:1-11. (c) 2020 SETAC

Name: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Zhang, WH; Sun, RH; Hou, YL; Qiu, YL; Li, Y or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Squaramide-Catalyzed Asymmetric Intramolecular Oxa-Michael Reaction of alpha,beta-Unsaturated Carbonyls Containing Benzyl Alcohol: Construction of Chiral 1-Substituted Phthalans WOS:000649101400068 published article about ENANTIOSELECTIVE SYNTHESIS; ORGANOCATALYSTS; BOND; 1,3-DIHYDROISOBENZOFURANS; STRATEGY; CASCADE in [Son, Eun Chae; Kim, Seung Yeon; Kim, Sung-Gon] Kyonggi Univ, Coll Nat Sci, Dept Chem, Suwon 16227, South Korea in 2021, Cited 50. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Formula: C8H6O2

Organocatalytic enantioselective intramolecular oxa-Michael reactions of benzyl alcohol bearing alpha,beta-unsaturated carbonyls as Michael acceptors are presented herein. Using cinchona squaramide-based organocatalyst, enones as well as alpha,beta-unsaturated esters containing benzyl alcohol provided their corresponding 1,3-dihydroisobenzofuranyl-1-methylene ketones and 1,3-dihydroisobenzofuranyl-1-methylene esters in excellent yields with high enantioselectivities. In addition, enantioenriched 1,3-dihydroisobenzofuranyl-1-methylene ketone could be obtained from the Wittig/oxa-Michael reaction cascade of 1,3-dihydro-2-benzofuran-1-ol.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recommanded Product: 87-41-2. Cimerman, R; Cibikova, M; Satrapinskyy, L; Hensel, K in [Cimerman, Richard; Cibikova, Maria; Hensel, Karol] Comenius Univ, Fac Math Phys & Informat, Dept Astron Phys Earth & Meteorol, Mlynska Dolina F2, Bratislava 84248, Slovakia; [Satrapinskyy, Leonid] Comenius Univ, Fac Math Phys & Informat, Dept Expt Phys, Mlynska Dolina F2, Bratislava 84248, Slovakia published The Effect of Packing Material Properties on Tars Removal by Plasma Catalysis in 2020, Cited 108. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Plasma catalysis has been utilized in many environmental applications for removal of various hydrocarbons including tars. The aim of this work was to study the tars removal process by atmospheric pressure DBD non-thermal plasma generated in combination with packing materials of various composition and catalytic activity (TiO2, Pt/gamma Al2O3, BaTiO3, gamma Al2O3, ZrO2, glass beads), dielectric constant (5-4000), shape (spherical and cylindrical pellets and beads), size (3-5 mm in diameter, 3-8 mm in length), and specific surface area (37-150 m(2)/g). Naphthalene was chosen as a model tar compound. The experiments were performed at a temperature of 100 degrees C and a naphthalene initial concentration of approx. 3000 ppm, i.e., under conditions that are usually less favorable to achieve high removal efficiencies. For a given specific input energy of 320 J/L, naphthalene removal efficiency followed a sequence: TiO2 > Pt/gamma Al2O3 > ZrO2 > gamma Al2O3 > glass beads > BaTiO3 > plasma only. The efficiency increased with the increasing specific surface area of a given packing material, while its shape and size were also found to be important. By-products of naphthalene decomposition were analyzed by means of FTIR spectrometry and surface of packing materials by SEM analysis.

Recommanded Product: 87-41-2. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about CARBON; NANOPARTICLES; COSIX/CNTS; XPS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21373038, 21403026]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [DUT18GJ206]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, LL; Chen, X; Chen, YJ; Peng, ZJ; Liang, CH. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. HPLC of Formula: C8H6O2

Chemoselective hydrogenation of phthalic anhydride is regarded as the most promising route for producing downstream high-performance phthalide. A series of intermetallic cobalt-nickel silicide catalysts embedded in a carbon matrix (CoxNi2-xSi@C) with acid-tolerance prepared by microwave-assisted chemical vapor deposition have been investigated in this reaction system. Activity measurements show a remarkable positive synergistic effect, forming a volcano-shaped plot over the nominal Co metal fraction for CoxNi2-xSi@C catalysts with a peak at x = 1.5, which corresponds to a 4.5-fold enhancement of the yield of phthalide over Co2Si@C and a 2.0-fold enhancement over the Ni2Si@C monometallic silicide catalysts, which can be correlated with the interaction of cobalt-nickel and metal-silicon bonds. In addition, the cobalt-rich bimetallic silicide exhibits an equal activity to the reference noble metal catalysts (Au, Pd, and Pt) and a significantly higher activity than transition metal catalysts. Moreover, the bimetallic silicide as an intermetallic compound catalyst has demonstrated robust acid corrosion resistance compared to the corresponding metal catalysts.

Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C8H6O2

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem