Heterocyclic Building Block-benzofuran

Safety of Isobenzofuran-1(3H)-one. In 2021 CHINESE CHEM LETT published article about C-H ALKYNYLATION; BRONSTED ACID; AMINE OXIDASE; DERACEMISATION; RACEMATE in [Chen, Xiaohan; Zhao, Ran; Liu, Ziqiang; Ma, Yingang; Liu, Lei] Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Jinan 250012, Peoples R China; [Chen, Xiaohan; Liu, Qingyun] Shandong Univ Sci & Technol, Coll Chem & Biol Engn, State Key Lab Min Disaster Prevent & Control Cofo, Qingdao 266590, Peoples R China; [Chen, Xiaohan; Liu, Qingyun] Shandong Univ Sci & Technol, Minist Sci & Technol, Qingdao 266590, Peoples R China; [Sun, Shutao; Liu, Lei] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China; [Liu, Lei] Shandong Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China; [Liu, Ziqiang; Sun, Xia] Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Pharmacol, Jinan 250012, Peoples R China in 2021, Cited 35. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Chiral alpha-substituted 1,3-dihydroisobenzofurans are key scaffolds in a number of bioactive natural products and synthetic pharmaceuticals. However, catalytic asymmetric approaches have been rarely developed. Here, a redox deracemization technology is adopted to address the catalytic asymmetric synthesis. A broad range of alpha-aryl substituted 1,3-dihydroisobenzofurans are effectively deracemized in high efficiency with excellent ee. alpha-Alkynyl substituted ethers were also compatible with the deracemization technology. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Safety of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Chen, XH; Zhao, R; Liu, ZQ; Sun, ST; Ma, YG; Liu, QY; Sun, X; Liu, L or send Email.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 J MED CHEM published article about PROTEASE INHIBITORS; PHARMACOKINETICS; GLECAPREVIR; NUCLEOSIDE; DESIGN; SAFETY; SINGLE in [Randolph, John T.; Voight, Eric A.; Greszler, Stephen N.; Uno, Brice E.; Newton, James N.; Gleason, Kenneth M.; Stolarik, DeAnne; Van Handel, Cecilia; Bow, Daniel A. J.; DeGoey, David A.] Abbvie Inc, Global Pharmaceut Res & Dev, N Chicago, IL 60064 USA in 2020, Cited 26. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Category: benzofurans

A research program to discover solubilizing prodrugs of the HCV NS5A inhibitor pibrentasvir (PIB) identified phosphomethyl analog 2 and trimethyl-lock (TML) prodrug 9. The prodrug moiety is attached to a benzimidazole nitrogen atom via an oxymethyl linkage to allow for rapid and complete release of the drug for absorption following phosphate removal by intestinal alkaline phosphatase. These prodrugs have good hydrolytic stability properties and improved solubility compared to PIB, both in aqueous buffer (pH 7) and FESSIF (pH 5). TML prodrug 9 provided superior in vivo performance, delivering high plasma concentrations of PIB in PK studies conducted in mice, dogs, and monkeys. The improved dissolution properties of these phosphate prodrugs provide them the potential to simplify drug dosage forms for PIB-containing HCV therapy.

Welcome to talk about 87-41-2, If you have any questions, you can contact Randolph, JT; Voight, EA; Greszler, SN; Uno, BE; Newton, JN; Gleason, KM; Stolarik, D; Van Handel, C; Bow, DAJ; DeGoey, DA or send Email.. Category: benzofurans

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Association of electroanalytical and spectrophotometric methods to evaluate the antioxidant activity of isobenzofuranone in primary cultures of hippocampal neurons WOS:000566428200014 published article about PEROXIDE-INDUCED DAMAGE; OXIDATIVE STRESS; 3-SUBSTITUTED ISOCOUMARINS; CELLS; CHEMISTRY in [Teixeira, Aniely dos Reis; Ribeiro, Iara Mariana Lellis; Oliveira, Laser Antonio Machado; Nogueira, Katiane de Oliveira Pinto Coelho] Univ Fed Ouro Preto, Dept Biol Sci, Neurobiol & Biomat Lab, Ouro Preto, MG, Brazil; [Teixeira, Robson Ricardo; Pereira, Wagner Luiz] Univ Fed Vicosa, Dept Chem, Vicosa, MG, Brazil; [Manhabosco, Taise Matte; de Brito, Ana Carolina Ferreira] Univ Fed Ouro Preto, Dept Phys, REDEMAT, Ouro Preto, MG, Brazil in 2020, Cited 52. Recommanded Product: Isobenzofuran-1(3H)-one. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

The isobenzofuran-1(3H)-ones (phthalides) exhibit various biological activities, including antioxidant activity on reactive oxygen species (ROS). An excess of ROS that cannot be naturally contained by cellular enzymatic systems is called redox imbalance, which damage cell membranes, proteins, and DNA, thereby possibly triggering neuronal death in several neurodegenerative diseases. Considering our ongoing efforts to find useful compounds to control redox imbalance, herein we evaluated the antioxidant activity of two phtalides (compounds 3 and 4), using primary cultures of hippocampal neurons. Spectrophotometric assays showed that compound 3 significantly reduced (p <= 0.05) ROS levels and lipid peroxidation compared to the control treatment, while compound 4 was unable at any of the tested concentrations. Despite their structural similarity, these compounds behave differently in the intracellular environment, which was reliably corroborated by the determination of oxidation potentials via cyclic voltammetry. It was demonstrated that compound 3 presents a lower oxidation potential. The combination of the mentioned methods allowed us to find a strong correlation between the chemical structure of compounds and their biological effects. Taking together, the results indicate that compound 3 presents desirable characteristics to act as a candidate pharmacological agent for use in the prevention and treatment of neurodegenerative diseases. Welcome to talk about 87-41-2, If you have any questions, you can contact Teixeira, AD; Teixeira, RR; Ribeiro, IML; Pereira, WL; Manhabosco, TM; de Brito, ACF; Oliveira, LAM; Nogueira, KDPC or send Email.. Recommanded Product: Isobenzofuran-1(3H)-one

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Authors Thatikonda, T; Deepake, SK; Kumar, P; Das, U in ROYAL SOC CHEMISTRY published article about AEROBIC OXIDATION; SELECTIVE OXIDATION; ETHERS; COPPER; ISOCOUMARINS; PHTHALIDES; ALKANES in [Thatikonda, Thanusha; Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India; [Deepake, Siddharth K.; Kumar, Pawan; Das, Utpal] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020, Cited 38. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

A metal-free organocatalytic system has been developed for highly efficient benzylic C-H oxygenations of cyclic ethers using oxygen as an oxidant. This oxidation reaction utilizes alpha-angelica lactone as a low cost/low molecular weight catalyst. The optimized reaction conditions allow the synthesis of valued isocoumarins and phthalides from readily available precursors in good yields. Mechanistic studies indicate that the reaction pathway likely involves a radical process via a peroxide intermediate.

Recommanded Product: 87-41-2. Welcome to talk about 87-41-2, If you have any questions, you can contact Thatikonda, T; Deepake, SK; Kumar, P; Das, U or send Email.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. In 2020 CHEMSUSCHEM published article about DIBAL-H REDUCTION; CATALYTIC-HYDROGENATION; CARBONYL REDUCTIONS; CHEMISTRY; GREEN; EFFICIENT; CINACALCET; TOOLS in [Oetvoes, Sandor B.; Kappe, C. Oliver] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria; [Kappe, C. Oliver] RCPE, Ctr Continuous Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria in 2020, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3 center dot DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 CHEMSUSCHEM published article about DIBAL-H REDUCTION; CATALYTIC-HYDROGENATION; CARBONYL REDUCTIONS; CHEMISTRY; GREEN; EFFICIENT; CINACALCET; TOOLS in [Oetvoes, Sandor B.; Kappe, C. Oliver] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, Heinrichstr 28, A-8010 Graz, Austria; [Kappe, C. Oliver] RCPE, Ctr Continuous Synth & Proc CCFLOW, Inffeldgasse 13, A-8010 Graz, Austria in 2020, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Product Details of 87-41-2

Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3 center dot DMS) was used to reduce various esters and amides under continuous-flow conditions. Taking advantage of the solvent-free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

Welcome to talk about 87-41-2, If you have any questions, you can contact Otvos, SB; Kappe, CO or send Email.. Product Details of 87-41-2

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Recently I am researching about MASS-SPECTROMETRY; FATTY-ACIDS; A-D; LIQUID-CHROMATOGRAPHY; KINASE INHIBITOR; FRUITING BODY; IDENTIFICATION; ANTIOXIDANT; HANABIRATAKE; METABOLITES, Saw an article supported by the Key Projects of Scientific Research Program of Beijing Municipal Commission of Education [KZ201811417049]. Published in MDPI in BASEL ,Authors: Wang, ZX; Liu, JY; Zhong, XJ; Li, JJ; Wang, X; Ji, LL; Shang, XY. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one. Recommanded Product: Isobenzofuran-1(3H)-one

Sparassis crispa is a kind of edible fungus widely grows in the north temperate zone, which shows various medicinal properties. Due to the complexity of chemical constitutes of this species, few investigations have acquired a comprehensive configuration for the chemical profile of it. In this study, a strategy based on ultra-high performance liquid chromatography (UPLC) combined with Orbitrap mass spectrometer (MS) was established for rapidly characterizing various chemical components in S. crispa. Through the summarized MS/MS fragmentation patterns of reference compounds and systematic identification strategy, a total of 110 components attributed to six categories were identified for the first time. Moreover, allergic rhinitis (AR) is a worldwide inflammatory disease seriously affecting human health, and the development of drugs to treat AR has been a topic of interest. It has been reported that the extracts of S. crispa showed obvious inhibitory effects on degranulation of mast cell- and allergen-induced IgE and proinflammatory mediators, but the active components and specific mechanism were still not clear. Src family kinases (SFKs) participate in the initial stage of allergy occurrence, which are considered the targets of AR treatment. Herein, on the basis of that self-built chemical database, virtual screening was applied to predict the potential SFKs inhibitors in S. crispa, using known crystal structures of Hck, Lyn, Fyn, and Syk as receptors, followed by the anti-inflammatory activity evaluation for screened hits by intracellular calcium mobilization assay. As results, sparoside A was directly confirmed to have strong anti-inflammatory activity with an IC50 value of 5.06 +/- 0.60 mu M. This study provides a useful elucidation for the chemical composition of S. crispa, and demonstrated its potential inhibitory effects on AR, which could promote the research and development of effective agents from natural resources.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Safety of Isobenzofuran-1(3H)-one. I found the field of Chemistry very interesting. Saw the article EXPLORATION OF MODERATE CONDITIONS AND SUBSTRATE VARIATION IN THE DIRECT CONDENSATION BETWEEN PHTHALIDE AND PRIMARY AMINE CATALYZED BY GaCl3. ARE ALIPHATIC AMINES LESS REACTIVE THAN AROMATIC ONES? published in 2019, Reprint Addresses Takahashi, I (corresponding author), Univ Fukui, Fac Engn, Dept Appl Chem & Biotechnol, Bunkyo Ku, Fukui 9108507, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one.

Direct condensation between phthalide and a primary amine in the presence of Lewis acid was achieved for the first time in organic solvent-diluted reaction systems catalyzed by GaCl3. The peripheral aspects of this reaction is discussed.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Quality Control of Isobenzofuran-1(3H)-one. Recently I am researching about ONE-POT SYNTHESIS; ARYLDIAZONIUM SALTS; EXPEDIENT SYNTHESIS; FLUORESCENCE; PET; CHEMISTRY; DYES; DERIVATIVES; MONOXIDE; DESIGN, Saw an article supported by the Ministere de l’Enseignement et de la Recherche; French Agence Nationale de la RechercheFrench National Research Agency (ANR) [ANR-15-CE18-0015-01]; Investments for the Future Program [ANR-10-LABX-57]; CESAMO [ISM UMR 5255]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Christine, T; Tabey, A; Cornilleau, T; Fouquet, E; Hermange, P. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Aiming the faster development from bench to bedside of new potential tracers, multimodal tracers for positron emission tomography (PET) and optical imaging (OI) have emerged as a very promising tool. Indeed, they combine the simplicity of use of optical techniques for in vitro/in vivo pre-clinical studies with the various clinical possibilities offered by PET imaging using their radioactive versions. In this context, the preparation of new tags detectable by fluorescence imaging and potentially suitable for PET imaging after a last-step C-11-labeling of the corresponding precursor has been investigated. Various designs and syntheses were explored by linking o-iodobenzyl alcohols and tetramethyl-BODIPY moieties together. Among them, the most promising structure was produced in 30% yield over five steps from a commercially available and inexpensive starting material. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

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Benzofuran – Wikipedia,
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Zou, J; Chen, GD; Zhao, H; Wang, XX; Zhang, ZJ; Qu, YB; He, RR; So, KF; Yao, XS; Gao, H in [Zou, Jian; Chen, Guo-Dong; Wang, Xiao-Xia; He, Rong-Rong; Yao, Xin-Sheng; Gao, Hao] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Coll Pharm, Guangdon Prov Key Lab Pharmacodynam Constituents, Guangzhou 510632, Guangdong, Peoples R China; [Zou, Jian] Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China; [Zhao, Huan] Jinan Univ, Coll Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China; [Zhang, Zai-Jun; So, Kwok-Fai] Jinan Univ, Inst New Drug Res, Coll Pharm, Guangzhou Key Lab Innovat Chem Drug Res Cardiocer, Guangzhou 510632, Guangdong, Peoples R China; [Qu, Yi-Bo] Jinan Univ, GMH Inst Cent Nervous Syst Regenerat, Guangdong Med Key Lab Brain Funct & Dis, Guangzhou 510632, Guangdong, Peoples R China published Triangeliphthalides A-D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism in 2019, Cited 18. Recommanded Product: 87-41-2. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Triangeliphthalides A-D (1-4), four novel phthalide trimers with two new linkage styles, were isolated from Angelica sinensis, together with two related phthalide dimers (5-6). Their structures including absolute configurations were determined. The production mechanism of phthalide polymers was proposed, and their bioactivities were also evaluated.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem