Heterocyclic Building Block-benzofuran

Recommanded Product: Isobenzofuran-1(3H)-one. Renzetti, A; Fukumoto, K in [Renzetti, Andrea; Fukumoto, Kozo] Univ Ryukyus, Fac Educ, 1 Senbaru, Nishihara, Okinawa 9030213, Japan published Synthesis of Phthalides and alpha,beta-butenolides by Transition Metal-Catalyzed Activation of CH Bonds in 2019, Cited 68. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

Phthalides and ,-butenolides are two related classes of oxygenated heterocycles with a wide range of biological activities. An innovative strategy to prepare these compounds is based on CH bond functionalization reactions, in which two simple, unfunctionalized molecules are coupled together with cleavage of a CH bond and formation of a CX bond (X=C or heteroatom). This paper reviews the methods for the synthesis of phthalides and ,-butenolides by CH bond functionalization from non-halogenated starting materials. Over 30 methods are reported, mostly developed during the past ten years.

Recommanded Product: Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Renzetti, A; Fukumoto, K or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

An article Aniline-Type Hypervalent Iodine(III) for Intramolecular Cyclization via C-H Bond Abstraction of Hydrocarbons Containing N- and O-Nucleophiles WOS:000647954700001 published article about REAGENTS; FUNCTIONALIZATION; REACTIVITY; CHEMISTRY in [Nishiguchi, Yuna; Moriyama, Katsuhiko] Chiba Univ, Grad Sch Sci, Dept Chem, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan; [Nishiguchi, Yuna; Moriyama, Katsuhiko] Chiba Univ, Soft Mol Activat Res Ctr, Inage Ku, 1-33 Yayoi Cho, Chiba 2638522, Japan in 2021, Cited 42. Category: benzofurans. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We developed a method for the preparation of (diacetoxyiodo)-2-(N-alkylamido)benzene as an aniline-type hypervalent iodine(III). We also achieved direct cyclizations via C-H bond abstraction, such as the Hofmann-Loffler-Freytag reaction, a direct amination, and a direct lactonization, using the aniline-type hypervalent iodine(III) to obtain corresponding products in high yields.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Application In Synthesis of Isobenzofuran-1(3H)-one. Authors Wang, CQ; Liu, G; Dou, GJ; Yang, Y; Chen, L; Ma, H; Jiang, ZY; Ma, HY; Li, CL; Li, L; Jiang, MD; Lu, QW; Li, P; Qi, HY in ELSEVIER GMBH published article about in [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Pharmaceut Sci, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Wang, Chengqiang; Liu, Gen; Dou, Guojun; Yang, Yi; Chen, Lu; Ma, Hui; Jiang, Zhuyun; Ma, Haoyue; Li, Li; Qi, Hongyi] Southwest Univ, Coll Chinese Med, 2 Tiansheng Rd, Chongqing 400715, Peoples R China; [Li, Chenglong] Sichuan Prov Peoples Hosp, Dept Hematol, Chengdu 610212, Sichuan, Peoples R China; [Jiang, Mingdong; Lu, Qianwei; Li, Pan] Chongqing Ninth Peoples Hosp, Dept Oncol & Hematol, Jialing Village 69, Chongqing 400700, Peoples R China in 2021, Cited 24. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

Background: Acute myeloid leukemia (AML) is a devastating hematologic malignancy with a high mortality. The nuclear receptors Nur77 and NOR-1 are commonly downregulated in human AML blasts and have emerged as key therapeutic targets for AML. Methods: This study aimed to identify Z-ligustilide (Z-LIG), the main phthalide of Rhizoma Chuanxiong, as a potential agent that can selectively target AML. The anti-AML activity of Z-LIG was evaluated in vitro and in vivo, and the effect and underlying mechanisms of Z-LIG on the restoration of Nur77 and NOR-1 was determined. Moreover, the role of Nur77 and NOR-1 in the regulation of Z-LIG-induced apoptosis and differentiation of AML cells was explored. Results: Z-LIG preferentially inhibited the viability of human AML cells, as well as suppressed the proliferation and colony formation ability. Notably, a concentration-dependent dual effect of Z-LIG was observed in AML cells: inducing apoptosis at relatively high concentrations (25 mu M to 100 mu M) and promoting differentiation at relatively low concentrations (10 mu M and 25 mu M). Importantly, Z-LIG restored Nur77 and NOR-1 expression in AML cells by increasing Ace-H3 (lys9/14) enrichment in their promoters. Meanwhile, Z-LIG enhanced the recruitment of p300 and reduced the recruitment of HDAC1, HDAC4/5/7, and MTA1 in the Nur77 promoter and enhanced the recruitment of p-CREB and reduced HDAC1 and HDAC3 in the NOR-1 promoter. Furthermore, Z-LIG-induced apoptosis was shown to be correlated with the mitochondria localization of Nur77/NOR-1 and subsequent Bcl-2 conformational change, converting Bcl-2 from a cyto-protective phenotype into a cyto-destructive phenotype. ZLIG-promoted differentiation was found to be related to Nur77/NOR-1-mediated myeloid differentiation-associated transcription factors Jun B, c-Jun, and C/EBP beta. Finally, silencing of Nur77 and NOR-1 attenuated anti-AML activity of Z-LIG in NOD/SCID mice. Conclusions: Our study suggests that Z-LIG may serve as a novel bifunctional agent for AML by restoring Nur77/NOR-1-mediated apoptosis and differentiation

Application In Synthesis of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Redox deracemization of alpha-substituted 1,3-dihydroisobenzofurans published in 2021. Name: Isobenzofuran-1(3H)-one, Reprint Addresses Liu, L (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Pharmaceut Sci, Jinan 250012, Peoples R China.; Liu, QY (corresponding author), Shandong Univ Sci & Technol, Coll Chem & Biol Engn, State Key Lab Min Disaster Prevent & Control Cofo, Qingdao 266590, Peoples R China.; Liu, QY (corresponding author), Shandong Univ Sci & Technol, Minist Sci & Technol, Qingdao 266590, Peoples R China.; Sun, X (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Basic Med Sci, Dept Pharmacol, Jinan 250012, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Chiral alpha-substituted 1,3-dihydroisobenzofurans are key scaffolds in a number of bioactive natural products and synthetic pharmaceuticals. However, catalytic asymmetric approaches have been rarely developed. Here, a redox deracemization technology is adopted to address the catalytic asymmetric synthesis. A broad range of alpha-aryl substituted 1,3-dihydroisobenzofurans are effectively deracemized in high efficiency with excellent ee. alpha-Alkynyl substituted ethers were also compatible with the deracemization technology. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Quality Control of Isobenzofuran-1(3H)-one. Authors Feng, XY; Pi, YH; Song, Y; Xu, ZW; Li, Z; Lin, WB in AMER CHEMICAL SOC published article about in [Feng, Xuanyu; Pi, Yunhong; Song, Yang; Xu, Ziwan; Lin, Wenbin] Univ Chicago, Dept Chem, Chicago, IL 60637 USA; [Pi, Yunhong; Li, Zhong] South China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China in 2021, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2

We report here the construction of two metal-organic frameworks (MOFs), Zr-6-Cu/Fe-1 and Zr-6–Cu/Fe-2, by integrating earth-abundant cuprous photosensitizers (Cu-PSs) and Fe catalysts for photocatalytic aerobic oxidation. Site isolation and pore confinement stabilize both Cu-PSs and Fe catalysts, while the proximity between active centers facilitates electron and mass transfer. Upon visible light irradiation and using O-2 as the only oxidant, Zr-6-Cu/Fe-1 and Zr-6-Cu/ Fe-2 efficiently oxidize alcohols and benzylic compounds to afford corresponding carbonyl products with broad substrate scopes, high turnover numbers of up to 500 with a 9.4-fold enhancement over homogeneous analogues, and excellent recyclability in four consecutive runs. Control experiments, spectroscopic evidence, and computational studies revealed the photooxidation mechanism: oxidative quenching of [Cu-PS]* by O-2 affords [Cu-II-PS], which efficiently oxidizes Fe-III-OH to generate a hydroxyl radical for substrate oxidation. This work highlights the potential of MOFs in promoting earth-abundant metal-based photocatalysis.

Welcome to talk about 87-41-2, If you have any questions, you can contact Feng, XY; Pi, YH; Song, Y; Xu, ZW; Li, Z; Lin, WB or send Email.. Quality Control of Isobenzofuran-1(3H)-one

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Computed Properties of C8H6O2. Mori, T; Ishii, C; Kimura, M in [Mori, Takamichi] Sanyo Onoda City Univ, Fac Engn, Dept Appl Chem, 1-1-1 Daigakudori, Yamaguchi 7560884, Japan; [Ishii, Chihiro; Kimura, Masanari] Nagasaki Univ, Grad Sch Engn, 1-14 Bunkyo Machi, Nagasaki 8528521, Japan published Pd-Catalyzed Dehydrogenative Oxidation of Alcohols to Functionalized Molecules in 2019, Cited 63. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2.

A dehydrogenative oxidation reaction of primary alcohols to aldehydes catalyzed by a simple Pd/Xantphos catalytic system was developed under an argon or nitrogen atmosphere without oxidizing agents or hydrogen acceptors. The reaction product could be easily changed: under aerobic conditions, esters were obtained in aprotic solvents, whereas the corresponding carboxylic acids were produced in aqueous media. These oxidizing processes were applicable to the efficient synthesis of useful nitrogen-containing heterocyclic compounds such as indole, quinazoline, and benzimidazole via intramolecular versions of this reaction from amino alcohols.

Computed Properties of C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Mori, T; Ishii, C; Kimura, M or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article Enantioselective Allylation of Oxocarbenium Ions Catalyzed by Bi(OAc)(3)/Chiral Phosphoric Acid published in 2020. Application In Synthesis of Isobenzofuran-1(3H)-one, Reprint Addresses Li, X (corresponding author), Nankai Univ, State Key Lab Elementoorgan Chem, Coll Chem, Tianjin 300071, Peoples R China.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Phthalides as the crucial core skeletons are found extensively in natural products and biological active molecules. Herein we disclose an asymmetric allylation of 3-hydroxyisoben-zofuran-1(3H)-ones with boron allylation reagents to construct chiral phthalide derivatives. The simple Bi(OAc)(3)/chiral phosphoric acid catalytic system proves to be efficient in this method, delivering the desired chiral 3-allylisobenzofuran-1(3H)-ones in good yields (up to 99%) and high enantioselectivities (up to 99.5:0.5 e.r.) under mild conditions. The large-scale reaction and diverse transformations of products to various scaffolds with potential biological activities render it more attractive. Moreover, the mechanism was preliminarily explored by control reactions, mass spectrometry, deuterium experiment, and DFT calculations.

Application In Synthesis of Isobenzofuran-1(3H)-one. Welcome to talk about 87-41-2, If you have any questions, you can contact Pan, YL; Zheng, HL; Wang, J; Yang, C; Li, X; Cheng, JP or send Email.

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Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Polymer Science very interesting. Saw the article Synthesis of Poly(Arylene Alkenylene)s by Pd-Catalyzed Three-Component Coupling Polycondensation of Diiodoarenes, Non-Conjugated Dienes, and Nucleophiles that Involves Chain Walking Isomerization published in . COA of Formula: C8H6O2, Reprint Addresses Takeuchi, D (corresponding author), Tokyo Inst Technol, Lab Chem & Life Sci, R1-03,4259 Nagatsuta, Yokohama, Kanagawa 2268503, Japan.; Takeuchi, D (corresponding author), Hirosaki Univ, Grad Sch Sci & Technol, Dept Frontier Mat Chem, 3 Bunkyo Cho, Hirosaki, Aomori 0368561, Japan.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and carbonucleophiles afforded poly(arylene alkenylene)s with moderate molecular weight in good yield. The reaction involves Mizoroki-Heck coupling, olefin migration via chain walking, and addition of the carbonucleophile to the resulting pi-allylpalladium species. The polymerization with a slight excess of nucleophile with respect to diiodoarene also proceeded to give the polymer without significant decrease in molecular weight in spite of the nonstoichiometric mixture of the monomers. The Pd-catalyzed three-component coupling polycondensation of diiodoarenes, nonconjugated dienes, and diimide also proceeded. The base used in the reaction is critical for yield and molecular weight of the product. The reaction using NaHCO3 afforded the product with low solubility, which can be explained by the high molecular weight of the polymer and/or the strong interaction of the electron donating dimethoxyphenylene groups and electron accepting diimide groups in the polymer. (c) 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019

COA of Formula: C8H6O2. Welcome to talk about 87-41-2, If you have any questions, you can contact Tan, LY; Takeuchi, D; Osakada, K or send Email.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In 2020 SCI CHINA CHEM published article about CATALYZED ASYMMETRIC HYDROGENATION; MOLECULAR-STRUCTURE; COORDINATION; COMPLEXES; PHOSPHORAMIDITE; DERIVATIVES; COMPOUND; LIGANDS; KETONES; ACIDS in [Yu, Chang-Bin; Wang, Heng-Ding; Song, Bo; Shen, Hong-Qiang; Fan, Hong-Jun; Zhou, Yong-Gui] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China; [Wang, Heng-Ding] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2020, Cited 57. The Name is Isobenzofuran-1(3H)-one. Through research, I have a further understanding and discovery of 87-41-2. Computed Properties of C8H6O2

For the metal-catalyzed asymmetric hydrogenation of alpha-substituted ketones, cis reductive products are generally obtained due to steric hindrance of substituents. Herein, an unprecedented trans reductive products were observed in palladium-catalyzed hydrogenative desymmetrization of cyclic and acyclic 1,3-diketones, providing the chiral trans beta-hydroxy ketones with two adjacent stereocenters including one alpha-tertiary or quaternary stereocenter with high enantioselectivity and diastereoselectivity. Mechanistic studies and DFT calculations suggested that the rarely observed diastereoselectivity reversal is ascribed to the charge-charge interaction between the palladium and aromatic ring of the substrate, which could not only result in the reversal of the diastereoselectivity, but also improve the reactivity.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

I found the field of Chemistry very interesting. Saw the article (Cyclopentadienone)iron-Catalyzed Transfer Dehydrogenation of Symmetrical and Unsymmetrical Diols to Lactones published in 2020. Safety of Isobenzofuran-1(3H)-one, Reprint Addresses Funk, TW (corresponding author), Gettysburg Coll, Dept Chem, Gettysburg, PA 17325 USA.. The CAS is 87-41-2. Through research, I have a further understanding and discovery of Isobenzofuran-1(3H)-one

Air-stable iron carbonyl compounds bearing cyclo-pentadienone ligands with varying substitution were explored ,as catalysts in dehydrogenative diol lactonization reactions using acetone as both the solvent and hydrogen acceptor. Two catalysts with trimethylsilyl groups in the 2- and 5-positions, [2,S-(SiMe3)(2)-3,4-(CH2)(4)(eta(4)-C4C=O))Fe(CO)(3) (1) and [2,5-(SiMe3)(2)-3,4(CH2)(3)(eta(4)-C4C=O)]Fe(CO)(3) (2), were found to be the most active, with 2 being the most selective in the lactonization of diols containing both primary and secondary alcohols. Lactones containing five-, six-, and seven-membered rings .were successfully synthesized, and no over-oxidations to carboxylic acids were detected. The lactonization of unsymmetrical diols containing two primary alcohols occurred with catalyst 1, but selectivity was low based on alcohol electronics and modest based on alcohol sterics. Evidence for a transfer dehydrogenation mechanism was found, and insight into the origin of selectivity in the lactonization of 1 degrees/2 degrees diols was obtained. Additionally, spectroscopic evidence for a trimethylamine-ligated iron species formed in solution during the reaction was discovered.

Safety of Isobenzofuran-1(3H)-one. Bye, fridends, I hope you can learn more about C8H6O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem