Heterocyclic Building Block-benzofuran

He, Xingcun published the artcileFlow injection analysis of platinum metals. VI. Iridium(IV)-potassium periodate-α-naphtholphthalein system, SDS of cas: 596-01-0, the publication is Fenxi Huaxue (1990), 18(3), 237-9, database is CAplus.

A flow-injection spectrophotometric method for determination of trace Ir(IV) was developed based on the catalytic effect of Ir(IV) on the oxidation of α-naphtholphthalein with KIO₄. The detection limit is 0.020 μg Ir/mL and the anal. rate is 61 sample/h. The method is simple, fast, and sensitive.

Fenxi Huaxue published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, SDS of cas: 596-01-0.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

He, Xingcun published the artcileCatalytic determination of osmium by using flow-injection analysis, Safety of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Huaxue Tongbao (1988), 41-2, database is CAplus.

Os(VIII) was determined by flow-injection spectrophotometry (monitored at 640 nm) based on the catalytic effect of Os(VIII) on the decolorization reaction of α-naphtholphthalein and KIO₄ in borate buffer solution at pH 9.20-9.80. The catalytic reaction is a zero-order reaction. The calibration curve is linear for 0.010-0.12 μg Os/mL. The detection limit is 0.010 μg/mL. The method is accurate, simple, and with an anal. rate of 75/h. Os was determined in ore concentrates and slags with satisfactory results.

Huaxue Tongbao published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Safety of 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Mongin, Florence published the artcileDeprotonation of furans using lithium magnesates, Quality Control of 69626-75-1, the publication is Tetrahedron Letters (2005), 46(46), 7989-7992, database is CAplus.

Furan was deprotonated on treatment with 1/3 equiv of Bu₃MgLi in THF at rt. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The highly coordinated magnesate Bu₄MgLi₂ (1/3 equiv) proved to be a better deprotonating agent than Bu₃MgLi; the monitoring of the reaction using NMR spectroscopy showed that the deprotonation of furan at rt required 2 h whereas the subsequent electrophilic trapping was instantaneous. The method was extended to benzofuran, allowing its functionalization at C2 in high yields. The deprotonation of 2-methylfuran and lithium furfurylalkoxide at C5 turned out to be difficult, requiring either long reaction times or higher temperatures

Tetrahedron Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Quality Control of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fiandanese, Vito published the artcileA straightforward synthesis of benzofuran- and indole-substituted 1,2,3-triazoles via click chemistry, Computed Properties of 69626-75-1, the publication is Synthesis (2009), 3853-3859, database is CAplus.

A convenient synthesis of benzofuran- and indole-substituted 1,2,3-triazoles, e.g., I (R = H, I; X = O, NH), has been devised starting from easily available 2-silylalkynyl-substituted benzofuran and indole derivatives

Synthesis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fiandanese, Vito published the artcileA straightforward synthesis of indole and benzofuran derivatives, Recommanded Product: 2-Iodobenzofuran, the publication is Tetrahedron (2008), 64(1), 53-60, database is CAplus.

A methodol. for the synthesis of indole and benzofuran derivatives has been devised. The starting materials, ortho-substituted aryl diynes, have been easily converted into unsaturated bis-indolyl and bis-benzofuran derivatives and into 2-ethynylindole and 2-ethynylbenzofuran. Both these products have been further elaborated into more complex unsaturated indole-benzofuran and bis-benzofuran derivatives

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Fiandanese, Vito published the artcileAn easy access to unsymmetrically substituted 4,4′-bis-1,2,3-triazoles, Application In Synthesis of 69626-75-1, the publication is Tetrahedron (2009), 65(51), 10573-10580, database is CAplus.

A convenient synthesis of 4-alkynyl-1,2,3-triazoles and novel unsym. substituted 4,4′-bi-1,2,3-triazole derivatives has been devised starting from easily available 1-trimethylsilyl-1,3-butadiyne. The starting compound was reacted with several azides, leading to 4-(silylalkynyl)-1,2,3-triazoles, which were easily transformed into 4-arylalkynyl-1,2,3-triazoles by a Pd catalyzed coupling reaction with aryl iodides, or into novel 4,4′-bis-1,2,3-triazole derivatives by a subsequent cyclization reaction with azides.

Tetrahedron published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Application In Synthesis of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Nicolle, Edwige published the artcileBreast cancer resistance protein (BCRP/ABCG2): New inhibitors and QSAR studies by a 3D linear solvation energy approach, Category: benzofurans, the publication is European Journal of Pharmaceutical Sciences (2009), 38(1), 39-46, database is CAplus and MEDLINE.

A series of compounds derived from naturally occurring flavonoids and synthetic analogs have been evaluated on cell lines overexpressing the wild-type breast cancer resistance protein (BCRP/ABCG2) half-transporter. Human ABCG2-transfected cells were used for screening their inhibitory activity. Five new natural compounds obtained from Morus mesozygia Stapf and one synthetic chromone, comprising a flavonoidic scaffold, were also evaluated. Based on the results obtained with a total of 34 compounds, a 3D linear solvation energy QSAR was investigated by VolSurf descriptors of mol.-interaction fields (MIFs) related to hydrophobic-interaction forces, polarizability and hydrogen-bonding capacity. Accuracy of the constructed 3D-QSAR model was attested by a correlation coefficient r² of 0.77. Shape parameters and hydrophobicity were revealed to be major physicochem. parameters responsible for the inhibition activity of flavonoid derivatives and synthetic analogs towards ABCG2, whereas hydrogen-bond donor capacity appeared highly unfavorable.

European Journal of Pharmaceutical Sciences published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, Category: benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Baillie, Sharon E. published the artcilePotassium-alkyl magnesiates: synthesis, structures and Mg-H exchange applications of aromatic and heterocyclic substrates, Recommanded Product: 2-Iodobenzofuran, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(85), 12859-12862, database is CAplus and MEDLINE.

Using structurally well-defined dipotassium-tetra(alkyl)magnesiates, a new straightforward methodol. to promote regioselective Mg-H exchange reactions of a wide range of aromatic and heteroaromatic substrates is disclosed. E.g., reaction of anisole with (PMDETA)₂K₂Mg(CH₂SiMe₃)₂ in hexane at 20° followed by excess I₂ gave p-IC₆H₂OMe in 92% yield. Contacted ion pair intermediates probably are involved, with K being the key to facilitate the magnesiation processes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Recommanded Product: 2-Iodobenzofuran.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

L’Helgoual’ch, Jean-Martial published the artcileDeprotonative cadmation of functionalized aromatics, Computed Properties of 69626-75-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2008), 5375-5377, database is CAplus and MEDLINE.

This communication describes the deproto-metalation of a large range of aromatics including heterocycles using a newly developed lithium-cadmium base; the reaction proceeds at room temperature with an excellent chemoselectivity and efficiency, and proved to be regioselective in most cases. Thus, treatment of PhOMe with CdCl₂·TMEDA/LiTMP in THF at room temperature followed by quenching with I₂ gave 74% 2-IC₆H₄OMe.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hedidi, Madani published the artcileSynthesis of C,N’-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells, Application In Synthesis of 69626-75-1, the publication is Bioorganic & Medicinal Chemistry (2014), 22(13), 3498-3507, database is CAplus and MEDLINE.

Benzothiophene, benzofuran, benzothiazole, and benzoxazole were deprotometalated using the lithium-zinc combination prepared from ZnCl₂.TMEDA (TMEDA = N,N,N’,N’-tetramethylethylenediamine, 1 equiv) and lithium 2,2,6,6-tetramethylpiperidide (LiTMP, 3 equiv). Subsequent interception of the 2-metalated derivatives using iodine as electrophile led to the iodides in 81%, 82%, 67%, and 42% yields, resp. These yields are higher (10% more) than those obtained using ZnCl₂.TMEDA (0.5 equiv) and LiTMP (1.5 equiv), except in the case of benzoxazole (10% less). The crude iodides were involved in the N-arylation of pyrrole, indole, carbazole, pyrazole, indazole, imidazole, and benzimidazole in the presence of Cu (0.2 equiv) and Cs₂CO₃ (2 equiv), and using acetonitrile as solvent (no other ligand) to provide after 24 h reflux the expected N-arylated azoles in yields ranging from 33% to 81%. Using benzotriazole also led to N-arylation products, but in lower 34%, 39%, 36%, and 6% yields, resp. A further study with this azole showed the impact of 2,2,6,6-tetramethylpiperidine on the N-arylation yields. Most of the C,N’-linked bis-heterocycles thus synthesized (in particular those containing benzimidazole) induced a high growth inhibition of A2058 melanoma cells after a 72 h treatment at 10^-5 M.

Bioorganic & Medicinal Chemistry published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Application In Synthesis of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem