Heterocyclic Building Block-benzofuran

Kortman, Gregory D. published the artcileCopper-Catalyzed Hydroarylation of Internal Alkynes: Highly Regio- and Diastereoselective Synthesis of 1,1-Diaryl, Trisubstituted Olefins, HPLC of Formula: 69626-75-1, the publication is ACS Catalysis (2017), 7(9), 6220-6224, database is CAplus.

The copper-catalyzed hydroarylation of internal, unsym. alkynes is presented. Trisubstituted alkenes are obtained as single diastereomers in good to excellent yields and excellent regioselectivities. The scope of the reaction is presented with respect to alkyne and aryl iodide coupling partners. Initial mechanistic experiments indicate a hydrocupration event followed by a two-electron oxidative addition/reductive elimination pathway.

ACS Catalysis published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, HPLC of Formula: 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Hao, Mimi published the artcileBioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis, SDS of cas: 56317-21-6, the publication is Fitoterapia (2021), 105018, database is CAplus and MEDLINE.

Twenty-two flavonoids and stilbenes (1-22) were obtained from the leaf of Morus alba var. multicaulis. Among them, morusalbanosides A (1), B1 (2), and B2 (3) were new compounds Moreover, compounds 1, 3, 4-11, 15-18, and 22 displayed inhibitory effects on triglyceride (TG) accumulation in HepG2 cells in a concentration dependent manner. Furthermore, compounds 1, 3, 11, and 22 could activate the phosphorylation of AMP-activated protein kinase α (AMPKα), reduce the synthesis of TG by inhibiting the expression of fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1). While, only compounds 1 and 11 could promote the phosphorylation of acetyl-CoA carboxylase 1 (ACC1) and accelerate the oxidation of fatty acids by up-regulating carnitine palmitoyltransferase 1A (CPT1A). In brief, this study found that most of the researched flavonoids and stilbenes could regulate TG metabolism in vitro. They might play the role by up-regulating phosphorylation of AMPKα, inhibiting TG biosynthesis, and promoting the oxidation of fatty acids.

Fitoterapia published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, SDS of cas: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Liu, Ai-hong published the artcileChemical constituents occurring in roots of Artocarpus nanchuanensis, HPLC of Formula: 56317-21-6, the publication is Zhongguo Shiyan Fangjixue Zazhi (2014), 20(22), 91-94, database is CAplus.

The chem. constituents of roots of Artocarpus nanchuanensis were studied. The constituents were isolated from the Et acetate portion of 95% ethanol extraction of A. nanchuanensis roots by column chromatog. over silica gel, Diaion HP20 macroreticular resin, MCI CHP 20P gel, Sephadex LH-20 gel, ODS gel, etc. Their structures were elucidated by anal. of phys. chem. properties and spectral data. Nine compounds were isolated and their structures were identified as p-hydroxybenzaldehyde (1), 2,4-dihydroxybenzoic acid (2), p-coumaric acid (3), (+)-catechin (4), (E)-ferulic acid Me ester (5), p-E-hedroxycinnamic acid Me ester (6), norartocarpetin (7), trans-oxyresveratrol (8) and moracin M (9). Compounds 1, 2, 5 and 6 were isolated from Moraceae for the first time. Compound 3 was firstly reported in the genus Artocarpus, and compounds 7-9 were characterized in A. nanchuanensis for the first time.

Zhongguo Shiyan Fangjixue Zazhi published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Matsuzawa, Tsubasa published the artcileTransition-Metal-Free Synthesis of N-Arylphenothiazines through an N- and S-Arylation Sequence, Quality Control of 69626-75-1, the publication is Organic Letters (2021), 23(6), 2347-2352, database is CAplus and MEDLINE.

An efficient synthetic method of N-arylphenothiazines, e.g., I, from o-sulfanylanilines under transition-metal-free conditions is disclosed. An N- and S-arylation sequence of o-sulfanylanilines enabled the authors to synthesize a wide variety of N-arylphenothiazines. In particular, one-pot synthesis of N-arylphenothiazines was accomplished from easily available modules through preparation of o-sulfanylanilines by thioamination of aryne intermediates and following N- and S-arylation sequence.

Organic Letters published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Quality Control of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Vo, Quan V. published the artcileThe radical scavenging activity of moracins: theoretical insights, Related Products of benzofurans, the publication is RSC Advances (2020), 10(60), 36843-36848, database is CAplus and MEDLINE.

Moracins are natural products that have been isolated from different plants such as Artocarpus heterophyllus, Cassia fistula, Morus alba, and Morus mesozygia. Studies showed that moracins may have various advantageous physiol. effects such as anticancer, anti-inflammatory, anticholinesterase and particularly antioxidant activities. Most of these bioactivities have not been studied systematically. In this study, the radical scavenging of a typical moracin (moracin M, MM) against HO and HOO radicals was evaluated by thermodn. and kinetic calculations in the gas phase as well as in water and pentyl ethanoate solvents. It was found that the overall rate constants for the HO radical scavenging in the gas phase and the physiol. environments are in the range of 10¹¹ to 10¹⁰ M^-1 s^-1, resp. For the HOO + MM reaction the rate constants are 4.10 x 10⁷ and 3.80 x 10⁴ M^-1 s^-1 in the polar and lipid media, resp. It is important to notice that the single electron transfer pathway of the anion state (MM-O6′-) dominated the HOO radical scavenging in the aqueous solution, whereas in lipid medium the neutral MM exerted its activity by the formal hydrogen transfer mechanism. The HOO radical scavenging of MM is comparable to that of Trolox in lipid medium, whereas it is 315.4 times more active in the polar environment.

RSC Advances published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C20H18BrN3, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Royer, Mariana published the artcileSecondary metabolites of Bagassa guianensis Aubl. wood: A study of the chemotaxonomy of the Moraceae family, HPLC of Formula: 56317-21-6, the publication is Phytochemistry (Elsevier) (2010), 71(14-15), 1708-1713, database is CAplus and MEDLINE.

In order to explain the durability of the Moraceae plant family, phytochem. of Bagassa guianensis was performed. Et acetate extract was obtained from the heartwood and 18 secondary metabolites were isolated, including 6 moracins [6-O-methyl-moracin M, 6-O-methyl-moracin N and moracin Z; previously identified: moracin M, moracin N and moracin P], 8 stilbenoids [presently identified: (-)-epialboctalol and arachidin 4; previously identified: alboctalol, trans-resveratrol, arachidin 2, trans-oxyresveratrol and artogomezianol], 3 previously identified flavonoids, steppogenin, katuranin and dihydromorin, β-sitosterol and resorcinol. Previous studies suggest that stilbenoids are responsible for the natural durability of wood. This study has determined that B. guianensis is closely related to Morus sp. in phylogeny and should be included in the Moreae sensu stricto tribe of the Moraceae family.

Phytochemistry (Elsevier) published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C14H10O4, HPLC of Formula: 56317-21-6.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Sun, Jian published the artcileAntioxidant and nitrite-scavenging capacities of phenolic compounds from sugarcane (Saccharum officinarum L.) tops, Product Details of C14H10O4, the publication is Molecules (2014), 19(9), 13147-13160, 14 pp., database is CAplus and MEDLINE.

Sugarcane tops were extracted with 50% ethanol and fractionated by petroleum ether, Et acetate (EtOAc), and Bu alc. successively. Eight phenolic compounds in EtOAc extracts were purified through silica gel and Sephadex LH-20 column chromatogs., and then identified by NMR and electrospray ionization mass spectra. The results showed that eight phenolic compounds from EtOAc extracts were identified as caffeic acid, cis-p-hydroxycinnamic acid, quercetin, apigenin, albanin A, australone A, moracin M, and 5′-geranyl-5,7,2′,4′-tetrahydroxyflavone. The antioxidant and nitrite-scavenging capacities of different solvent extracts correlated pos. with their total phenolic (TP) contents. Amongst various extracts, EtOAc extracts possessed the highest TP content and presented the strongest oxygen radical absorbance capacity (ORAC), 1,1′-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging capacity, 2,2′-azobis-3-ethylbenthiaazoline-6-sulfonic acid (ABTS) radical-scavenging capacity, ferric reducing antioxidant power (FRAP) and nitrite-scavenging capacity. Thus, sugarcane tops could be promoted as a source of natural antioxidant.

Molecules published new progress about 56317-21-6. 56317-21-6 belongs to benzofurans, auxiliary class Metabolic Enzyme,PDE,Natural product, name is 5-(6-Hydroxybenzofuran-2-yl)benzene-1,3-diol, and the molecular formula is C9H7NO2, Product Details of C14H10O4.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Cai, Yaqi published the artcileStudy on the flow injection-catalytic photometric determination of rhodium, Related Products of benzofurans, the publication is Yejin Fenxi (1991), 11(1), 34-6, database is CAplus.

In this paper, a new method is recommended for the determination of rhodium by flow injection anal. The proposed method is based on the catalytic action of Rh(III) on the oxidation of α-naphtholphthalein with KIO₄. The method is sensitive, rapid, and simple. In the concentration range of 0.020-0.40 μg/mL, rhodium can be determined at the rate of 64 per h.

Yejin Fenxi published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Related Products of benzofurans.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Cai, Yaqi published the artcileStudies on flow injection analysis of platinum metals. III. Ruthenium(III)-potassium periodate (KIO₄)-α-naphtholphthalein system, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, the publication is Fenxi Huaxue (1989), 17(3), 213-16, 212, database is CAplus.

A method was developed for the determination of trace Ru(III) by flow-injection anal. based on the catalytic effect of Ru(III) on the oxidation of α-naphtholphthalein with KIO₄ in borate buffer (pH 9-11.5). The decoloration was monitored. The proposed method is rapid, simple, and sensitive. The detection limit for Ru(III) is 0.010 μg/mL and 65 determinations can be achieved in 1 h. The method was applied to determine Ru in refined ores and slags; good results were obtained.

Fenxi Huaxue published new progress about 596-01-0. 596-01-0 belongs to benzofurans, auxiliary class Benzofuran,Naphthalene,Alcohol,Ester, name is 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one, and the molecular formula is C28H18O4, Name: 3,3-Bis(4-hydroxynaphthalen-1-yl)isobenzofuran-1(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem

Chen, Kai published the artcileSynthesis of aryl trimethylstannanes from aryl halides: an efficient photochemical method, Computed Properties of 69626-75-1, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(58), 9125-9128, database is CAplus and MEDLINE.

An efficient transition-metal-free photochem. method featuring excellent functional group tolerance, mild reaction conditions and short reaction times has been discovered and developed for the synthesis of (hetero)aryl trimethylstannanes from (hetero)aryl halides. A photo-initiated radical chain mechanism was proposed based on preliminary mechanistic studies.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69626-75-1. 69626-75-1 belongs to benzofurans, auxiliary class Iodide,Benzofuran, name is 2-Iodobenzofuran, and the molecular formula is C8H5IO, Computed Properties of 69626-75-1.

Referemce:
https://en.wikipedia.org/wiki/Benzofuran,
Benzofuran | C8H6O – PubChem