Heterocyclic Building Block-benzofuran

A natural coumestan wedelolactone targets inflammatory cytokines to initiate apoptosis in human cervical cancer cells was written by Christobel, R. Gloria Jemmi;Jaganathan, Shyam Sundar;Abirami, M. P.;Rasappan, P.;Shila, S.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2019.Application of 524-12-9 The following contents are mentioned in the article:

Wedelolactone is a naturally (WDL) occurring coumestan of phytoestrogen category that possess anticancer and anti-inflammatory property. In this study, the anti-inflammatory effect of WDL on human cervical cancer cells (HeLa) and initiation of apoptosis mechanism were investigated. MTT assay and Trypan blue assay were demonstrated to detect the inhibitory effects of WDL on cell proliferation. The mRNA expression of IL-1β, TNFα, IL-6, TGFβ, and NF_κB were detected by RT PCR. Western blotting was performed to detect the expression of apoptosis-associated proteins; cleaved caspase-3, cleaved PARP, Bcl-2, and Bax. WDL significantly inhibited the growth and proliferation of HeLa cells in a concentration dependent manner with the IC50 of 10μM. mRNA expression of inflammatory cytokines and NFκB was significantly reduced in WDL treated groups. Moreover, WDL promoted the apoptosis of HeLa cells dose-dependently by down-regulating Bcl-2 and up-regulating cleaved caspase-3, cleaved PARP, and Bax. Collectively, WDL exerted anti-inflammatory effect through the suppression of NF-_kB activation, IL-1β, TNFα, IL-6 and promoted apoptosis in HeLa cells. Thus, use of WDL, especially through its anti-inflammatory effect, may have future applications in treating human cancers by sensitizing cancer cells to conventional cancer therapies. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Facile green preparation of PLGA nanoparticles using wedelolactone: Its cytotoxicity and antimicrobial activities was written by Vinayagam, Ramachandran;Eun Lee, Kyung;David, Ernest;Nurul Matin, Muhammad;Gu Kang, Sang. And the article was included in Inorganic Chemistry Communications in 2021.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

We synthesized a novel wedelolactone (I)-loaded poly-lactic-co-glycolic acid nanoparticle (WDL-PLGA NPs) and evaluated its antibacterial and induced cytotoxicity against breast cancer MDA-MB-231 cell line growth. The physicochem. properties of the WDL-PLGA NPs were defined by Fourier transform IR spectroscopy (FTIR), and dynamic scattering scanning (DLS) analyzer, and transmission microscopy (TEM) were anal. FTIR results showed that functional groups of WDL were involved in stabilizing as capping agents. The WDL-PLGA-NPs were spherical shaped with a crystallinity of 53.1 nm in average sizes and a surface charge of -33.0 mV predicted from TEM and zeta potential, resp. WDL-PLGA NPs exhibit significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. The half-inhibitory concentration (IC₅₀) of the formulated WDL-PLGA NPs was 23μg/mL but 57μg/mL in WDL in the breast cancer MDA-MB-231 cell line. The apoptotic effect, nuclear condensation, ROS generation, the loss of mitochondrial membrane potential (Δψm) of WDL-PLGA NPs were analyzed. Thus, WDL-PLGA NPs reduced the levels of Bcl-2 but increased the levels of Bax, which results in driving the cells to undergo apoptosis. Thus, the WDL-PLGA NPs were biocompatible with antibacterial and anticancer properties. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Screening of novel phytochemicals as secreted frizzled-related protein 4 inhibitors: an early stage biomarker of type 2 diabetes was written by Yasmin, Aysha;Bukhari, Shazia Anwer;Zahoor, Muhammad Kashif;Mustafa, Ghulam;Rasul, Azhar. And the article was included in Pakistan Journal of Pharmaceutical Sciences in 2020.Reference of 524-12-9 The following contents are mentioned in the article:

Diabetes is increasing at an alarming rate worldwide with high mortality and posing severe health and economic burden. Secreted frizzled related protein 4 (SFRP4) is released from adipose tissues to suppress insulin exocytosis from β-cells of pancreas and acts as a biomarker for early detection of T2D. In present study, the 3D structure of human SFRP4 was predicted using comparative modeling approach and evaluated through online bioinformatics tools. The best predicted model of SFRP4 was used as a receptor in mol. docking studies. Phytochems. from already reported antidiabetic plants were docked and screened using mol. operating environment (MOE) software to target SFRP4. The ligands were optimized and a database was constructed in MOE. Out of 850 compounds from 150 antidiabetic plants taken from PubChem database, singrin was found to be the most potent one with root mean square deviation (RMSD) value of 1.39, S-score of -10.06 and by interactions to five amino acids of SFRP4 active pocket. Furthermore, boeravinone E, boeravinone D, wedelolactone, squamosamide and taxifolin also interacted strongly to SFRP4 by exhibiting RMSD values of 1.00, 0.94, 1.89, 1.37, 1.28 and S-scores of -12.45, -11.26, -9.25, -7.26, -10.66, resp. These phytochems. are proposed to act as potential medicine for delaying the onset and treating T2D by specifically targeting SFRP4. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Reference of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Reference of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone enhances osteoblastogenesis through ERK- and JNK-mediated BMP2 expression and Smad/1/5/8 phosphorylation was written by Zhu, Di;Deng, Xue;Han, Xiao-Fei;Sun, Xiao-Xin;Pan, Tao-Wen;Zheng, Lu-Ping;Liu, Yan-Qiu. And the article was included in Molecules in 2018.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Our previous study showed that wedelolactone, a compound isolated from Ecliptae herba, has the potential to enhance osteoblastogenesis. However, the mol. mechanisms by which wedelolactone promoted osteoblastogenesis from bone marrow mesenchymal stem cells (BMSCs) remain largely unknown. In this study, treatment with wedelolactone (2 μg/mL) for 3, 6, and 9 days resulted in an increase in phosphorylation of extracellular signal-regulated kinases (ERKs), c-Jun N-terminal protein kinase (JNK), and p38. Phosphorylation of mitogen-activated protein kinases (MAPKs), ERK and JNK started to increase on day 3 of treatment, and p38 phosphorylation was increased by day 6 of treatment. Expression of bone morphogenetic protein (BMP2) mRNA and phosphorylation of Smad1/5/8 was enhanced after treatment of cells with wedelolactone for 6 and 9 days. The addition of the JNK inhibitor SP600125, ERK inhibitor PD98059, and p38 inhibitor SB203580 suppressed wedelolactone-induced alk.-phosphatase activity, bone mineralization, and osteoblastogenesis-related marker genes including Runx2, Bglap, and Sp7. Increased expression of BMP2 mRNA and Smad1/5/8 phosphorylation was blocked by SP600125 and PD98059, but not by SB203580. These results suggested that wedelolactone enhanced osteoblastogenesis through induction of JNK- and ERK-mediated BMP2 expression and Smad1/5/8 phosphorylation. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer was written by Tsai, Chin-Hsien;Tzeng, Sheue-Fen;Hsieh, Shih-Chuan;Yang, Yu-Chih;Hsiao, Yi-Wen;Tsai, Mong-Hsun;Hsiao, Pei-Wen. And the article was included in Scientific Reports in 2017.Recommanded Product: 524-12-9 The following contents are mentioned in the article:

Wedelia chinensis is rich in luteolin, apigenin, and wedelolactone that act synergistically to suppress androgen receptor activity in prostate cancer. Interestingly, our evaluation of a standardized Wedelia chinensis herbal extract (WCE) concluded its efficacy on hormone-refractory prostate cancer through systemic mechanisms. Oral administration of WCE significantly attenuated tumor growth and metastasis in orthotopic PC-3 and DU145 xenografts. Genome-wide transcriptome anal. of these tumors revealed that WCE suppressed the expression of IKKa/6fb phosphorylation and downstream cytokines/chemokines, e.g., IL6, CXCL1, and CXCL8. Through restraining the cytokines expression, WCE reduced tumor-elicited infiltration of MDSCs, TAMs and endothelial cells into the tumors, therefore inhibiting angiogenesis, tumor growth, and metastasis. In MDSCs, WCE also reduced STAT3 activation, downregulated S100A8 expression and prevented their expansion. Use of WCE in combination with docetaxel significantly suppressed docetaxel-induced NFkB activation, boosted the therapeutic effect and reduced the systemic toxicity caused by docetaxel monotherapy. These data suggest that a standardized preparation of Wedelia chinensis extract improved prostate cancer therapy through immunomodulation and has potential application as an adjuvant agent for castration-resistant prostate cancer. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Recommanded Product: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

PTP1B inhibitory and anti-inflammatory properties of constituents from Eclipta prostrata was written by Le, Duc Dat;Nguyen, Duc Hung;Ma, Eun Sook;Lee, Jeong Hyung;Min, Byung Sun;Choi, Jae Sue;Woo, Mi Hee. And the article was included in Biological & Pharmaceutical Bulletin in 2021.Related Products of 524-12-9 The following contents are mentioned in the article:

The white-flowered leaves of Eclipta prostrata L. together with leaves of Scoparia dulcis and Cynodon dactylon are mixedly boiled in water and given to diabetic patients resulting in the significant improvement in the management of diabetes. However, the active constituents from this plant for antidiabetic and anti-obesity properties are remaining unclear. Thus, this study was to discover anti-diabetes and anti-obesity activities through protein tyrosine phosphatases (PTP)1B inhibitory effects. We found that the fatty acids (23, 24) showed potent PTP1B inhibition with IC₅₀ values of 2.14 and 3.21 μM, resp. Triterpenoid-glycosides (12-15) also exhibited strong to moderate PTP1B inhibitory effects, with IC₅₀ values ranging from 10.88 to 53.35 μM. Addnl., active compounds were investigated for their PTP1B inhibitory mechanism and docking anal. On the other hand, the anti-inflammatory activity from our study revealed that compounds (1-4, 7, 8, 10) displayed the significant inhibition nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Especially, compound 9 showed the potent inhibitory effects in LPS-induced NO production on RAW264.7 cell. Therefore, further Western blot anal. was performed to identify the inhibitory expression including heme oxygenase-1 (HO-1) and inhibitor of kappa B (IκB) phosphorylation. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Development and validation of an ultra-performance liquid chromatography method for the determination of wedelolactone in rat plasma and its application in a pharmacokinetic study was written by Chen, Qing;Wu, Xiaoxue;Gao, Xuemin;Song, Hua;Zhu, Xuan. And the article was included in Molecules in 2019.Related Products of 524-12-9 The following contents are mentioned in the article:

Wedelolactone is a coumarin ether with significant hepatoprotective effects. However, there are few pharmacokinetic studies of wedelolactone, which will affect the studies of its efficacy and potential toxicity. In this study, a selective ultra-performance liquid chromatog. (UPLC) method was developed to confirm the pharmacokinetic parameters of wedelolactone in rat plasma. The chromatog. separation was carried out on a Kromasil C18 UPLC column (250 × 4.6 mm; 5.0 mum) by gradient mobile phase of methanol-water containing 0.5% acetic acid (volume/volume). Perfect linearity was obtained and the samples were stable under different conditions. The intra-day and inter-day precisions (relative standard deviation, %) were within 3.81% and accuracies (relative error, %) ranged from -4.01% to 7.12%. The extraction recoveries in rat plasma ranged from 95.98% to 108.93%. This rapid method was successfully applied in the pharmacokinetic study of wedelolactone in rat plasma. Following the oral administration of 5.00 mg/kg wedelolactone, the wedelolactone was rapidly absorbed. Pharmacokinetic parameters were used to quant. describe the dynamic changes of wedelolactone in vivo, providing a theor. basis for pharmacol. research on drugs and preclin. medication. The study of wedelolactone can provide a theor. basis and quick anal. for the study of other traditional Chinese medicine. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Caspase-1 Specific Light-Up Probe with Aggregation-Induced Emission Characteristics for Inhibitor Screening of Coumarin-Originated Natural Products was written by Lin, Hao;Yang, Haitao;Huang, Shuai;Wang, Fujia;Wang, Dong-Mei;Liu, Bin;Tang, Yi-Da;Zhang, Chong-Jing. And the article was included in ACS Applied Materials & Interfaces in 2018.Formula: C16H10O7 The following contents are mentioned in the article:

Caspase-1 is a key player in pyroptosis and inflammation. Caspase-1 inhibition is found to be beneficial to various diseases. Coumarin-originated natural products have an anti-inflammation function, but their direct inhibition effect to caspase-1 remains unexplored. To evaluate their interactions, the widely used com. coumarin-based probe (Ac-YVAD-AMC) is not suitable, as the background signal from coumarin-originated natural products could interfere with the screening results. Therefore, fluorescent probes using a large Stokes shift could help solve this problem. In this work, we chose the fluorophore of tetraphenylethylene-thiophene (TPETH) with aggregation-induced emission characteristics and a large Stokes shift of about 200 nm to develop a mol. probe. Bioconjugation between TPETH and hydrophilic peptides (DDYVADC) through a thiol-ene reaction generated a light-up probe, C1-P3. The probe has little background signal in aqueous media and exerts a fluorescent turn-on effect in the presence of caspase-1. Moreover, when evaluating the inhibition potency of coumarin-originated natural products, the new probe could generate a true and objective result but not for the com. probe (Ac-YVAD-AMC), which is evidenced by HPLC anal. The quick light-up response and accurate screening results make C1-P3 very useful in fundamental study and inhibitor screening toward caspase-1. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Formula: C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Formula: C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Phytochemical and antioxidant assay of Eclipta alba (L.) leaf extract was written by Tripathi, K. Sharad;Jha, Saket;Dikshit, Anupam;Kumar, Rajesh. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2021.Category: benzofurans The following contents are mentioned in the article:

Currently, pharmacol. activities of Eclipta alba (L.) plant extracts and individual phytoconstituents have revealed anticancer, hepatoprotective, snake venom neutralizing, anti-inflammatory and antimicrobial properties. The role of antioxidants is increasing day by day due to their multiple roles to reduce the harmful effects of oxidative stress. Phytoconstituents like wedelolactone and ursolic and oleanolic acids as well as luteolin and apigenin can form the basis of new drugs against cancer, arthritis, gastrointestinal disorders, skin diseases, and liver disorders. Plants have all these activities due to biol. active compounds, and for this, we have analyzed phytochem. screenings and antioxidant activity through the DPPH, ABTS·+, and reducing power assay and we got maximally phenols then flavonoids and flavonols and a good natural antioxidant agent. The best-known compound in E. alba i.e., Wedelolactone. It was analyzed by TLC, and it was present as 0.52 Rf value and present in pet ether extract and acetone extract and min. in ethanol extract The antioxidant activity was assessed through DPPH, ABTS·+ free radical scavenging activity and reducing power assay, this was explained in terms of effective concentration EC50 / IC₅₀ and Anti-oxidant Radical Power (ARP) values. The maximum free radical scavenging activity was showed in pet ether compared to other extracts This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Category: benzofurans).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Wedelolactone improves the renal injury induced by lipopolysaccharide in HK-2 cells by upregulation of protein tyrosine phosphatase non-receptor type 2 was written by Zhi, Deyuan;Zhang, Meng;Lin, Jin;Liu, Pei;Wang, Yajun;Duan, Meili. And the article was included in Journal of International Medical Research in 2021.Synthetic Route of C16H10O7 The following contents are mentioned in the article:

To explore the effects of wedelolactone (WEL) on sepsis-induced renal injury in the human renal proximal tubular epithelial cell line HK-2. HK-2 cells were stimulated by 1μg/mL lipopolysaccharide (LPS) to trigger renal injury in vitro. HK-2 cells were pretreated with or without WEL (0.1, 1 and 10μM) before LPS stimulation. Protein and mRNA analyses were performed using enzyme-linked immunosorbent assays, Western blot anal. and quant. reverse transcription-polymerase chain reaction. The MTT assay and flow cytometry were used to measure cell viability and the rate of cell apoptosis. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) knockdown was induced by the transection of HK-2 cells with short hairpin RNA. Cell viability was significantly increased in a dose-dependent manner by WEL in LPS-induced HK-2 cells. WEL also decreased the levels of four inflammatory cytokines and cell apoptosis in LPS-induced HK-2 cells. The level of PTPN2 was increased after WEL treatment. PTPN2 knockdown partly abolished the inhibitory effects of WEL on cell apoptosis, the levels of inflammatory cytokines and on p38 mitogen-activated protein kinase/nuclear factor-kappaB signalling in LPS-induced HK-2 cells. WEL improved renal injury by suppressing inflammation and cell apoptosis through upregulating PTPN2 in HK-2 cells. PTPN2 might be used as a potential therapeutic target for LPS-induced sepsis. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Synthetic Route of C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Synthetic Route of C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem