Heterocyclic Building Block-benzofuran

Wedelolactone mitigates UVB induced oxidative stress, inflammation and early tumor promotion events in murine skin: plausible role of NFkB pathway was written by Ali, Farrah;Khan, Bilal Azhar;Sultana, Sarwat. And the article was included in European Journal of Pharmacology in 2016.Category: benzofurans The following contents are mentioned in the article:

UVB (Ultra-violet B) radiation is one of the major etiol. factors in various dermal pathol. viz. dermatitis, actinic folliculitis, solar urticaria, psoriasis and cancer among many others. UVB causes toxic manifestation in tissues by inciting inflammatory and tumor promoting events. We have designed this study to assess the anti-inflammatory and anti-tumor promotion effect of Wedelolactone (WDL) a specific IKK inhibitor. Results indicate significant restoration of anti-oxidative enzymes due to WDL treatments. We also found that WDL was effective in mitigating inflammatory markers consisting of MPO (myeloperoxidase), Mast cells trafficking, Langerhans cells suppression and COX 2 expression up regulation due to UVB exposure. We also deduce that WDL presented a promising intervention in attenuating early tumor promotion events caused by UVB exposure as indicated by the results of ODC (Ornithine Decarboxylase), Thymidine assay, Vimentin and VEGF (Vascular-endothelial growth factor) expression. This study was able to provide substantial cues for the therapeutic ability of Wedelolactone against inflammatory and tumor promoting events in murine skin depicting plausible role of NFkB pathway. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Category: benzofurans).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Formulation of wedelolactone enriched extract with enhanced potential to inhibit cytokines in experimental arthritis was written by Atre, B. N.;Arulmozhi, S.;Sathiyanarayanan, L.;Dhapte-Pawar, V. V.;Mahadik, K. R.. And the article was included in International Journal of Research in Pharmaceutical Sciences in 2021.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Eclipta alba Linn. (Asteraceae) is traditionally claimed and reported to possess antarthritic and anti-inflammatory activity. Wedelolactone, an active constituent of Eclipta alba Linn responsible for its therapeutic effectiveness, is poorly water soluble and less bioavailable. Hence in the present study, we proposed a SNEDDS formulation of wedelolactone rich extracts of Eclipta alba Linn. (EAF) and evaluated its effect in Freund’s complete adjuvant (FCA) induced arthritis in rats. EAF reduced increase in paw volume and hyperalgesia in 50, 100 and 200 mg/kg doses significantly. It restored all cytokines (Tumor Necrosis Factor- α , Interleukin-1β and Interleukin-6); hematol. and biochem. parameters altered due to FCA induction. The histopathol. further supported the potential of EAF in arresting the progress of the disease. It protected cartilage destruction and exudation of inflammatory cells dose dependently. In conclusion, the EAF exhibited potent antarthritic potential due to the increased bioavailability of wedelolactone and other constituents. The mechanism of action is mainly mediated through inhibition of cytokines, anti-inflammatory and antioxidant potential of wedelolactone. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ailanthus altissima-derived ailanthone enhances gastric cancer cell apoptosis by inducing the repression of base excision repair by downregulating p23 expression was written by Wang, Chun-ming;Li, Hua-fu;Wang, Xiao-kun;Li, Wu-guo;Su, Qiao;Xiao, Xing;Hao, Teng-fei;Chen, Wei;Zhang, Ya-wei;Zhang, Hai-yong;Wu, Wang;Hu, Zhen-ran;Zhao, Guang-yin;Huo, Ming-yu;He, Yu-long;Zhang, Chang-hua. And the article was included in International Journal of Biological Sciences in 2021.SDS of cas: 524-12-9 The following contents are mentioned in the article:

Chemotherapy plays an irreplaceable role in the treatment of GC, but currently available chemotherapeutic drugs are not ideal. The application of medicinal plants is an important direction for new drug discovery. Through drug screening of GC organoids, we determined that ailanthone has an anticancer effect on GC cells in vitro and in vivo. We also found that AIL can induce DNA damage and apoptosis in GC cells. Further transcriptome sequencing of PDX tissue indicated that AIL inhibited the expression of XRCC1, which plays an important role in DNA damage repair, and the results were also confirmed by western blotting. In addition, we found that AIL inhibited the expression of P23 and that inhibition of P23 decreased the expression of XRCC1, indicating that AIL can regulate XRCC1 via P23. The results of coimmunoprecipitation showed that AIL can inhibit the binding of P23 and XRCC1 to HSP90. These findings indicate that AIL can induce DNA damage and apoptosis in GC cells. Meanwhile, AIL can decrease XRCC1 activity by downregulating P23 expression to inhibit DNA damage repair. The present study sheds light on the potential application of new drugs isolated from natural medicinal plants for GC therapy. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9SDS of cas: 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.SDS of cas: 524-12-9

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Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Jasmonates promote enhanced production of bioactive caffeoylquinic acid derivative in Eclipta prostrata (L.) L. hairy roots was written by Maciel, Geveraldo;Lopes, Adriana Aparecida;Cantrell, Charles L.;de Castro Franca, Suzelei;Bertoni, Bianca Waleria;Lourenco, Miriam Verginia. And the article was included in Plant Cell, Tissue and Organ Culture in 2022.Name: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Eclipta prostrata (L.) L. is widely used in traditional medicine for treatment of hepatitis, poisoning from snake bites and viral infections. Pharmacol. studies confirmed its antioxidant, anti-inflammatory and anticancer activities. The efficacy of E. prostrata (L.) L. extracts has been correlated to phenylpropanoids such as flavonoids, coumestans and caffeoylquinic acid derivatives In this work, the production of wedelolactone, demethylwedelolactone and 3,5-di–caffeoylquinic acid (3,5-diCQA) in hairy root cultures of E. prostrata (L.) L. C19 clone was increased after addition of eliciting agents jasmonic acid (JA) or Me jasmonate (MeJA) at multiple concentrations Cultures elicited with 100μM of JA saw a 5.2 fold increase in wedelolactone (from 0.72 to 3.72 mg/g d.w.), a 1.6 fold increase in demethylwedelolactone (from 5.54 to 9.04 mg/g d.w.) and a 2.47 fold increase in 3,5-diCQA (from 18.08 to 44.71 mg/g d.w.). Obtained data validate the potential of E. prostrata (L.) L. hairy root cultures as a production system of wedelolactone, demethylwedelolactone and especially 3,5-diCQA, which has recently been reported to possess activity against coronavirus disease (Covid-19) by in silico computational studies. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Name: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antioxidant, antitubercular, antiplasmodial, insecticidal.Name: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Unraveling mechanisms of pentraxin 3 secretion in adipocytes during inflammation was written by Lin, Te-Yueh;Guo, Hong;Chen, Xiaoli. And the article was included in Journal of Molecular Endocrinology in 2021.Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor playing an important role in immune response and inflammation. Lipopolysaccharide (LPS) stimulation can significantly induce PTX3 expression and secretion in adipocytes. Appropriate regulation of PTX3 secretion is critical for inflammatory homeostasis. Using chem. inhibitors of conventional and unconventional protein secretion, we explored the mechanisms that control LPS-stimulated PTX3 secretion in 3T3-L1 adipocytes. Inhibiting the conventional protein secretion blocked LPS-stimulated PTX3 secretion, resulting in cellular PTX3 accumulation in adipocytes. We also detected PTX3 in exosomes from LPS-treated adipocytes; inhibiting exosome trafficking attenuated PTX3 secretion. However, only 4.3% of secreted PTX3 was detected in exosomes compared to 95.7% in the non-exosomal fractions. The fractionation of isolated exosomes by the iodixanol d. gradient centrifugation confirmed that a small portion of secreted PTX3 overlapped with exosomal markers in small extracellular-vesicle fractions. We conclude that PTX3 is secreted mainly through conventional protein secretion, and a small percentage of PTX3 is released in exosomes from LPS-stimulated adipocytes. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Recommanded Product: 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Ultra-high-pressure-assisted extraction of wedelolactone and isodemethylwedelolactone from Ecliptae Herba and purification by high-speed counter-current chromatography was written by Zhao, Hongwei;Cheng, Supan;Zhang, Longfei;Dong, Hongjing;Zhang, Yongqing;Wang, Xiao. And the article was included in Biomedical Chromatography in 2019.Quality Control of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:

Ultra-high-pressure extraction combined with high-speed counter-current chromatog. was employed to extract and purify wedelolactone and isodemethylwedelolactone from Ecliptae Herba. The operating conditions of ultra-high-pressure extraction were optimized using an orthogonal exptl. design. The optimal conditions were 80% aqueous methanol solvent, 200 MPa pressure, 3 min extraction time and 1:20 (g/mL) solid-liquid ratio for extraction of wedelolactone and isodemethylwedelolactone. After extraction by ultra-high pressure, the extraction solution was concentrated and subsequently extracted with Et acetate; a total of 2.1 g of crude sample was obtained from 100 g of Ecliptae Herba. A two-phase solvent system composed of petroleum ether-Et acetate-methanol-water (3:7:5:5, volume/volume) was used for high-speed counter-current chromatog. separation, by which 23.5 mg wedelolactone, 6.8 mg isodemethylwedelolactone and 5.5 mg luteolin with purities >95% were purified from 300 mg crude sample in a one-step separation This research demonstrated that ultra-high-pressure extraction combined with high-speed counter-current chromatog. was an efficient technique for the extraction and purification of coumestans from plant material. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Quality Control of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Quality Control of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid characterization of chemical constituents and metabolites of Qi-Jing-Sheng-Bai granule by using UHPLC-Q-TOF-MS was written by Wu, Ran;Lin, Shan;Wang, Jinxin;Tian, Saisai;Ke, Xisong;Qu, Yi;Tian, Xinhui;Qi, Xiaopo;Ye, Ji;Zhang, Weidong. And the article was included in Journal of Separation Science in 2018.Category: benzofurans The following contents are mentioned in the article:

Qi-Jing-Sheng-Bai granule is an effective traditional Chinese medicine formula that has been widely used for the treatment of leukopenia post radiotherapy or chemotherapy. However, its chem. constituents were still unclear, which hindered interpreting bioactive constituents and studying integrative mechanisms. In this study, we developed a three-step strategy to characterize the chem. constituents and metabolites of Qi-Jing-Sheng-Bai by using ultra-high performance liquid chromatog. coupled with quadrupole time-of-flight mass spectrometry. As a result, a total of 143 compounds, including 56 flavonoids, 51 saponins, and 36 other compounds, of which contained six pairs of isomers, were tentatively identified and characterized via reference standards and by comparing mass spectrometry data with literature. After oral administration of 15 g/kg Qi-Jing-Sheng-Bai, a number of 42 compounds including 24 prototype compounds and 18 metabolites have been detected in the serum of rats. This work serves as the first reference for Qi-Jing-Sheng-Bai chem. components and metabolites. Moreover, it provided a rapid and valid anal. strategy for characterization of the chem. compounds and metabolites of traditional Chinese medicine formula. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Category: benzofurans).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Disease modifying potential of wedelolactone rich fraction of Eclipta alba in adjuvant induced arthritis in rats by inhibition of pro-inflammatory cytokines was written by Atre, B. N.;Arulmozhi, S.;Sathiyanarayanan, L.;Dhapte, V. V.;Mahadik, K. R.. And the article was included in International Journal of Pharmaceutical Sciences and Research in 2020.Application of 524-12-9 The following contents are mentioned in the article:

Eclipta alba (Family-Asteraceae) is a herb commonly used in traditional Ayurvedic medicine for the treatment of inflammation, pain, and wounds. The present study is aimed to validate the ethnobotanical use of Eclipta alba in an animal model. The animals were induced with arthritis by injection of FCA on day 0 and treated with wedelolactone rich fractions of Eclipta alba (100, 200 and 400 mg/kg) from day 12 to day 28. WEA caused a significant effect in arthritis by inhibiting the joint inflammation and decreasing hyperalgesia and allodynia. WEA significantly decreased the biochem. markers and serum Tumor Necrosis factor-alpha, Interleukin 1beta and Interleukin-6 levels and significantly increased the antioxidant profile. WEA (400 mg/kg) exhibited anti-rheumatic activity as evidenced by altered hematol. milieu (ESR, CRP, WBC, RBC and Hb), histopathol. of ankle joints, reduced cytokine levels, paw volume and related parameters associated with arthritis. Taken together, these results demonstrated the antiarthritic activity of WEA against exptl. arthritis, and the underlying mechanism behind this efficacy might be mediated by inhibition of proinflammatory cytokines by wedelolactone in combination with other phytoconstituents. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. In nature, benzofurans have occupied an important role among the plant phenols & several pharmacologically active compounds.Application of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Protective effects of wedelolactone on dextran sodium sulfate induced murine colitis partly through inhibiting the NLRP3 inflammasome activation via AMPK signaling was written by Wei, Wencheng;Ding, Meiling;Zhou, Kai;Xie, Haifeng;Zhang, Mian;Zhang, Chaofeng. And the article was included in Biomedicine & Pharmacotherapy in 2017.COA of Formula: C16H10O7 The following contents are mentioned in the article:

It has been reported that the ethanol extract of Wedelia chinensis attenuates murine colitis. Wedelolactone (WEL), a coumestane-type compound with many pharmacol. activities, was isolated from W. chinensis. The present study aims to investigate the beneficial effects and underlying mechanisms of WEL on ulcerative colitis. In a dextran sodium sulfate (DSS)-induced mouse model, oral administration of WEL (50 mg/kg) significantly attenuated pathol. colonic damage and inhibited inflammatory infiltration, myeloperoxidase and alk. phosphatase activities through MAPKs and NF-κB signaling pathways, while activating AMPK in colons treated with DSS. Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1β release in colons treated with DSS. In addition, WEL effectively regulates the disorder of skeleton proteins in colonic epithelial cells NCM460 exposed to TNF-α and protects the intestinal barrier function by activating AMPK in vivo. In summary, the AMPK-NLRP3-IL-1β signaling axis plays an important role in colitis following WEL treatments. These findings provide new insights into the pharmacol. actions of WEL as a potential therapeutic agent for colitis. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9COA of Formula: C16H10O7).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is a core structural unit found in many naturally occurring compounds with multidirectional biological activities. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.COA of Formula: C16H10O7

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Cytotoxicity of Geotrigona, melipona and Scaptotrigona ecuadorian pot-honeys in human ovarian cancer cell model was written by Huq, Fazlul;Yu, Jun Qing;Pedro, Silvia RM;Perez-Perez, Elizabeth;Maza, Favian;Vit, Patricia. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2021.Related Products of 524-12-9 The following contents are mentioned in the article:

Honey is a traditional natural medicine constantly revisited as an anticancer agent administered alone and in combination. Chemotherapy with cytotoxic agents decrease the quality of life of patients. Hence, the need of studies on complementary and alternative medicine to improve therapeutic outcomes, as investigated here for honey. The human ovarian cancer model based on MTT tetrazolium salt colorimetric assay was used to determine cytotoxicity of three types of pot-honey produced by Ecuadorian stingless bees known with ethnic names “abeja de tierra”, “catiana” and “bunga negra” corresponding to Geotrigona leucogastra, Scaptotrigona sp and Melipona grandis. The honeys were characterized for their antioxidant activity measured with three methods, flavonoid, polyphenols and protein contents. The Melipona grandis pot-honey was the most active with IC₅₀ value of 0.15 mg mL^-1 for the A2780, and also in overcoming cisplatin resistance with a remarkably low IC₅₀ 0.05 mg mL^-1 for the A2780^cisR, and a resistance factor of 0.32. This pot-honey demonstrated a distinctive characteristic illustrated by a wide reduction of the IC₅₀ value in the cisplatin resistant A2780^cisR cell line. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Related Products of 524-12-9).

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Many natural or synthetic compounds containing benzofuran skeletons have been found to possess remarkable activity as agrochemicals and pharmaceuticals. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 524-12-9

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem