Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51 was written by Zhao, Shizhen;Wei, Peng;Wu, Mengya;Zhang, Xiangqian;Zhao, Liyu;Jiang, Xiaolin;Hao, Chenzhou;Su, Xin;Zhao, Dongmei;Cheng, Maosheng. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Recommanded Product: 1646-27-1 This article mentions the following:
To further enhance the anti-Aspergillus efficacy of the previously discovered antifungal lead compound, a series of benzoheterocycle analogs were designed, synthesized and evaluated for their in vitro antifungal activity. The most promising compounds I and II exhibited excellent antifungal activity against C. albicans, C. neoformans, A. fumigatus and fluconazole-resistant C. albicans strains, that was superior or comparable to those of the reference drugs fluconazole and voriconazole. GC-MS analyses suggested that the novel compound I might have a similar mechanism to fluconazole by inhibiting fungal lanosterol 14α-demethylase (CYP51). Furthermore, compounds I and II exhibited low inhibition profiles for various human cytochrome P 450 isoforms as well as excellent blood plasma stability. In the experiment, the researchers used many compounds, for example, Methyl benzofuran-2-carboxylate (cas: 1646-27-1Recommanded Product: 1646-27-1).
Methyl benzofuran-2-carboxylate (cas: 1646-27-1) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Introduction of benzofurans in organic synthesis, particularly drug synthesis, involves generally the use of their metalated species as nucleophiles in addition reactions or in metal-catalysed cross-coupling reactions.Recommanded Product: 1646-27-1
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem