Protective effect of wedelolactone on acute D-galactosamine-induced acute liver injury in mice was written by Wang, Wenjie;Tian, Chunfang;Lv, Yongshun;Wang, Guojie. And the article was included in Latin American Journal of Pharmacy in 2020.SDS of cas: 524-12-9 The following contents are mentioned in the article:
This study aimed to investigate the protective effect of wedelolactone on D-galactosamine-induced acute liver injury (ALI) in mice. Fifty mice were divided into normal, model and 5, 10, and 20 mg/kg wedelolactone groups, 10 mice for each group. The latter three groups were treated with 5, 10, and 20 mg/kg by intragastric administration, resp., for consecutive days. Then, the D-galactosamine-induced ALI model was prepared in the latter four groups. Results showed that the wedelolactone pre-treatment could decrease the liver index, serum ALT, and AST levels, and liver tissue xanthine oxidase, malondialdehyde, nitric oxide, inducible nitric oxide synthetase (iNOS), interferon-γ and tumor necrosis factor α levels, and increase the liver tissue superoxide dismutase, glutathione peroxidase, interleukin 4 and interleukin 10 levels in ALI mice. In conclusion, wedelolactone has protective effect on acute D-galactosamine ALI in mice. The mechanism might be related to its resisting free radical damage and lipid peroxidation, inhibiting iNOS over-expression and regulating Th1/Th2 balance. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9SDS of cas: 524-12-9).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran derivatives have shown many biological activities, including antifungal and antimicrobial properties, and acting as antagonists of H3 receptors and angiotensin II. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.SDS of cas: 524-12-9
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem