Facile green preparation of PLGA nanoparticles using wedelolactone: Its cytotoxicity and antimicrobial activities was written by Vinayagam, Ramachandran;Eun Lee, Kyung;David, Ernest;Nurul Matin, Muhammad;Gu Kang, Sang. And the article was included in Inorganic Chemistry Communications in 2021.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one The following contents are mentioned in the article:
We synthesized a novel wedelolactone (I)-loaded poly-lactic-co-glycolic acid nanoparticle (WDL-PLGA NPs) and evaluated its antibacterial and induced cytotoxicity against breast cancer MDA-MB-231 cell line growth. The physicochem. properties of the WDL-PLGA NPs were defined by Fourier transform IR spectroscopy (FTIR), and dynamic scattering scanning (DLS) analyzer, and transmission microscopy (TEM) were anal. FTIR results showed that functional groups of WDL were involved in stabilizing as capping agents. The WDL-PLGA-NPs were spherical shaped with a crystallinity of 53.1 nm in average sizes and a surface charge of -33.0 mV predicted from TEM and zeta potential, resp. WDL-PLGA NPs exhibit significant antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa. The half-inhibitory concentration (IC50) of the formulated WDL-PLGA NPs was 23μg/mL but 57μg/mL in WDL in the breast cancer MDA-MB-231 cell line. The apoptotic effect, nuclear condensation, ROS generation, the loss of mitochondrial membrane potential (Δψm) of WDL-PLGA NPs were analyzed. Thus, WDL-PLGA NPs reduced the levels of Bcl-2 but increased the levels of Bax, which results in driving the cells to undergo apoptosis. Thus, the WDL-PLGA NPs were biocompatible with antibacterial and anticancer properties. This study involved multiple reactions and reactants, such as 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one).
1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one (cas: 524-12-9) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Application In Synthesis of 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c]chromen-6-one
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem