Borrowing Carbonate-Enabled Allylic Amination Reactions under Additive- and Reductant-Free Nickel Catalysis Employing Allylic Alcohols was written by Vaidya, Gargi Nikhil;Nagpure, Mithilesh;Kumar, Dinesh. And the article was included in ACS Sustainable Chemistry & Engineering in 2021.Product Details of 54802-10-7 This article mentions the following:
“Borrowing carbonate”-enabled allylic cross-amination reactions employing allylic alcs., e.g., cinnamyl alc., (E)-3-(4-methoxyphenyl)prop-1-en-1-ol, and (E)-3-(furan-2-yl)prop-1-en-1-ol, were discovered via merging acyl/allyl C-O bonds activation under nickel catalysis. The key component of this protocol is the ability of nickel [Ni(II)-Ni(0)] to execute a relay process via the nucleophilic trapping of the generated acyl Ni complex, resulting from the acyl C-O bond cleavage of dialkyl carbonates, followed by selective allylic C-O bond activations (allylic C-O vs alkyl C-O vs acyl C-O) to yield π-allyl-Ni-complexes. The finding truly represents Ni-catalyzed green allylic amination reactions under additive(s)-free conditions with excellent chemo- (N vs O), regio- (linear vs branched), and stereoselectivity (E vs Z) with a wide range of fundamentally challenging N-heterocycles, e.g., 2(1H)-pyridone, isoquinolin-1(2H)-one, and benzo[d]thiazol-2(3H)-one, and allylic alcs. The reaction is scalable, does not require harmful reaction media and a globe box, and is successfully applied to the scale-up synthesis of pharmaceuticals (cinnarizine, flunarizine, and naftifine) with promising yields. In the experiment, the researchers used many compounds, for example, 3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7Product Details of 54802-10-7).
3-Aminobenzofuran-2-carboxamide (cas: 54802-10-7) belongs to benzofurans derivatives. Benzofuran derivatives are one of the most important oxygen-containing heterocycles. Benzofurans have also made significant and distinctive contributions to biology. They exhibit several biological activities that range from antiviral, antimicrobial, antitumor, anti-inflammatory.Product Details of 54802-10-7
Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem