Tag: M.W=300-400

In an article, author is Pouramiri, Behjat, once mentioned the application of 66357-35-5, COA of Formula: C13H22N4O3S, Name is Ranitidine, molecular formula is C13H22N4O3S, molecular weight is 314.4038, MDL number is MFCD00081180, category is benzofurans. Now introduce a scientific discovery about this category.

Design, synthesis and biological evaluation of new substituted benzofuran-based derivatives via C-H bond activation

A series of biologically active disubstituted benzofuran derivatives (3a-d) have been designed and synthesized via C-H bond activation reaction. The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro anti acetylcholinesterase (AChE) activities of these novel compounds were evaluated and showed low to moderate results. Among them, compound 3d moderately inhibited AChE activities with 68.12 % value.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S. In an article, author is Vargas, David A.,once mentioned of 66357-35-5, COA of Formula: C13H22N4O3S.

Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

2,3-Dihydrobenzofurans are key pharmacophores in many natural and synthetic bioactive molecules. A biocatalytic strategy is reported here for the highly diastereo- and enantioselective construction of stereochemically rich 2,3-dihydrobenzofurans in high enantiopurity (>99.9% de and ee), high yields, and on a preparative scale via benzofuran cyclopropanation with engineered myoglobins. Computational and structure-reactivity studies provide insights into the mechanism of this reaction, enabling the elaboration of a stereochemical model that can rationalize the high stereoselectivity of the biocatalyst. This information was leveraged to implement a highly stereoselective route to a drug molecule and a tricyclic scaffold featuring five stereogenic centers via a single-enzyme transformation. This work expands the biocatalytic toolbox for asymmetric C-C bond transformations and should prove useful for further development of metalloprotein catalysts for abiotic carbene transfer reactions.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: Ranitidine, 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a document, author is Chan, Eric Wei Chiang, introduce the new discover.

Phenolic constituents and anticancer properties of Morus alba (white mulberry) leaves

Flavonoids are by far the most dominant class of phenolic compounds isolated from Morus alba leaves (MAL). Other classes of compounds are benzofurans, phenolic acids, alkaloids, coumarins, chalcones and stilbenes. Major flavonoids are kuwanons, moracinflavans, moragrols and morkotins. Other major compounds include moracins (benzofurans), caffeoylquinic acids (phenolic acids) and morachalcones (chalcones). Research on the anticancer properties of MAL entailed in vitro and in vivo cytotoxicity of extracts or isolated compounds. Flavonoids, benzofurans, chalcones and alkaloids are classes of compounds from MAL that have been found to be cytotoxic towards human cancer cell lines. Further studies on the phytochemistry and anticancer of MAL are suggested. Sources of information were PubMed, PubMed Central, ScienceDirect, Google, Google Scholar, J-Stage, PubChem and China National Knowledge Infrastructure. (C) 2020 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 66357-35-5. Recommanded Product: Ranitidine.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry, like all the natural sciences, Recommanded Product: Ranitidine, begins with the direct observation of nature¡ª in this case, of matter.66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a document, author is Mujovic, Nebojsa, introduce the new discover.

The role of amiodarone in contemporary management of complex cardiac arrhythmias

Amiodarone is an iodinated benzofuran derivative, a highly lipophilic drug with unpredictable pharmacokinetics. Although originally classified as a class III agent due to its ability to prolong refractoriness in cardiac regions and prevent/terminate re-entry, amiodarone shows antiarrhythmic properties of all four antiarrhythmic drug classes. Amiodarone is a potent coronary and peripheral vasodilator and can be safely used in patients with left ventricular dysfunction after myocardial infarction or those with congestive heart failure or hypertrophic cardiomyopathy. Its use is regularly accompanied with QT and QTc-interval prolongation but rarely with ventricular proarrhythmia. It is the most powerful pharmacological agent for long-term sinus rhythm maintenance in patients with atrial fibrillation. Amiodarone, particularly if co-administered with beta-blockers, reduces the rate of arrhythmic death due to ventricular tachyarrhythmias in patients with heart failure, but its benefit on cardiovascular and overall survival in these patients is uncertain. In addition, amiodarone is an important adjuvant drug for the reduction of shocks in patients with an implantable cardioverter-defibrillator. Over the past 40 years, amiodarone became the most prescribed antiarrhythmic. Nevertheless, the slow onset of its antiarrhythmic action requires a loading dose while the high risk of non-cardiac toxicity and common drug-drug interactions limit its long-term use. Furthermore patients treated with amiodarone require a close supervision by the treating physician. Therefore amiodarone is generally considered a secondary therapeutic option. Long-term treatment with amiodarone should be based on the use of minimal doses for satisfactory arrhythmia outcome and serial screening for thyroid, liver and pulmonary toxicity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 66357-35-5. Recommanded Product: Ranitidine.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 66357-35-5, 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, in an article , author is Lichitsky, Boris V., once mentioned of 66357-35-5.

Synthesis of substituted benzofuran-3-ylacetic acids based on three-component condensation of polyalkoxyphenols, arylglyoxals and Meldrum’s acid

Substituted benzofuran-3-ylacetic acids were obtained by three-component condensation of polyalkoxyphenols, aryl-glyoxals and Meldrum’s acid.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S, Recommanded Product: 66357-35-5, belongs to benzofurans compound, is a common compound. In a patnet, author is Zhou, Ji, once mentioned the new application about 66357-35-5.

Chiral Bronsted Acid-Catalyzed Asymmetric 1,4-Addition of Benzofuran-Derived Azadienes with 3-Substituted indoles

A chiral phosphoric acid-catalyzed asymmetric 1,4-addition of benzofuran-derived azadienes with 3-substituted indoles has been established, which offered enantioenriched tri(hetero)arylmethane products in generally good yields (up to 98 %) and high enantioselectivities (up to 99 : 1 er). This reaction has not only realized the application of chiral phosphoric acid as a competent catalyst in the asymmetric transformations of benzofuran-derived azadienes, but also has accomplished the task of developing chiral Bronsted acid-catalyzed asymmetric 1,4-additions of benzofuran-derived azadienes, which will enrich the research contents of chiral phosphoric acid catalysis and the chemistry of benzofuran-derived azadienes.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 66357-35-5, Name is Ranitidine, formurla is C13H22N4O3S. In a document, author is An, Cui, introducing its new discovery. SDS of cas: 66357-35-5.

Selenium Radical Mediated Cascade Cyclization: Concise Synthesis of Selenated Benzofurans (Benzothiophenes)

Presented in this work is a novel methodology for the synthesis of selenated benzofurans (or benzothiophenes) via AgNO2-catalyzed radical cyclization of 2-alkynylanisoles (or 2-alkynylthioanisoles), Se powder, and arylboronic acids. This method enables the construction of a benzofuran (benzothiophene) ring, two C-Se bonds, and a C-O(S) bond as well as the cleavage of a C-O(S) bond in a single step. Preliminary mechanistic studies imply that the AgNO2-catalyzed cyclization proceeds via an aryl selenium radical intermediate.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Electric Literature of 66357-35-5, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 66357-35-5, Name is Ranitidine, SMILES is O=[N+]([O-])/C=C(NCCSCC1=CC=C(O1)CN(C)C)NC, belongs to benzofurans compound. In a article, author is Baydas, Yasemin, introduce new discover of the category.

Asymmetric reduction of aromatic heterocyclic ketones with bio-based catalyst Lactobacillus kefiri P2

Chiral heterocyclic secondary alcohols have received much attention due to their widespread use in pharmaceutical intermediates. In this study, Lactobacillus kefiri P2 biocatalysts isolated from traditional dairy products, were used to catalyze the asymmetric reduction of prochiral ketones to chiral secondary alcohols. Secondary chiral carbinols were obtained by asymmetric bioreduction of different prochiral substrates with results up to>99% enantiomeric excess (ee). (R)-1-(benzofuran-2-yl)ethanol 5a, which can be used in the synthesis of pharmaceuticals such as bufuralols potent nonselective beta-blockers antagonists, Amiodarone (cardiac anti-arrhythmic), and Benziodarone (coronary vasodilator), was produced in gram-scale, high yield and enantiomerically pure form using L. kefiri P2 biocatalysts. The gram-scale production was carried out, and 9.70 g of (R)-5a in enantiomerically pure form was obtained in 96% yield. Also, production of (R)-5a in terms of yield and gram scale through catalytic asymmetric reduction using the biocatalyst was the highest report so far. This is a cost-effective, clean and eco-friendly process for the preparation of chiral secondary alcohols compared to chemical processes. From an environmental and economic perspective, this biocatalytic method has great application potential, making it a green and sustainable way of synthesis.

Electric Literature of 66357-35-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 66357-35-5 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Guo, Sidan, once mentioned the application of 66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S, molecular weight is 314.4038, MDL number is MFCD00081180, category is benzofurans. Now introduce a scientific discovery about this category, HPLC of Formula: C13H22N4O3S.

Photochromism and Fluorescence Switch of Furan-Containing Tetraarylethene Luminogens with Aggregation-Induced Emission for Photocontrolled Interface-Involved Applications

It is extremely challenging to design photocontrolled molecular switches with absorption and fluorescence dual-mode outputs that are suited for a solid surface and interface. Herein, we report a group of furan-containing tetraarylethene derivatives with unique photophysical behavior of aggregation-induced emission (AIE) and distinct photochemical reaction-triggered photochromic behaviors by combining a photoactive furan or benzofuran group and an AIE-active triphenylethene molecule. The introduction of a furyl or benzofuryl group into the AIE luminogen endows the molecules with significant reversible photochromism and solid-state fluorescence. The coloration and decoloration of these molecules can be switched by respective irradiation of UV and visible light in a reversible way, and the photochromic changes are accompanied by a switch-on and switch-off of the solid-state fluorescence. It is revealed that the photocontrolled cyclization and cycloreversion reactions are responsible for the reversible photochromism and fluorescence switching based on experimental data and theoretical analysis. Both the position and conjugation of the introduced photoactive units have significant influence on the color and strength of the photochromism, and the simultaneous occurrence of photoinduced fluorescence change in the solid state is perfectly suited for surface-involved applications. The demonstrations of dual-mode signaling in photoswitchable patterning on a filter paper and anti-counterfeiting of an anti-falsification paper strongly highlight the unique advantage of these photochromic molecules with an aggregation-induced emission characteristic in various practical applications. This work proposes a general strategy to design photochromic molecules with AIE activity by introducing photoactive functionals into an AIEgen and demonstrates incomparable advantage in dual-mode signaling and multifunctional applications of these molecules.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is an experimental science, COA of Formula: C13H22N4O3S, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 66357-35-5, Name is Ranitidine, molecular formula is C13H22N4O3S, belongs to benzofurans compound. In a document, author is Suzuki, Shunsuke.

Formation of Polycyclic Aromatic Hydrocarbons (PAHs) and Oxygenated PAHs in the Oxidation of Ethylene Using a Flow Reactor

Interest in polycyclic aromatic hydrocarbons (PAHs) including a functional group in its chemical structure, particularly oxygenated PAHs (OPAHs), has been growing due to the toxicity and wide presence of the compound. Understanding the formation mechanism of OPAHs is very important for reducing their emission during combustion. However, studies on the quantitative evaluation of OPAHs have been very limited. In this study, the formation of OPAHs was quantitatively evaluated in addition to that of PAHs using a flow reactor system in which a mixture of ethylene, O-2, and N(2)reacted at atmospheric pressure. 5 types of OPAHs were targeted in this study: phenol, benzofuran, dibenzofuran, 9-fluorenone, and benzanthrone. 3 types of monocyclic aromatic hydrocarbons (MAHs) and 17 types of PAHs were also analyzed by gas chromatography mass spectrometry. Measurements were performed at different reaction gas temperatures (1050 to 1350 K), residence times (0.40 to 1.5 second), and equivalence ratios (3.0 to 12.0). Some measured data, mainly MAHs and PAHs, were compared with the concentrations predicted using existing kinetic models. Finally, we evaluated the reaction pathways that contributed to the formation of the OPAHs such as benzofuran, dibenzofuran, 9-fluorenone, and benzanthrone quantified in this study.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 66357-35-5, in my other articles. COA of Formula: C13H22N4O3S.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem