Tag: M.W=0-100

Related Products of 497-23-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Yu Shuyan, introduce new discover of the category.

Recent Progress in the Reactions of Aurone-Derived Azadienes

Owing to the important physiological and pharmacological activities of benzofuran compounds, the exploration for efficient synthesis methods is of great value and wide application. Aurone-derived azadienes have been identified to be effective reactants in the field of organic synthesis owing to the driving force of aromatization. A large number of reactions based on 1,4-conjugate addition and tandem cyclization have been reported, which exhibited great advantages in the construction of heterocycles with benzofuran skeletons. In this paper, the recent progress in the chemical transformations of aurone-derived azadienens is reviewed, with emphasis on the employed catalytic system and the plausible mechanism of some reactions.

Related Products of 497-23-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 497-23-4 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 591-11-7, Name is 5-Methylfuran-2(5H)-one, formurla is C5H6O2. In a document, author is Shrestha, Rajeev, introducing its new discovery. Formula: C5H6O2.

Base-Mediated Denitrogenative Sulfonylation/Benzannulation of Conjugated N-Sulfonylhydrazones with 3-Formylchromones for the Construction of Polyfunctionalized Biaryl Sulfones

Base-promoted benzannulation of conjugated N-sulfonylhydrazones and 3-formylchromones for the synthesis of diverse biaryl sulfones is described. The approach facilitates new C-C and C-S bond formation via the cascade diazo formation/Michael addition/ring opening/denitrogenative sulfonylation/intramolecular cycloaddition/dehydration and introduces diverse functional groups onto biaryl sulfones. The synthesized compounds are converted to aryl sulfones bearing bioactive benzisoxazole and benzofuran frameworks. Moreover, the synthesized biaryl sulfones possess potent turn-on fluorescence sensing and UV absorbance properties.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Quality Control of 5-Methylfuran-2(5H)-one, 591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a document, author is Yang, Jing, introduce the new discover.

Tuning the optoelectronic properties of vinylene linked perylenediimide dimer by ring annulation at the inside or outside bay positions for fullerene-free organic solar cells

Among various perylenediimide (PDI)-based small molecular non-fullerene acceptors (NFAs), PDI dimer can effectively avoid the excessive aggregation of single PDI and improve the photovoltaic performance. However, the twist of perylene core in PDI dimer will destroy the effective conjugation. Thus, ring annulation of PDI dimer is a feasible method to balance the film quality and electron transport, but the systematic study has attracted few attentions. Herein, we choose a simple vinylene linked PDI dimer, V-PDI2, and then conduct further studies on the structure-property-performance relationship of four kinds of derived fused-PDI dimers, namely V-TDI2, V-FDI2, V-PDIS2 and V-PDISe2 respectively. The former two are incorporated thianaphthene and benzofuran at the inside bay positions, and the latter two are fused thiophene and selenophene at the outside bay positions, respectively. Theoretical calculations reveal the inside- and outside-fused structures largely affect the skeleton configuration, the former two tend to be planar structure and the latter two maintain the distorted backbone. The photovoltaic characterizations show that the inside-fused PDI dimers offer high open circuit voltage (V-OC), while the outside-fused PDI dimers afford large short-circuit current density (J(SC)). This variation tendency results from the reasonably tunable energy levels, light absorption, molecular crystallinity and film morphology. As a result, PBDB-T:V-PDISe2 device exhibits the highest power conversion efficiency (PCE) of 6.51%, and PBDB-T:V-FDI2 device realizes the highest V-OC of 1.00 V. This contribution indicates that annulation of PDI dimers in outside or inside bay regions is a feasible method to modulate the properties of PDI-based non-fullerene acceptors. (C) 2019 Sience Press and Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. and Science Press. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 591-11-7 is helpful to your research. Quality Control of 5-Methylfuran-2(5H)-one.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 591-11-7, Name is 5-Methylfuran-2(5H)-one, SMILES is O=C1OC(C)C=C1, belongs to benzofurans compound. In a document, author is Mohamed, Shaaban K., introduce the new discover, Recommanded Product: 591-11-7.

Synthesis, Spectroscopic Investigation, Anti-Bacterial and Antioxidant Activites of Some New Azo-Benzoft, ran Derivatives

THIS Article deals with the stepwise synthesis and spectroscopic characterization of some 1 new azo benzofuran derivatives, started from the diazotization of substituted aniline coupled with 2-hydroxy benzaldehyde. On reacting of the azo of 2-hydroxy benzaldehyde with p-bromo phenacyl bromide, the benzofuran (3a-g) are obtained. The structure of the new benzofuran derivatives have been characterized by using FT-IR, 1H-NMR,13C-NMR and DEPT-135 NMR. The biological activity of some new synthesized compound was obtained by vitro anti oxidant and anti microbial activity with both Staphylococcus aureus and Escherichia coli .The results showed that the newbenzofurans have mild anti oxidant activity compared to the standard ascorbic acid.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 591-11-7 is helpful to your research. Recommanded Product: 591-11-7.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Dong, Mei-Yue,once mentioned of 497-23-4, COA of Formula: C4H4O2.

Benzofuran derivatives with nerve growth factor-potentiating activity fromPhellinus ribis

Three new benzofuran derivatives, namely ribisin E(1)ribisin F(2)along with ribisin G(3)were isolated from the MeOH extract of the fruiting bodies ofPhellinus ribis.Their structures were elucidated based on the NMR analysis. Furthermore, the absolute configuration of ribisin E(1)and ribisin G(3)were deduced by the CD calculations, and the absolute configuration of ribisin F(2)was determined by comparing its CD spectrum and specific rotation with the data of known analogues. All compounds(1-3)exhibited the activity of promoting neurite outgrowth in nerve growth factor (NGF)-ediated PC 12 cell at concentrations ranging from 1 to 30 mu M.

Interested yet? Keep reading other articles of 497-23-4, you can contact me at any time and look forward to more communication. COA of Formula: C4H4O2.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Electric Literature of 4412-91-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 4412-91-3, Name is 3-Furanmethanol, SMILES is OCC1=COC=C1, belongs to benzofurans compound. In a article, author is Jin, Li-Ping, introduce new discover of the category.

Design, synthesis, and biological activity of a novel series of benzofuran derivatives against oestrogen receptor-dependent breast cancer cell lines

A docking study of a novel series of benzofuran derivatives with ER alpha was conducted. In this study, we report the synthesis of a novel series of benzofuran derivatives and evaluation of their anticancer activity in vitro against MCF-7 human breast cancer cells, as well as their potential toxicity to ER-independent MDA-MB-231 breast cancer cells, human renal epithelial HEK-293 cells, and human immortal keratinocytes (HaCaT cells) by using the MTT colorimetric assay. The screening results indicated that the target compounds exhibited anti-breast cancer activity. The target compound 2-benzoyl-3-methyl-6-[2-(morpholin-4-yl)ethoxy]benzofuran hydrochloride (4e) exhibited excellent activity against anti-oestrogen receptor-dependent breast cancer cells and low toxicity. The preliminary structure-activity relationships of the target benzofuran derivatives have been summarised. In conclusion, the novel benzofuran scaffold may be a promising lead for the development of potential oestrogen receptor inhibitors.

Electric Literature of 4412-91-3, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 4412-91-3 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Related Products of 497-23-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 497-23-4, Name is Furan-2(5H)-one, SMILES is O=C1OCC=C1, belongs to benzofurans compound. In a article, author is Simon, Tamir, introduce new discover of the category.

The Role of Oxygen in the Electrochemical Reduction of Ethyl 2-(2-(Bromomethyl)phenoxy)acetate at Carbon Cathodes in Dimethylformamide

Cyclic voltammetry (CV) and controlled-potential electrolysis (CPE) were employed to examine the direct reduction of ethyl 2-(2-(bromomethyl)phenoxy)acetate at carbon cathodes in dimethylformamide (DMF) containing tetramethylammonium tetrafluoroborate (TMABF(4)) as the electrolyte. Cyclic voltammogram of the substrate exhibits a single irreversible cathodic wave with a peak potential of -1.75 V vs SCE, which is characteristic for the reduction of organic halides in aprotic solvents. Bulk electrolyses of ethyl 2-(2-(bromomethyl)phenoxy)acetate were carried out in the absence and presence of oxygen. The product distributions were obtained by gas chromatograph (GC) as well as gas chromatograph coupled to a mass spectrometer (GC-MS). Two bicyclic compounds, ethyl 2,3-dihydro-1-benzofuran-2-carboxylate and ethyl benzofuran-2-carboxylate, were found to be formed in a total yield of more than 40% in the presence of oxygen. The reaction mechanism, in which the oxygen plays a significant role, was proposed and discussed on the basis of this study. (c) 2020 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited.

Related Products of 497-23-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 497-23-4 is helpful to your research.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 591-11-7, Name is 5-Methylfuran-2(5H)-one, molecular formula is C5H6O2, belongs to benzofurans compound. In a document, author is Gao, Chengcheng, introduce the new discover, Recommanded Product: 591-11-7.

A Novel Benzofuran Derivative Moracin N Induces Autophagy and Apoptosis Through ROS Generation in Lung Cancer

Introduction The leaves of Morus alba L is a traditional Chinese medicine widely applied in lung diseases. Moracin N (MAN), a secondary metabolite extracted form the leaves of Morus alba L, is a potent anticancer agent. But its molecular mechanism remains unveiled. Objective In this study, we aimed to examine the effect of MAN on human lung cancer and reveal the underlying molecular mechanism. Methods MTT assay was conducted to measure cell viability. Annexin V-FITC/PI staining was used to detect cell apoptosis. Confocal microscope was performed to determine the formation of autophagosomes and autolysosomes. Flow cytometry was performed to quantify cell death. Western blotting was used to determine the related-signaling pathway. Results In the present study, we demonstrated for the first time that MAN inhibitd cell proliferation and induced cell apoptosis in human non-small-cell lung carcinoma (NSCLC) cells. We found that MAN treatment dysregulated mitochondrial function and led to mitochondrial apoptosis in A549 and PC9 cells. Meanwhile, MAN enhanced autophagy flux by the increase of autophagosome formation, the fusion of autophagsomes and lysosomes and lysosomal function. Moreover, mTOR signaling pathway, a classical pathway regualting autophagy, was inhibited by MAN in a time- and dose-dependent mannner, resulting in autophagy induction. Interestingly, autophagy inhibition by CQ or Atg5 knockdown attenuated cell apoptosis by MAN, indicating that autophagy serves as cell death. Furthermore, autophagy-mediated cell death by MAN can be blocked by reactive oxygen species (ROS) scavenger NAC, indicating that ROS accumulation is the inducing factor of apoptosis and autophagy. In summary, we revealed the molecular mechanism of MAN against lung cancer through apoptosis and autophagy, suggesting that MAN might be a novel therapeutic agent for NSCLC treatment.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 591-11-7. Recommanded Product: 591-11-7.

Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

In an article, author is Corre, Michelle F., once mentioned the application of 497-23-4, Recommanded Product: Furan-2(5H)-one, Name is Furan-2(5H)-one, molecular formula is C4H4O2, molecular weight is 84.07, MDL number is MFCD00005376, category is benzofurans. Now introduce a scientific discovery about this category.

Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands – Functional characterization and modeling studies on H-3 and H(4 )receptors

Histamine acts through four different receptors (H1R-H4R), the H3R and H4R being the most explored in the last years as drug targets. The H3R is a potential target to treat narcolepsy, Parkinson’s disease, epilepsy, schizophrenia and several other CNS-related conditions, while H4R blockade leads to anti-inflammatory and immunomodulatory effects. Our group has been exploring the dihydrobenzofuranyl-piperazines (LINS01 series) as human H3R/H4R ligands as potential drug candidates. In the present study, a set of 12 compounds were synthesized from adequate (dihydro)benzofuran synthons through simple reactions with corresponding piperazines, giving moderate to high yields. Four compounds (1b, 1f, 1g and 1h) showed high hH(3)R affinity (pK(i) > 7), compound 1h being the most potent (pK(i) 8.4), and compound if showed the best efficiency (pKi 8.2, LE 0.53, LLE 5.85). BRET-based assays monitoring G alpha(i) activity indicated that the compounds are potent antagonists. Only one compound (2c, pK(i) 7.1) presented high affinity for hH(4)R. In contrast to what was observed for hH(3)R, it showed partial agonist activity. Docking experiments indicated that bulky substituents occupy a hydrophobic pocket in hH(3)R, while the N-allyl group forms favorable interactions with hydrophobic residues in the TM2, 3 and 7, increasing the selectivity towards hH(3)R. Additionally, the importance of the indole NH in the interaction with Glu5.46 from hH(4)R was confirmed by the modeling results, explaining the affinity and agonistic activity of compound 2c. The data reported in this work represent important findings for the rational design of future compounds for hH(3)R and hH(4)R.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 497-23-4, Name is Furan-2(5H)-one, molecular formula is C4H4O2. In an article, author is Tian, Peng,once mentioned of 497-23-4, Computed Properties of C4H4O2.

Effects of different vegetable oils on the aroma characteristics of deep-fried shallot flavoring evaluated by HS-SPME/GC-MS coupled with PLSR

In this study, four fried shallot-flavored oil (FSO) samples prepared with different oil were analyzed by gas chromatography-mass spectrometry (GC-MS), descriptive sensory analysis (DSA), and electronic nose (E-nose). A total of 75 volatile compounds were identified, and 44, 34, 32, and 25 of these compounds were found in the FSOs with rapeseed oil, peanut oil, soybean oil and sunflower oils, respectively, which were conducted for comparison and evaluation of the aroma characteristics of FSOs. Seven sensory attributes (oily, pungent, cooked vegetable, grease, burnt, pickled, and shallot scent) were chosen to evaluate FSOs. DSA results showed a significant difference among these FSO samples for shallot scent and grease, and FSO2 heated by peanut oil presented strong in these two notes, but weaker in burnt, FSO3 also has the weaker burnt flavor. Moreover, E-nose analysis confirmed the results of GC-MS and DSA. Results of correlation analysis partial least squares regression (PLSR) among 50 volatile compounds and DSA data, indicated that 2-Ethyl-3,5-dimethyl-pyrazine, 2,3-Dihydro-benzofuran, and benzaldehyde contribute to grease flavor; 2-Ethyl-3,5-dimethyl-pyrazinemay contribute to shallot scent flavor, and further confirmed that peanut oil may be a suitable carrier oil for the sensory characteristics of FSO. Practical applications The unique shallot flavor and rich fat fragrance of FSO play an increasingly important role in the cooking and processing of dishes. However, there is relatively little research on FSO. In this study, FSO prepared by different types of oil can produce different flavor of FSO with dissimilar volatiles and sensory characteristics. We used PLSR to analyze the relationship between sensory attributes and compounds. These research contents will provide a basis for the industrialization of fried shallot oil.

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Reference:
Benzofuran – Wikipedia,
,Benzofuran | C8H6O – PubChem