Tag: 366.3194

Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection was written by Zhang, Yimin;Chen, Zhiyong;Xu, Xiaokun;Zhou, Qiang;Liu, Xiaolong;Liao, Liping;Zhang, Zijia;Wang, Zhengtao. And the article was included in Journal of Separation Science in 2017.Category: benzofurans This article mentions the following:

Psoraleae Fructus is one of the most popular traditional Chinese medicines. Coumarins, flavonoids, and meroterpenes are the main contributors to the biol. activity of Psoraleae Fructus. In this study, a new method for the quality control of Psoraleae Fructus was developed, through the quant. anal. of multicomponents by single marker with diode array detector. Thirteen components, including psoralenoside, isopsoralenoside, psoralen, isopsoralen, psoralidin, neobavaisoflavone, bavachin, corylin, isobavachalcone, corylifol A, bavachinin, bavachalcone, and bakuchiol were rapidly separated and identified within 12 min by the newly developed method. The feasibility and reliability of this method were corroborated. The method was also compared to the external standard method and detection by corona charged aerosol detector. The results of percent difference (%) and cos (θ) have shown that there were no significant differences observed between the quant. anal. of multicomponents by single marker and external standard method analyses; psoralen and isopsoralen were undetectable with the corona charged aerosol detector due to their but the sensitivity for all the compounds except bakuchiol detected by corona charged aerosol detector are higher than those obtained by diode array detector. In addition, the newly method developed was applied to the quality evaluation of Chinese patent medicines containing Psoraleae Fructus. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Category: benzofurans).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Establishment of a UPLC-MS/MS Method for studying the effect of salt-processing on tissue distribution of twelve major bioactive components of qing’e pills in rats was written by Hou, Jingxia;Lin, Shangyang;Lu, Jinlan;Wu, Yu;Wu, Li;Chen, Zhipeng;Li, Weidong. And the article was included in Journal of Analytical Methods in Chemistry in 2020.Application of 905954-17-8 This article mentions the following:

Qing’e pills is clin. used for treating osteoporosis in postmenopausal women in China. Eucommiae Cortex and Psoraleae Fructus are the main herbs of Qing’e pills and are both required to be salt-processed. In order to study the influence of salt-processing on the tissue distribution of Qing’e pills, a UPLC-MS/MS method was established for studying the tissue distribution of 12 main bioactive ingredients of Qing’e pills in rats. The linear relationships of the 12 compounds in each tissue were good. The method was fully validated for its selectivity, accuracy, precision, stability, matrix effect, and extraction recovery. Then, the validated method was successfully applied for simultaneous determination of the 12 chem. components in Qing’e pills in tissues for the first time. Areas under the curve (AUC) results showed that, except for pinoresinol diglucoside, psoralen, and isopsoralen, the distribution of the other components was increased in the kidney, uterus, ovary, and testes. Relative targeting efficiency (RTE) results showed that all 12 chem. components targeted the kidney and sexual organs. The results indicated that the Eucommiae Cortex and Psoraleae Fructus after salt-processing could significantly increase the distribution of components to the kidney and generative organs. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Application of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Transitional features of benzofuran glycosides part from Psoraleae Fructus in rat plasma was written by Yan, Dong-mei;Gao, Xiu-mei;Kang, Li-yuan;Wang, Yue-fei;Chang, Yan-xu. And the article was included in Zhongguo Shiyan Fangjixue Zazhi in 2015.Related Products of 905954-17-8 This article mentions the following:

Objective: To investigate transitional features of rat plasma after administration of benzofuran glycosides part from Psoraleae Fructus. Methods: A HPLC-UV method was established to determine contents of psoralenoside and isopsoralenoside in rat plasma after administration of benzofuran glycosides part, mobile phase composed of acetonitrile and 0.1% formic acid water in gradient elution, detection wavelength was set at 246 nm. Plasma concentration-time data were treated with SPSS 11.0 software. Results: Psoralenoside and isopsoralenoside appeared in plasma after 15 min of administration of benzofuran glycosides with 0.003 g·g^-1, and reached the peak concentration in 1.5 h, also their metabolites (psoralen and isopsoralen) were found in plasma. Conclusion: Specificity and characteristic of plasma HPLC were good, which was successfully used for quantification of psoralenoside and isopsoralenoside in rat plasma after administration of benzofuran glycosides part, benzofuran glycosides could be transformed into corresponding coumarins in rat. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Related Products of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Variation of 4 kinds of compounds in psoralea corylifolia processed by different methods was written by Song, Xiao;Qi, Aidi;Wang, Yuefei;Jing, Yakun;Chai, Xin;Liu, Yanan. And the article was included in Zhongguo Zhongyao Zazhi in 2011.Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid This article mentions the following:

An efficient method for simultaneous quantification of 7 compounds belonging to 4 chem. types in Psoralea corylifolia processed by different methods was presented to elucidate variations of 4 kinds of compounds in different processed P. corylifolia. The chromatog. separation was performed on an ACUITY C₁₈ column using acetonitrile and 0.1% formic acid aqueous solution in the gradient elution at 0.4 mL/min^-1. Detection wavelength was set at 246 nm. Column temperature was fixed at 50°. The 4 kinds of compounds, including psoralenoside, isopsoralenoside (benzofuran glycosides), psoralen, isopsoralen, psoralidin (coumarins), bavachin (flavonoids), and bakuchiol (meroterpenes), were separated in 25 min. The correlation coefficients of those compounds were over 0.999 3 in the tested range. The intra-and inter-day precisions were below 1.5%. The average recoveries ranged from 99.2% to 106%. This method is simple, rapid, and accurate, which can be used for the determination of the 4 kinds of compounds in different processed P. corylifolia. In P. corylifolia processed by different methods, the contents of benzofuran glycosides, flavonoids, and meroterpenes in P. corylifolia processed by Leigong’s method are decreased obviously, while the contents of psoralen and isopsoralen are increased significantly. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection was written by Zhang, Yimin;Chen, Zhiyong;Xu, Xiaokun;Zhou, Qiang;Liu, Xiaolong;Liao, Liping;Zhang, Zijia;Wang, Zhengtao. And the article was included in Journal of Separation Science in 2017.Category: benzofurans This article mentions the following:

Psoraleae Fructus is one of the most popular traditional Chinese medicines. Coumarins, flavonoids, and meroterpenes are the main contributors to the biol. activity of Psoraleae Fructus. In this study, a new method for the quality control of Psoraleae Fructus was developed, through the quant. anal. of multicomponents by single marker with diode array detector. Thirteen components, including psoralenoside, isopsoralenoside, psoralen, isopsoralen, psoralidin, neobavaisoflavone, bavachin, corylin, isobavachalcone, corylifol A, bavachinin, bavachalcone, and bakuchiol were rapidly separated and identified within 12 min by the newly developed method. The feasibility and reliability of this method were corroborated. The method was also compared to the external standard method and detection by corona charged aerosol detector. The results of percent difference (%) and cos (θ) have shown that there were no significant differences observed between the quant. anal. of multicomponents by single marker and external standard method analyses; psoralen and isopsoralen were undetectable with the corona charged aerosol detector due to their but the sensitivity for all the compounds except bakuchiol detected by corona charged aerosol detector are higher than those obtained by diode array detector. In addition, the newly method developed was applied to the quality evaluation of Chinese patent medicines containing Psoraleae Fructus. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Category: benzofurans).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. Substituted benzofurans find applications such as fluorescent sensors, oxidants, in drug discovery, and in another field of chemistry and agriculture.Category: benzofurans

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Establishment of a UPLC-MS/MS Method for studying the effect of salt-processing on tissue distribution of twelve major bioactive components of qing’e pills in rats was written by Hou, Jingxia;Lin, Shangyang;Lu, Jinlan;Wu, Yu;Wu, Li;Chen, Zhipeng;Li, Weidong. And the article was included in Journal of Analytical Methods in Chemistry in 2020.Application of 905954-17-8 This article mentions the following:

Qing’e pills is clin. used for treating osteoporosis in postmenopausal women in China. Eucommiae Cortex and Psoraleae Fructus are the main herbs of Qing’e pills and are both required to be salt-processed. In order to study the influence of salt-processing on the tissue distribution of Qing’e pills, a UPLC-MS/MS method was established for studying the tissue distribution of 12 main bioactive ingredients of Qing’e pills in rats. The linear relationships of the 12 compounds in each tissue were good. The method was fully validated for its selectivity, accuracy, precision, stability, matrix effect, and extraction recovery. Then, the validated method was successfully applied for simultaneous determination of the 12 chem. components in Qing’e pills in tissues for the first time. Areas under the curve (AUC) results showed that, except for pinoresinol diglucoside, psoralen, and isopsoralen, the distribution of the other components was increased in the kidney, uterus, ovary, and testes. Relative targeting efficiency (RTE) results showed that all 12 chem. components targeted the kidney and sexual organs. The results indicated that the Eucommiae Cortex and Psoraleae Fructus after salt-processing could significantly increase the distribution of components to the kidney and generative organs. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Application of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives.Benzofuran is one of the most significant oxygen-containing heterocycles consisting of fused benzene and furan ring, which are widely presented in various naturally occurring and synthetically active compounds. As benzofurans are prone to undergo ring opening of the heterocycle, examples of reduction of this type of aromatics by using dissolving metals are rather scarce.Application of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Transitional features of benzofuran glycosides part from Psoraleae Fructus in rat plasma was written by Yan, Dong-mei;Gao, Xiu-mei;Kang, Li-yuan;Wang, Yue-fei;Chang, Yan-xu. And the article was included in Zhongguo Shiyan Fangjixue Zazhi in 2015.Related Products of 905954-17-8 This article mentions the following:

Objective: To investigate transitional features of rat plasma after administration of benzofuran glycosides part from Psoraleae Fructus. Methods: A HPLC-UV method was established to determine contents of psoralenoside and isopsoralenoside in rat plasma after administration of benzofuran glycosides part, mobile phase composed of acetonitrile and 0.1% formic acid water in gradient elution, detection wavelength was set at 246 nm. Plasma concentration-time data were treated with SPSS 11.0 software. Results: Psoralenoside and isopsoralenoside appeared in plasma after 15 min of administration of benzofuran glycosides with 0.003 g·g^-1, and reached the peak concentration in 1.5 h, also their metabolites (psoralen and isopsoralen) were found in plasma. Conclusion: Specificity and characteristic of plasma HPLC were good, which was successfully used for quantification of psoralenoside and isopsoralenoside in rat plasma after administration of benzofuran glycosides part, benzofuran glycosides could be transformed into corresponding coumarins in rat. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Related Products of 905954-17-8).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofurans are only weakly aromatic in nature and they are cleaved by many oxidative and reductive conditions. Benzofurans are stable towards alkali and readily polymerize on treatment with sulfuric acid, due to which they are useful for the preparation of low cost chemically relatively inert resins.Related Products of 905954-17-8

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem

Variation of 4 kinds of compounds in psoralea corylifolia processed by different methods was written by Song, Xiao;Qi, Aidi;Wang, Yuefei;Jing, Yakun;Chai, Xin;Liu, Yanan. And the article was included in Zhongguo Zhongyao Zazhi in 2011.Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid This article mentions the following:

An efficient method for simultaneous quantification of 7 compounds belonging to 4 chem. types in Psoralea corylifolia processed by different methods was presented to elucidate variations of 4 kinds of compounds in different processed P. corylifolia. The chromatog. separation was performed on an ACUITY C₁₈ column using acetonitrile and 0.1% formic acid aqueous solution in the gradient elution at 0.4 mL/min^-1. Detection wavelength was set at 246 nm. Column temperature was fixed at 50°. The 4 kinds of compounds, including psoralenoside, isopsoralenoside (benzofuran glycosides), psoralen, isopsoralen, psoralidin (coumarins), bavachin (flavonoids), and bakuchiol (meroterpenes), were separated in 25 min. The correlation coefficients of those compounds were over 0.999 3 in the tested range. The intra-and inter-day precisions were below 1.5%. The average recoveries ranged from 99.2% to 106%. This method is simple, rapid, and accurate, which can be used for the determination of the 4 kinds of compounds in different processed P. corylifolia. In P. corylifolia processed by different methods, the contents of benzofuran glycosides, flavonoids, and meroterpenes in P. corylifolia processed by Leigong’s method are decreased obviously, while the contents of psoralen and isopsoralen are increased significantly. In the experiment, the researchers used many compounds, for example, (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid).

(Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid (cas: 905954-17-8) belongs to benzofurans derivatives. Benzofuran is the “”parent”” of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. They are also prone to polymerisation in the presence of concentrated mineral acids and Lewis acids.Safety of (Z)-3-(6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzofuran-5-yl)acrylic acid

Referemce:
Benzofuran – Wikipedia,
Benzofuran | C8H6O – PubChem